TPO - Science topic

Forest disturbance is one of the main drivers of forest carbon flux change. How to accurately estimate the carbon flux caused by forest disturbance is an important research problem. In a previous study, the authors proposed a Grid-based Carbon Accounting (GCA) model that used remote sensing data to estimate forest carbon fluxes in North Carolina fr...

Background/Objectives: A modern classification distinguishes between two nosological entities posing an intermediate risk between differentiated and anaplastic carcinoma: poorly differentiated thyroid carcinoma and differentiated high-grade thyroid carcinoma. There are currently few studies searching for the preoperative molecular genetic markers o...

To evaluate the anterior chamber (AC) inflammation in the early postoperative period after cataract surgery and before Descemet membrane endothelial keratoplasty (DMEK) by quantifying oxidative stress and inflammatory mediators in aqueous humor of patients with Fuchs’ endothelial corneal dystrophy (FECD). In this prospective single-center study, 15...

The development of immunological methods in the 1970s and 1980s led to the identification of thyroid peroxidase (TPO) and thyroid stimulating hormone receptor (TSHR) as key players in the onset of autoimmune thyroid diseases (AITD). TSHR is primarily associated with hyperthyroidism, while TPO is linked to hypothyroidism. Advances in understanding T...

The system focuses on automation of conventional training and placement management system. This system can be used as an application for the Training & Placement Officers in the college to manage the student information with regard to placement and providing assistance using the assistance portal where students can post their query to the TPO and c...

Different CeO2 nanostructures were synthesized using a hydrothermal method and treated with alkaline NaOH, followed by drying at 120 °C for 16 h and calcined at 400 °C for the direct oxidation of kenaf stalks to vanillin under microwave irradiation. The catalysts were characterized for their physicochemical properties using XRD, BET, Raman spectros...

Lactic acid (LA) is an essential chemical that produces high-value-added products across various industries. However, its traditional production via sugar fermentation raises environmental concerns, highlighting the need for alternative, biomass-based production methods. This study investigates the production of LA from hydroxyacetone (HA) oxidatio...

This paper presents the development of the photocurable resin material based on the graphene reinforced polyethylene glycol diacrylate (gPEGDA) for vascular stent fabrication using a commercial 3D printer. 3D printing with digital light processing (DLP) technique is an attractive alternative for low-cost fast fabrication with high accuracy. Four ph...

Background Graves’ disease (GD) is an autoimmune disease associated with an increased incidence of other autoimmune diseases. To investigate the causality between GD and Diabetes mellitus (DM), we designed bidirectional two-sample Mendelian randomization (MR) and multivariable MR (MVMR) studies. Methods Single-nucleotide polymorphisms (SNPs) assoc...

Hashimoto’s thyroiditis (HT) is a prevalent autoimmune disorder marked by chronic inflammation of the thyroid gland, predominantly affecting children and adolescents. In a previous study, we developed a “maximal” mathematical model of thyroid physiology to simulate the complex interactions within the thyroid gland. The present research introduces a...

Background The Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathways are evolutionarily conserved transmembrane signaling mechanisms that ensure the ability of normal cellular communication with the external environment. Various cytokines, interferons, growth factors, and other specific molecules can activate JAK-S...

Recombinant human thrombopoietin (rhTPO) is commonly used to improve low platelet status in immune thrombocytopenia (ITP), as one protein product, even with a very low rate, there is still the possibility to produce neutralizing antibodies of thrombopoietin (TPO). We described a 7-year-old boy with ITP and normal TPO levels who had previously recei...

Alongside their well-established role in hemostasis, platelets are key modulators of immune cell function. This is particularly the case for macrophages, as platelets can either promote or dampen macrophage activation in a context-specific manner. Whilst the role of platelets in modulating classical (M1) macrophage activation following bacterial ch...

Background Coexisting parathyroid adenoma, thyroid carcinoma, and tuberculosis of thyroid is a very rare phenomenon. Primary thyroid tuberculosis is itself very rare despite high global prevalence of tuberculosis in developing countries. Majority of thyroid tuberculosis identified in postoperative histopathology or cytopathology. The coexistence of...

