Science topic
Skin Absorption - Science topic
Uptake of substances through the skin.
Questions related to Skin Absorption
I am looking for a plain/empty gel system, which we can directly buy and load the drug for the purpose of transdermal delivery. Your kind help will be appreciated.
Every time i working with hyaluronic acid I got some bubbles inside gel. It desn't matter in lab and do not affect on the acid. Few days ago I saw syringe (with a needle) with clear hyaluronic acid without any bubbles. Friend send me a photo of bottle with the product without bubbles too. How do they made it??? I was trying vacuum suction but did not get proper effect.
We want to calculate the topical dose of a peptide drug which isn't used on wounded skin before but we have the systemic i.p dose
Per- and polyfluoroalkyl substances (PFASs)are a ubiquitous group of environmental chemicals that cause numerous detrimental impacts on the environment and human health. According to performed studies, these metabolically inert chemicals enter the body of humans and animals and transfer into target tissues such as liver, kidney, bone, skin, etc. with the help of protein carriers in the bloodstream. From a dermatological point of view, what toxic consequences are most likely to occur in response to the dermal bioaccumulation of environmental contaminants such as PFASs? What are the differences between possible toxic effects caused by internal dermal exposure (dermal bioaccumulation) to a chemical and external dermal exposure (dermal absorption) to the same chemical?
Thanks in advance.
If I want a certain antioxidant in a formulation to be penetrated into the skin , Is it ok to load it into ethosomes or the loading means that the whole package will be delivered ?
I'm interested in hearing from the experts in pharmacology/drug delivery: in transdermal drug delivery, which drug parameters are most important in determining the rate of removal from the skin via uptake by cutaneous vasculature? For example: lipophilic, small MW and unchanged compounds enter the stratum corneum with greatest ease. In the same vein, what is the relationship between an individual drug's physicochemical properties and its absorption/removal to local skin circulation.
Onr of my patient reported that several workers in factory are suffering from diabetes and it might be due to absorption of sugar through inhalation or skin absorption.
I know how to calculate how much time you can spend in the Sun before starting to burn, or which SPF you should choose according the UV Index for the day and your Skin Type and if you are using SPF, etc. There is several formulas to know it. But I don´t find when you can return to be sun exposure if you have if you've already spent this time
For example: A person with Skin Type 3 at sea level exposed to a UV Index of 10 would start to suffer from sunburn after 30 minutes. My question is If he have already spend this 30 min. When this person can return to be sun exposed? The following day? and Why?
Thanks
Ksenia Bystrova speculated in 2009 that c-tactile fibers might be stimulated by amniotic fluid via lanugo hair. If this were accurate, the potential involvement of c-tactile fibers in hydrotherapy might deserve a closer look – warm currents have a lot in common with gentle stroking, which is the main modality c-tactile fibers respond to.
How to create and analyze cubical tissue model, and What is meaning of SAR 10g ?
I want to know further about this in order to understand further why the veins are blue when the baby get the cyanosis?
We know that, skin get its color by the subtractive mechanism of color mixture. And in the dermis there are many substance for instant, protein, hemoglobin, melanin etc that removed color and I think it is kind of a transfer function.
What is the relationship between transfer function, H(f) with molar extinction of oxyhemoglobin & deoxyhemoglobin? So far, we know that a control system of H(f) is = 1/s-1, 1/s.
Can i assume that the transfer function of the skin chromophores (skin tissue, fat, melanin etc) = 1 / molar extinction of oxyhemoglobin/ deoxyhemoglobin?
Or can I assume that a transfer function of hemoglobin = molar extinction coefficient itself?
If so, can you suggest any papers or articles that related with this.
Thank you.
Is there any method to reduce the absorption or penetration of a drug in topical formulation since the action is sought only on the surface of the skin and not beneath the skin? Your input helps me a lot.
Thanks in advance.
Cell sheet attachment in the skin during transplantation.
When we select any drug for topical use, first we talk about the skin partition coefficient of that drug. How can we determine the skin partition coefficient of any drug selected for topical use?
I think it also depends on the drug delivery system. i.e. if we are talking about transdermal patches, then during selection of drug it is required, but in case of elastic vesicles, skin partition coefficient is not a mandatory parameter.
Are the experienced researchers in such a type of investigation agreeing with me?