Questions related to Regulation
If a Transcription Factor is discovered to bind to a few genes, is it possible that those genes have a relation between them? Is there a possibility that just because there is TF binding to 2 genes, can we say that those genes may regulate each other? If it is possible to assume that they can regulate each other, how can we find out those 2 genes have a realtion between them?
Do you believe that it has considerable importance in public?
The vast legislative regulation, if not performed, doesn't guarantee that things work in the right way.
Does politics care about it?
Hello, I am working on a project in which I need to regulate the speed of the DC motor using the PID controller in Verilog for the FPGA Spartan 3e, is there any code I can start with?
Hypothetically, can the body use the 25(OH)vitamine D derived from skin and sunlight (initially D3, then processed in liver) and that is further metabolized by CYP27B1 to active-D-vit - if you have no PTH?
From Pubmed PMID: 17656568 Parathyroid hormone regulates histone deacetylases in osteoblasts Emi Shimizu, Nagarajan Selvamurugan, Jennifer J Westendorf, Nicola C Partridge:
Vitamin D undergoes two enzymatic steps to form the active compound 1,25-dihydroxyvitamin D3 (1,25(OH)2D3).2 CYP27B1 is a cytochrome P450 enzyme that performs the second step in this process, metabolizing 25-hydroxyvitamin D3 to 1,25(OH)2D3 (1, 2), and thus controls the biological activity of vitamin D.
CYP27B1 is tightly regulated. A primary signal in mediating induction of 1,25(OH)2D3 in the kidney is elevated parathyroid hormone (PTH). This was demonstrated in early animal studies in which thyroparathyroidectomy resulted in reduced production of 1,25(OH)2D3, whereas administration of parathyroid extract restored 1,25(OH)2D3 production almost to control levels (5).
1,25(OH)2D3 is known to regulate its own production by inhibiting CYP27B1. In addition to 1,25(OH)2D3, the phosphaturic factor fibroblast growth factor 23 (FGF23), which acts as an endocrine factor, also suppresses expression of renal CYP27B1 (1, 2) (Fig. 1). But, what are the molecular mechanisms connecting these hormones to CYP27B1 and each other? Some initial hints have emerged. Early studies showed that 1,25(OH)2D3 treatment could suppress Cyp27b1 expression in both thyroparathyroidectomy and sham-operated rats, suggesting that activation by PTH and suppression by 1,25(OH)2D3 are two distinct events (6). It was suggested that 1,25(OH)2D3-mediated suppression may not be based on direct binding of the vitamin D receptor to a consensus vitamin D response element in the Cyp27b1 gene but rather may be indirect (7).
While the regulation of artificial intelligence (AI) is still at its infancy in the EU and the US, it is already becoming apparent that there are different approaches among countries on how to regulate AI. Does this mean that an international agreement will become necessary later on? What are the pros and cons of such an international regulatory approach?
Is there a need for regulations of private stablecoins such as Tether, USD Coin, Binance USD, or DAI?
The market capitalization of stablecoins issued has been growing rapidly in recent years. There are more than 130 billion USD in stablecoins in circulation worldwide. The potential uses of stablecoins go beyond cryptocurrency trading to include also global payment systems. Do we need regulations of the stablecoin market to address user protection and financial market stability, or is the market rather better off regulating itself? Can government regulation stop the rapid growth of the stablecoin market, or will it rather inevitably lead to a new ‘offshore financial system’ beyond the control of policymakers? What are the pros and cons of a recent plan by the US Federal Reserve to regulate stablecoins?
I have a neutral peptides that is insoluble in pH 7.4 solvent. I need solution to be pH 7.4 for the subsequent reaction. I have tried DMSO to help dissolve the peptide, but it would be precipitate if I regulated the pH to 7.4. What can I do to try solving this problem?
Does anyone know an online browser in which it is possible to search for transcription factor’s binding sites of a certain gene? I have treated my cellular model with retinoic acid and I noticed a strong increase in the mRNA expression of my gene of interest. Hence, I wonder if this increase it is directly dependant on RA-RAR modulation and I am looking for a bionformatic hint. Thanks in advance to those who answer me.
Specially, I am looking for a database or software which give me the name of transcription factors and mRNAs which are being regulated by them.
