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Article
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Approaches for antibody discovery have seen substantial improvement and success in recent years. Yet, advancing antibodies into the clinic remains difficult because therapeutic developability concerns are challenging to predict. We developed a computational model to simplify antibody developability assessment and enable accelerated early-stage scre...
Article
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Background Miridesap depletes circulating serum amyloid P (SAP) and dezamizumab (anti-SAP monoclonal antibody) targets SAP on amyloid deposits, triggering amyloid removal. In a phase 1, first-in-human study (FIHS), progressive amyloid removal was observed in some patients after ≤ 3 cycles of miridesap/dezamizumab. Methods This observational, non-i...
Article
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Background Acute pancreatitis (AP) is an inflammatory process of the pancreas resulting from biliary obstruction or alcohol consumption. Approximately, 10–20% of AP can evolve into severe AP (SAP). In this study, we sought to explore the physiological roles of the transcription factor serum response factor (SRF), annexin A2 (ANXA2), and nuclear fac...
Presentation
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SAP Concur - Hear how Electrolux has transformed their spend management process
Article
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Background Arterial hypertension is a worldwide public health problem. While it is currently diagnosed and monitored non-invasively using the oscillometric method, having the ability to measure blood pressure (BP) using a smartphone application could provide more widespread access to hypertension screening and monitoring. In this observational stud...
Article
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In most applications of wireless sensor networks the specification of the corresponding topology can be useful for the optimization of some important features, such as: node energy consumption, connectivity and coverage area. This is known as the Sensor Allocation Problem (SAP). Our work proposes an approach based on memetic algorithm concepts to f...
Article
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Background Pulmonary infection is a frequent complication among stroke patients and adversely affects clinical outcomes, increases the length of hospitalization stay and costs, and aggravates the financial burden of the national medical health system. Early identification and management of high-risk patients are necessary and imperative to reduce t...
Article
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PurposeA number of studies performed in the operating room evaluated the hemodynamic effects of the fluid challenge (FC), solely considering the effect before and after the infusion. Few studies have investigated the pharmacodynamic effect of the FC on hemodynamic flow and pressure variables. We designed this trial aiming at describing the pharmaco...
Article
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Pain treatment services and clinical indicators of pain chronicity focus on afferent nociceptive projections and psychological markers of pain perception with little focus on motor processes. Research supports a strong role for the motor system both in terms of pain related disability and in descending pain modulation. However, there is little unde...
Article
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Background Hereditary transthyretin amyloidosis (ATTRv) is a rare, debilitating and fatal disease, mostly characterized by progressive axonal peripheral neuropathy. Diagnosis is still challenging and diagnostic delay in non-endemic area is about 3–4 years. The aim of this study was to arrange a clinical and electrophysiological score to select pati...
Article
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At present, the growing environmental concerns have strengthened the use of biodegradable and natural polymers in the synthesis of superabsorbent polymer (SAP) particularly in agriculture applications as natural polymers are much more efficient and environmentally friendly than synthetic ones. Starch is the most abundant carbohydrate polymer, biode...
Article
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To provide information about the clinical relevance of blood pressure (BP) measurement differences between a new smartphone application (OptiBP™) and the reference method (automated oscillometric technique) using a noninvasive brachial cuff in patients admitted to the emergency department. We simultaneously recorded three BP measurements using both...
Article
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Background Pneumonia is a frequent medical complication after stroke. A few studies showed that the use of anticholinergic medication is associated with a higher risk of community acquired pneumonia in the elderly. We aimed to determine if there is any association between anticholinergic medication used before stroke and stroke-associated pneumonia...
Article
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Bangladesh has a long history of earthquakes and the largest one that occurred here is of 8.7 magnitudes Great Indian Earthquake. Several international researchers showed the possibility of large earthquake to occur in this area in near future, which will cause damages of infrastructures resulting in loss of human lives. It has been observed that m...
Article
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Background: At present, a number of systematic reviews (SRs) on Xuebijing injection (a patent in China) in the treatment of acute pancreatitis (AP) or severe acute pancreatitis (SAP) have been published. However, the quality of evidence is uneven and has not been comprehensively evaluated. Aim: We evaluated the efficacy of Xuebijing injection for A...
