Wound Healing - Science topic

The utilization of sustainable biomaterials in pharmaceutical and medical applications has gained significant momentum in recent years due to their dual ability to address environmental concerns and meet the evolving demands of modern healthcare. As the need for greener alternatives in healthcare intensifies, this review presents a comprehensive ov...

Gelatin-based biomaterials have emerged as promising candidates for bioadhesives due to their biodegradability and biocompatibility. However, they often face limitations due to the uncontrollable phase transition of gelatin, which is dominated by hydrogen bonds between peptide chains. Here, we developed controllable phase transition gelatin-based (...

Cesarean section is a common delivery method in Indonesia, with a prevalence of 17.6%. This method is used when vaginal delivery is not possible or in emergency cases, in an effort to prevent maternal and infant fatalities. Enhanced Recovery After Cesarean Surgery (ERACS) is a new method whose effectiveness has not been widely studied. The aim of t...

Photothermal therapy (PTT) demonstrates significant potential in cancer treatment, wound healing, and antibacterial therapy, with its efficacy largely depending on the performance of photothermal agents (PTAs). Metal‐phenolic network (MPN) materials are ideal PTA candidates due to their low cost, good biocompatibility and excellent ligand‐to‐metal...

Blood-derived biomaterials with high platelet content have recently emerged as attractive products for tissue engineering and regenerative medicine (TERM). Platelet-derived bioactive molecules have been shown to play a role in wound healing and tissue regeneration processes by promoting collagen synthesis, angiogenesis, cell proliferation, migratio...

ABSTRAK Luka bakar adalah kondisi di mana terjadi kerusakan pada lapisan epidermis hingga lapisan dermis. Struktur kulit mengalami kerusakan dari epitelium hingga lapisan basal dermis. Anda dapat menggunakan lada Cina herbal (Peperomia pellucida L.) untuk perawatan luka bakar. Studi ini bertujuan untuk mengevaluasi dampak pemberian salep daun sirih...

Bacterial infections can lead to severe medical complications, including major medical incidents and even death, posing a significant challenge in clinical trauma repair. Consequently, the development of new, efficient, and non‐resistant antimicrobial agents has become a priority for medical practitioners. In this study, a stepwise hydrothermal rea...

Chronic limb-threatening ischemia (CLTI) occurs in the advanced stage of peripheral artery disease and is associated with high risks of mortality and amputation. Universal management strategies are not always applicable, owing to population diversity, and the Western trials may not be applicable to Japanese patients, owing to differences in demogra...

Cancer-related deaths primarily occur due to metastasis, a process involving the migration and invasion of cancer cells. In most solid tumors, metastasis occurs through collective cell migration (CCM), guided by “cellular leaders”. These leader cells generate forces through actomyosin-mediated protrusion and contractility. The cytoskeletal mechanis...

This study evaluated the impact of platelet‐rich plasma (PRP) and platelet‐rich fibrin (PRF) on burn wound with dual‐species biofilm. Pseudomonas aeruginosa (P. aeruginosa) and Staphylococcus aureus (S. aureus) were applied to infect the burn wound in rats to establish a dual‐species biofilm model. After infection, the wound was treated with ionize...

This article examines the complex relationship between disease perception, negative emotions, and their impact on postoperative recovery in patients with perianal diseases. These conditions not only cause physical discomfort, but also carry a significant emotional burden, often exacerbated by social stigma. Psychological factors, including stress,...

Wound repair in adults lacks natural regenerative capacity seen during fetal period, frequently resulting in the formation of tissue fibrosis and functional impairments. By transforming the repair process into regenerative healing, it is possible to restore the original tissue state and significantly enhance human health. Advanced treatment methods...

This study aimed to investigate the role of transforming growth factor-beta 3 (TGF-β3) secreted by adipose-derived stem cells (ADSCs) in suppressing melanin synthesis during the wound healing process, particularly in burn injuries, and to explore the underlying mechanisms involving the cAMP/PKA signaling pathway. ADSCs were isolated from C57BL/6 mi...

Objective Soft tissue defects and postoperative wound healing complications related to calcaneus fractures may result in significant morbidity. The aim of this study was to investigate whether percutaneous minimally invasive screw internal fixation (PMISIF) can change this situation in the treatment of calcaneal fractures, and aimed to explore the...

Negative pressure wound therapy (NPWT) is a very effective method in the treatment of dehiscent, infected, and non‐healing wounds. Difficult wound healing occurs especially in late pregnancy due to the rapid enlargement of the uterus and the constantly increasing tension of the entire abdominal wall. In cases of dehiscence of the surgical wound dur...

