Ulcer - Science topic

Good evening,

As far as I know, ESWT extracorporeal shock waves can improve wound healing, especially in diabetics. The ISMST (a learned society on ESWT) could provide you with more detailed information on this subject. ESWT are known to act on macrophages.

Kind regards.

Grégory VIEQUE

The endoform is a type of advanced wound care product, specifically a natural extracellular matrix (ECM) scaffold derived from ovine (sheep) sources. It is used to support wound healing by providing a structure that mimics the natural human ECM, which plays a critical role in tissue repair and regeneration. Here are some key applications and benefits of using Endoform in wound care:

Applications of Endoform

Benefits of Using Endoform

Mechanism of Action

Impression:-

Endoform is a versatile and effective wound care product that leverages the principles of extracellular matrix biology to support and enhance the natural wound healing process. Its applications in chronic, acute, and infected wounds make it a valuable tool for clinicians in promoting faster and more efficient wound healing, thereby improving patient outcomes several times

.

Really? Crazy! Did they tell you why? I googled a little, and it's in the Cochrane Library, Cochrane Central Registry of Controlled Trials.

I'm a medical historian, and my intrepid interlibrary loan staff never failed to unearth articles for me, even articles over a century old.

Hello Osmel Companioni Napoles

Ulceration may occur when tumors develop subcutaneously. The cause could be in situation where large tumors develop on the ventral surface and are subjected to constant abrasion, or sometimes these ulcerations could be caused due to the cell's origin type. There are cell lines that are predisposed to ulcerate.

I would suggest you change the initial tumor cell dose. Inject reduced cell number, and if ulceration is characteristic of the tumor line, you should try to complete the experiment in the latent period before ulceration.

Best.

Here you go:

This is the SUSTech dataset. Details are available here: https://www.nature.com/articles/s41597-020-0360-7#citeas

In adults, a quarter of SRUS may appear as polypoid lesions. Rectal prolapse can be seem in about 1/5 of SRUS in adults.

Topical sucralfate, salicylate, corticosteroids, mesalazine have been reported to be effective. Surgery is considered only for patients not responsive to conservative measures and biofeedback.

I think that the types of microorganisms to be of great importance in predicting wound healing and infection. Although appropriate systemic antibiotics are essential for the treatment of deteriorating, in addition to controlling the growing conditions

Hi Bikash

The plaques could be amyloid (secondary to myeloma) deposits. You may want to biopsy them. If the suspicion is confirmed, ideally the patient should have a SAP scan. As to treatment, the choice would be a velcade based combination. (eg VCD).

Best wishes

Siva

I forget to mention that our study group also showed a large colon lengh, a symptom of reduced colitis.

In summary, our study group showed the same weigh loss, less disease symptoms and increased colon lengh but worse colon histology.

Than you

Sincerely

Jose Maria

The volume of dissolution medium to be used is defined considering "sink condition." The solubility of the drug substance is quantitatively determined in several dissolution media within the physiological pH range at 37 °C. Using this value, the volume of dissolution medium necessary to obtain a saturated solution of the highest dose of the product to be marketed is calculated. Sink condition is considered as at least 3 times this volume. Some companies work with 5 times or 10 times this value. There are some instances where the dissolution test is more discriminative if sink condition is not followed. The volume of dissolution medium has no relationship with the volume of gastric fluids in humans. According to information available in the literature, a realistic volume to simulate the total fluid available in the stomach in the fasted state is in the range of 250-300 mL.

Interested

Try decreasing the number injected vital cells

Ophthalmomyiasis is actually infestation of eyes with larvae of house flies that is maggots in eye. Usually occurs either implantation of hatching egg in eye or long standing open wounds in eye such as cancers of eyes. On these open wounds the fly gives it larvae which eats up the decaying tissues. while eye ulcers usually refers to the corneal ulcer caused following trauma or otherwise by microbes bacteria, fungi and viruses.Lid ulceration can occur in lid cancers on which fly lay larvae developing in maggots that can be called ophthamomyiasis.

I have already evaluated the forest plot. Now I want to swap the data that means i want to exchange the control and experimental group. When I swap the Group label 1 and 2, why the data in the table is not swapping automatically? Can anyone tell me how to do it?

The problem is one of stress and possibly poor nutritional intake leading to reduced immunological response to the bacteria. Without a knowledge of what plants you have available that have a bacteraicidical effect (without other adverse effect) all I can recommend is garlic. This has a well documented antibiotic effect when taken raw. I cannot recommend a dose as the plant varies in efficacy.

