Uveitis - Science topic

Purpose: The purpose of the study was to determine the rate of endophthalmitis in intravitreal injection (IVI) cases performed in the IVI cabinet inside the semi-sterile room developed in accordance with the operating room conditions and to evaluate the results of the performance tests of the IVI cabinet. Methods: The number of IVIs, the type of dr...

Introduction: Blau syndrome is a rare autosomal dominant condition resulting from mutations in the Nucleotide Oligomerization Domain of 2 ;(NOD2) gene. The disease typically presents in early childhood with a triad of arthritis, dermatitis, and uveitis. In this report, we describe retinal vasculitis as a rare phenotype in a family affected by Blau...

SERENA is a recently completed, non-interventional, multinational, 5-year study evaluating retention, effectiveness, patient-reported outcomes and safety of secukinumab in patients with moderate-to-severe psoriasis, active psoriatic arthritis (PsA), and active ankylosing spondylitis (AS) treated in real-world settings. Three-year interim data from...

Objective: To investigate the occurrence and characteristics of the "Fern-like pattern" (FLP) on ultra-wide field fluorescein angiography (UWFA) across a variety of uveitic conditions, challenging the traditional association of FLP primarily with Behçet's disease (BD). Methods: This observational study at a tertiary care centre in India analysed th...

Uveitis is known for its association with HLA-B27 as well as systemic autoimmune diseases including sarcoidosis and arthritis. However, the association of uveitis with recurrent lower urinary tract infections without kidney disease or involvement is not established or commonly seen. Here is documented a case of an elderly female patient with multip...

Purpose To determine if significant correlations occur between recorded values for a) annual temperature, b) air pollution levels, and the prevalence of acute ophthalmic inflammation among patients attending an eye emergency department in an urban setting between 2011 and 2023. Patients and Methods A data bank of cases that attended an eye emergen...

Background Faricimab is a bispecific antibody targeting vascular endothelial growth factor (VEGF) and angiopoietin-2 (Ang-2), offering a novel therapeutic approach for ocular diseases. However, its long-term safety profile remains under evaluation. This study analyzes its adverse events (AEs) using the U.S. FDA Adverse Event Reporting System (FAERS...

Aim To emphasize the importance of promptly assessment of punctate outer retinal toxoplasmosis (PORT), and to present a case series in a third-level reference center in Mexico City. Methods Retrospective, observational case series of eight eyes of eight patients who presented PORT between January 2020 to February 2023. Diagnosis was made by uveiti...

To explore the relationship between DED and sleep disorders and examine the impact of DED’s duration on sleep disorders. This multi-institutional, retrospective cohort study used the TriNetX database. We recruited participants with and without DED diagnosis from 2004 to 2023. Dry eye patients were propensity-matched to individuals from our non-DED...

Background Uveitis is a common recurrent autoimmune disease that seriously endangers the visual health of patients. MicroRNAs (miRNAs) are closely related to a series of autoimmune diseases. Methods The present study aimed to investigate the effect of miR-30b-5p on experimental autoimmune uveitis (EAU) and its role in Notch signal activation as we...

Purpose To characterize current global status and frontiers in the field of vitreous floaters research. Methods The Web of Science Core Collection was used to retrieve the international scientific publications on vitreous floaters from 1999 to 2023. Scientometric data were analyzed and visualized using VOSviewer (1.6.18 Edition) and CiteSpace (6.3...

The incidence of syphilis is rising, particularly among men who have sex with men. Ocular involvement, often manifesting as bilateral uveitis, typically occurs in later stages and is more severe and difficult to recognise in individuals living with HIV. We describe the case of a man with HIV infection who presented to our outpatient clinic with vis...

Lipid metabolism is closely linked with antitumor immunity and autoimmune disorders. However, the precise role of lipid metabolism in uveitis pathogenesis is not clear. In our study, we analyzed the single-cell RNA-Seq (scRNA-Seq) data from cervical draining lymph nodes (CDLNs) of mice with experimental autoimmune uveitis (EAU), revealing an increa...

Background This study aimed to investigate the outcomes of gonioscopy-assisted transluminal trabeculectomy (GATT) surgery in patients with Fuchs’ uveitis syndrome (FUS) related glaucoma. Case presentation The clinical and surgical records of 4 FUS patients who underwent GATT surgery between 2021 and 2023 were retrospectively reviewed. The preopera...

Background and Aim: Uveitis is a group of inflammatory eye disorders with various etiologies, including genetic susceptibility. Certain Human Leukocyte Antigen (HLA) types are known to be associated with different forms of uveitis. This study aims to identify disease-susceptible HLA types (DSHTs) for each type of uveitis. Methods: 120 patients with...

