Monica Maria Castañeda CNational University of Colombia | UNAL · Departamento de Biología (Bogotá)
Monica Maria Castañeda C
BSc,MSc U Nacional Colomb
About
9
Publications
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Introduction
Monica Maria Castañeda C does research in Genetics and Neuroscience. Their most recent publication is 'ANÁLISIS DE POLIMORFISMOS EN LOS GENES ADAM10, BACE1 Y NCSTN EN PACIENTES CON ENFERMEDAD DE ALZHEIMER DE TIPO ESPORÁDICO.'
Additional affiliations
August 2011 - July 2013
Education
February 2009 - December 2013
December 1990 - December 1998
Publications
Publications (9)
Rev. Cienc. Salud. 10 (3): 429-664 / 651
Introducción La enfermedad de Alzheimer es el tipo de demencia más común y se caracteriza por la pérdida de memoria y otras funciones cognitivas. Los marcadores histopatológicos de la enfermedad son las placas neuríticas (compuestas principalmente por el péptido beta amiloide) y los ovillos neurofibrilares. El péptido beta amiloide se genera a part...
The E280A mutation of the presenilin 1 gene has been found to be the most common associate in Alzheimers patients with a family history of this disease. Presenilin 1 is a critical component of the g-secretase complex and plays an essential role in the production of amyloid-beta peptide. This peptide has been strongly associated with the physiopatho...
Introducción. La mutación E280A en el gen de presenilina 1 se encuentra asociada al grupo familiar más grande del mundo con enfermedad de Alzheimer. La presenilina 1 es un componente esencial del complejo g-secretasa, responsable de la producción del péptido b-amiloide, considerado clave en la fisiopatogenia de la enfermedad.
Objetivo. Determinar s...
To perform linkage analysis between the Short Tandem Repeats (STR) microsatellite markers D19S923, D19S929, D19S22, which are in strong genetic linkage to Notch3 gene in order to contrast the hypothesis that the vascular hereditary dementia phenotype described in a multigenerational extended pedigree from Colombia correspond to CADASIL (Cerebral Au...
orrespond to CADASIL than to other vascular dementia. The non parametric results were compatibles with the parametric ones. When the migraine symptom was considered as a part of the affected status, the LOD score values showed not linkage. Conclusions. The results of the linkage analysis to these STR microsatellite mark ers suggest that the vascula...
