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CR and Cellular Pathways for Longevity Promotion-Various metabolic alterations in Body fat mass, Cytokines, IIS signaling, Thyroid hormones and Adiponection levels, accompanied by Activation of SIRT1, PI3K/Akt and Erk ½ signaling, and Activation of Stress defence plus Survival Pathways and Attenuation of Proinflammatory mediators.
Source publication
CR - THE CONCEPT: The energy needs are determined by the body composition, especially the fat free lean mass and level of physical activity, and there is a change in nutritional needs during the middle age and later. The diet-gene interaction is a major determinant of health and illness, and the amount and type of food ingestion and caloric intake,...
Similar publications
METABOLIC DISEASE AND AGING: There is increasing evidence that metabolic disequilibrium and disorders influence the aging process and survival including the quality of life (QOL). The adipose tissue mediates various age-associated metabolic disorders such as insulin resistance (IR), metabolic syndrome (MetS), dyslipidemia and type 2 diabetes mellit...
CR - THE CONCEPT: The energy needs are determined by the body composition, especially the fat-free lean mass and level of physical activity, and there is a change in nutritional needs during the middle age and later. The diet-gene interaction is a major determinant of health and illness, and the amount and type of food ingestion and caloric intake,...
Citations
Purpose
Calorie restricted diets are known to improve health and promote healthy aging. This happens because of controlled inflammation and metabolism in the body. This study aims to evaluate the differences in anthropometric and biochemical parameters in Sprague Dawley (SD) rats because of consumption of a calorie restricted diet.
Design/methodology/approach
The study divided SD rats ( n = 15) into 3 groups consuming high calorie intake (HCI), medium calorie intake and low calorie intake (LCI). Anthropometric parameters were determined through measurement of abdominal circumference (AC), thoracic circumference (TC), body length and body weight (BW). Biochemical parameters analyzed in this study were fasting blood glucose level and full blood lipid profile. Nutritional status was obtained based on food consumption, energy intake (EI) and food efficiency rate. Measurements were taken for a period of four weeks.
Findings
Analysis on anthropometric parameters indicates a significant difference in mean BW between HCI (230.44 ± 1.47 g) and LCI (188.54 ± 1.50 g). There is a significant difference in abdominal TC ratio ( p < 0.001; F = 13.599) in the LCI group (1.01 ± 0.00714) compared to the HCI group (1.04 ± 0.00858). Post hoc for nutrition parameters indicates a significant difference in mean EI between HCI (9.71 ± 0.006 kJ) and LCI (3.21 ± 0.001 kJ). There is a significant effect ( p < 0.0001; F = 3042872.02) of EI on rats in all three groups. HDL levels were significantly higher ( p < 0.0001; F = 1536.89) in the LCI group (68.60 ± 0.55 mg/dL) compared to the HCI group (49.40 ± 0.55 mg/dL). The Pearson’s correlation results show a strong positive correlation in EI with BW ( p < 0.01; r = 0.988), AC ( p < 0.01; r = 0.970) and body mass index ( p < 0.01; r = 0.972).
Originality/value
Low calorie diet has been proven to affect anthropometric development and has shown improvements in biochemical parameters of the rats. This may result in healthy aging which could prevent later-life diseases.
