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... (plants) and ergosterol (fungi and protozoans among them being T. cruzi). Biosynthesis of these compounds follows the same route until the formation of squalene, where phytosterol fol- lows an exclusive pathway. The synthesis of ergosterol and cholesterol shares common steps up to lanosterol formation after which specific pathways emerge (Fig. 3). Enzymes that act on sterol biosynthesis of parasites are potential targets for chemotherapy of T. cruzi infection. Sterol biosynthesis in- hibitors (SBI) have been found to be particularly useful, as endogenous sterols are essential for the survival of these pathogenic parasites [46]. Four classes of SBI were tested in vitro and/or in ...
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... the three classes of drugs described above follow the steps of ergosterol biosynthesis common in cho- lesterol biosynthesis (Figs. 3 and 4) and their use in humans could be dangerous due to side effects for the host cells. On the other hand, after lanosterol synthesis, the next steps for cholesterol or ergosterol biosyntheses follow exclusive ways, involving production of distinct compounds and the partici- pation of specific enzymes. In recent years, ergosterol bio- ...