Objective To assess the long-term safety profile of bimekizumab (BKZ) in patients with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA). Methods Safety data pooled from six integrated phase IIb/III studies in axSpA and PsA are reported (to the July 2022 data-cut for phase III) for patients who received ≥1 dose of BKZ 160 mg every 4 we...

PURPOSE: To analyse the evolution of uveitis diagnosis over a 10-year period, emphasizing the change in etiological diagnosis, and the factors associated with recurrences. DESIGN: Retrospective chart review. METHODS: A total of 15,000 patients with uveitis presented at our tertiary care institute in North India between 1992 and 2023. Of these,123 p...

Purpose: To describe our real-life experience with patients with endogenous endophthalmitis (EE) presenting at the Eye Unit of Royal Bournemouth Hospital over an 8-year period. Materials/Methods: Retrospective study using data from our medical records from 01/01/2016 until 31/12/2024. Cases with previous ocular trauma, ocular surgery, primary corn...

Background The study objective was to compare the effectiveness of adalimumab (ADA) in monotherapy and in combination with methotrexate (MTX) for paediatric noninfectious uveitis (NIU). Methods Registry‐based observational study. Children receiving ADA for active uveitis were divided into the ADA monotherapy group (group 1) and the ADA plus MTX co...

Background Eyes are recognized as immunological privileged site. However, the onset of autoimmune uveitis (AU) prompts an influx of dendritic cells (DCs) into the retinas, tasked with presenting auto-antigens, thereby exacerbating the inflammatory response. Monocyte-derived DCs (moDCs) implicated in various autoimmune disorders, but their specific...

Objectives This study aims to assess the risk of non‐infectious uveitis (NIU) relapse in pediatric patients undergoing Adalimumab (ADA) tapering, evaluating potential predictors of such risk Methods We conducted a multicenter retrospective cohort study involving pediatric NIU patients who underwent ADA tapering due to inactive uveitis. Cox proport...

Bilateral acute iris transillumination (BAIT) is a recently described entity, usually following moxifloxacin intake or respiratory tract infections. Interest in the disease has increased since the COVID-19 pandemic; however, its etiopathogenesis remains unclear. This study presents five cases in Greece with symptoms and signs suggestive of BAIT aft...

Purpose To identify the subtypes among patients clinically diagnosed as herpetic anterior uveitis (HAU) and characterize their clinical features and visual prognosis. Methods Three hundred and seventeen patients were clinically diagnosed as HAU in our department. Aqueous humor (AqH) and serum were collected from 43 of 317 HAU patients during eye s...

Purpose Uveitis‐associated macular edema (UME) is a significant cause of visual impairment in non‐infectious uveitis (NIU). However, the UME incidence remains unclear. Here, we evaluated the cumulative incidence of UME. Methods Medical records of patients registered with a uveitis diagnosis code between 2010 and2024 were assessed to validate uveit...

We herein report an autopsy case of multiple cerebral infarctions caused by varicella-zoster virus (VZV) vasculopathy. A 60-year-old man, previously diagnosed with VZV uveitis, subsequently developed cerebral infarction with multiple cerebral vessel stenoses. Based on the results of a polymerase chain reaction test of cerebrospinal fluid, the patie...

Background Noninfectious uveitis, a chronic ocular inflammatory disease, is characterized by the activation of immune cells in the eye, with most studies focusing on the role of the adaptive immune system in the disease. However, limited data exist on the potential contribution of the innate immune system, specifically the nucleotide‐binding oligom...

Introduction Acute retinal necrosis is a rare, severe retinitis that may lead to loss of vision. This condition is caused mainly by the Herpesviridae. It can affect both immunocompromised and immunocompetent patients of all ages. Case report A 54-year-old female patient, came to the eye emergency department with a history of rapid and progressive...

Immune checkpoint V‐domain Ig suppressor of T‐cell activation (VISTA) exhibits distinct expression patterns and non‐redundant immunoregulatory mechanisms in different autoimmune diseases. This study aims to investigate the expression of VISTA in patients with autoimmune uveitis and experimental autoimmune uveitis (EAU) mice, and explore its clinica...

Syphilis is one of sexually transmitted infections (STIs). The incidence of Treponema pallidum infection has increased in the last 20 years. This rise is also evident in ophthalmological practice, with cases of ocular syphilis becoming more frequent. We present a case of a 29-year-old patient with blurred vision in his left eye. Patient showed no g...

Background Despite uveitis subspecialty workforce shortages, uveitis specialists remain engaged in research. This study examines the relationship between the proportions of uveitis-focused articles in high-impact ophthalmology journals and fellowship-trained uveitis specialists on their editorial boards. Methods A bibliometric analysis was conduct...

