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This paper first gives an overview of the development of the idea of a phenomenological language in Wittgenstein's work during the year 1929. I summarize the way in which Wittgenstein outlines the idea in his paper "Some Remarks on Logical Form" and then demonstrate how his considerations regarding the representation of time in the phenomenological...
Article
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With the continuous development of nanomaterials in recent years, the application of nanocatalysts in catalytic ozone oxidation has attracted more and more researchers' attention due to their excellent catalytic properties. In this review, we systematically summarized the current research status of nanocatalysts mainly involving material categories...
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ABSTRACT: This systematic review aimed to (1) identify and summarize studies that have examined the effects of re-warm-up (RWU) protocols on the physical performance of soccer players (vertical height jump and sprinting time) and (2) establish a meta-comparison between performing a re-warm-up and not performing one regarding the outcomes of the afo...
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The application of the data-driven machine learning (DDML) for the disposal of the high-level nuclear waste (HLW) is of emerging interest in the recent years. This review aims to systematically elaborate, analyze, and summarize recent advances related to DDML in the area of disposal of the HLW. Firstly, a comprehensive work on the DDML for the disp...
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The cohesive and adhesive performances of bituminous materials significantly affect the service life of asphalt pavement. The molecular dynamics (MD) simulation method has been proved as an effective tool to predict the thermodynamics parameters of different multi-substance and multi-phase bitumen models during different diffusion, self-healing, an...
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Smallholder farming systems are important for global food security, but these faces multiple environmental challenges hindering sustainable development. Although sustainable smallholder agriculture issues have been widely discussed and addressed by scientists globally, harmonized approaches in evaluating sustainability are still lacking. This paper...
Conference Paper
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The growth performance of Spirulina platensis was studied in four different concentrations of poultry feather waste media (PFWM) (T1; 0%, T2; 20%, T3; 40%, and T4; 60% w/v) and in control, Jourdan Medium (JM) in triplicate in a small-scale outdoor culture system. The initial cell weight of S. platensis was 0.35 mg/l which attained a maximum cell we...
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Music is the language of emotions. In recent years, music emotion recognition has attracted widespread attention in the academic and industrial community since it can be widely used in fields like recommendation systems, automatic music composing, psychotherapy, music visualization, and so on. Especially with the rapid development of artificial int...
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This chapter summarizes an emerging sub-discipline of both empirical bioethics and experimental philosophy (“x-phi”) which has variously been referred to as experimental philosophical bioethics, experimental bioethics, or simply “bioxphi” (Earp, Latham and Tobia, 2020; Earp et al., 2020; Lewis, 2020; Mihailov, Hannikainen and Earp, 2021). Like empi...
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Circular RNAs (circRNAs) have become a research hotspot in recent years with their universality, diversity, stability, conservativeness, and spatiotemporal specificity. N ⁶ -methyladenosine (m ⁶ A), the most abundant modification in the eukaryotic cells, is engaged in the pathophysiological processes of various diseases. An increasing amount of evi...
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The complexity of oral ulcerations poses considerable diagnostic and therapeutic challenges to oral specialists. The expert consensus was conducted to summarize the diagnostic work-up for difficult and complicated oral ulcers, based on factors such as detailed clinical medical history inquiry, histopathological examination, and ulceration-related s...
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Although the multimessenger detection of the neutron star merger event GW170817 confirmed that mergers are promising sites producing the majority of nature’s heavy elements via the rapid neutron-capture process ( r -process), a number of issues related to the production of translead nuclei—the actinides—remain to be answered. In this short review p...
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Peptide drug development has made great progress in the last decade thanks to new production, modification, and analytic technologies. Peptides have been produced and modified using both chemical and biological methods, together with novel design and delivery strategies, which have helped to overcome the inherent drawbacks of peptides and have allo...
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Background The global population of older individuals is growing, and ageing is a key risk factor for atherosclerotic cardiovascular diseases. Abnormal accumulation of senescent cells can cause potentially deleterious effects on the organism with age. As a vital marker of cellular senescence, the senescence-associated secretory phenotype (SASP) is...