Article
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This work is aimed at exploring the mechanism of inflammatory factors and soluble vascular cell adhesion molecule-1 (sVCAM-1) regulated by nuclear transcription factor-κB (NF-κB) in unstable angina pectoris (UAP). 60 patients with unstable angina pectoris (UAP), 60 patients with stable angina pectoris (SAP), and some healthy people (controls) were...
Article
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The purpose of this article is to examine the server activation policy (SAP) in a multi-server queuing-inventory system (MQIS). The queue has a total of c number of multi-threshold stages as well as c-homogeneous servers. The activation of each server begins one by one if there is an adequate queue length and inventory in the system; otherwise, the...
Article
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Background: An effective use of surgical antibiotic prophylaxis (SAP) appears essential to prevent the development of infections linked to surgery while inappropriate and excessive prescriptions of prophylactic antibiotics increase the risk of adverse effects, bacterial resistance and Clostridium difficile infections. In this study, we aimed to an...
Article
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There is limited evidence that Enterobacter hormaechei can improve plant physiology and yield through soil phosphate (P) and potassium (K) amelioration. This study unraveled the effect of different soil inoculation methods i.e., free-cell and encapsulated (alginate bead containing sugar-protein hydrolysate and molasses) E. hormaechei 40a with diffe...
Article
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Superabsorbent polymers (SAPs) are environmentally friendly stabilizers to improve the engineering properties of excavated soils with high water contents. The present study aims to evaluate the durability of stabilized soil with SAP subjected to wetting–drying cycles. A series of laboratory experiments were conducted to evaluate the variation in ma...
Article
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Background Stroke‐associated pneumonia (SAP) occurs frequently after a stroke. Geriatric Nutritional Risk Index (GNRI) is a valuable indicator of elderly individuals’ nutritional status. This research was designed to obtain insight into the link between GNRI and SAP. Methods Patients with acute ischemic stroke (AIS) were categorized into the SAP a...
Article
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A novel way which uses the concept of modular arithmetic is proposed to solve Solid Assignment Problem. SAP is a special case of STP where the quantities corresponding to supply, demand and conveyance are assumed to be one and hence one to one allocation is required. In this method given problem with three constraints is solved by considering three...
Article
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Ultrasound-guided interfascial plane blocks performed on the anterior and lateral thoracic wall have become an important adjuvant method to general anesthesia and an independent method of local anesthesia and pain management. These procedures diminish the harmful effects of anesthesia on respiratory function and reduce the risk of phrenic nerve par...
Article
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BACKGROUND Treatment for severe acute severe pancreatitis (SAP) can significantly affect Health-related quality of life (HR-QoL). The effects of different treatment strategies such as endoscopic and surgical necrosectomy on HR-QoL in patients with SAP remain poorly investigated. AIM To critically appraise the available evidence on HR-QoL following...
Article
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This paper discusses the possibility of developing a lightweight self-compacting concrete (SCC) with self-curing capabilities. In this regard, a supplementary cementitious material metakaolin, a presoaked lightweight expanded clay aggregate (LECA), and a chemical agent, superabsorbent polymer (SAP), were incorporated in developing a self-compacting...
Article
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The process of how multimeric transmembrane proteins fold and assemble in the endoplasmic reticulum is not well understood. The alpha7 nicotinic receptor (α7 nAChR) is a good model for multimeric protein assembly since it has at least two independent and specialized chaperones: Resistance to Inhibitors of Cholinesterase 3 (RIC-3) and Nicotinic Acet...
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In the context of digital changes taking place in the world, there is a need to use an end-to-end competency-based approach in the implementation of the Federal State Educational Standards of Higher Education. The use of effective data mining tools as a tool for understanding digital transformation processes is becoming especially relevant. The pro...
Article
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Introduction: Inappropriate antibiotic use in the world leads to an increase in both health care costs and antibiotic resistance. Surgical antibiotic prophylaxis (SAP) is used by most surgeons, especially in the postoperative period. Objective The aim of the study is to determine the approach of ear, nose, and throat (ENT) specialists to surgical a...
Article
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Abstrak Tujuan penelitian ini adalah untuk mengetahui kesesuaian RSUD X antara SAP No. 1 Tahun 2010 tentang penyajian laporan keuangan dan pengungkapan biaya lingkungannya. Penelitian ini merupakan penelitian kualitatif dengan metode deksriptif. Analisis data yang digunakan dalam penelitian ini yaitu: Pengumpulan data, reduksi data, penyajian data,...