Sažetak Rad "Diskurzivna (ne)pravda: analiza olakšavajućih i otežavajućih okolnosti prilikom donošenja sudskih presuda u slučajevima rodno zasnovanog nasilja u Bo-sni i Hercegovini" bavi se temom pravne interpretacije i utjecaja diskursa u sluča-jevima rodno zasnovanog nasilja. Autori su analizirali 232 osuđujuće sudske presu-de u Bosni i Hercegovi...

This study aims to examine TPO gene mutations in congenital hypothyroidism (CH) within consanguineous Iranian Azeri families. Three families were subjected to next-generation sequencing and were subsequently validated using Sanger sequencing. The investigation revealed three homozygous pathogenic variants, one of which was identified as a novel var...

PT. Indonesia Plafon Semesta is a company engaged in manufacturing, this company produces various kinds of PVC ceilings. Problems faced by PT. Indonesia Plafon Semesta is the activity of making PVC ceilings in the packing section, where the activity conditions or workers' posture is not good. When packing by squatting and bending, the position is l...

17β-estradiol plays a crucial role in regulating cellular processes in both reproductive and non-reproductive tissues, including the thyroid gland. It modulates oxidative stress and contributes to sexual dimorphism in thyroid diseases, with ROS production, particularly H2O2, generated by NOX/DUOX enzymes. This study aimed to investigate the effects...

Background: The natural course of subclinical hypothyroidism (SCH) is variable. Several studies have shown that not all SCH progresses to overt hypothyroidism (OH). Little data are available regarding the natural course of SCH in diabetes mellitus (DM). We aimed to investigate the natural course of SCH in DM patients. Methods: A total of 118 patien...

Purpose Accurate detection and resection of the epileptogenic zone (EZ) in patients with long-term epilepsy-associated tumors (LEATs) are significantly correlated with favorable seizure prognosis. However, the relationship between tumors and the EZ remains unknown. This study aimed to evaluate the spatial relationship between LEATs and the EZ, as w...

Introduction Des taux élevés d’anticorps antithyroïdiens (AAT), notamment les anti-TPO et les anti-TG, sont associés à des troubles de la fertilité et des complications de grossesse chez la femme, indépendamment des taux de TSH. Le mécanisme sous-jacent à cette association n’est pas entièrement élucidé. Cette étude vise à rechercher l’expression d’...

The development of immunological methods in the 1970s and 1980s led to the identification of thyroid peroxidase (TPO) and thyroid stimulating hormone receptor (TSHR) as key players in the onset of autoimmune thyroid diseases (AITD). TSHR is primarily associated with hyperthyroidism, while TPO is linked to hypothyroidism. Advances in understanding T...

The choice between thrombopoietin receptor agonists (TPO‐RAs) and anti‐CD20 as the preferred second‐line therapies for immune thrombocytopenia remains in the eye of the beholders. Each has major advantages and certain weaknesses. Stolz et al. describe a single‐centre experience that whets our appetite for a large randomized controlled trial compari...

In primary immune thrombocytopenia (ITP), predictors of disease evolution and treatment response are needed. Data based on the site of platelet destruction are scarce. We performed a retrospective single‐centre study of adult patients with primary ITP undergoing at least one Indium‐111 platelet scintigraphy (IPS) between 2009 and 2018. Thirty‐three...

This study was carried out to determine some hormonal and immunological parameters in women who attended Maternity and Children teaching hospital in Ramadi city , from 1 st of August 2014 to 1 st of April 2015. Ages of patients ranged from 16-49 years. The study included 358 blood samples from pregnant and non-pregnant women. sixty five samples wer...

Alergias alimentares são respostas exacerbadas do sistema imune após ingestão ou contato com determinado alimento. Na atualidade, elas se tornam cada vez mais frequentes, o que leva à necessidade de identificar e diagnosticar os casos de maneira eficiente. Desse modo, este estudo tem como objetivo relacionar a sintomatologia de pacientes com alergi...

The influence of residual cuts on the deactivation of hierarchical Y zeolite-based catalysts during the co-processing of vacuum gas oil (VGO) with atmospheric residue (ATR) was investigated. The experiments were conducted in a laboratory-scale MAT-type reactor. The conversion of VGO, ATR, and their 70:30 (mass basis) mixture was examined using two...

Thyroid autoimmunity (TAI) has been linked to fertility disorders and pregnancy complications, even in euthyroid women. However, the exact pathophysiological mechanism underlying this association is not fully understood. This study seeks to investigate the expression of thyroid antigens within the human female reproductive system, potentially ident...