To cater to wide head & power variation , in run off river projects with head range from 5-25m , & output from 15-40 MW triple regulation bulb turbines will be very suitable option . (Triple regulation means In addition to Guide vanes & runner blade regulation , variable speed by changing excitation frequency) . Has this technology been used on actual projects ?. Which manufacturers have this technology. like GE, Voith , Andritz , Hitachi , Toshiba or other chineses / European OEMs
Any technical papers or literature on Variable speed bulb turbines with triple regulation for runoff river plants, references, what is todays status of this technology ?
The appearance of schizophrenia patients have been in society for a very long time. If we do not consider the regime and social structures and systems, how much percentage of schizophrenia patients are acceptable in a normally regulated well-being society without war, or other crisis?
(I have asked this questions previously, but I believe it was too general. I have tried to be more specific here)
I am trying to establish an islanded microgrid with 2 inverters running in parallel to supply a single load. I want to use droop control so I can then adjust the power sharing between them.
I am struggling to get 2 inverters to synchronise. I can get them to supply the same voltage, but the currents work against each other in the load.
What I have tried:
1. Grid forming and Grid feeding. When I add the Grid feeding inverter, I can not control the voltage that it injects the current at. If I give it it a Reactive power reference, it will inject current into the grid at that power level, it doesn't regulate the voltage. Therefore, it pushes the voltage of the load up I get instability in the system.
2. Grid supporting Voltage x 2. I have tried to put 2 Grid supporting Voltage sources in parallel. The problem here, is that if each inverter supplies a different power, this then adjusts the frequency that is injects its power into the grid and the miss match between the two frequencies of the inverters causes instability.
3. Grid supporting Voltage and Grid supporting Current. This has the same issue as point number 1. As there is no way to pin the voltage to anything, it is simply a current source that cant control the voltage it injects at. This causes instability in the microgrid I created.
Am I doing something wrong ?
The following paper has exactly what I am trying to achieve, but I get different results:
Does anyone have a Simulink model of 2 parallel inverters supplying a load in islanded mode?
Attached is the model of the Grid Supporting Voltage inverters in parallel that I have been working on. You can see that the currents of each inverter are working against each other.
I want to check the impact of the index and interaction term of regulation on the financial sustainability of bank.In the interaction term of index and regulation ,regualtion is dummy variable.The time period for the research is 7 years.I wnat to inquire which panel data regression models are appropriate for conducting the analysis.
fixed effect model
random effect model
I am looking for information that mentions the control strategies in direct current to direct current converters, which can facilitate a summary of the state of the art. Any information is welcome.
If you know of some control methods / strategies and can mention it, it would be helpful.
According to EU F-Gas regulation ((EU) No 517/2014) refrigerants with GWP >150 are prohibited from 01/01/2022 does it consider only HFC or all refrigerants with GWP > 150 like HFO's as well?
I am a Master's thesis student with a task to understand F-Gas regulation and devise a solution for my company's system. We currently use R513A which is an HFO with a GWP of 631. The F-Gas Regulation gives norms for HFCs only are they also valid for HFO's with GWP > 150.
I would look forward to your response. Thank You for your time.
I am working on a project and we need to use an DC to AC inverter for the battery power supply. I am searching for devices that conver the current and also are capable of controlling the motor. I know that this kind of inverters can regulate the speed. But what about the torque? Does it need to be regulated with a variable resistor? How does it normally work?
Thank you a lot
I'm a MSc Biotechnology student and I have graduated in the same field. I've been becoming aware of my interests and I am inclined towards how the diet can potentially be used to regulate the health. What should I do after my Masters to pursue this interest? I'm not sure what it's called therefore I cannot accurately google it. Any help would be appreciated!
What is the most acceptable method to measure the impact of regulation/policy so far?
I only know the Difference-in-Difference (DID), Propensity Score Matching (PSM), Two-Step System GMM (for dynamic) are common methods. Expecting your opinion for 20 years long panel for firm-level data.
Wyoming recently recognized a new legal entity called a DAO LLC, or a decentralized algorithmic organization, which can be managed by an algorithm. The Wyoming law is largely silent on the legal requirements for the algorithm manager and its design, features, or policies. Any suggestion?
