Magdalena Chłopecka

Warsaw University of Life Sciences - SGGW | SGGW · Division of Pharmacology and Toxicology INSTITUTE OF VETERINARY MEDICINE

For centuries, various species from the genus Cirsium have been utilized in traditional medicine worldwide. A number of ethnopharmacological reports have pointed out that Cirsium plants can be applied to diminish digestive problems. Among them, Cirsium palustre (L.) Scop. (Asteraceae) stands out as a promising herbal drug candidate because its cons...

Cannabinoids are a group of organic chemical compounds that affect the endocannabinoid system. The endocannabinoid system (ECS) is a biochemical system responsible for regulating many physiological and cognitive functions. It consists of endogenous cannabinoids, enzymes that regulate the biosynthesis and biodegradation of endogenous cannabinoids an...

Cirsium palustre (L.) Scop. (Asteraceae) is a species commonly found in Europe, Siberia, northern USA and Canada. Previous studies have proven the effect of extracts and fractions obtained from this plant on intestinal motility. The study presented herein was aimed to verify the usefulness of flavonoids apigenin (AP), luteolin (LUT), apigenin 7-O-g...

Asian pennywort (Centella asiatica) is a widespread plant of tropical and subtropical zones, also known as gotu kola. It belongs to celery (Apiaceae) family and the material used in medicine and cosmetology is the herb. The main active substances of Asian pennywort are triterpens: asiatic and madecasic acids and their glycosides: asiaticosid and...

Introduction The purpose of this study was to perform a morphometric examination of the coronary ostia, including their location in the area of the aortic sinuses, and to describe variations in ostia structure in the domestic dog. Material and Methods The study was conducted on the hearts of 91 pedigree dogs of both sexes, aged 1 to 18 years (medi...

Melissa officinalis (lemon balm) has a long history of being used in traditional medicine for the treatment of gastrointestinal tract disorders in human thanks to its spasmolytic and stress reducing effects. These pharmacological properties have been confirmed in laboratory animals. Unfortunately, in the case of veterinary medicine, the effect of l...

Introduction Due to the growing interest in the use of cannabinoids in supportive therapies, they are increasingly used together with anti-inflammatory drugs. Cannabinoids inhibit gastrointestinal motility, while steroidal and nonsteroidal anti-inflammatory drugs influence motility in other ways. The aim of the research was to study the interaction...

The presence of deoxynivalenol (DON) in feed may increase intestinal barrier permeability. Disturbance of the intestinal barrier integrity may affect the absorption of antibiotics used in animals. Since the bioavailability of orally administered antibiotics significantly affects their efficacy and safety, it was decided to evaluate how DON influenc...

Inflammatory bowel disease and many other functional gastrointestinal disorders represent a modern global threat to human health. Due to the complex etiology of the problem, the available treatment methods do not completely cure the disease and thus are not entirely satisfactory, and new treatment alternatives are intensively searched for. Thus, th...

After the European Union ban of antibiotic growth promoters, works on different methods of improving gut health have intensified. The poultry industry is struggling with problems that were previously controlled by antibiotic growth promoters, therefore the search for optimal solutions continues. Simultaneously, there is also increasing social press...

Ethnopharmacological relevance: Based on traditional medicine, infusions of Bidens species (Asteraceae) have been successfully used in the treatment of acute and chronic enteritis. Additionally, ethnopharmacological reports demonstrating the gastrointestinal, gastroprotective, anti-inflammatory, antiulcerogenic and immunomodulatory potency of Biden...

Regardless of the efforts put into preventing or reducing fungal growth, extensive mycotoxin contamination has been reported in animal feeds. In the case of pigs, one of the mycotoxins of major concern is deoxynivalenol (DON). The use of adsorbents as feed additives represents one of the strategies to control mycotoxins’ contamination in feedstuff....

Vascular disorders are a major problem as their pathophysiology has not been fully understood, therefore animal models are implemented to extrapolate the results obtained on animals to humans. The isolated tissue bath technique is a classical pharmacological tool for evaluating concentration-response relationship and to measure the isometric contra...

The study was aimed to estimate the effect of plant secondary metabolites present in ruminants diet and phytogenic feed additives on liver microsomal metabolism of albendazole and fenbendazole. The selected phytocompounds comprised of flavonoids (apigenin, quercetin) and saponins (hederagenin, medicagenic acid). The experiments were performed on li...

The application of pyriproxyfen (PPF) to drinking water and constant exposure of the whole population to this insecticide is an unprecedented action on a world scale and presents a new and serious challenge for toxicology. The aim of the study was to evaluate the potential effect of PPF on the intestine muscle activity. The experiments were perform...