Article
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Extracellular vesicles (EVs) contain proteins, mRNAs, and microRNAs, and their cargos have emerged as novel diagnostic markers in various diseases. We aimed to discover novel and noninvasive biomarkers of liver fibrosis by proteomic analysis using serum EVs in patients with chronic hepatitis C. We performed shotgun proteomics using serum EVs isolat...
Article
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ABSTRACT This study aims to determine the effect of the application of Government Accounting Standards, Regional Financial Information Systems, and HR competencies on the quality of local government financial reports in Wajo Regency with transparency as a moderating variable. This study uses a quantitative method with an associative causal approach...
Article
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Outer water relieving is perhaps the most ordinary and notable applied to restore technique to moderate the autogenous shrinkage anyway once the slender pores depreciate, giving satisfactory outside water to curing will be more troublesome. So scientists moved their regard for inside relieving, another restoring strategy that may extraordinarily up...
Article
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Superabsorbent polymers (SAPs) efficiently reduce total shrinkage and cracking susceptibility of fibre reinforced mortars (FRM). This paper discusses the effects of SAPs on the microstructure and mechanical properties of FRM containing fly ash (FA) and ground granulated blast-furnace slag (GGBS) during a period of 180 days. Three types of cement in...
Article
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Superabsorbent polymers (SAP) may provide internal curing in cementitious materials, consequently , they reduce autogenous shrinkage caused by low water/cement ratios and autodesse-cation of pores. This paper aimed to analyze the effect of Superabsorbent polymers in high-strength mortars, using metakaolin as supplementary cementitious material (SCM...
Article
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Dao-Chi powder (DCP) has been widely used in the treatment of inflammatory diseases in the clinical practice of traditional Chinese medicine, but has not been used in acute pancreatitis (AP). This study aimed to evaluate the effect of DCP on severe AP (SAP) and SAP-associated intestinal and cardiac injuries. To this end, an SAP animal model was est...
Article
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Background: Evidence have shown that gut microbiota plays an important role in the development of severe acute pancreatitis (SAP). In addition, matrix metalloproteinase-9 (MMP9) plays an important role in intestinal injury in SAP. Thus, we aimed to determine whether gut microbiota could regulate the intestinal injury during SAP via modulating MMP9....
Article
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Corn starch, a biodegradable material, was used to modify the properties of a hydrogel, also commonly called superabsorbent polymer, SAP. The starch was used to enhance the gel strength while providing an improved polymer biodegradability. The starch suspension was prepared by agitating the starch in deionized water and was used for treating the SA...
Article
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This study investigates the effect of individual and combined additions of CaO-based expansive agent (EA), shrinkage reducing admixture (SRA), and super absorbent polymer (SAP) on key characteristics of flowable cement paste mixtures proportioned with a water-to-cement ratio of 0.40. Of special interest is the effectiveness of these admixtures to m...
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Purpose Migration of the staple line is the definition of sliding hiatus hernia in sleeve gastrectomy patients. The main aim was to determine the frequency and measurement of intrathoracic staple line migration and its correlation with GERD symptoms and pH monitoring. Materials and Methods This was a prospective clinical trial including all patien...
Article
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Objective The aim of this study was to compare effects with conventional (needle and electroacupuncture, NAP) and shockwave stimulation of acupuncture points (SAP) on chronic multilimb lameness in horses. Study Design Randomized crossover block design; ten mature Standardbred mares with multilimb lameness (< 4/10) underwent 3-weekly point stimulati...
Article
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Background Proton pump inhibitors (PPI) have no effect on non‐acid reflux events which can continue to provoke gastro‐oesophageal reflux disease (GERD) symptoms. Baclofen, a γ‐aminobutyric acid agonist, can decrease non‐acid reflux but its symptomatic benefit in refractory GERD symptoms is understudied. Aims To assess the efficacy of baclofen 10 m...
Article
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Amyloid fibrils and fibril-like structures are currently estimated to represent many different products of several genes in humans and play a key role in many types of proteinopathies, commonly associated with ageing process. They share the mutual feature of aggregation-prone proteins and the building up of molecular-supramolecular structure, such...
Article
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Background Surgical antibiotic prophylaxis (SAP) is one of the most effective measures to prevent surgical site infections (SSIs). According to WHO SAP guidelines, SAP requires appropriate indication for administration and delivery of the antimicrobial agent to the operative site through intravenous administration within 60–120 min before the initi...