NFKb is a transcription factor that activates various genes. We have found the differential regulation of Pax6, as well as, NFkb in response to UV treatment under in vitro conditions. Can someone help me to design experiments that will help me to find out if NFkb is binding to the promoter of Pax 6 gene?
Thanks a lot!
I am working on a project of DNA regulation of Nanoenzymes and need to do simulations of nanoenymes. Can anyone tell me how to do MD simulations of inorganic nanoparticles (nanosomes) through GROMACS? I already read some literature about MD simulations of nanoparticles but specifically with GROMACS I couldn't find any literature about simulations.
Your answers will be much appreciated.
I'm having a hard time finding a self-report measure of emotion regulation or emotional reactivity for children under the age of 13. Can someone recommend a measure of any of these two constructs that I can use? Thank you!
I have a list of differentially expressed genes from which I want to :
- Identify the potential transcription factors involved in the regulation of my differentially expressed genes.
Could you please suggest some tools/R packages or platforms to perform this kind of analysis?
I am struggling to find a scale that measures this specific construct besides the one used by Caprara (2008). I want to measure (if possible) these beliefs as a state in an experimental design but I am not satisfied with any measure that I found. Would be really grateful for any help!
I am a beginner in slider control studies and am trying to design a discrete time integral slider controller. I know that the basic idea of the sliding mode is that once the states reach the sliding surface, they must remain on it, according to the first attached figure (SMC - State trajectory). Is it possible for states to make a similar trajectory to this other figure (SMC - possible)? The initial condition of my simulation was x1 = 1 and x2 = 2, with the controller acting as a regulator. When I apply a step-type reference signal (r = 2) to state x1, in half the simulation time, the behavior of the states is shown in the third figure (SMC - reference). My doubt is due to the "turn" of the trajectory of the states, apparently they cross the sliding surface but do not start sliding on the first pass.
I am interested to see the impact of Renewable Energy Sources on the frequency regulation on a smart grid. Any recommended references and papers?
Indian Govt. is planning to introduce regulated crypto-currency. Does it not violate the real essence of cryptocurrency which itself is decentalized?
Crypto-currecy in real sense is decentralized which means that there is no regulatory body who governs the entire system. Does " Regulated crypto-currency" doesn't violate this structure.
I'm planning to do a bit of action research at home.
I have access to a child of 13 who challenged me on why I restricted his time on his online game. I suggested it was because children of his age did not have the capacity to regulate themselves when playing online games. He challenged me on that.
I'm looking for any literature on this.
I have found studies regarding access to sugar for children and the impact of restricted diets leading to more of a fixation on sugar or food.
I'm going to trial it for two weeks where he has access to the PS4 from 7am to 8.30pm each day, 9.30pm on non school days. My question is whether the child will be able to regulate their own intake of Fortnite over that two-week period.
I am going to build in some provisos regarding attendance at school but one week will be a usual school holiday. I'm going to take hourly observations to see how much time he spends online, gaming, outside with friends etc.
Any comments or know of any research which has looked into this already?
I've done three treatment groups of RNA-SEQ, one group is Normal, the second is alcohol-withdrawal, the third one is alcohol-withdrawal injected with Drug-A. I want to find the genes and pathways that are regulated by DrugA, so which two groups I should compare with, withdrawal vs Drug-A or Normal vs drugA, or Normal vs withdrawal?
I'm looking for information on how chemicals and mixtures are regulated in Canada. I have found that the hazardous products regulations (HPR) specify the criteria for hazard classification and that the Canadian Environmental Protection Act (CEPA) gives a definition of "toxic substances" according to the risk posed by the substance or group of substances. As far as I understood, toxic substances are added to a list and risk management measures can be considered. Does it mean that the classification, for instance as carcinogen, does not imply directly a regulation? What about mixtures and alloys?
Thanks for any information and examples you may provide!
I am trying to locate the promoter of Rop gene on this plasmid. Is Rop co-expressed with TetR?
FYI- https://benchling.com/s/seq-0Ase2F7wGoygIi4iVpxn It is from NEB.
I want to extract the ori and rop to put in another plasmid to get a copy number ~20.