Purpose The purpose of this study is to develop an innovative solution for chronic wounds in high-mobility areas, such as joints, where conventional treatments are hindered by passive healing mechanisms and the need for immobilization. By designing a micro-electro-Nanofiber dressing composed of piezoelectric polyvinylidene fluoride (PVDF) integrate...

Opioids are a challenging class of drugs due to their dual role. They alleviate pain, but also pose a risk of dependency, or trigger constipation, particularly in cancer patients, who require the more potent painkillers in more advanced stages of the disease, closely linked to pain resulting from general inflammation, bone metastases, and primary o...

Objetivos: Investigar sobre las propiedades y composición del aceite de rosa mosqueta y su eficacia como agente cicatrizante en heridas de humanos y animales. Metodología: Por un lado, se ha realizado una revisión narrativa exploratoria cuyo fin fue describir la composición y propiedades del aceite de rosa mosqueta. Asimismo, se realizó una revisió...

Background Dysregulation of SF3A3 has been related to the development of many cancers. Here, we investigated the functional role of SF3A3 in hepatocellular carcinoma (HCC). Methods SF3A3 expression in HCC tissues and cell lines was examined using RT-qPCR. Changes in malignant behavior of HCC cells after downregulation of SF3A3 were assessed by EdU...

Introduction: The eyelids, the curtain of eyes the plays an important role in globe protection, lubrication and beautification. The chances of survival of eyelid avulsed flaps with a narrow pedicle is excellent as the arterial and venous blood supply is profuse. Method: 35-year-old male patient with the avulsion injury to the right lower eyelid at...

Background Any deviation from the normal process of wound healing leads to excessive scar formation in the form of keloid or hypertrophic scar. Materials and Methods The study included 120 candidates with keloids divided equally into two groups, A and B, of 60 patients each. After surgical excision, group A received combination therapy of intramarg...

Barrier tissues like the skin, gastrointestinal tract, and respiratory system exhibit high IL-33 expression. IL-33 expression increases in humans and mice during cutaneous wound healing. Following skin injury, IL-33 alerts immune cells via its receptor ST2, modulating the inflammatory response and acting as a nuclear transcription factor to regulat...

Birth represent the physiologist event. However, if there are complication, action must be taken1. Nutrition is the factors that influence wound curing2. One behavior process is also influenced with knowledge3. The purpose of the research is to identify correlation between the knowledge of nutrition to the curing of post sectio caesarea wound. Desi...

Despite rapid developments of wearable self-powered sensors, it is still elusive to decouple the simultaneously applied multiple input signals. Herein, we report the design and demonstration of stretchable thermoelectric porous graphene foam-based materials via facile laser scribing for self-powered decoupled strain and temperature sensing. The res...

In cleaning wounds, little attention has been given to the solutions, waiting for the natural process without the user agent, but these problems can cause chronic injuries and inflammation. Povidone-iodine is a tropical antiseptic agent that popularly used to prevent infection and aid healing of wounds. However, the effects of povidone-iodine on th...

Chitosan, a multifaceted amino polysaccharide biopolymer derived from chitin, has extensive antibacterial efficacy against diverse pathogenic microorganisms, including both Gram-negative and Gram-positive bacteria, in addition to fungi. Over the course of the last several decades, chitosan nanoparticles (NPs), which are polymeric and bio-based, hav...

Inadequate tendon healing and heterotopic bone formation result in substantial pain and disability, yet the specific cells responsible for tendon healing remain uncertain. Here we identify a CD26⁺ tendon stem/progenitor cells residing in peritendon, which constitutes a primitive stem cell population with self-renewal and multipotent differentiation...

The dysregulation of matrix metalloproteinases (MMPs) in skin cutaneous melanoma (SKCM) represents a critical aspect of tumorigenesis. In this study, we investigated the diagnostic, prognostic, and therapeutic aspects of the MMPs in SKCM. Thirteen SKCM cell lines and seven normal skin cell lines were cultured under standard conditions for experimen...

The demand for aesthetic surgery continues to increase, and it is therefore essential to ensure that the next generation of plastic surgeons are adequately trained. We propose a safe method in aesthetic training in abdominoplasty and facelift, utilizing free deep inferior epigastric perforator (DIEP) flap and parotidectomy for training aesthetic pr...