Transfer-RNA-derived fragments (tRFs) are a novel class of small non-coding RNAs that have been implicated in oncogenesis. tRFs may act as post-transcriptional regulators by recruiting AGO proteins and binding to highly complementary regions of mRNA at seed regions, resulting in the knockdown of the transcript. Therefore, tRFs may be critical to tu...

“Myxedema heart” is a rare syndrome that results from severe untreated hypothyroidism. It is characterized by relative bradycardia, low-voltage electrocardiogram (EKG), cardiomyopathy, and pericardial effusion. Here, we present a case of cardiac tamponade in untreated hypothyroidism. A 49-year-old male with no prior medical or psychiatric history p...

The current study aimed to evaluate the therapeutic role of bee pollen (BP) in reducing the harmful effects resulting from hypothyroidism compared to the drug thyroxine on some physiological indicators and improving their levels, which included weight gain (gm), hormone level (T3, T4, TSH), level TPO, cholesterol levels, HDL, LDL, VLDL, and liver e...

Chronic spontaneous urticaria (CSU) affects about 1% of population, and its prevalence is increasing. The disease occurs in both children and adults, with predominance among women. At least two possible causes of CSU have been identified, two autoimmune endotypes, with different types of autoantibodies associated with activation of skin mast cells....

Objective: The study aimed to investigate the correlation between Helicobacter pylori (H. pylori) and thyroid autoimmunity. Material and Methods: To demonstrate the possible correlation between H. pylori infection and autoimmune hypothyroidism, 200 individuals were enrolled in this research (100 patients with active H. pylori infection and 100 heal...

Romiplostim, a thrombopoietin (TPO) receptor agonist, is a clinically approved drug that is clearly effective in reconstituting hematopoiesis in refractory aplastic anemia and idiopathic thrombocytopenic purpura. However, the mechanism underlying its biological effect is unknown, and its differences from other TPO receptor agonists remain unclear....

Objectives Scheduled delivery of adequate dose of chemotherapy is important to replicate the results expected from original trials. In head and neck malignancies, undue delay of chemotherapy is likely to be associated with poor control or progression. Chemotherapy-induced thrombocytopenia (CIT) is one of the reasons to delay chemotherapy. Thrombopo...

Perovskite as an emerging semiconductor luminescent material has attracted widespread attention due to its simple preparation, high luminescence quantum yield, high color purity, tunable spectrum, and ability to cover the entire visible light band. However, due to the influence of water or other highly polar solvents, oxygen, temperature, and radia...

Platelets play a crucial role in tissue regeneration, and their involvement in liver regeneration is well‐established. However, the specific contribution of platelet‐derived Transforming Growth Factor Beta 1 (TGFβ1) to liver regeneration remains unexplored. This study investigated the role of platelet‐derived TGFβ1 in initiating liver regeneration...

Background: Participation represents the most relevant indicator of successful functioning after a severe traumatic brain injury (sTBI), since it correlates with a higher perceived quality of life by patients, their families, and healthcare professionals. Nevertheless, studies on Italian population are lacking. Aim: The aim of this study was to...

Environmental pollutants capable of interfering with the thyroid hormone (TH) system increasingly raise concern for both human and environmental health. Recently, resorcinol has received attention as a compound of concern due to its endocrine disrupting properties. It is a known inhibitor of thyroperoxidase (TPO), an enzyme required in TH synthesis...

The pyrolysis of waste tyres was carried out in a batch pyrolyzer reactor at a temperature of 500°C and atmospheric pressure. The tyre pyrolyzed oil (TPO) obtained recorded an average yield of 43% and the pyrolyzed carbon black (PCB) was found to be 39% while the steel wire was found to be 9%, the remaining 9% was mainly pyrolyzed gas. The average...

Bio-oil combined steam/dry reforming (CSDR) with H2O and CO2 as reactants is an attractive route for the joint valorization of CO2 and biomass towards the sustainable production of syngas (H2 + CO). The technological development of the process requires the use of an active and stable catalyst, but also special attention should be paid to its regene...

