Figure 1 - available via license: CC BY-NC
Content may be subject to copyright.
Early-stage morphea. Pautrier-like collections and linear arrangement of lymphocytes in dermal-epidermal junction (H&E ×40).
Source publication
Morphea is a skin disorder characterized by thickening of dermis and subcutaneous tissues and loss of adnexal structures. In the early inflammatory stage of morphea, diagnostic histological findings are absent and this may lead to confusion with other inflammatory dermatoses such as mycosis fungoides (MF). We report two cases of early stage morphea...
Context in source publication
Context 1
... patients with erythematous to dusky violaceus patches presented to our outpatient clinic of dermatology. The first patient was a 27-year-old woman with an asymptomatic annular erythematous patch on her trunk measuring 4×4 centimeters with central poikiloderma and fine scale that first appeared three months ago. The patient was otherwise normal and physical examination was unremarkable. Skin biop- sy was performed and histopathologic examination demonstrated parakeratosis, acanthosis and obvious lymphocytic epi- dermotropism composed of activated lym- phocytes with large hyperchromatic nuclei and irregular nuclear contour that arranged in small pautrier-like collections with lin- ear arrangement in dermal-epidermal junc- tion (DEJ), which was suggestive for mycosis fungoides (Figure ...
Citations
... The early lesions of morphea clinically present as erythematous patches and plaques, while fully developed lesions are asymmetric sclerotic plaques. 2 Although morphea lesions are generally reported to be relatively large (>5 cm), 3 the clinical features of small-sized lesions (<5 cm) have been poorly discussed. In this study, we report two cases of small-sized superficial circumscribed morphea which probably represent the early lesion of the disease, and discuss the importance of early recognition of morphea. ...
Morphea is a rare fibrosing disorder of the skin and underlying tissues. To date, the size of morphea has not been adequately discussed. Here, we report two cases of small-sized superficial circumscribed morphea. Both cases clinically revealed single circumscribed, round to oval area of shiny sclerotic plaque at distal extremities. There are several options for the treatment of superficial circumscribed morphea, such as topical corticosteroid and phototherapy. The early recognition of small-sized morphea enables appropriate diagnosis and follow-up, leading to improve disease prognosis.
... Kelati et al. (18) also noticed the loss of pan-Tcell markers (CD2, CD5, and CD7) preferring a diagnosis of MF. Basir et al. (21) observed that tumor cells of M. fungoides regularly deficiency expression of CD7, and this is a valuable feature that helps in differentiating reactions from neoplastic procedures. However, Murphy et al. (22) noted that gradual loss of CD7-expression in BCID is the probable expansion outcome of antigenelected +CD4+CD7-T-cells. ...
Background: For primary cutaneous lymphoma, mycosis fungoides (MF) is the most prevalent form with skin-homing T cells plus clonal proliferation of CD4. In many CTCLs, thymocyte selection associated with the HMG-box (TOX) is an uncontrolled gene, together with MF in comparison with controls.
... Kelati et al. (18) also noticed the loss of pan-Tcell markers (CD2, CD5, and CD7) preferring a diagnosis of MF. Basir et al. (21) observed that tumor cells of M. fungoides regularly deficiency expression of CD7, and this is a valuable feature that helps in differentiating reactions from neoplastic procedures. However, Murphy et al. (22) noted that gradual loss of CD7-expression in BCID is the probable expansion outcome of antigenelected +CD4+CD7-T-cells. ...
Background: For primary cutaneous lymphoma, mycosis fungoides (MF) is the most prevalent form with skin-homing T cells plus clonal proliferation of CD4. In many CTCLs, thymocyte selection associated with the HMG-box (TOX) is an uncontrolled gene, together with MF in comparison with controls.
IntroductionMycosis fungoides (MF) is the most frequent subtype of primary cutaneous T cell lymphomas (pCTCL). The diagnosis may be particularly difficult in the early stages as well as in atypical and rare clinical presentations. Furthermore, MF may simulate a large variety of common dermatologic disorders and patterns, both histopathologically and clinically.MethodsA literature search was performed to provide a comprehensive update on the rare and atypical MF manifestations as well as the dermatoses and dermatological patterns that could be imitated by MF.ResultsA total of 114 publications were found describing a series of different dermatoses and dermatological patterns mimicked by MF, as well as some particular localizations of MF lesions and dermatoses that occur in preexisting MF lesions.Conclusions
The number of dermatoses that can be imitated by MF is ever-increasing. Patients with common dermatologic conditions that prove to be treatment refractory should be biopsied without delay, and sequentially as necessary, to prevent delay in diagnosis and progression of disease. Clinicopathologic correlation is the best way of diagnosis.
Cutaneous pseudolymphomas are a heterogeneous group of reactive lymphocytic infiltrates, which simulates cutaneous lymphomas clinically and histologically. Although in many cases the pathogenesis is not understood, a broad spectrum of different agents inducing pseudolymphomas has been reported. Cutaneous pseudolympomas are distinguished in four main groups: (a) nodular pseudolymphomas, (b) pseudo-mycosis fungoides (pseudo-MF) and simulators of other CTCLs, (c) other pseudolymphomas and (d) an intravascular pseudolymphoma. This article focuses on pseudolymphoma entities related to infections or inflammatory skin diseases. The integration of the clinical presentation and patients’ history is mandatory for the correct diagnosis.
