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Effect of ruscogenin on levels of proinflammatory cytokines in the serum of B(a)P-induced experimental animals. Results are expressed as mean ± S.D. for six mice in each group. Statistical significance at p < 0.05. * indicates compared with control group (group I); # indicates compared with group II
Source publication
Lung cancer, one of the most often diagnosed malignancies, is the top cause of death in both men and women globally. In both developed and emerging countries, high incidences of cancer are becoming a huge health burden. Natural resources, including plants, have always been a possible source of lead compounds in the identification of optimal medicat...
Citations
... In benzo[a]pyrene-challenged lung cancer model in mice, treatment with RUS (30 mg/kg i.g.) for 16 weeks reduced tumor induction by ameliorating factors associated with immunomodulatory effects. This effect was mediated via up-regulating serum immunoglobulin IgG and IgM levels and down-regulating IgA levels (Zhao et al., 2022). ...
Background:
Ophiopogon japonicus (Thunb.) Ker Gawl., a well-known Chinese herb, has been used in traditional Chinese medicine for thousands of years. Extensive in vitro and in vivo studies have shown that O. japonicus and its active compounds exhibit potential anticancer effects in a variety of cancer cells in vitro and suppress tumor growth and metastasis without causing serious toxicity in vivo.
Purpose:
This review aims to systemically summarize and discuss the anticancer effects and the underlying mechanisms of O. japonicus extracts and its active compounds.
Methods:
The review is prepared following the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Various scientific databases including Web of Science, PubMed, Scopus, and Chinese National Knowledge Infrastructure were searched using the keywords: Ophiopogon japonicus, tumor, cancer, carcinoma, content, pharmacokinetics, and toxicity.
Results:
O. japonicus extracts and the active compounds, such as ruscogenin-1-O-[β-d-glucopyranosyl(1→2)][β-d-xylopyranosyl(1→3)]-β-d-fucopyranoside (DT-13), ophiopogonin B, and ophiopogonin D, exert potential anticancer effects, including the induction of cell cycle arrest, activation of apoptosis and autophagy, and inhibition of metastasis and angiogenesis. In addition, the mechanisms underlying these effects, as well as the pharmacokinetics, toxicity and clinical utility of O. japonicus extracts and active compounds are discussed. Furthermore, this review highlights the research and application prospects of these compounds in immunotherapy and combination chemotherapy.
Conclusions:
The traditional herb O. japonicus and its phytochemicals could be safe and reliable anticancer drug candidates, alone or in combination with chemotherapeutic drugs. We hope that this review, which highlights the anticancer properties of O. japonicus, will contribute to drug optimization, therapeutic development, and future studies on cancer therapies based on this medicinal plant.
... In benzo[a]pyrene-challenged lung cancer model in mice, treatment with RUS (30 mg/kg i.g.) for 16 weeks reduced tumor induction by ameliorating factors associated with immunomodulatory effects. This effect was mediated via up-regulating serum immunoglobulin IgG and IgM levels and down-regulating IgA levels (Zhao et al., 2022). ...
