Michal Majewski

Michal Majewski
University of Warmia and Mazury in Olsztyn · Department of Pharmacology and Toxicology

Doctor of Pharmacy; MRPharmS UK
Vascular studies in the intervention of obesity, hypertension, and diabetes. Dietary intervention with/out medicines.

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46
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Publications (46)
Article
Vascular defects in the mechanical properties of aorta and muscular arteries have been previously reported in animals with copper-deficient feed. However, the interaction between copper nanoparticles (CuNPs) and mechanical properties of arteries has not been reported. Hence, the present study was aimed to evaluate the effect of copper nanoparticles...
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Magnesium deficiency among oncological patients is a complex condition. Hypomagnesaemia is observed during anti-cancer chemotherapy and during treatment of certain co-existing disorders. Assessing magnesium status is difficult, as serum levels have little correlation with total body magnesium status. Thus, the aim of this study was to provide more...
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Oncological diseases are a major global public health concern. Magnesium deficiency is a complex condition and assessing magnesium status is difficult, as serum levels have little correlation with total body magnesium status. The aetiology of certain forms of cancer is partly related with intake of magnesium especially in colorectal cancer patients...
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Developmental abnormalities due to fresh garlic (Allium sativum L.) juice exposure have been previously reported on zebrafish (Danio rerio) embryos. Freshly made garlic juice (FGJ) containing allicin as a main ingredient and aged garlic extract (AGE) containing mainly S-allyl-L-cysteine were evaluated to investigate the lethality during a 5-day ass...
Article
Introduction The presence of fish and seafood in the diet of people at high risk of heart disease, pregnant women and the elderly is conducive to the preservation of health. Food originating from the sea is a good source of niacin and should be consumed by all, regardless of age and/or physiological state. Therefore, it is recommended by physicians...
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Context: Vascular dysfunction is considered a hallmark of ageing that has been associated with altered vasomotor responses, in which nitric oxide (NO) and reactive oxygen species participate. The consumption of Spirulina extracts, with antioxidant properties, increased recently. Objective: This study investigates the effect of Spirulina aqueous ex...
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The aim of this experiment was to test the effect of the partial or complete replacement of traditional CuCO3 in the diet of rats with copper nanoparticles (CuNPs) on the biochemical pa- rameters, redox status, and histomorphometry of their tissues. Normotensive male Wistar–Kyoto rats (WKY) were allocated to three groups. Three analogous groups of...
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Oxidative stress induces functional changes in arteries. Therefore, the effect of myo-inositol, a possible anti-inflammatory/antioxidant agent was studied on human plasma and rat thoracic arteries. Aortic rings from male Wistar rats (3 months of age) were incubated with myo-inositol (1, 10 and 100 μM, 120 min) and analyzed using the gas chromatogra...
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Recently, the addition of copper nanoparticles (NPs) in a daily diet (6.5 mg/kg) was studied in different animal models as a possible alternative to ionic forms. Male Wistar–Kyoto rats (24-week-old, n = 11) were fed with copper, either in the form of carbonate salt (Cu6.5) or metal-based copper NPs (NP6.5), for 8 weeks. The third group was fed with...
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Seeds of industrial hemp (Cannabis sativa L.) contain a large amount of protein (26.3%), dietary fiber (27.5%), and fatty acids (33.2%), including linoleic, α-linolenic, and some amount of γ-linolenic acid. In our study, obese male Zucker rats (n = 6) at 8 weeks of age were supplemented for a further 4 weeks with either ground hemp seeds (12% diet)...
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The carry-over of zearalenone (ZEN) to the myocardium and its effects on coronary vascular reactivity in vivo have not been addressed in the literature to date. Therefore, the objective of this study was to verify the hypothesis that low ZEN doses (MABEL, NOAEL and LOAEL) administered per os to prepubertal gilts for 21 days affect the accumulation...
Article
In the present experiment it was hypothesised that dietary strawberry ellagitannin-rich extracts would mitigate negative consequences associated with consumption. Therefore, two extracts rich in dimeric (D-ET) or monomeric (M-ET) ellagitannins (ETs) were added to a standard or high-fat diet fed to rats for four weeks. The D-ET-rich extract containe...
