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This systematic review is aimed to identify, evaluate and summarize the role of oral Coenzyme Q10 supplementation in prevention and treatment of cardiovascular diseases (CVD). CoQ10 is concentrated primarily in the cellular mitochondria where it functions as a co-factor transferring electrons from Complex I to Complex II, III ultimately resulting i...
Context in source publication
Context 1
... essential step regulating the synthesis of CoQ10 seems to be the hydroxymethylglutaryl (HMG)-coenzyme A reductase reaction, common with a step in cholesterol synthesis. (Figure 2) Dietary Sources: Coenzyme Q10 is found naturally in dietary sources. It is present in a wide variety of food from animal and vegetable sources. ...
Citations
... The functions of CoQ10 extend beyond its role in the mitochondria, it functions as a potent anti-oxidant and anti-inflammatory [17,18]. Accumulating evidence suggests a beneficial role of CoQ10 supplementation on the metabolic status in patients with T2D and CVD [19,20]. ...
The prevalence of metabolic syndrome (MetS) has been rising alarmingly and it has now become a global concern causing an enormous economic burden on the health care system. MetS is generally linked to complications in lipid metabolism, oxidative stress and low grade inflammation. The aim of the current study was to evaluate the effect of rosuvastatin, co-enzyme Q10 (CoQ10), and their combination on blood pressure, blood sugar, dyslipidemia, and liver function in rats with MetS induced by high fructose and high fat diet (HF-HFD) and the possible underlying mechanism. Oral administration of rosuvastatin (10 mg/kg/day), CoQ10 (10 mg/kg/ day) and their combination for 4 weeks in HF-HFD-fed rats elevated serum high density lipoprotein and reduced glutathione. On the other hand, treatment with rosuvastatin, CoQ10 or their combination decreased the serum levels of malondialdehyde, triglycerides, total cholesterol, and low density lipoprotein-cholesterol as well as systolic blood pressure, body weight and fasting blood glucose level. In addition, the drugs or their combination declined serum pro-inflammatory cytokines, namely tumor necrosis factor-α and interleukin-1β. In conclusion, our results showed that rosuvastatin or CoQ10 protected against HF-HFD-induced MetS through the regulation of dyslipidemia, elevated blood glucose, elevated blood pressure, antioxidant defenses and inflammatory response. Rosuvastatin or CoQ10 also alleviated the impairment of liver function that was induced by HF-HFD. Interestingly , CoQ10 augmented rosuvastatin's effect in ameliorating MetS, via exerting synergistic modulatory effects on oxidative stress and inflammation. Thus, rosuvastatin and CoQ10 combination therapy may have possible applications in ameliorating metabolic disorders.
... CoQ10 has been reported to have an important role in various clinical aspects. It is known to exert beneficial effect under mitochondrial conditions and neurodegenerative, diabetes, cardiovascular, male infertility and a few other diseases (De Blasio et al., 2015;Maladkar et al., 2016;Yang et al., 2016). Pyo and Oh (2011) determined ubiquinone from various Korean fermented foods. ...
Background:
Multiple micronutrient supplementation has been suggested to have a role on health outcomes in patients with heart failure (HF), but the evidence is inconclusive.
Objective:
To elucidate the role of multiple micronutrient supplementation in heart failure we performed a comprehensive review of the literature.
Methods and results:
The search in databases included PUBMED (until June 2018) to detect randomized controlled trials (RCTs) and meta-analyzes that investigated the impact of micronutrient supplementation in HF.
Results:
With more than 2357 titles and abstracts reviewed, we included only the studies suitable for the final review. Whether alone or in combination, micronutrients have been found to improve the health outcomes of patients with HF by improving symptoms, work capacity and left ventricular ejection fraction (LVEF), thus increasing the quality of life in these patients.
Conclusion:
Future studies are needed to document the effects of multiple micronutrient associations in order to include them in nutritional guidelines to increase survival and to improve quality of life in patients with heart failure.
