Figure 1 - uploaded by Badri Man Shrestha
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12: Electron microscopy showing (A) A normal glomerulus (E: endothelial cell; P: podocytes; Lumen: capillary lumen); and (B) Transplant glomerulopathy with presence of a well-developed basement membrane (BM) along the entire capillary circumference, mesangial expansion (M) and accumulation of subendothelial deposit (D) (Source: Northern General Hospital, Sheffield).
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INTRODUCTION: Chronic allograft nephropathy (CAN), the leading cause of kidney transplant failure, is associated with progressive interstitial fibrosis, tubular atrophy, glomerulosclerosis and obliterative arteriolopathy, which are secondary to expansion of the extracellular matrix (ECM). Experimental rat models of renal transplantations (RT) have...