Orbital inflammation is one of numerous adverse effects of bisphosphonates. The symptoms include palpebral oedema, conjunctival chemosis, ocular motility impairment, proptosis and decreased visual acuity. This condition may coincide with other ocular adverse effects, as presented in this case report of a patient who developed orbital inflammation a...

Objective: To identify gender based clinical and radiological differences in patients with axial spondyloarthropathy. Study Design: Comparative, cross-sectional study. Place and Duration of Study: Rheumatology Department, Fauji Foundation Hospital, Rawalpindi Pakistan, from june to Dec 2021. Methodology: 100 patients (50 males and 50 females) were...

Objectives: The aim of this study was to establish the etiology of uveitis and to examine its relationship with anatomical localization, age, and gender. Methods: A prospective study on patients with uveitis was conducted over a 13-year period at the Department of Ophthalmology, University Hospital “St. George”, Plovdiv, Bulgaria. Each case was dia...

Background Retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and headache (ROSAH) syndrome is an autosomal dominant disorder caused by a heterozygous missense mutation in alpha kinase 1 (ALPK1). This series reports the presentation and treatment outcomes of three first-degree relatives with ROSAH syndrome. Methods Retrospective chart...

Background: In routine care, Danish patients with psoriatic arthritis are monitored in the DANBIO registry. In March 2022, patient-reported outcome measures (PROMs) on selected non-musculoskeletal manifestations (NMM) were implemented. Aim: To validate PROMs for current dactylitis, skin and nail psoriasis, and recent uveitis in patients with psoria...

Aims: Spondyloarthropathies (SpA) constitute a category of multisystemic inflammatory seronegative arthritis. A genetic correlation exists between SpA and the human leukocyte antigen (HLA)-B27 gene. HLA-B27 positive is observed in roughly 90% of patients with ankylosing spondylitis. This study seeks to ascertain the prevalence of HLA-B27 positivity...

Objective We have previously shown that HLA‐B27 was negatively associated with remission status eight years after the onset of juvenile idiopathic arthritis (JIA). We now aimed to study the associations of HLA‐B27 with clinical features and disease outcomes 18 years after the onset of JIA. Methods We studied 434 patients from the population‐based...

Background Juvenile idiopathic arthritis-associated uveitis (JIAU) typically takes a chronic course, frequently leading to ocular complications and often requiring long-term treatment. The present study assesses the 5-years outcome of JIAU by analyzing data from a prospective study initiated in 2010. Methods Data from 75 patients with onset of uve...

Background To our knowledge, limited information is available about the differences in the characteristics of rheumatoid factor (RF)-negative polyarticular juvenile idiopathic arthritis (JIA) throughout the world. This study was aimed to compare the demographic and clinical features of patients with RF-negative polyarthritis across the world. Meth...

Purpose: To evaluate the visual outcomes and complications of a foldable acrylic intraocular lens (IOL) sutured to the iris through a small incision as a primary option in aphakic patients without capsular support. Methods: Iris-sutured PC IOL operations performed at Giresun University Faculty of Medicine, Giresun Training and Research Hospital Oph...

Immune cells such as macrophages play a significant role in ocular inflammation by activating or inhibiting several cellular pathways. Systemic infections and autoimmune diseases could activate macrophages by releasing various pro-inflammatory cytokines, chemokines, and growth factors, which reach the eyes through the blood-retina barrier and cause...

Purpose To assess the prevalence of ocular findings in patients with psoriasis and compare the odds of developing these conditions between the psoriatic and control population through a systematic review and meta-analysis. Methods A comprehensive literature search was conducted using PubMed, Embase, Cochrane, and Web of Science databases to identi...

Purpose Deficiency of adenosine deaminase 2 (DADA2) is a rare monogenic autoinflammatory disease resulting from biallelic loss-of-function mutations in ADA2 gene. It has variable clinical manifestations, some of which can mimic Behçet’s disease (BD). Herein, we present a family of three siblings diagnosed with DADA2, two of whom were initially misd...

Uveitis, an intraocular inflammatory condition, can lead to significant visual impairment and is often associated with abnormal immune system activation. While vaccination stands as a pivotal defense against numerous infectious diseases, its safety and effectiveness in individuals with uveitis have come under heightened scrutiny. This concern arise...

The modulation of inflammatory mediators has emerged as a critical therapeutic strategy in uveitis management. Current nonsteroidal anti-inflammatory therapies face limitations due to systemic side effects. Caffeic acid (CA), a natural polyphenol with anti-inflammatory properties, holds therapeutic potential but suffers from poor solubility and ocu...

