Tics - Science topic
Habitual, repeated, rapid contraction of certain muscles, resulting in stereotyped individualized actions that can be voluntarily suppressed for only brief periods. They often involve the face, vocal cords, neck, and less often the extremities. Examples include repetitive throat clearing, vocalizations, sniffing, pursing the lips, and excessive blinking. Tics tend to be aggravated by emotional stress. When frequent they may interfere with speech and INTERPERSONAL RELATIONS. Conditions which feature frequent and prominent tics as a primary manifestation of disease are referred to as TIC DISORDERS. (From Adams et al., Principles of Neurology, 6th ed, pp109-10)
Questions related to Tics
I am currently working on a growth model with time-invariant and time-varying covariates.
I came across a model a latent basis growth model. However, I am having trouble finding
articles that enlighten me on how I might be able to incorporate TIC or TVC in the model.
It would be much appreciated if someone can point to some articles where I would be able
to find more information on it, and if possible how to model it in Mplus.
Thank you all in advance.
I study the synthesis of MXene (Ti2C) from Ti2AlC.
As a result of immersing Ti2Alc in 40% hydrochloric acid for 5 hours, cubicTiC was obtained.
In the book 2D Metal Carbides and Nitrides (MXenes), the reason for this phenomenon is the dissolution of Ti2AlC in acid.
If anyone can explain in detail the breaking and formation of bonds in this reaction?
The below XIC chromatogram is from TIC of parent ion scan of various metabolite of the drug in the plasma of rat.
LC MS/MS is done, equipped with Triple Quad (QTOF) instrument. Fragment ion is fixed and parent ion is scanned in this data driven experiment.
The XIC chromatogram of each metabolite is overlapped in the attached figure, can I say that the largest peak in the XIC chromatogram is the most abundant metabolite in the plasma, qualitatively ?
Any kind of help/clarification regarding the same will be highly appreciated. Thanks in advance!
I am working on the synthesis of MXene Ti3C2.I use the pressureless sintering method using basic elements with stoichiometric ratio.Unfortunately, I have not succeeded in making MAX phase Ti3AlC2 so far.
At the temperature of 1100 degrees Celsius MAX phase Ti2AlC was observed, but at the temperature of 1400 degrees Celsius only TiC was obtained. The furnace was kept at the maximum temperature for two hours.heating rate=10 Degrees Celsius per minute
Instead of graphite, I also used TiC as a raw material and also slightly changed the molar ratios of the raw materials, but the result was still the formation of TiC.
According to articles in this field, MAX phase should have been made, but I don't know what the problem is.
Thank you for taking the time to read and answer my question.
I have bought a compound from macrocylics. I have analysed it using LC-MS where it shows multiple peaks. I have selected the peaks and did an area integration. The quantitative analysis of TIC gave be 85% purity whereas the product is endorsed as 95% pure.
I have a problem with signal stability in LC-MS/MS apparatus. It was turned off during the summer break and after turning it on again last week we can see a dift in signal for analytes that we did before the break. This loss is around 30-50% in every sample (around 7 min). Noise also is lower with every sample. We also noticed that after changing polarity back and forth for consecutive samples signal was higher over time. Then after few samples in negative ion mode signal begin to fall again.
Ion source was cleaned before first analysis but after turning it on.
Can we do something about this problem without hiring a service technician?
1.png is a TIC over 10 min with calibration solution.
Thank you for help.
Alklinity can be calculated by titration of acid on pH endpoint. I have a data set with bounches of water quality parameters, only without Alklinity. Is there a way to get Alklinity only by calculation from other parameters (pH, TIC, Dissolved CO2, temp, and cations, onions, ect.)
I am looking for sources which provide pH of ceramic Compounds; for oxides, nitrides, carbides and... . for example: TiN, TiC, SiC, ZrN, TiF3, ZrO2, Si3N4 and...
Does any one know about it?
please help me
in most of the investigation grain core's still remain ZrB2 or TiC after SPS mixture of ZrB2-TiC, i need to attain Fully (Zr-Ti)B2-(Zr-TiC solid solution composite.
I have done an LC-MS analysis for one of my samples in which it is expected to contain sugar molecules whose molecular weights are less than 200 Da. When I am using a method there is a big hump in TIC obtained for that sample but when I extracted the BPC chromatogram I could see the clear separation. What are the possible ways to optimize the method o obtain a neat and clear chromatogram.
I am attaching both TIC & BPC with method parameters in details.
If we are to add 10g each of TiC, TiN, NbC, ZrO2, TiB2 in a matrix let say Austenitic steel, I would like to know if the solubility of each reinforcement in the steel to form a composite could be predicted using software and how it could be done.
People may experience: Behavioural: aggression, antisocial behaviour, compulsive behaviour, fidgeting, hyperactivity, impulsivity, repetitive movements, screaming, self-harm, social isolation, or persistent repetition of words or actions Muscular: inability to combine muscle movements, poor coordination, tic, or clumsiness Mood: anger, anxiety, apprehension, or loneliness Also common: depression, learning disability, nightmares, restricted behavior, sensitivity to sound, or stuttering
I have analyzed the sample of one Essential Oil to identify its chemical components by GC-MS. The report shows the qualitative data having R. time, I. time, F. time, area, area %, height, height %, and A/H against each identified peak. How can I calculate the percent concentration of each identified compound by using the mentioned data? Please guide.
