Figure - available from: Dermatologic Therapy
This content is subject to copyright. Terms and conditions apply.
Effects of Momordica charantia treatment on natural aging of the mouse dorsal skin. At the end of the study, we measured body weights (A, D), transepidermal water loss (TEWL) (B, E), corneometer values (C, F), skin thicknesses (G, H), wrinkle scores (I, J), and the expression of collagen (K, L) in the dorsal skin of male and female hairless mice. Blue and red columns correspond to male and female mice, respectively. MC, Momordica charantia. The values are expressed as means ± SD derived from six animals. *P < .05. Scale bar = 100 μm
Source publication
Although various methods for improving the natural aging of skin have been examined, an effective method is currently unavailable. Therefore, in this study, we investigated the effects of Momordica charantia on the natural aging of skin of mice and how sex differences influenced these effects. To this end, we bred female and male hairless mice with...
Similar publications
Epicutaneous exposure to allergenic proteins is an important sensitization route for skin diseases like protein contact dermatitis, immunologic contact urticaria, and atopic dermatitis. Environmental allergen sources such as house dust mites contain proteases, which are frequent allergens themselves. Here, the dependency of T-helper (TH) cell recal...
Citations
... Furthermore, we have repeatedly investigated the effects of gender differences on natural aging [7,8]. A comparison of males and females showed that females suppressed aging more, and that estradiol was involved in this effect. ...
Background:
Lactic acid bacteria consumption serves several health benefits to humans. However, their effect on natural skin aging is still unclear.
Methods:
This study examined the effects of skin naturalization (particularly skin drying) by administering a spore-bearing lactic acid bacteria (Bacillus coagulans) in mice for 2 years.
Results:
B. coagulans administration improved the natural skin of mice and significantly increased proportions of the genera Bacteroides and Muribaculum, among other intestinal bacteria. As metabolites, increases in nicotinic acid, putrescin, and pantothenic acid levels and a decrease in choline levels were observed. Increased hyaluronic acid, interleukin-10, and M2 macrophage levels indicate aging-related molecules in the skin. Intestinal permeability was also suppressed. Thus, these changes together improved natural skin aging.
Conclusions:
This study revealed that B. coagulans administration improved the natural skin aging in mice. This enhancement might be induced by the interaction of alterations in intestinal flora, metabolites, or inflammatory substances.
... As for the countries where the experiments were conducted, China had the most cases (n = 20) [8,9,13,15,16,19,23,[26][27][28][29][30]32,36,38,39,[46][47][48][49], followed by Japan (n = 8) [12,20,[40][41][42][43][44][45], Korea (n = 6) [24,31,[33][34][35]37] and Taiwan (n = 3) [21][22][23]. Thailand [18], the United States [17], Mexico [11] and Poland [25] were each associated with one study. ...
... The animals used in the experiments were Sprague-Dawley rats (n = 15) [11,[13][14][15][16]18,22,24,29,30,[32][33][34][35]47], C57BL/6 mice (n = 8) [8,10,28,31,36,[44][45][46], Kunming mice (n = 4) [19,23,26,27], ICR mice (n = 3) [9,39,48], senescence-accelerated mouse-prone 8 (SAMP8) mice (n = 3) [12,20,40], BALB/c mice (n = 2) [37,38], hairless mice (n = 2) [42,43], CB6F1 mice (n = 1) [17], Swiss mice (n = 1) [25], Wistar Kyoto rats (n = 1) [21], Wild-type and NPY knockout mice (n = 1) [44] and Klotho-hypomorphic (kl/kl/) mice (n = 1) [41]. Regarding sex, five studies used both male and female mice or rats [17,27,29,43,44]; four studies used only female mice or rats [28,[36][37][38]; and three studies did not mention the sex of the animals used [34,42,46]. ...
... The animals used in the experiments were Sprague-Dawley rats (n = 15) [11,[13][14][15][16]18,22,24,29,30,[32][33][34][35]47], C57BL/6 mice (n = 8) [8,10,28,31,36,[44][45][46], Kunming mice (n = 4) [19,23,26,27], ICR mice (n = 3) [9,39,48], senescence-accelerated mouse-prone 8 (SAMP8) mice (n = 3) [12,20,40], BALB/c mice (n = 2) [37,38], hairless mice (n = 2) [42,43], CB6F1 mice (n = 1) [17], Swiss mice (n = 1) [25], Wistar Kyoto rats (n = 1) [21], Wild-type and NPY knockout mice (n = 1) [44] and Klotho-hypomorphic (kl/kl/) mice (n = 1) [41]. Regarding sex, five studies used both male and female mice or rats [17,27,29,43,44]; four studies used only female mice or rats [28,[36][37][38]; and three studies did not mention the sex of the animals used [34,42,46]. The remaining studies used all male mice or rats. ...
Background:
The world's population is rapidly aging, and attention to and research on the increase in life expectancy and age-related diseases are needed. This study aimed to review the in vivo studies on the anti-aging effects of herbal medicines.
Methods:
In vivo studies of single or complex herbal medicines for anti-aging that were published in the last five years were included in this review. The following databases were used: PubMed, Scopus, ScienceDirect, Web of Science and EMBASE.
Results:
A total of 41 studies were considered eligible for the review. The articles were classified into body organs and functions, experimental country, herbal medicine, extraction method, administration route, dosage, duration, animal model, aging-induced method, sex, number of animals per group, and outcomes and mechanisms A single herbal extract was used in a total of 21 studies including Alpinia oxyphylla Miq., Acanthopanax senticosus and Lyceum barbarum, and a multi-compound herbal prescription was used in a total of 20 studies, including Modified Qiongyu paste, Wuzi Yanzong recipe, etc. Each herbal medicine had anti-aging effects on learning and memory, cognition, emotion, internal organs, gastrointestinal tracts, sexual functions, musculoskeletal function and so on. The common mechanisms of action were antioxidant and anti-inflammatory, and various effects and mechanisms for each organ and function were identified.
Conclusions:
Herbal medicine exhibited beneficial effects on anti-aging in various parts of the body and its function. Further investigation of the appropriate herbal medicine prescriptions and their components is recommended.
... Several medicinal properties of MC, including its hypoglycemic, anti-bacterial, anti-viral, anti-tumor, immunomodulatory, anti-oxidant, anti-diabetic, anthelmintic, antimutagenic, antilipolytic, antifertility, hepatoprotective, and anti-inflammatory activities, as well as anti-ulcerogenic, anti-oxidative, and immune-modulatory activities [13] [14] [15], have been studied. We previously reported that natural aging of the skin is ameliorated in MC-administered mice [16]. This effect due to MC administration is induced via the regulation of 17β-estradiol/mast cell/matrix metalloprotease (MMP)-1/hyaluronidase (HYAL) 2 and testosterone/mast cell/interleukin (IL)-33 signaling pathways. ...
The separation and identification of bioactive substances that come from natural resources have aroused increasing attention. Momordica charantia ( M. charantia ) has a variety of bio-activities, containing anti-oxidation, immune regulation, anti-tumor, radiation protection, anti-diabetes, and liver protection. After the extraction new substances from Momordica charantia , their treatment effect on lung cancer combined with Hedyotis diffusa was determined and the related mechanism was explored as well in this study. Firstly, the CCK-8 assay was conducted and the inhibition of the new substances combined with Hedyotis diffusa . Next, the real time RT-PCR was conducted and the relative expression of the VEGF in the cancer cells was determined. In addition, the complete chloroplast genome sequence of M. charantia is followed by the phylogenetic analysis.
