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Regulation - Science topic

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If a Transcription Factor is discovered to bind to a few genes, is it possible that those genes have a relation between them? Is there a possibility that just because there is TF binding to 2 genes, can we say that those genes may regulate each other? If it is possible to assume that they can regulate each other, how can we find out those 2 genes have a realtion between them?
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1. Of course it's possible, these two genes may involved in a same or related pathways and regulated by this TF, which may regulated a biological process. But it's only a possibility and need more stronger evidences (e.g. co-expression, functional, or pathway, even the functional experiments).
2. No, there is no direct evidence that these genes could regulate each other only because of binding with a same TF, at least in my opinion.
3. If assuming that they can regulate each other, maybe you can check their co-expression, or directly knock down one genes and measure another gene expression/protein level. I'm not expert in the experiments, so no more advice could be given on this subject.
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I need a list of genes that are differentially regulated in diseases like Atopic dermitis. Is there a database for that?
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Markus Glaß thank you!
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Do you believe that it has considerable importance in public?
The vast legislative regulation, if not performed, doesn't guarantee that things work in the right way.
Does politics care about it?
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The occupational and environmental medicines have high importance in public health. Unfortunately, they are not getting due importance because of following-
1) Lack of research evidences
2) Lack of support from various stakeholders, including political leadership
3) Environmental regulations are restricted by the boundaries of pollution - they are yet to go into finer details
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Hello, I am working on a project in which I need to regulate the speed of the DC motor using the PID controller in Verilog for the FPGA Spartan 3e, is there any code I can start with?
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Check this github profile and you may see the relevant codes over there
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Hypothetically, can the body use the 25(OH)vitamine D derived from skin and sunlight (initially D3, then processed in liver) and that is further metabolized by CYP27B1 to active-D-vit - if you have no PTH?
From Pubmed PMID: 17656568 Parathyroid hormone regulates histone deacetylases in osteoblasts Emi Shimizu, Nagarajan Selvamurugan, Jennifer J Westendorf, Nicola C Partridge:
Vitamin D undergoes two enzymatic steps to form the active compound 1,25-dihydroxyvitamin D3 (1,25(OH)2D3).2 CYP27B1 is a cytochrome P450 enzyme that performs the second step in this process, metabolizing 25-hydroxyvitamin D3 to 1,25(OH)2D3 (1, 2), and thus controls the biological activity of vitamin D.
CYP27B1 is tightly regulated. A primary signal in mediating induction of 1,25(OH)2D3 in the kidney is elevated parathyroid hormone (PTH). This was demonstrated in early animal studies in which thyroparathyroidectomy resulted in reduced production of 1,25(OH)2D3, whereas administration of parathyroid extract restored 1,25(OH)2D3 production almost to control levels (5).
1,25(OH)2D3 is known to regulate its own production by inhibiting CYP27B1. In addition to 1,25(OH)2D3, the phosphaturic factor fibroblast growth factor 23 (FGF23), which acts as an endocrine factor, also suppresses expression of renal CYP27B1 (1, 2) (Fig. 1). But, what are the molecular mechanisms connecting these hormones to CYP27B1 and each other? Some initial hints have emerged. Early studies showed that 1,25(OH)2D3 treatment could suppress Cyp27b1 expression in both thyroparathyroidectomy and sham-operated rats, suggesting that activation by PTH and suppression by 1,25(OH)2D3 are two distinct events (6). It was suggested that 1,25(OH)2D3-mediated suppression may not be based on direct binding of the vitamin D receptor to a consensus vitamin D response element in the Cyp27b1 gene but rather may be indirect (7).
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Thank you Thomas! I believe we came to the same conclusion when we discussed the matter at a conference, there doesn't seem to be enough research ATM to fully answer the question.
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While the regulation of artificial intelligence (AI) is still at its infancy in the EU and the US, it is already becoming apparent that there are different approaches among countries on how to regulate AI. Does this mean that an international agreement will become necessary later on? What are the pros and cons of such an international regulatory approach?
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The advantages of this organization are to give ideas to all countries about how to legislate this issue in their internal laws and ways to address the obstacles that face this issue. From one country to another, and the conclusion of such agreements may negatively affect these differences in ideas, cultures and social customs and tries to unify them, contrary to the desire of the behaviour of the members of those countries.