Autophagy is a vital cellular process that facilitates the degradation and recycling of cellular components, thereby maintaining homeostasis and promoting cell survival under stress conditions. Recent studies have illuminated the significant role of autophagy in enhancing immune responses, facilitating tissue regeneration, and promoting effective w...

Background and Aims Honey has long been studied for its healing abilities in wound care. This narrative review examines its properties and their impact on wound healing, particularly its ability to accelerate wound closure and promote tissue regeneration. The review focuses on how honey's botanical origins affect its medical properties and wound‐he...

Objective The surgical team in this study examined the efficacy of a modified reverse sural neurocutaneous flap repair in treating soft tissue defects of the ankle and foot caused by accidents. Methods This study enrolled 89 patients treated for soft tissue defects of the ankle or foot between January 2007 and December 2023. The patients were divi...

This letter shares insights and reflections on recent findings related to autophagy and its implications in wound healing.

Random walks and related spatial stochastic models have been used in a range of application areas, including animal and plant ecology, infectious disease epidemiology, developmental biology, wound healing and oncology. Classical random walk models assume that all individuals in a population behave independently, ignoring local physical and biologic...

Objective: Hemorrhoidal disease is a prevalent anorectal disorder that significantly impacts patients' quality of life. Surgical intervention, including Minimally Invasive Procedure for Hemorrhoids (MIPH) and Open Hemorrhoidectomy, plays a crucial role in managing symptomatic hemorrhoids. However, the comparative effectiveness and safety of these s...

Background In recent years, there has been a growing number of case reports documenting delayed seroma in patients with a history of breast surgery and reconstruction. The occurrence of these seromas has been associated with prior SARS-CoV-2 infection or SARS-CoV-2 vaccination. So far, there are few systematic analyses on postoperative complication...

Diabetic foot ulcers (DFUs) represents a significant public health issue, with a rising global prevalence and severe potential complications including amputation. Traditional treatments often fall short due to various limitations such as high recurrence rates and extensive resource utilization. This editorial explores the innovative use of acellula...

Objective To present and analyze eight clinical cases illustrating the use of rose stem cell‐derived exosomes (RSCEs) in treating various dermatological conditions and to review current literature on plant‐derived exosomes in medicine and dermatology. Background RSCEs possess low cytotoxicity, high biocompatibility, and effective cellular uptake,...

Diabetes Mellitus affects more than 400 million people worldwide and that number is growing rapidly. India is the country with largest number of diabetic patients in the world. Diabetic foot ulcer is one of the common causes of hospital admissions among diabetics in India. This study was aimed at creating a database on biochemical profile of diabet...

Platelet-derived extracellular vesicles (PEVs) are rich in growth factors and have significant potential for facilitating tissue repair and regeneration. Therefore, we conducted this meta-analysis to assess the efficacy of PEVs in treating diabetic wounds. To assess the efficacy and safety of PEVs in treating diabetic wounds, we conducted a systema...

BACKGROUND Diabetic foot ulcers (DFUs) are a significant contributor to disability and mortality in diabetic patients. Macrophage polarization and functional regulation are promising areas of research and show therapeutic potential in the field of DFU healing. However, the complex mechanism, the difficulty in clinical translation, and the large het...

The management of wound exudate is of vital importance for wound healing. Exudate accumulation around wound prolongs inflammation and hinders healing. Although traditional dressings can absorb wound exudate, they are unable to drain exudate in time, often resulting in a poor feature with wound healing. In recent years, the appearance of asymmetric...

GPR15LG, a chemokine-like ligand for the G-protein coupled receptor 15 (GPR15), is abundantly expressed in the gastrointestinal mucosa and inflamed skin. Emerging evidence suggests its involvement in inflammatory disorders and cancers. This study investigates the effects of GPR15LG on the signaling and downstream functions of C-X-C chemokine recept...

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Background: It is widely documented that delays in wound healing are costly to the health service but more importantly detrimental to patients and their wellbeing. Aim: This study explores: (1) factors that tissue viability nurse specialists (TVNS) think affect psychological stress in delayed wound healing; and (2) to better understand whether any...

Chitosan functional material is a promising material in manufacturing bone scaffolds, as it has antibacterial properties, low toxicity, biodegradability, biocompatibility with human tissues, and facilitates regenerative processes in wound healing. Graft placement is prone to bacterial invasion, and alternatives are made scaffolds with antibacterial...

As hydrogel research progresses, hydrogels are becoming essential tools in bioelectronics and biotechnology. This review explores the diverse range of natural and synthetic gel materials tailored for specific bioelectronic applications, with a focus on their integration with electronic components to create responsive, multifunctional systems. The r...

