breast neoplasms - Science topic

Purpose: Timely detection of breast cancer is essential for improving treatment outcomes, particularly in the field of oncology. Several diagnostic techniques are available, and one promising approach is the use of Quantum Dots (QDs) for accurate and early detection. This study focuses on the utilization of cadmium selenium QDs with and without sil...

Purpose: Timely detection of breast cancer is essential for improving treatment outcomes, particularly in the field of oncology. Several diagnostic techniques are available, and one promising approach is the use of Quantum Dots (QDs) for accurate and early detection. This study focuses on the utilization of cadmium selenium QDs with and without sil...

Nowadays, rapid and facile diagnosis of cancer using user friendly processes has attracted much attention. In this regard, an electrochemical (EC) biosensor with high sensitivity was fabricated by merging MIL156 MOF@COF nanocomposite with Au nanoparticles for the detection of CA15-3. Herein, metal clusters of MIL-156 as a Metal organic frameworks (...

Invasive micropapillary carcinoma of the breast is characterized by clusters of cells presenting with inverted polarity. Although the apico–basal polarity is a fundamental property of the epithelium, the biological alterations leading to the inside-out pattern observed in invasive micropapillary carcinoma (IMPC) remain mostly unknown. The regulatio...

Objective A pilot study to evaluate the correlation between multimodal imaging features and the expression of the human epidermal growth factor receptor type 2 (HER-2) in breast cancer to provide a basis for clinical treatment and prognosis evaluation. Methods We included a total of 62 patients with breast cancer admitted to the Affiliated Hospita...

Zusammenfassung Hintergrund Die Kombination unterschiedlicher Methoden in der Magnetresonanztomographie (MRT) wird als multiparametrische MRT (mpMRT) beschrieben und nimmt in der Brustkrebsdiagnostik einen großen Stellenwert ein. Derzeit inkludiert die mpMRT die kontrastmittelverstärkte und diffusionsgewichtete MRT. Für eine umfassendere Charakter...

The early recognition and appropriate diagnosis of lesions or growths which do not appear to have probable aetiology is of utmost importance. In such cases metastatic lesion or secondary tumours should be considered in differential diagnosis. Metastasis from distinct organs, outside the head and neck region, accounts for about 1% of all malignancie...

Background: Carcinoma cervix is the second most common gynecological malignancy amongst Indian women aged 25-44 years after carcinoma breast. But it is preventable as it has a long pre-invasive phase. Various methods are available for screening the cervical cancer which can detect disease in early stages of pre-invasive phase. Present study has bee...

Background Investigate incidence and identify predictors of axillary lymph node metastases in early breast cancer in women >74 years Australia and New Zealand to inform decision making about sentinel lymph node (SLN) biopsy in this population. Methods Retrospective review of invasive breast cancer in women in Australia and New Zealand between 2010...

Background With improvements in cancer treatment and early detection, the number of people living with cancer is increasing. Objective This study aimed to investigate the association between combined prediagnostic lifestyle factors, assessed by a Healthy Lifestyle Index (HLI) score, and mortality among women diagnosed with breast cancer (BC), colo...

Materials and methods: 1) 46-year-old female with lesion(40 mm)QSE right 2) 84-year-old female with two lesions at QSI(24 mm) and QSE left(26 mm). Multidisciplinary decision: quadrantectomy(1), mastectomy(2), sentinel lymph node removal (1-2) HER2 HETEROGENEITY IN INVASIVE BREAST CARCINOMAS IN BREAST UNIT(BU) ASL2 LIGURIA Subtitle: Breast Pathology...

Oligometastastic disease has been defined as not more than five metastases found in radiological workup within not more than two different distant organs of the body [1]. Starting in 1995, several authors claimed that local treatment, especially radiotherapy, may have a positive impact on oligometastatic patients. However, prospective trials demons...

Background Metaplastic breast carcinoma (MpBC) is a rare histological subtype of breast cancer, and its prognosis is relatively poor. The survival trend of MpBC with different hormone receptor statuses has remained unclear over the past two decades. Methods MpBC patient data were collected from the Surveillance, Epidemiology, and End Results datab...

