Figure 3 - uploaded by Richmond Ronald Gomes
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&4: Showing multiple, erythematous, raised rashes with no color change or no crusting all over the face sparing the nasolabial folds.
Source publication
Systemic Lupus Erythematosus (SLE) is a chronic, infl ammatory, autoimmune, multisystem connective tissue disease characterized by various autoantibodies to nuclear and cytoplasmic antigens and commonly affects the joints and a variety of organs due to an over activation of the body's immune system. There is wide heterogeneity in presentation of SL...
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Citations
... If the patient fulfills the criteria for SLE despite seronegative, the diagnosis should not be delayed. 6,7 We herein, report a case of a 15-year-old female diagnosed with systemic lupus erythematosus due to its rare occurrence the in pediatric age group. ...
BACKGROUND: Systemic lupus erythematosus (SLE) is an autoimmune disorder affecting multiple organs with different degrees of severity. SLE is typically diagnosed based on the presence of antinuclear antibodies (ANA) in the serum. However, seronegative SLE is rare and is diagnosed by clinicians when the patient’s ANA is negative but fulfills other diagnostic criteria.
CASE REPORT: We report a case of a 15-year-old South Asian female with SLE who had negative antinuclear antibodies yet displayed the typical clinical presentations of photosensitive maculopapular rash, joint pain, alopecia, anemia, and thrombocytopenia. Clinical evaluations in conjunction with lab results were used to establish a diagnosis of ANA-negative SLE.
CONCLUSION: ANA positivity is an entry criterion for SLE; rarely, cases of ANA-negative SLE may present. A typical clinical presentation may help determine the diagnosis in such a scenario. However, still, the physician should rule out immunodeficiency and other systemic illnesses before reaching a diagnosis of ANA-negative pediatric SLE.