Continued ingestion of plant secondary metabolites by ruminants can provoke pharmacological interactions with pharmaceutical agents used in animals. As some drugs and phytocompounds affect smooth muscle activity, the aim of this study was to verify the possible interaction between selected pharmaceutical agents and plant secondary metabolites towar...

The increasing requirement for implementing new feed additives in livestock, especially ruminants, results predominantly from two issues: the urgent need of reduction of greenhouse gas emissions and the necessity of finding replacements of antibiotics which must not be preventively used in animals feeding. A group of additives that has gained a pro...

The study was aimed at evaluating the effect of Roundup, polyoxyethylene tallow amine (POEA) and mixture of glyphosate and POEA in different levels on the motoric activity of jejunum strips. The incubation in the Roundup solutions caused a significant, mostly miorelaxant, reversible reaction of smooth muscle; only in the highest tested dose which i...

Citrus flavonoids are acknowledged for numerous pharmacological activities, including the myorelaxant effect on various smooth muscles. However, there is no data on their effect on jejunum contractility. Therefore, the aim of the study at hand was to evaluate the impact of hesperetin and diosmetin along with their glycosides on the motoric activity...

Saponins, a vast group of secondary plant metabolites, occur naturally in plants that are commonly present in ruminants’ diet or plants that are used as phytogenic feed additives. They have gained particular attention among ruminant nutritionists due to numerous health benefits resulting in improved animal performance and feed conversion efficiency...

Flavonoid supplementation is likely to be beneficial in improving rumen fermentation and in reducing the incidence of rumen acidosis and bloat. Flavonoids are also said to increase the metabolic performance during the peripartum period. Ruminants are constantly exposed to flavonoids present in feed. However, it is not clear if these phytochemicals...

Imperatorin, a psoralen-type furanocoumarin, is a potent myorelaxant agent acting as a calcium antagonist on vascular smooth muscle. Its effects on other types of smooth muscle remain unknown. Therefore, the aim of this study was to investigate the hypothesized myorelaxant effect of imperatorin on gut motor activity and, possibly, to define the und...

Plants of the genus Heracleum L. (Apiaceae) have a long history of being used in traditional medicines for the treatment of alimentary tract disorders, and these biological effects have been ascribed to the presence of furanocoumarins (including bergapten). This study aimed to develop an efficient, preparative, counter-current chromatographic separ...

Glyphosate is an active substance of the most popular herbicides worldwide. Its common use results from the belief that it affects exclusively plants. However, studies on glyphosate and its trade formulations reveal that it causes numerous morphological, physiological and biochemical disturbances in cells and organisms of animals, including mammals...

Ethnopharmacological relevance: The dry extract of Hedera helix leaves, due to its secretolytic and antispasmodic effects, is commonly used to produce pharmaceuticals applied in case of cough and other respiratory symptoms. The results of some in vitro studies as well as the clinical signs of poisoning caused by Hedera helix suggest however strong...

The dry extract of Hedra helix leaves and its main active compounds, predominantly α-hederin and hederacoside C, has been traditionally believed to act spasmolytic. However, it has been recently proved that both, the extract of ivy and triterpenoid saponins, exhibit strong contractile effect on rat isolated stomach smooth muscle strips. It turned o...

Ethnopharmacological relevance: The long tradition of using the dry extract of Hedera helix (common ivy) leaves in traditional and contemporary alternative medicine caused that many biological and pharmacological studies have been aimed at evaluating the effects of ivy. Some of the results suggest that Hedera helix extract possesses bronchodilatat...

Experiments were performed on rat isolated gastrointestinal (GI) strips. The study was carried out in isotonic conditions during a long-term (5-8 h) incubation in modified Krebs-Henseleit solution, (M K-HS) at 37 degrees C. The reaction of GI muscle strips to acetylcholine (ACh) and histological images of the tissues strips were studied. Additional...

Usually practicing veterinarians and animal keepers have to deal with inadequate supplementation of copper which causes deficiency diseases. However, instead of curing, the consequential intake of copper is likely to cause copper intoxication. Copper poisoning is observed particularly frequently, in sheep--the most sensitive domestic animal to copp...

The aim of this research was to study the possibilities of using papaverine as a reference substance to control the ability of isolated gastrointestinal (GI) tract strips to relax. The effects of papaverine hydrochloride (0.001-100 μM) dissolved in distilled water, or in DMSO (0.5%), on the mechanical activity of isolated rat GI strips (stomach fun...