Skin Aging - Science topic

"In the laboratory, exosomes have been effectively used to delay the onset of skin aging. They do this by encouraging the development of fibroblast cells, which are crucial to maintaining skin elasticity and strength" ( https://colgrove.com/exosomes-for-anti-aging-skin-rejuvenation/ ).

We want to calculate the topical dose of a peptide drug which isn't used on wounded skin before but we have the systemic i.p dose

I would like to know other plants different from the already commercially known, and establish if the major phytochemical content is related to their activity

There are published reports that oral collagen supplements in the form of collagen hydrolysate, collagen tripeptide or collagen dipeptide improves the quality of skin and gives anti-aging property. How does it work? How is it metabolized in the body? When supplement is given is there any down regulation of collagen synthesis by fibroblasts?

Wrinkling of skin happened due to multiple factors including ageing, genetic bases, sunlight exposure, eating behavior etc. we can control these factors by applying anti age creams available in the market which slow down the wrinkling and promote collagen and elastin protein, while collaginase breaks it, now what are anti aging creams which are really beneficial and having what ingredients in it, some suggestions needed,

Phenolic compounds could be potentially effective in the treatment of various skin disorders, including signs of aging, diseases and injury. Numerous studies have shown the potent biological activity of polyphenols, especially in skin cell cultures, a reconstituted skin model and rodents (mice, rats). Plant phenolics possess a significant potential to inhibit or even reverse the signs of aging, such as wrinkles or hyperpigmentation marks; hence they are promising molecules for development of new cosmetic formulations. On the other hand, particular phenolic compounds may act in a specific and effective way in order to inhibit or slow down the development of various skin-related diseases. The plant phenolics may be efficient in the treatment of both serious life-threatening dermal diseases (cancer) and minor skin problems (acne). Despite the beneficial influence of polyphenols on the skin aging effects and dermal diseases, they were also reported to be effective in healing of wounds (including chronic wounds) and burns. As regards skin disorders, therapeutic properties were shown by either a single compound or a combination of phenolics present in the plant extracts. The natural character and high effectiveness of phenolic compounds are promising features for developing novel topical formulations and dressings that might replace hitherto known remedies with limited application.

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Besides the previously discovered circadian clock (the 24-hour timekeeper) is there another master regulator clock controlling aging and other time scheduled events of life, such as fetal development and puberty (and ultimately over-watching the whole cycle of aging) which are precisely time-dependent, by keeping the track of solar “years” passed?

We recently develop a kind of dissolving micro-needle which can dissolve in dermal system to deliver medicine, skin-care product inside of it.

We first want to make an application in skin-care area because it is not regulated as medicine does.

Here are what we have in mind, we want to use this microneedle to  Wrinkles, scars, hair growth, hair removal. But we do not know which chemicals or compound should we use for those applications?

Besides, are there some treatment only can be performed by needle injection?

Any suggestion and comment are welcome! Thanks

I would like to analyse proapoptotic activity of a compound to be used on Actinic keratosis. Is there any cell line that might represent early phases of photocarcinogenesis?

In measuring aged skin, what other instruments can I use beside cutometer, corneometer and visioscan?

I will start projects in order to model with finite element approach the human skin ageing. Are you aware about such models ?

When applied topically,  is there any substance that induces the production,  synthesis of elastin? How about increasing elasting in the skin?

Considering the intensity of wrinkles or grade of wrinkles and dose of Botox. is there any formula?How does one decrease the metabolism of botox?

(1)Assessing for ECM degradation ( antielastase, anticollagenase and anti hyaluronidase)

(2) Assessing anti-tyrosinase activity (hyperpigmentation)

Other?

What role do cosmetics play in the prevention and reversal of skin aging? Is the hype created by cosmetic manufacturers justifiable?

I am looking for a set of comprehensive review papers on the mechanisms of wrinkle formation and will highly appreciate the reference. 

Acne patients often ask doctors: Which food do I have to avoid? Which kind of food may improve the symptoms of acne?

Is there any consensus with regard to so called recommended UVB dose used in in vitro experiments? From the literature review conducted by me so far it seems that different doses are used.

We would like to conduct an experiment to check the potential of our compounds against UVB induced skin ageing.

I'm interested in assessing the properties of skin in orthopaedic trauma patients, in particular instrumented measures of 'thickness' and elasticity. Could anyone please advise the best methods/instruments to use? I'm aware of the Ballistometer and Cutometer and obviously skin fold callipers.

What challenges have you encountered in doing this assessment?

Aging affects the body, is there any relation between early aging and the risk of heart stroke or brain stroke.how does one reverse it