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... of sodium acetate [8]. The resultant mixture was continued for reflux up to 3 h, cooled the mixture and 25 ml of water was added, followed by extraction with ethyl acetate (30 ml × 2). The organic layer was separated, dried over magnesium sulfate and dried thoroughly to attain desired flavanone derivatives (FA1-FA13 & HFA1-HFA7) as mentioned in Fig. (1). The title compounds were recrystallized using aqueous ethanol. Table 1 illustrated the substitution pattern of synthesized ...
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... the results, it was found that synthesized analogues exhibited IC 50 values in the range between 54.8±0.51 and 131.6±0.93 compared to standard acarbose (21.2±0.64). ADME properties and drug-likeness scores of the synthesized compounds (FA1-FA13 & HFA1-HFA7) t o a n y o n e o r a n y w h e r e . ...
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... TBARS level, CAT levels are also increased in the rats treated with synthesized flavanones HFA5 & HFA7 (HFA5: 40.8 micromoles; HFA6:39.2 micromoles) and standard tested (41.2 micromoles). In addition, Table 4. Toxicity prediction of synthesized compounds (FA1-FA13 & HFA1-HFA7) t o a n y o n e o r a n y w h e r e . Fig. (2). ...
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... per the protocol, the chalcones were prepared and cyclized to form novel flavanones (FA1-FA13 & HFA1- HFA7). The synthesized candidates were characterized by various spectroscopic techniques such as UV, IR, H 1-NMR, C 13 -NMR and GCMS. ...
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... reason behind this is π→π * and n→π * transitions due to the presence of α, β unsaturated carbonyl groups in the title compounds. In IR spectroscopy, C-Cl stretching of flavanones (FA1, FA2, FA3, HFA2 & HFA3) produced their absorbance in the region of 609-680 cm -1 . A peak at 1352-1365 cm -1 in IR spectroscopy confirms the presence of Ar-NO 2 stretching in compound FA5 & FA11. ...