In this paper, we theoretically investigate the optical properties of defective one-dimensional crystals as a biosensor for the early detection of breast tumors. The theoretical model of defective 1D photonic crystal consists of Si/SiO2 layers and a defect layer consists of the dispersion of normal breast tissue and breast cancer tissue into the wa...

Background: Trastuzumab, a monoclonal antibody for breast cancer, faces global accessibility challenges, primarily due to high costs. This study examines how changes in medical insurance policies and price adjustments influence Trastuzumab utilization in China, focusing on implementation challenges and their impact on drug accessibility and afforda...

Purpose A significant proportion of many populations remain uninsured. The aim of the study was to assess differences in breast cancer outcomes before and after the implementation of an innovative approach to the multidisciplinary treatment of uninsured breast cancer patients. Methods Retrospective review was performed of patients seen at a safety...

Macrophages are pivotal in driving breast tumor development, progression, and resistance to treatment, particularly in estrogen receptor-positive (ER+) tumors, where they infiltrate the tumor microenvironment (TME) influenced by cancer cell-secreted factors. By analyzing single-cell RNA sequencing data from 25 ER+ tumors, we elucidated interactions...

Introduction The use of axillary marking prior to Neoadjuvant Systemic Therapy (NST) is a controversial matter regarding patients with positive Lymph Nodes (LN). Several methods were tested to make possible the decrease of false negative rate in comparison to sentinel lymph node adding more accuracy to the results. This study aims to evaluate the o...

One of the important and conserved microRNAs (miRNAs), miR-7-5p, is involved in several pathological mechanisms, including cell proliferation, apoptosis, migration, and metastasis. Dysregulation of this miRNA’s expression is correlated with multiple diseases, especially cancer. Its role as a tumor suppressor has been demonstrated in various types o...

Background The breast neuroendocrine neoplasms (NENs) represent a heterogeneous group of tumors and account for less than 1% of all NENs. The 5th edition of the WHO Classification of Breast Tumors in 2019 introduced a more stringent definition for breast NENs including neuroendocrine tumors (NETs) (G1, G2) and neuroendocrine carcinomas (NECs) (smal...

Introduction The use of axillary marking prior to Neoadjuvant Systemic Therapy (NST) is a controversial matter regarding patients with positive Lymph Nodes (LN). Several methods were tested to make possible the decrease of false negative rate in comparison to sentinel lymph node adding more accuracy to the results. This study aims to evaluate the o...

Neuroendocrine breast carcinoma (NEBC), an infrequent malignancy, accounts for 2–5% of all invasive breast cancer cases. The minimal occurrence of these tumours has resulted in knowledge primarily acquired from unique case reports or short retrospective studies. NEBC is diagnosed by identifying morphological characteristics related to gastrointesti...

effect of cancer breast on sexual life in female patient

Breast carcinoma exhibits the highest incidence among various cancers and is the foremost cause of mortality in women. Increasing evidence shows that SUMOylation of proteins plays a critical role in the progression of breast cancer; however, the role of SENP2 and its molecular mechanism in breast cancer remain underexplored. Here, we discerned that...

Based on high-throughput metabolomics data, the recently introduced inverse differential Jacobian algorithm can infer regulatory factors and molecular causality within metabolic networks close to steady-state. However, these studies assumed perturbations acting independently on each metabolite, corresponding to metabolic system fluctuations. In con...

Brain metastases (BM) are a frequent and severe complication in patients with lung cancer, breast cancer, and melanoma. Immune checkpoint inhibitors (ICIs) have become a crucial treatment option for BM, whether used alone or in combination with chemotherapy and stereotactic radiosurgery (SRS). However, ICIs are associated with immune-related advers...

Infertility due to ovarian toxicity is a common side effect of cancer treatment in premenopausal women. Tamoxifen (TAM) is a selective estrogen receptor modulator that prevented radiation- and chemotherapy-induced ovarian failure in preclinical studies. In the current study, we examined the potential regulatory role of long noncoding RNAs (lncRNAs)...

