Secondary Prevention - Science topic
Secondary Prevention is the prevention of recurrences or exacerbations of a disease that already has been diagnosed. This also includes prevention of complications or after-effects of a drug or surgical procedure.
Questions related to Secondary Prevention
Is there a "J" curve, below which the risk outweighs the benefits with the more intensive statin dosing?
Lower cut-off points among patients using statins for either primary or secondary prevention?
I would like to know the changes in statin prescription rates and cholesterol treatment guidelines over time (i.e. from the introduction of statins until the present time in the United States and Europe). I am especially interested in the context of secondary prevention of embolic stroke. Are you aware of any published data or do you know where I can find out-dated versions of cholesterol treatment guidelines? Thank you for your suggestions.
- The use of acetylsalicylic acid (ASS) is the standard therapy for secondary prevention following atherotrombotic brain infarction or myocardial infarction.
Due to the risk of bleeding complications, platelet inhibitors are not recommended for primary prevention in patients with cerebrovascular risk. According to Goltz L et al. (2014) there are inconsistent data concerning the use of ASS for primary prevention in patients with increased cardiovascular risk and cerebrovascular risk.
(L Goltz, U Bodechtel, T Siepmann: Statins and ASS for primary prevention of cardiovascular and cerebrovascular disease. DMW 2014; 139(6):283-286)