Thanks in anticipation.
I have the following results from wastewater with samples taken every two hours.
The first four samples are off-spec while the last two samples indicate a regular COD/TOC ratio.
Can someone explain the increase in COD/TOC ratio to me? What is causing the COD and TC to increase and TIC to decrease this much? I will have to note that there was some sort of sludge (bacteria?) in the samples but unfortunately I did not measure the BOD. The amount of chloride, Kjeldahl nitrogen and phosfor doesn't seem to be the problem.
I'm guessing that bacteria from the sludge turned some of the inorganic carbon into organic carbon and thus decreases the TIC which resullts in a higher TOC. But how does this explain the increase in TC and COD?
I know that chloride will interfere with COD but with other interferences can I expect with TOC (catalytic combustion)?
Thanks in advance!
For my B.Tech final year project I want to test multilayer coated carbide insert and test it for tool life and wear properties. I am looking for CVD and PVD facilities that can coat tungsten carbide inserts with materials like TiC, Al2O3, TiB2 etc., in India.
TiB2 and TiC particles are heterogeneous nucleation sites for α-Al and advantangeous secondary phases with high modulus. The addition of them can enhance the strength of alloys. However, the agglomeration phenomenon is usual to be seen in microstructure, both intragranular and intergranular distribution.
Autosampler on platform was replaced with a new make and model and unable to obtain the same levels of intensity.
Some info on platform:
- MRM scan method using a flow program in Analyst software (ABSciex) (ie at time of 0.01, inject at a rate of 300 uL/min, then at time of 0.15, inject at 100 uL/min and so on)
- flow program is producing desired TIC peak shape (akin to a bell curve) but intensity only about 8.5e5 when it was 5e6 historically
- using Shimzadzu autosampler, no column (just an inline filter)
- all instruments have been PM'd and no performance issues
- may have to do with configuration of peek tubing - currently using red from autosampler to inline filter then tan to mass spec
- also tried lowering dilution of samples to increase concentration, but same TIC observed.
I have a problem . I want to calculate the time in m / s from While loop so that I can integrate the values. I tried a lot, unfortunately that didn't work. I use the MPU6050 accelerometer . Can you help please, best regards
serialPort = 'COM2';
x = fscanf(s);
m = str2num(x);
if isempty(m); continue; end
ax = m(1);
ay = m(2);
az = m(3);
%vx = cumtrapz(vec_ax, vec_t)
%vy = cumtrapz(vec_ay, vec_t)
%vz = cumtrapz(vec_az, vec_t)
I want to know how to interpret spectra generated from LC-MS/MS. After subjecting my protein band to in-gel tryptic digestion followed by LC-MS/MS, I got two plots (TIC) of relative abundance against retention time( i.e ) ms1 and ms2. May I know if the two plots correspond to the same experiment run twice or they are entirely different.
The raw data was analyzed by Proteome Discoverer 2.1. Data base search was done using Mascot and Sequest HT for protein identification. I discovered that there are multiple spectra corresponding to different precusor ions (peptide fragments). I don't seem to understand this. Please I need clarification on this aspect.
The emergence of innovative technological programs such as Augmented Reality (AR), Kahoot and so on, have allowed the development of new teaching techniques in foreign language learning. However, are you in favour, against or sceptical about this methodologies?
Is it possible/right way to match % impurity level observed in HPLC-UV to LC-HRMS. To my understanding HPLC gives the % area profile based on the UV absorptivity of the analytes (main & impurity molecules), whereas HRMS gives the peak profile (TIC/EIC) based on the m/z ion intensity. Is there any other way to quantitate % impurity in LC-HRMS such that to match % impurity observed in the HPLC-UV.
Estoy revisando literatura y la mayoría habla del simulador, sin embargo mi interés es comprender la acción de simulación en las clases de matemática de secundaria con las TIC.
I am working on Power system modles in MATLAB with some adaptive controllers. The simulation run for different time duration like 8,10, and 15 sec. Now i need to get the computational time taken by the computer to solve the iteration behind theses simulations. I found tic and toc command but need more detailed explanation to use it. Thanks
La literatura revisada expresa la visualización relacionada al GeoGebra, pregunto para explorar otros objetos matematicos como las funciones, la probabilidad etc, existe literatura que amplia la visualización a esos aspectos?
I have this molecule that is somewhat unstable and fragments. What can I do to increase sensitivity/signal so that I can see these unknown fragments in TIC? I am given the sample dissolved in solution.
What is the amount of electrical current that employed during the ZrB2, TiB2 and TiC sintering process?
can you introduce me some experimental articles or data related to current and sintering conditions (heating rate, sintering temperature, etc ) for ZrB2, TiB2, and TiC?