I also looked at addgene https://blog.addgene.org/plasmid-101-origin-of-replication . They mentioned a pColE1 with ~20-25 copies but I actually didn't find this plasmid. not sure about whether it is this one: https://benchling.com/s/seq-9zEdeLxgNETJ8VfFbDTB
I've looked they are both the ColE1 family, does it mean they both regulated with similar mechanism with Rop?
Concerning the dissolution testing, I don't understand why we work in NON-SINK conditions when we doing development (for example if I test the solubility of my active ingredient) and in SINK conditions when we have to do regulation...
Hello, I am wondering whether there is any legal regulation about the duration of the non-compete agreement between influencers and advertisers or not. It is well-known that It is not uncommon for an influencer to work with other companies. Some companies may offer the same or similar products or services. It is crucial for the parties to discuss the exclusivity. If the company requires the influencer to be exclusive, they may require a non-compete agreement. Definitely, this noncompetition should continue during the main agreement. Nonetheless, is there any legal regulation which can indicate that the duration of the noncompetition might be extended after the expiration of the main agreement?
Thanks in advance.
Concerning the dissolution testing, I don't understand why we work in NON-SINK conditions when doing development (for example if I test the solubility of my active ingredient) and in SINK conditions when we have to do regulation...
i tried to extract globulin from oat bran by using 5% Nacl, but failed to get considerable amount of globulin.
i used the method of
The globulin yield from 100g, was less than 0.5 g.while reference artical claimed more than 70 % yield.
Good day experts,
I am currently designing a research project where my partners and I are investigating the difference in effectiveness of thermal regulation in a highly color variable ectotherm species. We wish to investigate how much of a difference coloration causes in the absorption and reflection of broad spectrum- and UV-light.
We are looking for a method that can be applied in a field situation with relatively high accuracy.
Are there anyone here who can point me in the right direction? Or do you know someone I should be talking to?
I would like to know if it's possible to do continuous absorbance readings within a CO2 incubator to regulate the CO2 concentration.
I will be working with some fastidious bacteria that require CO2 to grow and some of the work requires to do some growth curves (OD600 vs time).
I already have an EPOCH 2 microplate reader (Biotek) and we should be getting a ICO CO2 incubator (Memmert) soon, with a modification that allows cables to pass through one of the sides of the incubator.
Can I make this two equipments work together?
Am I doomed to buy a more expensive microplate reader with built in gas control unit?
Thanks in advance!
Has anyone ever tried to deliver CO2 with a CGA 300 regulator? I know that a CGA 320 regulator is standard for CO2. The issue is that I currently do not have any free CGA 320 regulators. I also noticed that the threads for the CGA 300 and 320 are the same size, as shown here: https://www.concoa.com/cgachart.html . Moreover, the cylinder pressure of a 50-LB CO2 tank is ~860psi, which is well within the max pressure for the first stage of a CGA 300 regulator. The only difference I see is that inner thread of a CGA 300 is tapered, whereas the inner thread of a CGA 320 is flat. What is the worst that can happen? A catastrophic regulator failure and explosion, obviously. However, it would seem that is unlikely if the max pressure of the CGA 300 is less than the cylinder pressure and if the threads perfectly overlay. What do you think?
Globally, late payment to construction contractors remain a lingering commercial issue in the construction industry. The problem is exacerbated by array of factors; with huge negative consequences on contractors and other supply chain in the sector (The National Audit Office (NAO) 2018). Recent statistic reveals that there has been substantial increase from 18% to 27% in the number of late-payment cases in the UK construction industry; with over £30 billion of unpaid invoices to Small and Medium-Sized (SMEs) contractors alone. Moreover, 82% of the total unpaid invoices were monies owed to subcontractors by different tiers of construction clients.
Standard forms of contract and various payment regulations exist to checkmate chronic late payments issues that is deep-rooted in the construction sector. Yet, there is hardly evidence or case law that suggest punitive measures against clients that are involved in unfair payment practices. For example, various payment laws such as the Payment Services Regulations 2017, the Late Payment of Commercial Debts Regulation (2013), The Small Business, Enterprise and Employment Act (2015) and the Public Contract Regulation (2015), etc clearly criminalises defaulters of payment laws.