Sorry no idea.

Yes you can if you is the only author or all authors do the same procedures: 1-Select the withdrawm manuscript from your puplication list 2- Click in the square icon (placed in the right of share rectangle) 3- Select remove 4- Select Permanently delete the publication page from ResearchGate

Thank you for your answers...

Start here:

Hi. Mostly aphthous ulcers, can be a result of stress, certain vitamin deficiency, hormonal fluctuations and even unintended mouth injuries.

Dear collegue

we have tried to test different models of colitis and made the conclusion that DSS colitis is the most easy, cheap and pathogenesis - related model.

But if you decided to use TNBS, you should be sure that all mice (or rats) have the similar microbiome. They should be SPF and parazites -free too. In our practice the presence of the ectromelia virus meets much more often than we think and it induce a very heavy colitis with the total death of the group. I recommend tp pay the attention to this side of the process

Aggressive cell lines like MDA-MB-231 can also lead to ulceration by invading into dermis and secreting MMP's. Interaction of inflammatory site with the NK and monocytes in the NSG will lead to ulceration.

Dear Obed

thanks for your question.

in this paper you can find good answers to your question:

Check this link

Good luck

I am interested - currently working at Ambo University - referal hospital.

A small unit is functioning at pediatric ward . We have to see the feasibility of study to do here .

You've misunderstood - we all perform ISR/ ULARs etc. And all of us who do are aware of the possibility of prolapse. The issue is having the facilities available to diagnose and know-how to manage the complication which technically, we have created.

Are you saying you have an ano-rectal physiology lab? If so, then those figures should help you make a decision as to whether surgery is indicated or not. The abstract above doesn't answer the query

Have a look on it..

Note: I am not attached to any of the above courses. I just came across about this piece of information and thought it might be useful to you

Hi

I agree with A.R. A. Al-Aqaby

regards

Apart from the Clinical trial Registries of various individual countries, Cochrane evidence/library could also help.

I have used in a few cases and the results were promising, Various studies prove the efficacy of PRP by the kits but a proper protocol is yet to be formulated

Yes, it can be used orally for managing hypoglycemia in conscious diabetic patients with intact swallowing function. Just make certain that patients take in plenty of water, because the dextrose will also cause the body to lose more water through urination. Monitor for signs of dehydration.

you are welcome

Thank you for your answers. We looked for metastases but they must be microscopic or not large enough to be seen on ultrasound. The dose of Toceranib is 75 mg each 48 hours resting the weekends. We have realized that the problem is that one of the cornerstones of treatment, corticosteroids, were not being taken because of osteoarthritis, our patient was taking NSAIDs and stopped taking them due side effects. 

 

Hi Mr. Majeed , may be help you

To my experience erythromelalgia is a vasodilating condition, an analogous to vascular algodystrophy. Primary treatment should focus on identifying and avoiding the triggering factor, which is most commonly the exposure to different and extreme temperatures or repetitive microtrauma. Elevating the extremities above the level of the body softens the symptoms and this can confirm if the condition is erythromelalgia or not.

Medications are rarely helpful. The use of analgesics and NSAIDS may help to subside symptoms but time is needed far from the triggering factor in order someone to be cured.

complex interaction between paracetamol and alcohol intak

the acute administration of ethanol inhibits the potentially toxic oxidative metabolism of paracetamol and protects against liver damage. This protection decreased when the concentration of ethanol decreased.the critical period is that the time between ethanol and paracetamol intak

while chronic alcoholism, microsomal enzyme induced with increased toxic metabolic activation of paracetamol and enhanced hepatotoxicity.  elevation of SGOT/SGPT ratio may be 5 times greater than normal

Medscape education guide may answer your question.

Maybe this is helpful:

Wada H, Sakata N, Tashiro T.Clinicopathological study on penetrating atherosclerotic ulcers and aortic dissection: distinct pattern of development of initial event. Heart Vessels. 2016 Nov;31(11):1855-1861. Epub 2016 Feb 18.

Buccal mucosal lesions can be induced by local injection of 50 μl of 99.7% acetic acid into the buccal mucosa.See:Therapeutic effect of rebamipide in a modified acetic acid-induced buccal mucosal ulcer model link.springer.com/article/10.1163/156856002321544864

I thank all for the scientific experience contribution.