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N6-methyladenosine (m ⁶ A) is a key area in Epigenetics and has been increasingly focused these years. In the m ⁶ A process, readers recognize the m ⁶ A modification on mRNAs or noncoding RNAs and mediate different downstream events. Emerging studies have shown that YTHDC1, an important m ⁶ A reader, plays a key role in many biological functions an...
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Flexible electronics have suggested tremendous potential to shape human lives for more convenience and pleasure. Strenuous efforts have been devoted to developing flexible organic field-effect transistor (FOFET) technologies for rollable displays, bendable smart cards, flexible sensors and artificial skins. However, these applications are still in...
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Due to their high safety and low cost, rechargeable aqueous Zn-ion batteries (RAZIBs) have been receiving increased attention and are expected to be the next generation of energy storage systems. However, metal Zn anodes exhibit a limited-service life and inferior reversibility owing to the issues of Zn dendrites and side reactions, which severely...
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Background Pulmonary sclerosing pneumocytoma is a kind of rare benign pulmonary tumor with potential malignancy. The clinical features, risk factors for prognosis, and optimal treatment have not been identified yet. This study aimed to investigate the clinical features and prognosis of pulmonary sclerosing pneumocytoma. Methods We retrospectively...
Article
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The evaluation of radiation burden in vivo is crucial in modern radiology as stated also in the European Directive 2013/59/Euratom—Basic Safety Standard. Although radiation dose monitoring can impact the justification and optimization of radiological procedure, as well as effective patient communication, standardization of radiation monitoring soft...
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Gut homeostasis is of importance to host health and imbalance of the gut usually leads to disorders or diseases for both human and animal. Postbiotics have been applied in manipulating of gut health, and utilization of postbiotics threads new lights into the host health. Compared with the application of probiotics, the characteristics such as stabi...
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Background Classic infantile onset of Pompe disease (c-IOPD) leads to hypotonia and hypertrophic cardiomyopathy within the first days to weeks of life and, without treatment, patients die of cardiorespiratory failure in their first 1–2 years of life. Enzymatic replacement therapy (ERT) with alglucosidase alfa is the only available treatment, but ad...
Article
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The modular multilevel converter (MMC) is one of the most critical implementation forms of high voltage direct current transmission (HVDC). However, the electromagnetic interference (EMI) problems in MMC are unavoidable and complex due to the nonlinear switching behavior of a considerable number of submodules (SMs). In this article, the state-of-th...
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In this conceptual paper, we describe the approach in storylines that builds on principles of project-based learning and focuses on supports for making science learning coherent from the students’ perspective. In storylines, students see their science work as addressing questions and problems their class has identified. We present design principles...
Article
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Medical devices are a major component of precision medicine and play a key role in medical treatment, particularly with the rapid development of minimally invasive surgery and wearable devices. Their tissue contact properties strongly affect device performance and patient health (e.g., heat coagulation and slipperiness on surgical graspers). Howeve...
Article
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Hypertension is a well-recognized risk factor for the development of cardiovascular disease, and the early detection of cardiac changes from hypertension can allow reversing these. Hypertensive heart diseases (HHD) refer to the complex and diverse change of the cardiac structure and function secondary to hypertension. Although conventional echocard...
Article
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As a major food crop and model organism, rice has been mostly studied with the largest number of functionally characterized genes among all crops. We previously built the funRiceGenes database including ~ 2800 functionally characterized rice genes and ~ 5000 members of different gene families. Since being published, the funRiceGenes database has be...
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The development of Ethnic Politics in China can date back to 80 years ago. As of today, its disciplinary system and norms have been established in a systematic approach, and many significant academic achievements have been made. After having systematically reviewed the academic history of Frontier Politics originating in the 1940s and the Ethnic Po...
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With rapid development of 5G communication technologies, electromagnetic interference (EMI) shielding for electronic devices has become an urgent demand in recent years, where the development of corresponding EMI shielding materials against detrimental electromagnetic radiation plays an essential role. Meanwhile, the EMI shielding materials with hi...