Conversely, victims of unfair payment practices are often reluctant to seek legal redress; though payment regulations clear stipulate punitive measures against unfair payment practices. Perhaps, withholding payment from contractors is not a financial crime; but a mere industry strategy that benefits both perpetrators and victims. Yet, research that seek to explain the relationship between misconduct (criminality) and business strategy underpinning lingering late payments quandary in the construction sector are scarce.
Thus, the research question: Is late payment to construction contractors a financial crime or magnificent commercial strategy?
Hello dear colleagues and experts!
When developing a model of a wind generator, I faced the problem of adjusting the PI controller for the pitch angle. I read a lot of articles, but the PI regulator failed ...
Please help with setting it up and getting characteristics
Thank you very much in advance!
What do you think about the balance between exploring widely different designs vs. local optimization at different levels of biology (genomics, transcriptomics, proteomics, anatomy, etc.)? Which levels are more or less modular or plastic?
In the endocrine system, for example, one feels that having tropic hormones (i.e., those controlling the release of other signaling hormones at other glands) may offer a finer and perhaps more robust regulation, compared to a being where all hormones were non-tropic. However, the anatomic location of elements in these networks is not trivial. For example, in the renin-angiotensin-aldosterone system, renin is produced in the kidney, and aldosterone eventually exerts its effects in the kidney as well. However, the intermediate step by angiotensin-converting enzyme (ACE) mainly occurs in the lungs, which could introduce a delay in the regulation.
Do we have good explanations for the sites of production and action of different hormones in the body? Are there common principles to be learned as optimized by evolution in this respect? Or are happenstances/contingent evolution stronger determinants?
Thank you for sharing your thoughts!
- hello, in fact I encountered problems during the simulation of the fuzzy regulator applied to the asynchronous machine. I replaced the PI regulator of the vector control with the fuzzy regulator, I made all the settings but the simulation does not work. I ask for help to carry out the simulation.
I been wondering if genes when stable transfected become regulated by the cell, or if the gene is constitutively express and translated and the protein previously made is degraded at a slower rate which allows protein accumulation. I have been wondering these since there need to reach an equilibrium in either case for the transfected gene (and the subsequent protein) and not to become toxic to the cell. I hope someone could direct me to a paper that explains this.
I ask this question because if a protein is inhibited by post-translational modification and is perpetually recycle (meaning the older protein is being ubiquitinated as new transcript are giving rise to new proteins) this means that the proteins are technically always active. However, if the transfected stable gene is regulated somehow, means that protein reaches a limit and all in time will become inhibited by this hypothetical post-translational modification. Then if the protein in question is naturally being regulated in transcription factors specifically present in certain cell lines (myeloid for example), but not in others. This could mean that the protein would not have activity in non-myeloid cells even if it's express since there is no way to activated unless other proteins that could undo the previous modification are also supplied.
I am thinking correctly, or this is just crazy talk?
Thank you, and stay safe
Hi, I have a question if anyone can answer. I have identified two co-factors for my transcription factor. But the mass spec data seems insignificant. Now I want to find if some other co-factors are involved in regulating my transcription factor? So, how can I do this? Should I cut my gel band at different molecular weight or should I go for ChIP-seq to determine their binding complex?
If each cell in our face were to undergo just one more cell division, we would be considered horribly malformed. If each cell in our arms underwent just one more round of cell division, we could tie our shoelaces without bending over. Our arms are generally the same size on both sides of the body. How is cell division so tightly regulated?
I have performed WB analysis and qPCR analysis to analyze the protein level and the rispective gene relative expression of mTOR, GBA1, LC3 genes in brain of mutant mice.
I observed a significant downregulation of all these genes in the mutant mouse compared to WT mice, but no alterations in the protein quantity. Moreover, I did the same for LAMP2 protein and transcripts levels. LAMP2 protein levels were increased, which its mRNA levels were downregulated.
Have anyone experienced this type of "compensation" mechanism between trascriptional regulation and protein levels?
Which kind of regulation can be responsible for this differences?
Thank you so much
Is there any possibilities I do explanatory study between two variables above mentioned? The first variable, think tank capacity, measured using close-ended questionnaire. The other one, research impact on policy, measured using content analysis where policy document (law, regulation) as unit of analysis.
