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-In vitro permeation profiles of patches formulations with the best adhesives. The results are expressed as mean ± SEM (n=6).
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Few topical products have been developed specifically to treat acute and chronic arthritis and inflammation, using non-steroidal anti-inflammatory drugs (NSAIDs). The lack of dosing accuracy commonly found in locally applied semisolid products for cutaneous use is a critical issue that leads to treatment failure. The aim of the present work is to d...
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Context 1
... assess the impact of the adhesive polymer on IBU amount permeated from patches, another in vitro skin permeation study was performed, now taking the formulation without adhesive (F 2 ) and the commercial one (Ozonol) as references (Figure 4). Unexpectedly, the results achieved in the permeation studies reversed the release profiles obtained in Figure 3. ...
Citations
... Patch thickness is an important parameter for transdermal drug delivery systems (TDDS) and it plays a vital role in applicability, physicochemical properties, and drug release kinetics [34,37]. As the majority of the published studies on transdermal patches have been reported with patch thickness of 100 μm to ~ 800 μm, we have chosen 100 μm as the minimum thickness [28,29,33,34]. ...
Herein, we report ethosome (ET) formulations composed of a safe amount of 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine (DMPC)-based ionic liquid with various concentrations of ethanol as a carrier for the transdermal delivery of a high molecular weight drug, insulin. The Insulin-loaded ET vesicles exhibited long-term stability compared to conventional DMPC ETs, showing significantly higher drug encapsulation efficiency and increased skin permeation ability.
... This feature makes it a cleaner, simpler, and safer application. Moreover, transdermal patches offer convenience by reducing the frequency of application to only once a week [53]. However, transdermal dosage forms have limits that can result in agglomeration and skin irritation [31]. ...
Objective: Proper wound care is essential to prevent complications and worsening of the injured patient. Everyone in the family needs to possess wound care knowledge, especially the mother, who plays a role in making decisions about health care and family health behaviors. This study aims to evaluate mothers' knowledge towards wound care in the Greater Bandung Area. Methods: This cross-sectional study involved 100 participants with varied backgrounds and had met the inclusion criteria. The study was conducted using questionnaires distributed online to the mother community living in the Greater Bandung Area, West Java, then data processing and analysis were carried out. Results: The results showed that mothers in the Greater Bandung Area had a good level of knowledge (27%), average (52%), and less (21%). In addition, plasters with wound care solutions were still the mothers' main choice in wound care. Nevertheless, there are many choices of pharmaceutical dosage forms for wound care that have been developed today to optimize the wound healing process. Conclusion: Most of the mothers already have an average level of knowledge to good. However, there are still quite a lot of mothers who have a lack of knowledge related to wound care. Therefore, educational programs must be developed to raise awareness about wound care and management, as well as knowledge about pharmaceutical dosage forms for wound care.
3D printing technologies, also referred to as additive manufacturing or rapid prototyping have gained attention over the past few years for tissue engineering, the printing of artificial organs and the bioprinting of 3D hydrogels for wound dressings applications. 3D printing can transform the virtual 3D model created by computer-aided design into layer-by-layer physical 3D objects by using different 3D printing technologies. Wounds are a major health fear which affects the lives of people. So, delay in the treatment can lead to the development of chronic wounds which may even lead to mortality. Recently, 3D printing technology is an emerging platform in the development the smart wound dressings which can be loaded with a variety of materials (antibiotics, antibacterial drugs and nanoparticles) that can help accelerate the wound healing rate. Hydrogels have been widely used in wound healing, as they are biocompatible, non-toxic materials. This review mainly focuses on the hydrogel-based biomaterial used in 3D bioprinting and their potential use as a wound healing material. The materials for 3D printing of hydrogels, such as synthetic polymers and natural polymers used as wound dressings are mainly discussed. It covers various 3D bioprinting technologies which include laser printing, stereolithography, extrusion printing, fused disposition printing, and inkjet printing. It also provides a comprehensive overview of the physical, mechanical and biological properties of biomaterial, enabling them as an ideal biomaterial for 3D printing. An outlook on applications and future prospects of hydrogel-based 3D printing is presented.
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