BSTRACT In arid and semi-arid regions of the world, water has become a limiting factor, particularly for agricultural and industrial development. Water resources planners are continually looking for additional sources of water to supplement the limited resources available to their region. Several countries of the Eastern Mediterranean region, for Example, where precipitation is in the range of 100-200 mm a-1. In such situations, source substitution appears to be the most suitable alternative to satisfy less restrictive uses, thus allowing high quality waters to be used for domestic supply. Consider low quality waters such as wastewater, drainage waters and brackish waters should, whenever possible, as alternative sources for less restrictive uses. Agricultural use of water resources is of great importance due to the high volumes that are necessary. Irrigated agriculture will play a dominant role in the sustainability of crop production in years to come. The use of appropriate technologies for the development of alternative sources of water is, probably, the single most adequate approach for solving the global problem of water shortage, together with improvements in the efficiency of water use and with adequate control to reduce water consumption. The use of wastewater constitutes an important element of a water resources policy and strategy. Many nations, particularly those in the arid and semi-arid regions such as the Middle Eastern countries, have adopted in principle the use of treated wastewater as an important concept in their overall water resources policy and planning. However, accompanied with an extensive implementation of sewage irrigation, some problems with sewage irrigation became gradually obvious in agriculture, especially those related with pollution and destruction of farmlands. In this paper, the effects of sewage irrigation on soil physical (soil bulk density, soil resistance to penetration and field capacity), chemical (pH, soil organic matter, nitrogen, phosphorus, potassium, heavy metal and organic pollutants) and biological characteristics (soil microorganisms and enzyme activities) were systematically reviewed. To ensure long-term sustainability, sufficient attention must be given to the social, institutional and organizational aspects of effluent use in agriculture and aquaculture. The reuse of WW finds increased application in irrigation but the presence of toxic elements and microorganisms limits its use for irrigation purpose. To reduce the contamination of WW for irrigation, drip system is seen as an appropriate choice due to restricted quantity of water application. Emitter clogging is viewed as the main problem associated with drip system for its large-scale use with WW. Physical and chemical characteristics of WW were restricted. Higher EC, pH, Mg, and CO3, higher turbidity, total solids, HCO3, and Ca were observed in the waste water treatments.