I work with Lorna Myers, PhD in the area of PNES. We are always looking for new ways to research this group. I think this questionnaire would be helpful for us in the area of understanding issues with emotional regulation.
I work with Lorna Myers, PhD in the area of PNES. We are always looking for new ways to research this group. I think this questionnaire would be helpful for us in the area of understanding issues with emotional regulation.
How can parents make sure that their kids only view webpages provided by schools or other learning agencies without digressing to adult sites online or be misled by pop up adds (from google or other search engines) into viewing adult stuffs online. This is a major concern for parents that are not always around to regulate what their kids view online. What can be done to alleviate this problem?
For example, if the regulation is allosteric or not. I did not find this information on PDB, protein human atlas, Kegg or BRENDA.. Do you know any database that can I find this information?
effect the sediment on discharge amount of lateral canals lining or do not lining at start joining of head regulator which at time reduce the discharge of canals with stay water level is constant or increasing because of detention of water due to sediment.
The knocking out of Gene A results in induced expression of another pathway. I want to find a link between KO phenotype and overexpressed pathways? I am new, so I am stuck at this point of how to create a link?
The GO analysis are heavily enriched with metabolic pathways (since KO gene and overexpressed pathways are metabolic-related). My understanding is that the KO gene may be the negative regulator of OE pathway, but the StringDB analysis did not bring anything.
I have created the network using GeneMania and then did Enrichment analysis, but all the terms are metabolism-related. Any help/hint in this regard is highly appreciated.
Sometimes, it is not required chemical or nuclear weapons for mass destruction, and unsafe storage of chemicals such as Ammonium nitrate is good enough for the mass destruction. Massive damages at the Ports of Texas in 1947 and Beirut in 2020 are bitter examples of unsafe handling of chemicals such as ammonium nitrate.
Therefore, unsafe storage and handling of such chemicals within the boundaries of international ports should be regulated.
Since this is an international concern, I would like to discuss this matter with relevant experts.
Plastic which is rather problematic waste. It wil require prior consent by importing nations according Basel Convention s amendment but not between EU member states for example. EU also introduced broader regulation of 4 phthalates, DEHP (di(2-ethylhexyl)phthalate), DBP (dibutylphthalate), BBP (butylbenzylphthalate) and DIBP (di-isobutylphthalate) but didn t include some other also problematic phthalates. It regulates also some flame retardants like PBDEs but only to certain level which still allows deca-BDE to be recycled in new product for example. So my question whether it is enough and the regulation should not go further based on current scientific knowledge?
Dear All Researcher,
Please help me, I need a questionnaire sample to analyse the impact of implementation of new regulation related to covid-19 to the company/organization.
I'm very thank you for your help.
For a particular gene of interest, how can i find the coding RNA sequence and non-coding RNA sequences regulating the expression of this gene?
Emotional regulation is known to be .associated with Non-suicidal self-injury. In order to understand this phenomenon in a systemic context we are looking for measurement tools that evaluate emotions and their regulations from a systemic perspective. Any lead would be appreciated. Thanks in advance.
I tried but I could not find suitable one for my study.
Relationship Between Emotional Regulation and Attachment and
(Their) Differences in Collectivist and Individualist Cultures.
I used correlation for relationship.
but their differences in Collectivist and Individualist Cultures?
Global E-Commerce is growing fast, replacing traditional trade transactions. This is an issue for Governments, not having regulation mechanisms, as it causes tax revenue losses.
DC current(or voltage) supply has to keep constant(DC) a current (or a voltage respectively) whatever the load ie evolution(AC) of the voltage (or the current respectively). This means that even DC, the supply has to react to any load fluctuation. So, this leads to an AC parameter, which is the bandwidth of this ability to compensate for fluctuations (?). have you any experience/example of power supply specifications showing the bandwidth of the regulations?
What happens, behind this bandwidths. What consequences on the biased (sensor, amplifier ...) system?
We have to design low noise current sources and we think about adding a passive current filter (with a parallel capacitor followed by a series inductor) to limit the noise bandwidth. Apart from the regulation stability, have you any recommendation/experience in such filtering. Assuming that a series inductor reacts to any currents fluctuation, we expect "passively" increase the regulation bandwidth, even if the active regulation is at the same time inhibited by this filter.