Breast tumor segmentation plays a critical role in the early diagnosis and treatment of breast diseases. However, existing segmentation methods yet have limitations in dealing with the complex structures and low contrast of breast ultrasound images. To address this issue, we propose a novel dual-attention patching network (DPNet) for breast tumor s...

Resisting chemotherapy is a significant hurdle in treating breast cancer. Locally advanced breast cancer patients undergo four cycles of Adriamycin and Cyclophosphamide, followed by four cycles of Paclitaxel before surgery. Some patients resist this regimen, and their cancer recurred. Our study aimed to understand the underlying mechanisms of acqui...

Fluorescence imaging in the second near‐infrared window (NIR‐II) is crucial for accurate tumor diagnosis, offering superior resolution and penetration capabilities. Current NIR‐II probes are limited by either being “always on” or responding to one stimulus, leading to low signal‐to‐noise ratios and potential false positives. We introduced a dual‐lo...

Primary breast lymphoma (PBL) is a rare entity, accounting for roughly 0.5% of all primary breast tumors. It commonly presents as a lump, which is frequently confirmed based on histopathological findings, as it is difficult to differentiate from other breast primaries on imaging. On histopathology, the most common subtype is diffuse large B-cell ly...

Bone metastases occur in the majority of advanced breast cancer patients, and the most common complications are osteolytic bone metastases. However, due to the limitations of models and methodologies for bone metastasis studies, the intricacies of bone metastasis have not been fully acknowledged and revealed in prior work. Our earlier study indicat...

Purpose To develop a combined approach using shear wave elastography (SWE) and conventional ultrasound (US) to determine the extent of positive axillary lymph nodes (LNs) following neoadjuvant therapy (NAT) in breast cancer patients with nodal involvement. Methods This prospective, multicenter study was registered on the Chinese Clinical Trial Reg...

Identification of the novel HLA‐A*24:02:01:144Q allele that differs from HLA‐A*24:02:01:01 at one position in intron 4.

Both patients and providers experience barriers to discussing complementary medicine during oncology consultations. This study describes the development of two communication tools—a question prompt sheet and a visual slideshow—and aims to evaluate their acceptability, perceived usefulness, and intention to use among patients with cancer. Nine (form...

Cuproptosis is an emerging mode of programmed cell death for tumor suppression but sometimes gets resisted by tumor cells resist under specific mechanisms. Inhibiting copper transporter ATPase (ATP7A) was found to disrupt copper ion homeostasis, thereby enhancing the effect of cuproptosis and eventually inhibiting tumor invasion and metastasis. In...

Background: This multicenter and retrospective study investigated the additive value of tumor morphologic features derived from the functional tumor volume (FTV) tumor mask at pre-treatment (T0) and the early treatment time point (T1) in the prediction of pathologic outcomes for breast cancer patients undergoing neoadjuvant chemotherapy. Methods: A...

Cancer diagnostic probe (CDP) as a newly entered tool in real-time breast cavity margin evaluation showed great improvement in smart margin shaving intra-operatively. This system increased the rate of involved margin detection to 30% with respect to frozen section. In this study for the first time we showed the independent role of CDP in finding th...

Chitinase-like proteins have multiple biological functions that promote tumor growth, angiogenesis and metastasis. Expression of CHI3L2, which is similar in structure to CHI3L1, is detected in glioma cells and tumor-associated macrophages (TAMs) in glioma and breast cancer. However, its exact role remains unclear. We analyzed the expression of CHI3...

Phosphate and phosphonate drugs are vital in building organisms, regulating physiological processes, and exhibiting diverse biological activities, including antiviral, antibacterial, antineoplastic, and enzyme‐inhibitory effects. However, their therapeutic potential is limited by the lack of advanced nanoengineering technologies. Herein, a competit...

Extensive evidence underscores the pivotal role of socioeconomic status (SES) in shaping cancer-related outcomes. However, synthesizing definitive and actionable insights from the expansive body of literature remains a significant challenge. To elucidate the associations between SES, cancer outcomes, and the overall cancer burden, we conducted a co...

With the development of deep learning technology, CNN (Convolutional Neural Network) models have shown great value in medical image analysis, especially in diagnosing early lung cancer, breast cancer, and brain tumors. In this study, we recall and organize the application and progress of CNN models in the field of cancer and tumor diagnosis in the...