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Background It is estimated that about 10% of pancreatic cancer cases have a genetic background. People with a familial predisposition to pancreatic cancer can be divided into 2 groups. The first is termed hereditary pancreatic cancer, which occurs in individuals with a known hereditary cancer syndrome caused by germline single gene mutations (e.g.,...
Article
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Distraction osteogenesis (DO) is widely used for bone tissue engineering technology. Immune regulations play important roles in the process of DO like other bone regeneration mechanisms. Compared with others, the immune regulation processes of DO have their distinct features. In this review, we summarized the immune-related events including changes...
Article
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Palliative care is an interdisciplinary care to optimize physical, psychosocial, and spiritual symptoms of patients and their families whose quality of life is impaired by serious, life-limiting illness. In 2021, the importance of providing palliative care in the intensive care unit (ICU) is well recognized by various studies to alleviate physical...
Article
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Electrical stimulation is used to elicit muscle contraction and can be utilized for neurorehabilitation following spinal cord injury when paired with voluntary motor training. This technology is now an important therapeutic intervention that results in improvement in motor function in patients with spinal cord injuries. The purpose of this review i...
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Non-medullary thyroid cancer (NMTC) is the most common type of thyroid cancer. With the increasing incidence of NMTC in recent years, the familial form of the disease has also become more common than previously reported, accounting for 5–15% of NMTC cases. Familial NMTC is further classified as non-syndromic and the less common syndromic FNMTC. Alt...
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In recent decades, a number of training environments have moved toward program approaches targeting the development of competencies. Because of their complexity, monitoring the development of those competencies is a considerable challenge. Our hypothesis is that a computerized system could help overcome this challenge if it is well accepted by its...
Article
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Background Secondary peripheral chondrosarcomas arising in solitary osteochondromas is an unusual complication, reported in small series. In this study, we aimed to present our experience with this rare variant of chondrosarcoma and compare results with already published data in order to determine prognostic factors for overall and disease-free sur...
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Developing highly efficient and durable electrocatalysts plays a central role in realizing a broad range of fuel cell application. Palladium (Pd)-nonmetal nanostructures, as a special class of Pd-based alloys, have exhibited diversified advantages for fuel cell reactions. In this minireview, the most recent progress in the synthesis of Pd-nonmetal...
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Markush structures are molecular skeletons containing not only specific atoms but also placeholders to represent broad sets of chemical (sub)structures. As genus claims, they allow a vast number of compounds to be claimed in a patent application without having to specify every single chemical entity. While Markush structures raise important questio...
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Highlights The processing methods of functional polymer composites (FPCs) are systematically summarized in “Toolbox”. The relationship of processing method-structure-property is discussed and the selection and combination of tools in processing among different FPCs are analyzed. A promising prospect is provided regarding the design principle for hi...
Article
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Calcific aortic valve disease (CAVD) is the most common valvular disease in the developed world with currently no effective pharmacological treatment available. CAVD results from a complex, multifactorial process, in which valvular inflammation and fibro-calcific remodelling lead to valve thickening and cardiac outflow obstruction. The exact underl...
Article
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YT521-B homology domain family member 2 (YTHDF2) is an N ⁶ -methyladenosine (m ⁶ A)-binding protein that was originally found to regulate the stability of mRNA. Growing evidence has shown that YTHDF2 can participate in multifarious bioprocesses, including embryonic development, immune response, and tumor progression. Furthermore, YTHDF2 is closely...
Article
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The Laser Interferometer Space Antenna (LISA) has the potential to reveal wonders about the fundamental theory of nature at play in the extreme gravity regime, where the gravitational interaction is both strong and dynamical. In this white paper, the Fundamental Physics Working Group of the LISA Consortium summarizes the current topics in fundament...
Article
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The development of highly facile synthetic procedures for the expedient synthesis of complex natural molecules is always in demand. As this aspect, the Diels–Alder reaction (DAR) has a versatile approach to the synthesis of complex natural compounds and highly regio-/stereoselcetive heterocyclic scaffolds. Additionally, α-pyrone and terpenoquinone...
Article
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Flexible perovskite solar cells (FPSCs) have attracted enormous interest in wearable and portable electronics due to their high power-per-weight and low cost. Flexible and efficient perovskite solar cells require the development of flexible electrodes compatible with the optoelectronic properties of perovskite. In this review, the recent progress o...
