Fig 4 - uploaded by Ilham Bunyan
Content may be subject to copyright.
Source publication
Uropathogenic E.coli (UPEC) is the source of numerous toxins that cause nosocomial and community-acquired UTIs,including -hemolysin, a secreted lipoprotein that is a powerful and ubiquitous cytolysin that belongs to the (RTX) family.Between March 2021 to December 2021, 123urine samples were collected from patients with urinary tract infectionswho w...
Context in source publication
Context 1
... HlyA gene in Figure 4 has several mutations in different locations, which may help to explain why some strains do not exhibit its function despite having the gene present in bacteria. Differences in the size and number of hospitals analyzed, the season of sample collection, and medications taken previous to sampling may all be factors in the discrepancy in isolate percentages expressing HlyA. ...
Citations
... Most of the tumor cells acquire the ability to resist apoptotic stimuli. Tumor cell survival can be induced by inactivating the proapoptotic signaling or activating the anti-apoptotic pathways [7][8][9]. One of the important pathways in the process of apoptosis is guided by Caspases; they are a family of genes that regulate homeostasis by regulating cell mortality and inflammation. ...
Glioblastoma multiform (GBM) is an invasive cancer that causes high mortality in patients. Disruption of the apoptosis process is one of the main pathogenesis of the disease. Recently, LncRNAs and miRNAs have been shown to play an important role in the process of apoptosis. To follow the aim of study, 100 patients participated in the two groups of 50 individuals, including 50 GBM patients and 50 healthy individuals as the control group. Mononuclear cells were isolated from peripheral blood samples and RNA extraction was done. The expression changes of miR-17-5p, miR-20-5p, LINC01605, FAS-AS1, and Caspase 3 were examined using RT-PCR in both groups. Expression of LINC01605, miR-20-5p, and miR-17-5p increased in patients, while Caspase 3 and FAS-AS1 decreased; the difference was statistically significant between the two groups. In addition, it was found that these factors have the appropriate sensitivity and specificity as diagnostic markers. Finally, It is suggested to use the LINC01605, FAS-AS1, miR-20-5p, miR-17-5p, and Caspase 3 as apoptosis predictors in the GM patients.
Various factors are effective in the development of minimal residual disease (MRD), one of which is MicroRNAsmiRNAs miRNAs and their dysfunction in gene expression have influential role in the pathogenesis of leukemia. Nowadays, treatments that lead to the suppression or replacement of miRNAs have been developed. Focusing on the role of miRNAs in managing the treatment of leukemia, in this review article we have investigated the miRNAs and signaling pathways involved in the process of apoptosis and cell proliferation, as well as miRNAs with oncogenic function in malignant leukemia cells. Among the studied miRNAs, miR-99a, and miR-181a play an essential role in apoptosis, proliferation and oncogenesis via AKT, MAPK, RAS, and mTOR signaling pathways. miR-223 and miR-125a affect apoptosis and oncogenesis via Wnt/B-catenin, PTEN/PI3K, and STAT5/AKT/ERK/Src signaling pathways. miR-100 also affects both apoptosis and oncogenesis; it acts via IGF1 and mTOR signaling pathways.