Clinical features in patients with the B-cell lymphoma, Waldenström macroglobulinemia (WM), include cytopenias, immunoglobulin M (IgM)–mediated hyperviscosity, fatigue, bleeding, and bruising. Therapeutics such as Bruton's tyrosine kinase inhibitors (BTKis) exacerbate bleeding risk. Abnormal hemostasis arising from platelet dysfunction, altered coa...

The analysis of rainfall patterns in the Indonesian region utilized the Empirical Orthogonal Function (EOF) method to identify spatial and temporal variations. The study evaluated the dynamic influence of the Tropical Indian Ocean (TIO) and the Tropical Pacific Ocean (TPO) on Indonesian rainfall using monthly data from the Southeast Asian Climate A...

A promising method for converting greenhouse gases such as CO2 and CH4 into useful syngas is the dry reformation of methane (DRM). 5Ni-ZSM-5 and 2 wt.% Ce, Cs, Sr, Fe, and Cu-promoted 5Ni-ZSM-5 catalysts are investigated for the DRM at 700 °C under atmospheric pressure. The characterization, including XRD, TPR, TPD, TPO, N2 adsorption–desorption, T...

IntroductionA growing body of evidence has shown the association between autoimmune thyroiditis and mental illness (Rege et al. AUS N J S Psychiatry 2013; 300 141-154). Identifying the neuropsychiatric features associated with thyroid antibody positivity could have significant implications for diagnostic and therapeutic strategies. However, the lin...

Bone marrow endothelial progenitor cells (BM EPCs) are crucial in supporting haematopoietic regeneration, while the BM EPCs of haematological patients with chemotherapy‐induced thrombocytopenia (CIT) are unavoidably damaged. Therefore, the present study aimed to examine the effect of thrombopoietin (TPO) on the recovery of BM EPCs of CIT patients a...

Femicid predstavlja ubistvo osoba ženskog spola motivisano mržnjom prema ženama, a svoje uzroke pretežno ima u predrasudama prema ženama. Cilj ovog istraživanja je bio utvrditi mogućnosti procesuiranja femicida u Bosni i Hercegovini. Provedena je analiza sadržaja krivičnih zakona u Bosni i Hercegovini te kvalitativna analiza 246 presuda koje se mog...

The paper shows the structural changes of copper and nickel catalysts in the presence of strong (O2) and weak (H2O) oxidizing agents and their influence on the course of methane conversion. The changes in oxidation states of investigated catalysts were studied during partial oxidation and steam reforming of methane using an X‐ray reactor chamber (X...

Color stability is crucial for dental materials to ensure they perfectly match a patient’s tooth color. This is particularly challenging in photoresist-based additive manufacturing. Although some studies have addressed this issue, the exact causes of discoloration and ways to minimize it remain unclear. In this study, the intrinsic causes of discol...

The Polycystic Ovarian Syndrome (PCOS) is considered as one of the most common endocrinopathies in women of reproductive age having the issues related to the hyperandrogenism and oligo-anovulation. The rate of prevalence in premenopausal women is between 6-10% worldwide and in India it is around 5-10%. Interaction of small number of key genes respo...

Introduction Vitiligo (VL) is associated with several autoimmune diseases, especially Hashimoto’s thyroiditis, VL and concomitant Hashimoto’s thyroiditis (HT) up to 34% in VL. Aim To assess the predictive value of serum inflammatory factors in guiding treatment response among patients with concurrent VL and concomitant HT. Material and methods Th...

Background Immune thrombocytopenia (ITP) is a common cause of severe thrombocytopenia in dogs. The pathogenesis of nonassociative, primary ITP (pITP) appears complex, with ill‐defined thrombopoietic response. Objectives Develop an immunoassay to measure plasma canine thrombopoietin (TPO) concentration and characterize TPO concentrations in dogs wi...

Introduction: Significant reduction of subjective health status is frequently reported by many patients with Hashimoto thyroiditis despite adequate thyroxine replacement therapy. Studies have shown that thyroidectomy improves quality of life (QoL) in patients with HT and persistence symptoms, however there are conflicting evidence and we do not hav...

Chemotherapy‐induced thrombocytopenia (CIT) is a common challenge of cancer therapy and can lead to chemotherapy dose reduction, delay, and/or discontinuation, affecting relative dose intensity, and possibly adversely impacting cancer care. Besides changing anticancer regimens, standard management of CIT has been limited to platelet transfusions an...