Legal regulation of records and archives management since the time of the Rzeczpospolita (1569-1795)
The John Molson School of Business at Concordia University kindly invites contributions to the forthcoming edited book Beyond the 2ºC - Business and Policy Trajectories to Climate Change Adaptation to be published by Palgrave Macmillan and being considered for the “Palgrave Studies in Sustainable Business: In Association with Future Earth” book series.
ABOUT THE BOOK
Climate change mitigation, understood as an approach to reduce human-induced emissions, has taken centre stage in climate action debates and efforts in the last decades. Currently published reports and studies present scenarios under which we can limit the global temperature rise to a 2°C threshold. However, to stay within the 2°C threshold, we need to move towards net-negative global emissions. This would require mobilization on a global scale and improvements in our approaches to mitigating global warming. After passing the symbolic 400 parts per million (PPM) threshold of carbon dioxide equivalents (CO2-eq) in the atmosphere in 2016, recent studies have highlighted that the current emission trajectory can easily lead to concentrations of up to 1,000 PPM of CO2-eq – leading to an average global warming of up to 5.4°C by the end of this century.
While many governments, businesses and researchers like to believe that a mitigation-focused approach can keep the 2°C threshold within reach, this edited book intends to investigate the business and policy adaptation trajectories beyond what are currently understood to be some of the major tipping points in the climate system. In these scenarios, the planet will be on an accelerated path towards deforestation, biodiversity loss, erosion of inhabited and uninhabited coastal areas, and the possible disappearance of entire island states. These events will be coupled with the possible proliferation of disease, human migration, and increased conflicts over resources. This calls for academics, practitioners, and policymakers to shift their attention away from the almost exclusive focus on climate change mitigation, to also consider adaptation plans.
Beyond the 2ºC - Business and Policy Trajectories to Climate Change Adaptation is an edited collection that will review and critically analyze new and innovative business and policy approaches to climate change adaptation across different economic sectors and for different locations. The edited collection will aim to ignite an academic discussion regarding the necessary, and potentially urgent, adaption strategies that could address the risks induced by the fast-changing climate. The contributions should demonstrate how we can adapt to a world where fresh water is scarce, where extreme weather events are a daily reality, where global sea levels are up to 2.4 m higher than today, and where flooding and wildfires are no longer discrete events. The collection plans to evaluate the readiness of our businesses and policies to adapting to this “new” world and to explore strategies that move beyond the current incremental approaches.
CALL FOR CONTRIBUTIONS
Beyond the 2ºC - Business and Policy Trajectories to Climate Change Adaptation aims to explore and propose business and policy solutions for climate-induced economic, technical, and societal challenges.
The editors are accepting contributions by experts in both the academic and practitioner communities in business and policy, as well as related fields such as economics, management, development studies, finance, and entrepreneurship. The editors are inviting contributions that:
· Shed new light on our understanding of climate-related vulnerabilities and risks
· Explore innovative risk management procedures
· Present new and emerging processes for internalizing adaptation in existing business and policy approaches
· Identify new barriers to large scale and/or local climate change adaptation
· Introduce methodologies for mapping and understanding synergies and trade-offs in adaptation
· Investigate approaches to overcoming conflicts in business and policy adaptation trajectories
The editors are encouraging contributions that move beyond the current disciplinary divides and present novel interdisciplinary approaches, which use scenario building methodologies in their investigations and study the social, economic, environmental, and cultural dimensions of the complex adaptation trajectories. Moreover, the editors will also be accepting chapters that incorporate new concepts or tools beyond the academic fields of business administration and political science. These fields will include the natural and social sciences, which make connections to the business and policy. The editors also encourage contributions that move beyond carbon emissions to focus on emerging challenges and themes regarding adaptation, which includes health, wellbeing, air quality, waste, and biodiversity. In addition, chapters that use case studies or comparative studies (between different solutions, applications in different industries, or variations between regions) are strongly encouraged. Finally, considering the global nature of climate change and its multi-scale consequences, the editors invite authors to critically consider the scalar relevance – local, regional, national, and supranational levels – of their contributions.