Self-antigens that are obscure to immune cells under homeostasis, are exposed following tissue damage and can trigger autoimmunity. Our previous work showed that conventional type 1 dendritic cells (cDC1s) mediate immunoregulation after traumatic skeletal muscle injury. Here, we found that, immune responses to injury in cDC1-depleted mice (Batf3-/-...

Background One of the common complications in spinal surgery patients is deep surgical site infections (SSIs). Deep SSIs refer to infections that involve the deeper soft tissues of the incision, such as the fascia and muscle layers. This complication can lead to prolonged hospitalization, repeated surgeries, and even life-threatening conditions. In...

Wound healing is a complex, multifaceted biological process broadly divided into four overlapping phases: hemostasis, inflammation, proliferation, and remodeling. Each stage of wound healing is critical to successfully restoring tissue integrity, and disruption or delay in any of these stages can lead to delayed healing. Various existing nanomateri...

Impaired wound healing affects the life quality of patients and causes a substantial financial burden. Hydrogen‐rich medium is reported to have antioxidant and anti‐inflammatory effects. However, the role of hydrogen‐rich saline (HRS) in cutaneous wound healing remains largely unexplored, especially by metabolomics. Thus, untargeted metabolomics pr...

Silver nanoparticles (AgNPs) are emerging as powerful tools in healthcare due to their unique properties, including antimicrobial activity, high surface area, and biocompatibility. They are widely used in medical applications such as wound healing, drug delivery, cancer therapy, and diagnostics, particularly for combating multidrug-resistant bacter...

The Hippo pathway regulates many physiological processes, including development, tumor suppression, and wound healing. One understudied Hippo pathway component is PTPN14, an evolutionarily conserved tyrosine-phosphatase that inhibits YAP/TAZ. While an established tumor suppressor, PTPN14's role in tissue homeostasis has remained unclear. We thus ge...

This study addresses a significant gap in the clinical validation and standardization of exosome-based applications within the domains of cosmetics and regenerative medicine. Despite offering a thorough overview of the potential therapeutic benefits and underlying mechanisms of exosomes, the manuscript underscores several unresolved challenges, inc...

Spiny mice (Acomys spp.) are warm‐blooded (homeothermic) vertebrates whose ability to restore missing tissue through regenerative healing has coincided with the evolution of unique cellular and physiological adaptations across different tissue types. This review seeks to explore how these bizarre rodents deploy unique or altered injury response mec...

The supraclavicular artery flap presents a promising solution for facial reconstruction challenges since 1997, surpassing limitations of traditional methods like the deltopectoral flap. Its extended pedicle and thin, pliable epidermis offer reliable outcomes with minimal donor site morbidity, making it a preferred choice for head and neck reconstru...

Wound healing represents a global public health problem when it is not treated correctly, which can cause complications for the patient, such as functional loss of an organ, amputation, and even death. At a biological level, wound healing involves a complex mechanism in which the immune system and cellular biochemical cascades intervene in a coordi...

Wound healing is a central physiological process that restores the barrier properties of the skin after injury, comprising close coordination between several cell types (including fibroblasts and macrophages) in the wound bed. The complex mechanisms involved are executed and regulated by an equally complex, reciprocal signalling network involving n...

Parasitic infestation of the body by dipterous larvae belongs to the most undesirable events in patients with post-excisional wounds after malignant skin lesions. wound myiasis is more common in tropical regions. We reported a case of 55 years old female with wound myiasis with a history of surgical removal of non-melanoma skin cancer-basal cell ca...

MEK inhibitors, such as trametinib, have shown therapeutic potential in head and neck squamous cell carcinoma (HNSCC). However, the factors influencing cancer cell sensitivity and resistance to MEK inhibition remain poorly understood. In our study, we observed that MEK inhibition significantly reduced the expression of MYC, a transcription factor c...

Diabetic foot wounds (DFW) are notoriously difficult to treat owing to poor vascularity, delayed healing and higher rates of infection. Human‐derived acellular dermal matrices (ADM) have been used in DFW treatment, utilizing a matrix scaffold for new tissue generation. We investigate the efficacy of a micronized injectable human‐derived ADM in the...

After endoscopic sinus surgery (ESS), nasal packing is often used to stop bleeding and promote wound healing. Because maintaining a moist environment is important to enhance wound healing, hydrogel-based wound dressings are effective to promote wound healing. Chitosan is used in the medical field because of its high hemostatic and wound healing pro...