Figure 1 - uploaded by Julia Borowczyk
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Expression of SSEA-4 antigen in human apocrine and eccrine sweat glands. Immunohistochemical detection of SSEA-4 antigen expression within (a) the entire apocrine and (b) eccrine sweat glands. Inserts show magnified views of respective parts of glands. Schematic illustrations of two types of sweat glands are included. (c) Major features of eccrine and apocrine sweat glands in humans. HF, hair follicle; SG, sebaceous gland; SSEA-4, stage-specific embryonic antigen-4. Scale bars ¼ 100 mm (low magnification) and 50 mm (high magnification). The ImageJ Stitching Plugin was used for image reconstruction (Preibisch et al., 2009).
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Citations
... Apocrine sweat glands and eccrine sweat glands are different in the distribution, structure and function. [7][8][9][10] In humans, apocrine sweat glands are mainly distributed in the axillae, ear canal, breast, eyelid, inguinal and perineal, and are associated with hair follicles. 5,7,11 Apocrine sweat glands are present at birth and do not become active until puberty, but little is known about their function in humans. ...
... 7,8,10 Morphologically, the ducts of the two glands are roughly similar and difficult to distinguish, while the secretory coils of the apocrine sweat glands and the eccrine sweat glands are different. 6,9,12 Generally, the lumens of the apocrine secretory coils are larger, while the lumens of the eccrine secretory coils are smaller. 7,8,10 Apocrine secretory coils have variable appearances in tissue sections, making it sometimes difficult to distinguish apocrine and eccrine sweat glands. ...
Bromhidrosis has a great negative impact on personal occupation and social psychology. It is not yet clear whether bromhidrosis is caused by apocrine sweat glands or the co-action of apocrine sweat glands and eccrine sweat glands. To distinguish between apocrine sweat glands and eccrine sweat glands, specific antigen markers for apocrine sweat glands and eccrine sweat glands must be found first. In the study, we detected the expression of K7, K18, K19, Na+-K+-2Cl- cotransporter 1 (NKCC1), carbonic anhydrase II (CAII), Forkhead transcription factor a1 (Foxa1), homeobox transcription factor engrailed homeobox1 (En1), gross cystic disease fluid protein-15 (GCDFP-15), mucin-1 (MUC-1), cluster of differentiation 15 (CD15) and apolipoprotein (APOD) in eccrine sweat glands and apocrine sweat glands by immunofluorescence staining. The results showed that K7, K18, K19, Foxa1, GCDFP-15 and MUC-1 were expressed in both apocrine and eccrine sweat glands, CD15 and APOD were only expressed in apocrine sweat glands, and CAII, NKCC1 and En1 were only expressed in eccrine sweat glands. We conclude that CD15 and APOD can serve as specific markers for apocrine sweat glands, while CAII, NKCC1 and En1 can serve as specific markers for eccrine sweat glands to differentiate the two sweat glands.
... Apocrine sweat glands and eccrine sweat glands are different in the distribution, structure and function (Lu and Morphologically, the ducts of the two glands are roughly similar and di cult to distinguish, while the secretory coils of the apocrine sweat glands and the eccrine sweat glands are different (Semkova et al. 2015;Wilke et al. 2006;Borowczyk-Michalowska et al. 2017). Generally, the lumens of the apocrine secretory coils are larger, while the lumens of the eccrine secretory coils are smaller (Lu and Fuchs 2014;Sato et al. 1989;Lin et al. 2021). ...
Bromhidrosis has a great negative impact on personal occupation and social psychology. It is not yet clear whether bromhidrosis is caused by apocrine sweat glands or the co-action of apocrine sweat glands and eccrine sweat glands. To distinguish between apocrine sweat glands and eccrine sweat glands, specific antigen markers for apocrine sweat glands and eccrine sweat glands must be found first. In the study, we detected the expression of K7, K18, K19, Na ⁺ -K ⁺ -2Cl ⁻ cotransporter 1 (NKCC1), carbonic anhydrase II (CAII), Forkhead transcription factor a1 (Foxa1), homeobox transcription factor engrailed homeobox1 (En1), gross cystic disease fluid protein-15 (GCDFP-15), mucin-1 (MUC-1), cluster of differentiation 15 (CD15) and apolipoprotein (APOD) in eccrine sweat glands and apocrine sweat glands by immunofluorescence staining. The results showed that K7, K18, K19, Foxa1, GCDFP-15 and MUC-1 were expressed in both apocrine and eccrine sweat glands, CD15 and APOD were only expressed in apocrine sweat glands, and CAII, NKCC1 and En1 were only expressed in eccrine sweat glands. We conclude that CD15 and APOD can serve as specific markers for apocrine sweat glands, while CAII, NKCC1 and En1 can serve as specific markers for eccrine sweat glands to differentiate the two sweat glands.