The submissions will be reviewed with an open mind and with a particular focus on the relevance of the chapter with respect to adapting to climate change and its consequences beyond the 2ºC threshold. The edited book will serve as an academic reference for senior undergraduate, graduate, and post-graduate scholars in the fields of business, public affairs, social science, environmental studies, and law across the globe. It will also function as a practical guide and a reference for emerging best practices on the topic of climate change adaptation for industry and business leaders, regulators, and policymakers around the world. Although the book can be used as a reference book in academic courses, it will not be specifically organized as a textbook.
POTENTIAL TOPICS FOR CHAPTERS
1. CLIMATE CHANGE HAZARDS AND THEIR MANAGEMENT
a. Understanding the hazards and their management
b. Technological hazards
c. Political hazards
d. Natural hazards (cyclones, floods, storms, floods, droughts)
e. Socio-economic risks
f. Human health risks
g. Planetary health and biodiversity risks
h. Geoengineering and climate management
i. Greenhouse gas management
ii. Solar radiation management
2. THE FUTURE OF FOSSIL FUELS AND EMISSIONS
a. Fossil fuel subsidies
b. Carbon pricing/carbon taxation
c. Biofuel and other alternative fuels
d. Renewable energy (wind, solar, geothermal)
e. The future of nuclear power (challenges and opportunities)
f. Battery electric vehicles (BEVs)
g. Hydrogen fuels
3. ADAPTING CITIES, URBAN SETTLEMENTS, AND CHANGES TO HUMAN BEHAVIOUR
a. Urban planning, urban design, and cities beyond the 2ºC
b. Waterfront settlements, island states, and other high-risk human settlements
c. Buildings and construction (design, materials, codes/standards/certifications, retrofitting)
d. Local modes of transportation (cars and other private transport, public transit, collective passenger transport, human-powered transport, etc.)
e. Intra-continental travel (rail, advanced trains and emerging technologies)
f. Inter-continental travel (aviation fuel, turbofan/turboprop engines, emissions and contrails, emerging technologies, etc.)
g. Global product transport and logistics
4. ADAPTING THE PRODUCTION AND CONSUMPTION PATTERNS
a. Agriculture, soil, and forests
i. Animal and marine farming
ii. Agriculture, agroforestry, reforestation
iii. Soil and its rehabilitation
b. Demand-side management
i. Incentive and financing programs
ii. Change and development in consumption patterns
iii. Consumer behaviour beyond a 2ºC warmer climate
c. Supply-side management
i. Change and development in production patterns
ii. Recycling, upcycling, reuse, and regeneration
iii. Closed-loop production models
iv. Living and biotic natural resources
v. Non-living natural resources (metals, minerals, and stone)
vi. Renewability of resources
d. New and emerging modes of production and consumption
5. FINANCING GLOBAL CLIMATE ADAPTATION
a. Microfinance (micro-credit, micro-insurance, risk, etc.)
b. Philanthropy and venture capital
c. ESG investment (trends, renewable energy investment, partnerships, water, etc.)
d. Climate finance (private climate finance, green funds, adaptation funds, the low carbon market, divestment, etc.)
e. Evaluating and managing the financial risks of adaptation
f. Natural capital accounting (efforts, innovations, and effects)
g. Financial policies
6. LIMITATION AND THE FUTURE OF CLIMATE ADAPTATION
a. The limits to climate change mitigation
b. Political and policy limits
c. Capital limits
d. Technological limits
e. Societal and cultural limits
· Abstract and CV submission deadline – June 30th, 2020
· Selection of abstracts and notification to successful contributors – July 31st, 2020
· Full chapter submission – November 30th, 2020
· Revised chapter submission – February 28th, 2021
GUIDELINES FOR CONTRIBUTORS
Submissions should be written in English using a non-technical writing style. The contributions may include diagrams/illustrations in order to present data, or photographs/figures (all in black & white) to better illustrate the topic of discussion. Submitted chapters should be original and exclusively prepared for the present book. No part of the article should be published elsewhere. Chapters must not exceed 7,000 words (including all references, appendices, biographies, etc.), must use 1.5-line spacing and 12 pt. Times New Roman font, and must us