ABSTRACT Objectives: The objectives of the study are to assess changes in the quality of life amongst breast cancer patients undergoing treatment at a cancer institute in Colombia. Materials and Methods: Analytical observational prospective cohort study in patients over 18 years of age diagnosed with breast cancer. Health-related quality of life (H...

Quinazolinones, particularly 9-azaglycophymines, and closely related derivatives and precursors were tested in vitro against various breast cancer cell lines representing the major types of breast tumors. Among the 49 compounds tested, azaglycophymine derivative 19 with an electron-withdrawing substituent demonstrated the most significant anti-prol...

Background To investigate the artifact sizes of four common breast clip-markers on a standard breast magnetic resonance imaging (MRI) protocol in an in vitro phantom model. Methods Using 1.5-T and 3-T whole-body scanners with an 18-channel breast coil, artifact dimensions of four breast biopsy markers in an agarose-gel phantom were measured by two...

Breast cancer, which has the highest mortality and morbidity rates among diseases affecting women, poses a significant threat to their lives and health. Early diagnosis is crucial for effective treatment. Recent advancements in artificial intelligence have enabled innovative techniques for early breast cancer detection. Convolutional neural network...

Breast cancer remains one of the most significant health threats to women, making precise segmentation of target tumors critical for early clinical intervention and postoperative monitoring. While numerous convolutional neural networks (CNNs) and vision transformers have been developed to segment breast tumors from ultrasound images, both architect...

Invasive Lobular Carcinoma (ILC) presents a distinct subtype of breast cancer, representing 10–15% of cases, with unique clinical and molecular features. Characterized by a non-cohesive, single-file invasion pattern, ILC is typically estrogen receptor (ER)- and progesterone receptor (PR)-positive but human epidermal growth factor receptor 2 (HER2)-...

Background There are various treatment options for breast cancer, but a delayed diagnosis at an advanced stage negatively affects overall survival. Our objective is to investigate the prognostic significance of the modified Glasgow Prognostic Score (mGPS) with different treatment modalities. Materials and methods The study was a longitudinal cohor...

Cancer is a heterogeneous disease requiring costly genetic profiling for better understanding and management. Recent advances in deep learning have enabled cost-effective predictions of genetic alterations from whole slide images (WSIs). While transformers have driven significant progress in non-medical domains, their application to WSIs lags behin...

An epidermoid cyst is a common benign skin lesion that can occur in any part of the body. However, epidermoid cysts occurring in the breast are extremely rare, rarely reported, and more prone to complications such as infection, rupture, and malignant alteration. Here, we report a case of a 50-year-old woman with a mammary epidermoid cyst. The patie...

Fibroadenomas are benign breast tumors, typically affecting middle-aged women, with rapid growth in some cases leading to compression of surrounding structures and presenting a clinical challenge. This case illustrates the successful use of thoracic spinal anesthesia (TSA) for excising a large fibroadenoma with characteristics suggestive of a phyll...

Breast lymphedema is a common sequela of breast conservation that delays healing and reduces quality of life. No rigorous classification system exists for this condition. We explored approaches for classifying breast lymphedema based on breast ultrasound, physical exam, and patient-reported outcomes. We enrolled 80 patients from two institutions. E...

Breast cancer is the most common cancer affecting women worldwide. The associated morbidity and mortality have been on the increase while available therapies for its treatment have not been totally effective. The most common treatment, chemotherapy, sometimes has dangerous side effects because of non-specific targeting, in addition to poor therapeu...

Aim : This research was conducted with the aim of analyzing the accuracy and diagnostic value of digital stereotactic breast biopsy compared to the postoperative histopathological findings. Methods : A retrospective-prospective study was carried out over a period of 10 months, involving 30 female patients who underwent stereotactic breast biopsy. D...

Immunotherapy for breast cancer is now being considered clinically, and more recently, the number of investigations aimed specifically at nano-biomaterials-assisted immunotherapy for breast cancer treatment is growing. Alterations of the breast cancer micro-environment can play a critical role in anti-tumor immunity and cancer development, progress...