Thank you for your answers. However, my question did not refer to the general use of PPI or H2 blockers in children.  In contrast, I wanted to know your practice regarding the ulcer-prophylactic application of PPI, H2 blockers and sucralfate in children on steroids or NSAIDs.

Perhaps some pathogens would invade peripheral nerve fibers during the pathogenesis as their skin lesions developed. So we know the existence of neurosyphillis and postherpetic neuralgia.

Some pathogens might numb nerve fibers, others might fire them.

The pathogens also might release some chemical substance into the periphery in the early phase.

Possible mechanisms include cytokines, inflammatory mediators, inhibitory neurotransmitters or anything.

You just asked a great question. It is a fundamental issue.

You could take down some samples of peripheral nerve fibers closely near the skin lesions to do pathology (even electric microscopy). To see what happened?

In this case, you can read this article

Fungating breast cancer and other malignant wounds: epidemiology, assessment and management. Sok Yuen Beha, Leong Chai Leowb. 137-144

Dear Gul,

Alternatively, persons that have GI ulcer are given COX-2 selective nonsteroidal anti-inflammatory drugs (NSAID) such as celecoxib as a replacement to NSAIDs such as naproxen since they do not negatively affect the GI.

For more on this class of drugs, please use the following link:

Hoping this along with my first answer will fully cover the answer to your question.

Rafik

May be topical use of Betadine 10% will be useful and also Bactroban 1% crem

My experience confirm that zeolite cures injuries, ulcers and other 

issues

Roque -Malherbe 

Thanks for the reference. 

Dear Anders,

I do not think that you can exclude any tumor from your statistical analyses, even if they are ulcerating.

WHich type of model are you using?

How big are the tumors when you are ending the experiment?

When do you see the first appearance of ulceration?

Best regards

Robert

Siewert type III

1. Laparoscopy

2. Jejunostomy temporary

3. Neoadjuvant treatment radio and chemotherapy

4. If advance disease total gastrectomy with distal esophagectomy transhiatal lympn nodes removal

5. If no advance disease 2 stage Yvor Lewis abdominal and thoracic approach

6. Paleative treatment if peritoneal disease

Greetings from Muller Family!

Thanks for reply.!can you inform me concentration of peroxide?It is literally burning!we tried at first with this but after stopping within months soreness comes back !

Collagen-containing wound dressings have been used in the treatment of diabetes-related foot ulcers (DFU). Collagen components, such as fibroblast and keratinocytes, are a major part of skin development. Collagen may be harvested from a variety of sources including living and nonliving bovine, porcine, and equine skin. Once harvested (via a proprietary process), a native collagen bioscaffold matrix is created that stabilizes the vascular and cellar components, which become incorporated into the wound bed.1 Preliminary findings suggest that collagen-containing wound dressings may have several advantageous features. Cullen et al2 reported the findings from the testing of an oxygenized regenerated cellulose (ORC)/collagen dressing. After use of the ORC/collagen dressing, researchers analyzed wound fluid and found a significant decrease in collagenase-like activity; gelatinase, matrix metalloproteinase (MMP)-2, and MMP-9 levels; and increased scavenged free radicals and binding of growth factors.For more please at the following link, its free paper.

Regards

I think it's better for cells migration and proliferation. 

Dear Dr. Khandare,

I think it is better localize your question in diabetic foot as the most common ulcer in diabetes.

Regards,

It ill also depend on the method of producing stress ulcers.  I would try a single oral dose.

One should distinguish the chronic ulcer and the multiple acute ulcers and erosions of the stomach depending on what you need to obtain. The aforementioned ways will cause rather the latter alterations. For the former to produce, I would recommend the Okabe acetic model. It is reliable, cheep, and may give longlasting ulcer with recurrences.

For reference:

Dear Mohamed Aoued

Personally I take acetylsalicylic acid 100 mg for over 4 years. This is an antiplatelet agent. I read a lot of studies have been performed on patients with cardiovascular disease. It Seems that gives excellent results.

Syncerely

FADEL  

 

There are at least 2 devices that seem promising"

- MOViNSESE by  kinematix

-Compliant cocept

If a foreign body is present without doubt, it should be extracted if the surgical risk is not prohibitive. Open abdominal exploration seems the best approach. Once you have diagnosed it, you have to inform the patient about what happened and what you are intending to do to help her. Failure to do so is potentially dangerous to her and to yourself.