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Is there a need for regulations of private stablecoins such as Tether, USD Coin, Binance USD, or DAI?
The market capitalization of stablecoins issued has been growing rapidly in recent years. There are more than 130 billion USD in stablecoins in circulation worldwide. The potential uses of stablecoins go beyond cryptocurrency trading to include also global payment systems. Do we need regulations of the stablecoin market to address user protection and financial market stability, or is the market rather better off regulating itself? Can government regulation stop the rapid growth of the stablecoin market, or will it rather inevitably lead to a new ‘offshore financial system’ beyond the control of policymakers? What are the pros and cons of a recent plan by the US Federal Reserve to regulate stablecoins?
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EU plans to regulate the digital asset market
The European Parliament has approved a draft of the new regulation for the digital asset market. The EU wants to regulate all issuers and service providers in the crypto asset market.
However, 46 European crypto industry organisations in a letter sent on 13 April 2022 to 27 EU finance ministers (letter accessed by Reuters) express their concerns that the new regulation "will put every digital asset owner at risk" as it ultimately leads to public disclosure of transaction details and wallet addresses.
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I have a neutral peptides that is insoluble in pH 7.4 solvent. I need solution to be pH 7.4 for the subsequent reaction. I have tried DMSO to help dissolve the peptide, but it would be precipitate if I regulated the pH to 7.4. What can I do to try solving this problem?
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ACN as co-solvent
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How much the individual attributes of the doctors regulate their emotions at work place?
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In my opinion; everything that all human beings do is influenced by their individual qualities, and hence their emotional qualities.
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Hi everyone,
Does anyone know an online browser in which it is possible to search for transcription factor’s binding sites of a certain gene? I have treated my cellular model with retinoic acid and I noticed a strong increase in the mRNA expression of my gene of interest. Hence, I wonder if this increase it is directly dependant on RA-RAR modulation and I am looking for a bionformatic hint. Thanks in advance to those who answer me.
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The MEME Suite web server provides a unified portal for online discovery and analysis of sequence motifs representing features such as DNA binding sites and protein interaction domains. Transcription factor motifs (including those discovered using MEME) can be compared with motifs in many popular motif databases using the motif database scanning algorithm TOMTOM. Transcription factor motifs can be further analyzed for putative function by association with Gene Ontology (GO) terms using the motif-GO term association tool GOMO
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Specially, I am looking for a database or software which give me the name of transcription factors and mRNAs which are being regulated by them.
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Thank you so much for your good recomendations.
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To cater to wide head & power variation , in run off river projects with head range from 5-25m , & output from 15-40 MW triple regulation bulb turbines will be very suitable option . (Triple regulation means In addition to Guide vanes & runner blade regulation , variable speed by changing excitation frequency) . Has this technology been used on actual projects ?. Which manufacturers have this technology. like GE, Voith , Andritz , Hitachi , Toshiba or other chineses / European OEMs
Any technical papers or literature on Variable speed bulb turbines with triple regulation for runoff river plants, references, what is todays status of this technology ?
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But this technology is already in use widely for reversible pump turbines , ship propulsion & also for tidal plants with four quadrant operation .
My question here is whether this design has been used on projects of run off river plants with Bulb units. Who are the established manufacturers & whether this practice is prevalent or in the nascent stage ?. Ant technical papers on this subject ?
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The appearance of schizophrenia patients have been in society for a very long time. If we do not consider the regime and social structures and systems, how much percentage of schizophrenia patients are acceptable in a normally regulated well-being society without war, or other crisis?
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Hi,
(I have asked this questions previously, but I believe it was too general. I have tried to be more specific here)
I am trying to establish an islanded microgrid with 2 inverters running in parallel to supply a single load. I want to use droop control so I can then adjust the power sharing between them.
I am struggling to get 2 inverters to synchronise. I can get them to supply the same voltage, but the currents work against each other in the load.
What I have tried:
1. Grid forming and Grid feeding. When I add the Grid feeding inverter, I can not control the voltage that it injects the current at. If I give it it a Reactive power reference, it will inject current into the grid at that power level, it doesn't regulate the voltage. Therefore, it pushes the voltage of the load up I get instability in the system.