This study aimed to conduct a comparative epidemiological survey of uveitis across various healthcare settings and elucidate the clinical characteristics. We conducted a retrospective cross-sectional study in the Ube-City medical region in Yamaguchi prefecture and recruited 268 patients from a university hospital (151 patients), municipal hospitals...

The health burden of ocular toxoplasmosis is substantial, and there is an unmet need for safe and curative anti-microbial drugs. One major barrier to research on new therapeutics is the lack of in vitro human-based models beyond two-dimensional cultured cells and tissue explants. We aimed to address this research gap by establishing a human retinal...

Background/Objectives: this study aims to assess the safety of ciliary sulcus-placed hydrophilic acrylic intraocular lenses (IOLs). Methods: In this retrospective cohort study, consecutive patients who underwent phacoemulsification with implantation of IOLs into the ciliary sulcus without suture fixation between 2014 and 2016 at the Meir Medical Ce...

Ocular involvement in sarcoidosis is frequent. Our aim was to evaluate visual outcomes and treatment in a cohort of patients with ocular sarcoidosis. Retrospective study of 342 patients with sarcoidosis from 1999 to 2019 in a university hospital. Ocular manifestations and systemic treatments were assessed: glucocorticoids (GC), conventional synthet...

Background/Objectives We aimed to investigate the potential of anterior segment OCT (AS-OCT) in differentiating anterior chamber (AC) pigment and inflammatory cells. Subject/Methods Cross-sectional study of adults with uveitis. The exclusion criterion was corneal opacity sufficient to obscure slit lamp examination of the anterior chamber. Referenc...

Background Observational studies have shown that ocular manifestations of inflammatory bowel disease (IBD) are common extraintinal manifestations, among which iridocyclitis, scleritis and episcleritis are the most common. However, whether there is a causal relationship between the two is unclear. The purpose of this study was to evaluate the causal...

Purpose To report our flicker electroretinographic (ERG) findings in a patient who developed uveitis after treatment with immune checkpoint inhibitors (ICIs) for a metastatic malignant melanoma. Methods ERGs were used to monitor retinal physiology in a patient with ocular complications following systemic ICI administration. Flicker ERGs were recor...

Uveitis involves a complex interplay of immune cell infiltration and cytokine imbalances, with Th17 cells playing a central role in this process. Th17 cells contribute to disease pathogenesis by promoting inflammation, recruiting additional immune cells, and directly damaging retinal tissues. This review discusses the current knowledge on therapeut...

Plain Language Summary Why was the study done? Macular edema (ME) is a leading cause of visual impairment, particularly in patients with conditions like diabetic retinopathy, retinal vein occlusion, and uveitis. Current treatments, such as anti-VEGF injections and corticosteroids, often need to be repeated frequently, placing a significant burden o...

Background Non-infectious paediatric granulomatous uveitis (PGU) is a rare disease that is idiopathic in more than half of affected children. The diagnosis of definite ocular sarcoidosis (OS) must be supported by the presence of non-caseating granulomas detected in biopsy, and is therefore a challenge in children with PGU. This study investigated t...

Background Inadequacies in medicine are manifold including inadequate influence of opinion leaders and consensus groups on terminology, diagnostic criteria and treatment guidelines, obsolete classifications and terms as well as misinterpretations of disease mechanisms. This is no different for uveitis and possibly even more pronounced as these are...

Purpose This study aimed to assess the efficacy of Janus kinase inhibitors (JAK-i) in the treatment of refractory isolated non-infectious uveitis. Case presentation We examined a case series involving three patients with isolated non-infectious uveitis, who were managed between December 2019 and December 2023 at The Eye Hospital, University Medica...

Cytokines influence cell-fate decisions of naïve lymphocytes and determine outcome of immune responses by transducing signals that regulate the initiation, intensity and duration of immune responses. However, aberrant regulation of physiological levels of cytokines contribute to the development of autoimmune and other inflammatory diseases. The Int...

Despite ocular immune privilege, circulating retina-specific T cells can trigger autoimmune uveitis, yet intraocular bleeding-a relatively common event-rarely leads to disease. Using an in vivo immune privilege model, we previously reported that all naive retina-specific T cells entering the eye become primed in situ; about 30% become Foxp3+ T-regu...

Purpose To present the demographic and clinical presentations of anterior scleritis among Iranian patients. Methods This retrospective case-series at a tertiary center in Iran, identified and analyzed anterior scleritis cases admitted from 2008 to 2018. Extracted data included demographics, clinical features, background systemic diseases, utilized...