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We hypothesised that the dietary addition of the bioactive antimicrobial protein lactoferrin (LF) and peptides melittin (MT) or cecropin A (CR) at a dosage of 100 mg/kg to the diet of Wistar rats would result in strong modulatory effects on faecal microbial enzymatic activity, short-chain fatty acid and ammonia concentrations. To date, the changes...
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Due to the demonstrated intestinal microbial transformation of strawberry ellagitannins (ET) into bioactive metabolites, in the current study on rats, we hypothesised that the dietary addition of a strawberry ET-rich extract (S-ET) to a high-fat diet (HFD) would attenuate disturbances in the redox and lipid status as well as in the inflammatory res...
Article
Ethnopharmacological relevance: Taraxacum officinale (L.), commonly called dandelion has been used for centuries as a natural medicine to treat inflammatory diseases including some metabolic alterations associated with obesity. Aim of the study: Based on animal experiments this study aims to explore the potential mechanisms of action of T. officina...
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Abstract: This study aimed to evaluate the protective role of ground raspberry seeds (RBS) as a source of polyphenols and essential fatty acids on blood plasma enzymatic antioxidant status, lipid profile, and endothelium-intact vasodilation during physiological and pathological conditions. Young normotensive Wistar–Kyoto rats (WKYs) and spontaneous...
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We aimed to study the physiological effects of diet supplemented with copper (Cu) nanoparticles (NPs). During the eight weeks of the experiment, young Wistar rats (at seven weeks of age, n = 9) were supplemented with 6.5 mg of Cu either as NPs or carbonate salt (Cu6.5). A diet that was not supplemented with Cu served as a negative control (Cu0). Th...
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Abstract: Alcoholic leaf and petal fractions of Taraxacum officinale (dandelion) were previously demonstrated to exert in vitro antioxidant and antithrombotic activities in blood plasma and platelets. Eight-week-old male Wistar rats (n = 6) were supplemented for four weeks with dandelion fractions (694 mg/kg of diet = 11.9 ± 0.6 mg daily). Dandelio...
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Male Wistar rats at 6 weeks of age were fed for 8 weeks with a Cu deficient diet (no added Cu, Cu = 0). In addition, Cu deficient rats were supplemented with RSV (500 mg/kg of diet, n = 9). Blood and intestinal samples were taken for further analysis together with internal organs and thoracic arteries. RSV supplementation resulted in elevated blood...
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The aim of the present study was to compare the content of cytokines, chemokines, and oxidative stress markers in the pancreas of spontaneously hypertensive rats (SHRs) and Wistar Kyoto Rats (WKYs) serving as controls. Enzyme-like immunosorbent assay (ELISA) and biochemical methods were used to measure pancreatic levels of interleukin-1ß, interleuk...
Article
Cardiovascular alterations can be improved by the long-term use of fish oil (FO), as well as an adequate supply of copper (Cu). Recently, copper nanoparticles (CuNPs), as an alternative to ionic forms (CuCO3) were found to decrease the level of protein/DNA oxidation. Male Wistar rats were supplemented for 8 weeks with FO (7 g/kg) together with 40 n...
Article
Background Experimental studies have emphasized that cardiovascular alterations can be improved by the long-term use of resveratrol (trans-3,5,4′-trihydroxystilbene; RSV) as well as dietary copper (Cu) intake. Methods Male Wistar rats were supplemented for 8 weeks with Cu (6.5 mg/kg diet) as either nanoparticles (40 nm, CuNPs) or carbonate (CuCO3...
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Majewski M., Ognik K., Juśkiewicz J. 2019. Copper nanoparticles enhance vascular contraction induced by prostaglandin F 2-alpha and decrease the blood plasma Cu-Zn ratio in Wistar rats. J. Elem., 24(3): 911-922. AbstrAct Both copper (Cu) deficiency and excessive dietary exposure can induce alterations within the endothelium and vascular smooth musc...
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The aim of the study was to compare the effects of chicory root inulin-rich meal (containing polyphenolic fraction as well) and pure fructooligosaccharides (FOS) on necrotic colitis induced with trinitrobenzenesulfonic acid (TNBS) in Wistar rats. Both chicory preparations significantly reduced the pH of colonic digesta and favourably lowered the ca...
Article
Background: We aimed to analyze whether a diet supplemented with a standard dose of copper (Cu) in the form of nanoparticles, as an alternative to carbonate, exerts beneficial effects within the vasculature and improves the blood antioxidant status. Methods: Male Wistar rats were fed for 8 weeks with a diet supplemented with Cu (6.5 mg Cu/kg in th...