2. Grid supporting Voltage x 2. I have tried to put 2 Grid supporting Voltage sources in parallel. The problem here, is that if each inverter supplies a different power, this then adjusts the frequency that is injects its power into the grid and the miss match between the two frequencies of the inverters causes instability.
3. Grid supporting Voltage and Grid supporting Current. This has the same issue as point number 1. As there is no way to pin the voltage to anything, it is simply a current source that cant control the voltage it injects at. This causes instability in the microgrid I created.
Am I doing something wrong ?
The following paper has exactly what I am trying to achieve, but I get different results:
Does anyone have a Simulink model of 2 parallel inverters supplying a load in islanded mode?
Attached is the model of the Grid Supporting Voltage inverters in parallel that I have been working on. You can see that the currents of each inverter are working against each other.
Thank you
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Synchronization is to agree in time. So, in order to synchronize multiple sources such as the power inverters you have to choose the strongest one as the reference synchronization source. This source is better to be referenced to a crystal controlled oscillator for high stability.
Then every other inverter is to be synchronized by the reference taken from the microgrid as I proposed in the first part of my answer.
This means the local oscillator of the inverter must be synchronized to the reference by means of phase locked loop.
In summary my proposal is to take the strongest power fed to the grid is to be taken as a reference for all other source fed to the grid.
To synchronize any inverter to the grid please refer to the papers in the links:
Best wishes
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Describe the role of temperature in spermatogenesis...
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I agree with @
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I want to check the impact of the index and interaction term of regulation on the financial sustainability of bank.In the interaction term of index and regulation ,regualtion is dummy variable.The time period for the research is 7 years.I wnat to inquire which panel data regression models are appropriate for conducting the analysis.
fixed effect model
random effect model
System GMM
Difference GMM
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I do not think that the black-box way of approaching the problem is right.
It depends on the level at which the variables vary, whether the model is or not dynamic, whether the variable of interest is potentially endogenous, etc.
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I am looking for information that mentions the control strategies in direct current to direct current converters, which can facilitate a summary of the state of the art. Any information is welcome.
If you know of some control methods / strategies and can mention it, it would be helpful.
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According to EU F-Gas regulation ((EU) No 517/2014) refrigerants with GWP >150 are prohibited from 01/01/2022 does it consider only HFC or all refrigerants with GWP > 150 like HFO's as well?
I am a Master's thesis student with a task to understand F-Gas regulation and devise a solution for my company's system. We currently use R513A which is an HFO with a GWP of 631. The F-Gas Regulation gives norms for HFCs only are they also valid for HFO's with GWP > 150.
I would look forward to your response. Thank You for your time.
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I requested this query to the German environmental agency and Honeywell I think they have given me good information please find below the SS of the same.
Honeywell Reply:
Currently, the heat pump sector is not regulated by F-gas and there is no ban on GWP of refrigerants used in them, so R-513A with GWP 631 can be used. Please be aware that the F-gas quota mechanism will impact prices and the availability of F-gases. Since R-513A is a medium-level GWP refrigerant, that impact should not be significant within a few years' time horizons. The alternative for R-513A is R-1234ze(E) which has GWP ~7 (AR 4). Advantages of ze are the following: -out of quota mechanism -sustainable GWP -provided that the market of main components (compressors, heat exchangers) is well developed for ze, there is an opportunity to develop new range of heat pumps with superior efficiency vs e.g. R-513A duet to lower operating pressures of ze.
German environmental agency (Umweltbundesamt) Reply: (Translated)
HFOs are HFCs from a chemical point of view. They are also referred to as HFCs in the regulation. However, the regulation distinguishes between Annex I substances and Annex II substances. Annex II substances (e.g., HFO as pure substances) are subject to certain reporting requirements, but not to the prohibitions.
You write that the company uses R513A as the refrigerant. This is a mixture of R1234yf and R134a. R134a is subject to phase-down, the associated quota system, and detection requirements under the "Third Chemicals Amendment Act - Combating Illicit Trade in Fluorinated Greenhouse Gases."