Article
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Background Limited data exist on dental practitioner use and perceptions of articaine. This study is a cross-sectional survey of dental practitioners from January, 2021 to ascertain the extent of their use of the dental local anaesthetic, articaine, the basis of their perceptions about articaine and whether current practices are in line with recent...
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Acute pancreatitis is a common emergent disorder, a significant population of which develops the life-threatening condition, called severe acute pancreatitis (SAP). It is generally accepted that bacterial infection is associated with the development and persistence of SAP. In addition to bacterial infection, recent clinical studies disclosed a high...
Article
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Surfactants play a vital role in the delignification and saccharification of lignocellulosic biomass. A strategy for coupling surfactant-assisted alkaline pretreatment (SAP) with surfactant-assisted enzymatic hydrolysis (SEH) has been proposed for improving sugar recovery from a potential energy crop, Miscanthus sinensis. Poly (ethylene glycol) 200...
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To investigate the possible relationship between procalcitonin (PCT) and stroke-associated pneumonia (SAP) as well as clinical outcomes after recombinant tissue plasminogen activator (rt-PA) treatment of AIS. From June 2015 to December 2019, 173 consecutive patients with AIS after IV rt-PA treatment were prospectively enrolled. Serum PCT concentrat...
Article
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Acute pancreatitis (AP) is pancreatic or systemic inflammation without or with motion organ dysfunction. Severe acute pancreatitis (SAP) is the main cause of death for patients with AP. A pro-/anti-inflammatory imbalance is considered the key regulation of disease severity. However, the real mechanism of SAP remains unclear. This study aimed to ide...
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Objective: To investigate the effects of low-density lipoprotein cholesterol (LDL-C) and serum cystatin C (CysC) combined with D-dimer (D-D) on patients with coronary atherosclerotic heart disease (CHD). Methods: 90 patients with CHD who were admitted to our hospital and diagnosed by coronary angiography (CAG) from February 2020 to June 2021 wer...
Article
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Conventional curing methods like water curing, ponding, spraying, etc., are mostly preferred methods for curing any type of concrete and are the external curing methods. In case of high-strength concrete due to its impermeable nature, it does not allow to penetrate the water in the concrete body. As a result, the conventional curing methods were fo...
Article
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Background B7-H5 is an important ligand which is deeply involved in the immune response in various diseases. However, its clinical usefulness as an early indicator in acute pancreatitis (AP) remains unclear. Aims To determine the role of B7-H5 in severe acute pancreatitis (SAP). Methods Whole blood samples from patients with SAP (n = 20) and heal...
Article
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Background: Sexual dimorphism with critical diseases has been documented. However, the role of serum sex hormones for the presence of acute kidney injury (AKI) in moderately or severe acute pancreatitis (MSAP and SAP) patients remains controversial. Here we set out to evaluate whether early (first 48 h) serum estradiol level is associated with AKI...
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Water uptake dynamics of superabsorbent polymers (SAP) in soil is of key importance for the optimum application of these materials in environmental engineering and agriculture, so goal of this paper is to determine time dependent values of coefficient of permeability for various SAP-soil mixtures. Retaining water in soil is a key requirement in cri...
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Sleep deprivation (SD) interferes with long-term memory and cognitive functions by overactivation of phosphodiesterase (PDEs) enzymes. PDE4, a nonredundant regulator of the cyclic nucleotides (cAMP), is densely expressed in the hippocampus and is involved in learning and memory processes. In the present study, we investigated the effects of Roflumi...
Research
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In this research article, the buzzwords of digital thread, digital twin, and Industry 4.0 are examined by means of a systematic literature review. The key concepts shaping these paradigms are investigated to achieve an overview of existing solutions. First, the body of the literature is explored to provide general observations on similarities and d...
Article
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Background Acute pancreatitis (AP) is a common gastrointestinal disease worldwide. Severe acute pancreatitis (SAP) is characterized as persistent organ failure with a mortality rate as high as 20–30%. Early assessment of the severity and screening out possible SAP is of great significance. Given that there is still a lack of both convenient and pra...
Article
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Dental caries is one of the most prevalent human diseases resulting from tooth demineralization caused by acid production of bacteria plaque. It remains challenges for current practice to specifically identify, intervene and interrupt the development of caries while restoring defects. In this study, inspired by natural dental plaque, a stimuli-resp...