¿Cambia la didáctica con la integración de las tecnologías de la información y las comunicaciones? ¿Cambian sus categorías: objetivo, contenido, métodos, medios, formas de organización y evaluación? ¿Cambia solo los medios de enseñanza? ¿Cambia el rol de profesor y del estudiante?
I'm looking for a way to create a nice figure of my GC-MS data so I can label important peaks in the sample. It's incredibly simple, I'm just looking to plot the TIC abundance against retention time. I'm working with Agilent directory .D files. I can view this TIC~RT graph in MassHunter Qualitative Navigator, but the lines are incredibly thin and not publication worthy.
If you have any tips on how to either customise (e.g. thicken the lines) and export the TIC image from MassHunter I would be grateful. I have ChemStation and the other programs in the MassHunter suite and would also be happy to use an open source program. Any advice is welcome!
I'm trying to identify the intermediates produced from a degradation of Sodium Diclofenac. I'm using a QTOF (Agilent) and the method in negative and positive mode is from Agilent but for LC-QQQ). I have tried the positive mode and the TIC chromatogram is different from the UV but I get one peak for my standard sample (10 ppm) and 3 peaks for the degraded sample. However, I cannot identify the products yet (the results are inconsistent).Then I tried the negative mode, and the TIC and UV chromatogram are the same (great).However, I get 2 peaks for the standard (10 ppm) where one of them is broader.And for the degraded sample I get overlapped peaks. I increased the concentration of the standard to 50 ppm then I got 1 peak. I tried to optimize the system with different gradient, collision energy, fragmentor voltage but no luck.
Does anyone has any idea of what is wrong, please?
Why when I'm at the negative mode I see 2 peaks for SD 10 ppm and at positive 1 peak for SD 10 ppm but no consistency with TIC and UV?
Recently i purchased some TiC nano particles from china supplier and i did EDS analysis and that showed very low percentage (around 7%) of TiC (spec says 98% w/w TiC percentage). I want to know is my method accurate for metal carbides such as TiC or is there any other more accurate methods than EDS. I will attach my obtained EDS for more clarification.
Thanks in advance.
I'd be grateful if you will provide me some literature data about quantitative analysis of mixtures using TIC chromatogrames.
I want to calculate the computing time between two controllers implemented with Simulink. But when I try to use the "tic toc " function,. I got for the same controller two different values and are not acceptable.What is the best method for calculating time consuming?
I am using a Shimadzu TOC analyzer for measuring organic carbon present in my sample. However, when I run my sample for TOC (TC-IC) analysis and TIC analysis, IC values in these two runs don't match. Technically, they must be the same.
Same sample tested for TOC (TC-IC) and TIC
TOC result: TOC: 85.24mg/L, TC:86.15 mg/L ,IC: 0.9127 mg/L
TIC result: IC: 57.32 mg/L
Why is this happening?
I am viewing the total ion chromatograms of my MS samples and most of them have the intensity on average below the ideal treshold of 1xE9 and I would like to know what is it most likely due to? I have read that it indicates poor sample injection but I would like to know if it's related to the sample compositions. Thanks for help.
I am comparing two extraction methods on an environmental sample. Triplicate protein extracts were analysed using an LTQ- ORB-trap (Thermo Scientific). Both extracts were equalized in terms of total protein quantity as far as possible before mass spectrometry. There are a range of protein quantification metrics provided by the Scaffold software. I have provisionally analysed my data using 4 methods :
1. Normalised spectral abundance factor (NSAF)
2. Normalised weighted spectra
3. The Exponentially Modified Protein Abundance Index (emPAI)
4. Normalized Total TIC.
My intention was to choose one of these metrics to descibe differences in protein representation between two extraction methods.Previously, I have been using NSAF but I wondered if normalized total TIC might be better ?
The amounts of carbonates calculated from total inorganic carbon are either higher or lower than the carbonates determined by XRD.
(Ti, Mo)C interphase precipitates have been widely used for creating stable strengthening steels without the effect of ageing at elevated temperature. This was believed due to Mo could retard the coarsening of (Ti, Mo)C precipitates.
I recently got some data for MS. The protein I work with dimerises both TICs seem to be very similar. Can one say something about the about the molecular weight from the TICs and also in the peak intensity, I noticed the peaks for the dimer were about 2x higher than that of the monomer.
I observed an increase in thermal conductivity with increase in temperature for PEEK polymer composite reinforced with TiC particles at all compositions. What may be the reason for this phenomena?
I'm interested in researches focused in applied anthropology and ITC's uses from a social perspective.
The sample is CNT reinforced Ti6Al4V MMC fabricated by SPS. TEM revealed TiC formed during powder preparation by HEBM, however XRD and RS did not reveal any TiC peaks
If a child is forced to reverse their natural handedness for cutlery use (i.e. fork in left rather than their natural, dominant preference of fork in right hand), could it lead to problems such as stress, anxiety and associated symptoms, such as tics or stammer? Additionally, what affect might such a practice have on a child who has ASD?