Intraocular ointment is conventionally placed on the eye to prevent infection after cataract surgery. The purpose of this study is to report a case and conduct a systematic review of a rare occurrence of intraocular ointment after cataract surgery. PubMed, Scopus, Embase, CNKI, WANFANG data, China Science and Technology Journal Database and Chinese...

Background Extraintestinal manifestations (EIMs) significantly affect the life quality of people with inflammatory bowel disease (IBD) and are crucial factors impacting occurrence rates and mortality among IBD patients. This study performed a Mendelian randomization (MR) analysis to investigate the causal relationships between genetically predicted...

Purpose The purpose of this study was to explore the underlying mechanism that Th17-like T follicular helper cells (Tfh) orchestrated by STING signaling have a pathogenic role in experimental autoimmune uveitis (EAU). Methods The differences of transcriptome and gene ontology (GO) pathway of Tfh between EAU and control mice were analyzed by single...

Importance: Hidradenitis suppurativa (HS) has been associated with spondyloarthritis (SpA) and inflammatory bowel disease (IBD) and proposed as a potential manifestation of these conditions. However, the relative rarity of HS, combined with the diverse methodologies used in previous studies, leaves several uncertainties surrounding its epidemiology...

Purpose To report a case of Vogt-Koyanagi-Harada (VKH) disease in a patient with retinitis pigmentosa (RP) in the right eye and pigmented paravenous retinochoroidal atrophy (PPRCA) in the left eye. Observations A 32-year-old woman with a history of RP visited our hospital with blurred vision in the left eye. She had a headache for four days before...

Schimmelinfecties vormen een diagnostische en therapeutische uitdaging. Ze starten meestal als een oppervlakkige en ogenschijnlijk onschuldige ulceratie. Indien een correcte behandeling niet tijdig wordt ingesteld, breidt de schimmelinfectie zich verder uit in de verschillende lagen van de cornea met een diep stromale ulceratie of abces tot gevolg....

Psoriasis is a chronic, inflammatory, immune-mediated skin disease affecting 1-3% of the adult population. It mainly involves the skin, nails, and joints. However, psoriasis can be associated with several comorbidities, including ocular complications. The most frequently reported pathologies are dry eyes syndrome, blepharitis, and uveitis. Being a...

Uveitis is an inflammatory reaction that occurs in intraocular tissues. Among them, non-infectious uveitis is a T cell-mediated autoimmune inflammatory response, but its pathogenesis is not fully understood. This article reviews its pathogenesis and treatment progress.

Introduction: Uveitis is a heterogeneous group of intraocular diseases that significantly causes vision disabilities in patients worldwide. Establishing an etiological diagnosis can be challenging because of the extensive and varied clinical patterns and differential diagnoses across regions. Knowledge of these patterns is crucial in aiding physici...

Behçet's uveitis (BU) is a severe ocular manifestation of Behçet's disease, typically accompanied by abnormal neutrophil infiltration and hyperactivation. However, the underlying causes of excessive neutrophil extracellular traps (NETs) production and mechanisms by which NETs contribute to the pathogenesis of BU remain incompletely understood. Neut...

Background Secukinumab is a monoclonal antibody that selectively neutralizes interleukin-17A and has shown efficacy in the treatment of psoriatic arthritis, psoriasis, and axial spondyloarthritis. Its use in non-anterior non-infectious uveitis is controversial, with evidence generally not supporting its effectiveness in these conditions. However, t...

Introduction Rho-associated protein kinases (ROCKs) are a key regulator of T cell function, influencing a wide range of processes from activation to differentiation. Experimental autoimmune uveoretinitis (EAU) is an animal model of human non-infectious uveitis. This study aimed to evaluate the suppressive effects of ripasudil, a ROCK inhibitor, on...

Aims This study aims to analyse peripapillary atrophy (PPA), its frequency, extent and relation with measures of visual function in patients with birdshot chorioretinitis (BSCR). Methods Patients of the single-centre prospective COhort of patients with BIRDshot chorioretinitis (ClinicalTrials.gov Identifier: NCT05153057 ) were included. The areas...

Background Frosted branch angiitis (FBA) is a rare form of retinal vasculitis that can lead to significant vision loss. This case report presents a unique case of idiopathic FBA in a 2-year-old boy following pentavalent vaccination. Case Presentation A previously healthy 2-year-old Emirati boy presented with sudden painless bilateral vision loss f...

Background To study the utility of interferon gamma (IFN-γ) as a differentiating biomarker by assessing the aqueous humour and serum of patients with infectious and noninfectious uveitis. Methods A total of 40 patients with acute uveitis were divided into 2 groups (18 patients with infectious uveitis and 22 patients with noninfectious uveitis). Al...