Article
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While conventional chemical fungicides directly eliminate pathogens, plant immunity inducers activate or prime plant immunity. In recent years, considerable progress has been made in understanding the mechanisms of immune regulation in plants. The development and application of plant immunity inducers based on the principles of plant immunity repre...
Article
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The ketogenic diet (KD) is a high-fat, adequate-protein, and very-low-carbohydrate diet regimen that mimics the metabolism of the fasting state to induce the production of ketone bodies. The KD has long been established as a remarkably successful dietary approach for the treatment of intractable epilepsy and has increasingly garnered research atten...
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The performance of artificial intelligence (AI) for brain MRI can improve if enough data are made available. Generative adversarial networks (GANs) showed a lot of potential to generate synthetic MRI data that can capture the distribution of real MRI. Besides, GANs are also popular for segmentation, noise removal, and super-resolution of brain MRI...
Article
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Prostate cancer is characterized by a high degree of heterogeneity, which poses a major challenge to precision therapy and drug development. In this review, we discuss how nongenetic factors contribute to heterogeneity of prostate cancer. We also discuss tumor heterogeneity and phenotypic switching related to anticancer therapies. Lastly, we summar...
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The present special issue represents the outcome of the Fourth Monaco Symposium on Luxury, organized by the International University of Monaco and OMNES Education. The Symposium is a biennial event that brings together academics and practitioners from around the globe. Due to the outbreak of Covid, the symposium was postponed twice, and a new call...
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The neoadjuvant and adjuvant anti-PD-1/PD-L1 treatment has been increasingly noticed. To summarize the global landscape of these clinical trials will provide essential data for all the stakeholders of drug development. Based on the Trialtrove database, a total of 668 clinical trials initiated by the end of 2020 were retrospectively analyzed. We fou...
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Pit thermal energy storage (PTES) is one of the most promising and affordable thermal storage, which is considered essential for large-scale applications of renewable energies. However, as PTES volume increases to satisfy the seasonal storage objectives, PTES design and application are challenged. These difficulties trigged an interest in PTES inve...
Conference Paper
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Doxing refers to the practice of disclosing sensitive personal information about a person without their consent. This form of cyberbullying is an unpleasant and sometimes dangerous phenomenon for online social networks. Although prior work exists on automated identification of other types of cyberbullying, a need exists for methods that are capable...
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The construction and building sectors are currently responsible globally for a significant share of the total energy consumption and energy-related carbon dioxide emissions. The use of Modern Methods of Construction can help reduce this, one example being the use of cold-formed steel (CFS) construction. CFS channel sections have inherent advantages...
Article
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Primary failure of eruption (PFE) is a rare disorder defined as incomplete tooth eruption despite the presence of a clear eruption pathway. PFE is known to be caused by rare variants in the parathyroid hormone 1 receptor gene (PTH1R). Although several PTH1R variants have been reported, the etiology of PFE remains unclear. However, important studies...
Article
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In recent years, voltage sags are one of the most critical research issues in the field of power quality. With the all-embracing study of voltage sag mitigation measures and equipment, the classification of voltage sag mitigation measures and equipment is becoming more and more necessary. Reasonable classification methods not only can guide users t...
Chapter
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Two‐dimensional (2D)‐materials membranes for gas separations are summarized in this chapter. Firstly, the emerging potential of various 2D‐materials membranes is introduced. Then these representative works on 2D‐materials membranes for gas separation are highlighted, being followed by the preparation methods, including top‐down method and bottom‐up...
Preprint
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Under the Dual Carbon Target in China, the flexible resource regulation and utilization in power and energy systems has become an important means to reduce carbon emissions and improve energy efficiency. With the development of the distributed new energy generation technology and the demand response technology, the energy system of urban building c...
Conference Paper
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The PVT technology combines solar PV and solar thermal in the same PVT panel. In this way, both electricity and heat are produced by the PVT panel. Compared to the PV technology and the solar heating technology the PVT technology is in the early market stage with only few small and weak industries active. Best practices for the PVT technology, whic...
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