Solitary caecal (better paravalvular) ulcer is well known.

In metropolitan France, it is usually idiopathic,sometimes to slow-release NSAID tablets rarely and  due to Behçet's disease.

It is very frequently asymptomatic and, when idiopathic, disappears within 2 months.

When NSAID induced, cicatrization occurs with 1 month after withdrawal.

In the my case of Behçet's, it has disappeard within 2 weeks after starting amiodarone for arrythmia, in parrallel with aphtous buccal ulcers.

Don't think so - Matrigel is primarily used to avoid dissemination upon injection - I think that the matrix is cleared and replaced by a proper matrix quire rapidly. Ulceration is more tumor-dependent I am afraid. It may be worsenen by the localization as well. Breast cancer (e.g., Mammary fat pad models) tend to ulcerate more frequently/rapidly since the tumor is more likely to be in contact with the ground when the mouse moved and frictions may increase the phenomenon.  When s.s.c. grafting on the flank or on the back, the same model (MDA231 for instance) showed fewer ulceration. It may depend on the tumor size as well - normally small tumors are less likely to ulcerate, based upon my own experience.  Reducing the number of cells to be injected could be a solution (we gave up the "1 million cells ssc" paradigm in my unit and start with 80-150 000 cells; works fine). I hope this helps?

Best, 

Yes, i have experience in management of patients with Buruli ulcer

We usually use IPP in critical period around transplantation, the risk of bacterial transposition could be decreased by appropriate food preparation.

Poly phramcy. this trend was recently strated with pantoprazole and domperidone.magine wht could happen when a lay man uses this medication along with bowel stopper.

there must be some strong reason if two drugs of the same category are added.

triple drug Anti diabetics have laimed more lives.

waht if an heart patient ahs to use cardiac drugs with PPI.

Since antiacids are used most often without prescriptions it wuld be best not to combine two drugs.

Ulcers pathogenesis is linked to first aphorisma of Swartz: No acid, no ulcer, successively modifed by Marshall into: No Helicobacter, no ulcer. These two apparent contradictions are easily reconcilable. Ulcer does not develop until there is a correct balance among aggressive intraluminal factors (expecially HCl and pepsin) and barrier function (epythelial turnover, mucosal levels of prostaglandins, neutral mucin production, microcirculation). Helicobacter pylori has the ability to induce a deregulation of these factors, but NSAIDs may do the same interacting with prostaglandins. And so uraemia or congestive gastropathy due to portal hypertension or diabetes by inducing delayed gastric emptying and altered micricirculation may alter the balance between protection and aggression to gastric mucosa. Stress could play a role through an alteration of rain-gut axis that at the moment is an interesting and promising field of investigation.

Upper endoscopy cannot be proposed as a routinary investigation, it needs to be performed in the case of alarm symptoms (haematmesis, melena or ulcer-like acitve clinical signs, which occur simultaneously to NSAID administration). Moreover, it may investigate only gastro-duodenal injuries and not intestinal ones which are more frequent than estimated. A specific histological picture does not exist for NSAID damage, it may be useful to detect a simultaneous presence of Helicobacter pylori. Dyspeptic symptoms may be related to a lot of factors and are not specific. On the light of cost-benefit ratio, I think that a good approach could be the detection of the blood in the stools and fecal calprotectin baseline and in the course of treatment. Chenges in the results may indicate a potential iatrogen effect and stimulate further investigations in a limted sample of patients.

Gastro Protector - its natural, Like a Preventing Particularly to GIT.

Anti- Ulcer - denotes Preventing from Ulcerative Problem(common Ulceration Preventor).

Ulcer index

The number of ulcers was counted by using the magnifying glass. Severity scores: normal coloration as 0, red coloration 0.5, spot ulcer 1.0, hemorrhagic stress 1.5, deep ulcer 2.0 and perforations as 3.0.

Ulcer index = (UN + US+ UP) x 10 rais to power -1

UN = Average of number of ulcer per animal

US = Average of severity score

UP = Percentage of animal with ulcer

Yes, Dear Najla. As a minimum, baseline laboratory tests are: Complete blood count with platelets, Liver function tests, serum creatinine, urine analysis. These must be repeated after a month, then every 2 months. One must also know if there is a history of hepatitis, and do a tuberculin test. In doubt, do get the full battery of viral tests for hepatitis B & C. Good luck. Usually azathioprine is very well tolerated if there are no infections.