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Vascular disorders are a major problem as their pathophysiology has not been fully understood, therefore animal models are implemented to extrapolate the results obtained on animals to humans. The isolated tissue bath technique is a classical pharmacological tool for evaluating concentration-response relationship and to measure the isometric contra...
Article
We investigated the potential effects of monosodium glutamate (MSG)-induced obesity with regards to nitric oxide and prostanoid production, as well as potassium channel function, in rat thoracic arteries. Newborn male Wistar rats were injected intraperitoneally with typically reported MSG (4.0 mg/g) once daily for 4 consecutive days. At 90 days pos...
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Since the onset of the HIV/AIDS epidemic, nutrition has been considered an important factor in the course of infection. The study enrolled 150 HIV-positive adults (21–58 years) and 150 control group adults from Gdansk and Bialystok, within the same age, sex and education. Dietary intake was assessed together with hematological and biochemical param...
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The present study investigated the influence of intravesically instilled resiniferatoxin (RTX) or tetrodotoxin (TTX) on the distribution, number, and chemical coding of noradrenergic and cholinergic nerve fibers (NF) supplying the urinary bladder in female pigs. Samples from the bladder wall were processed for double-labelling immunofluorescence wi...
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ABSTRACT A higher sensitivity and the cytotoxic effects of garlic have been previously reported on culture cells. No studies, however have investigated the developmental toxicity of fresh garlic in zebrafish model. In this study freshly made garlic juice, which chemically is a combination of sulphur containing compounds, was evaluated to investigat...
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In sport, proper nutrition exerts a significant impact on the obtained results. Scientific data about the nutritional habits of elite European athletes are limited and, therefore, it is not clear whether athletes are following nutritional recommendations and maintaining proper diets. The aim of this study was to determine the content of niacin in t...
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M. MAJEWSKI1, A. KOZLOWSKA2, M. THOENE3, E. LEPIARCZYK2, W.J. GRZEGORZEWSKI1 OVERVIEW OF THE ROLE OF VITAMINS AND MINERALS ON THE KYNURENINE PATHWAY IN HEALTH AND DISEASE 1Department of Pharmacology and Toxicology, Faculty of Medical Sciences, University of Warmia and Mazury, Olsztyn, Poland; 2Department of Human Physiology, Faculty of Medical Scie...
Conference Paper
Piotr Jakubowski, Michał Majewski, Piotr Podlasz, Anna Jakimiuk, Natalia Kasica Epilepsy is one of the most common neurological diseases with 50–60 million people affected worldwide. Unfortunately, only 70% of patients are effectively treated with currently available antiepileptic drugs (AEDs). One of the leading hypothesis for refractory epilepsy...
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Introduction: A rich and natural source of readily assimilated dietary protein together with invaluable vitamins and minerals are fish, particularly the saltwater species. The quality of any given foodstuff is determined by its nutritional value, which in turn depends on the food type and methods used for manufacture, processing and storage. Many...
Conference Paper
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SUMMARY The results do confirm the variable influence of the amino acids on the analyzed blood vessel. L- KYN in the concentration above 500μM caused relaxation of the rat isolated arteries (P < 0.01). Observed diastolic response had a permanent character, and its strength was dependent on the applied concentration. The second of the tested amino a...
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Garlic (Allium sativum L. fam. Alliaceae) is one of the most researched and best-selling herbal products on the market. For centuries it was used as a traditional remedy for most health-related disorders. Also, it is widely used as a food ingredient--spice and aphrodisiac. Garlic's properties result from a combination of variety biologically active...
Article
Introduction Doxycycline was introduced into medical practice over 40 years ago but because of increasing bacterial resistance its value has decreased. It remains, however, the treatment of choice for infections caused by atypical organisms such as chlamydia, rickettsia, brucella and the spirochete. Recent studies indicate other possible benefits....
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Concentrations of niacin in canned tuna fish were determined by microbiological assay. The concentrations of niacin in the tested samples varied considerably. The results of our study show that consumption of canned tuna fish may be a good source of niacin
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The present study provides information about the concentrations of niacin in butterfish products. The concentrations of vitamin were determined by microbiological analytical methods. The results demonstrate that the analyzed fish were a good source ofniacin. Butterfish can provide the human organism with contents of niacin corresponding to 27 - 43%...

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