This study considers the development of a kinetic model for the n-butane oxidative dehydrogenation (ODH) to C4-olefins using a VOx/MgO−γAl2O3 catalyst. The prepared catalyst contained 5 wt% V on an MgO modified γAl2O3 support. The developed catalyst exhibited both weak and medium acid sites, as revealed by NH3-temperature-programmed desorption. TPR...

Developing high-efficiency, high-stability, and low-cost deoxygenation and hydrocracking catalysts could be considered one of the most significant breakthroughs in catalytic hydroprocessing. The present study utilized aluminophosphate (AlPO4-18), a zeolite-like molecular sieve, as catalyst support for producing carbon-coated β-Mo2C, Ni3C, and WC na...

Introduction IDH2 mutation is an unfavorable prognostic factor in patients with primary myelofibrosis (PMF) but its effect on myelofibrosis (MF) remains largely unclear. Methods In this study, we aimed to elucidate the roles of IDH2 mutation in the development and progression of MF by transcriptomic and molecular techniques using the Idh2 R172K tr...

Background: Ultrasound examination of the thyroid has emerged as a useful diagnostic and prognostic tool, along with measuring serum titers of anti-thyroid peroxidase (TPO), anti-thyroglobulin (Tg), and thyroid hormones, in patients with Hashimoto's thyroiditis. So, we aimed at considering correlations of ultrasonographic, antibodies, and thyroid h...

Perturbation of thyroid hormone (T4) synthesis is known to cause numerous developmental, metabolic, and cognitive disorders in humans. Due to species differences in sensitivity to chemical exposures, there is a need for human-based in vitro approaches that recapitulate thyroid cellular architecture and T4 production when screening. To address these...

Despite increased understanding of the genomic landscape of Myeloproliferative Neoplasms (MPNs), the pathological mechanisms underlying abnormal megakaryocyte (Mk)-stromal crosstalk and fibrotic progression in MPNs remain unclear. We conducted mass spectrometry-based proteomics on mice with Romiplostim-dependent myelofibrosis to reveal alterations...

Background and Objectives: Immune thrombocytopenia (ITP) is an autoimmune disease characterized by the autoantibody-mediated destruction of platelets. The treatment of ITP aims to maintain a sufficient platelet count to prevent bleeding. First-line treatment options include corticosteroids and intravenous immunoglobulin (IVIg), while second-line tr...

Background Hashimoto’s disorder is an autoimmune disease affecting cells of the thyroid gland via the diffusion of the lymphocytes into thyroid cells. Calcitriol is the active form of Vit.D3; there were a strong correlation between low Vit-D levels and development of autoimmune diseases exists and calcitriol supplementation might play a protective...

Background and Objectives: Congenital thyroid dyshormonogenesis is caused by alterations in the synthesis of thyroid hormones in a newborn. Additionally, 10 to 20% of these cases are hereditary, caused by defects in proteins involved in hormonal synthesis. One of the most common causes is mutations in the thyroid peroxidase (TPO) enzyme gene, an au...

SLC26A4 causes Pendred syndrome (PS) and nonsyndromic hearing loss. In some patients, PS is distinguished based on perchlorate discharge test abnormality, goiter, and hypothyroidism. The pathophysiology of thyroid dysfunction in PS differs from that of autoimmune thyroid disease, in that it is considered to be caused by an iodide organification def...

An air cathode (AC) is one of the main components in an AC-based biofuel cell (BFC). Its cost accounts for nearly half of the total cost of the cell as specific requirements must be met for it to perform as an effective site for the oxygen (O2) reduction reaction (ORR) to occur. In most applications where the AC is totally submerged in the electrol...

In a recent contributions, [102], 3D imaging-processing Isodosezones [ Casesnoves, 2022 ], delimited by 3D Isodoselines were explained in lung cancer and other tumor types, such a sprostate. The radiotherapy model applied was the classical BED one algorithm. Modern biological-model-based Treatment Planning Optimization can get objective improvement...

The aim of this case report is to underline the possible etiological link between paroxysmal supraventricular tachycardia and hypothyroidism, although supraventricular arrhythmias are ordinary features of hyperthyroidism. We present a case of a young patient with first time episodes of PSVT, symptomatic, the possible triggers of arrhythmia were inv...