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Hello,
I am working on a project and we need to use an DC to AC inverter for the battery power supply. I am searching for devices that conver the current and also are capable of controlling the motor. I know that this kind of inverters can regulate the speed. But what about the torque? Does it need to be regulated with a variable resistor? How does it normally work?
Thank you a lot
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I'm a MSc Biotechnology student and I have graduated in the same field. I've been becoming aware of my interests and I am inclined towards how the diet can potentially be used to regulate the health. What should I do after my Masters to pursue this interest? I'm not sure what it's called therefore I cannot accurately google it. Any help would be appreciated!
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What is the most acceptable method to measure the impact of regulation/policy so far?
I only know the Difference-in-Difference (DID), Propensity Score Matching (PSM), Two-Step System GMM (for dynamic) are common methods. Expecting your opinion for 20 years long panel for firm-level data.
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recent development
(1) Wooldridge two-way Mundlak regression and fixed effects and dif-in-dif
(2) synthetic control
(3) Cerulli, G. 2015. Econometric Evaluation of Socio-Economic Programs: Theory and Applications.
(4) Pesaran (2015) Time Series and Panel Data Econometrics
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Wyoming recently recognized a new legal entity called a DAO LLC, or a decentralized algorithmic organization, which can be managed by an algorithm. The Wyoming law is largely silent on the legal requirements for the algorithm manager and its design, features, or policies. Any suggestion?
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Interesting question but it is away from my field
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NFKb is a transcription factor that activates various genes. We have found the differential regulation of Pax6, as well as, NFkb in response to UV treatment under in vitro conditions. Can someone help me to design experiments that will help me to find out if NFkb is binding to the promoter of Pax 6 gene?
Thanks a lot!
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ClusPro is software that can help you in finding if they can bind via generating a binding model for them.
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Hello Everyone!
I am working on a project of DNA regulation of Nanoenzymes and need to do simulations of nanoenymes. Can anyone tell me how to do MD simulations of inorganic nanoparticles (nanosomes) through GROMACS? I already read some literature about MD simulations of nanoparticles but specifically with GROMACS I couldn't find any literature about simulations.
Your answers will be much appreciated.
Thanks
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Ali Khodayari I already working on learning with GROMACS tutorials but i want to know that steps for nanoparticles simulation is same for protein-ligand simulations? like water model etc and input files? If you have any tutorial regarding nanoparticles simulations with GROMACS please share.
it will be very helpful.
thanks
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The laws are generally aimed at regulating life, livelihoods, commercial and industrial transactions... Etc., as well as the protection of ecosystems systems and biodiversity …
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Yes, if properly formulated and enforced.
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I'm having a hard time finding a self-report measure of emotion regulation or emotional reactivity for children under the age of 13. Can someone recommend a measure of any of these two constructs that I can use? Thank you!
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Self-reports from children under age 13 are challenging. However you decide to measure emotion regulation, make sure to also collect social desirability data (e.g., Children's Social Desirability scale. That is a significant confound with such assessments.
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Hi everyone,
I have a list of differentially expressed genes from which I want to :
  • Identify the potential transcription factors involved in the regulation of my differentially expressed genes.
Could you please suggest some tools/R packages or platforms to perform this kind of analysis?
Thank you.
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The short answer is that this is not easy nor are there accurate ways to gauge TFs from a set of differentially expressed genes. For starters any DEGs may be directly affected by a TF or indirectly affected by something else regulated by a TF. You can search promoters for consensus sites or patterns but again this is not easy. Sometimes you have to do an experiment to get the results.
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Gene expression in Prokaryotes and Viruses?
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Gene expression is the transcription of a specific gene and the translation of its mRNA into a protein. Regulation is the modulation of this expression by environmental factors or other metabolites.
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I am struggling to find a scale that measures this specific construct besides the one used by Caprara (2008). I want to measure (if possible) these beliefs as a state in an experimental design but I am not satisfied with any measure that I found. Would be really grateful for any help!
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If it doesn't exist, it deserves to be created
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I am a beginner in slider control studies and am trying to design a discrete time integral slider controller. I know that the basic idea of the sliding mode is that once the states reach the sliding surface, they must remain on it, according to the first attached figure (SMC - State trajectory). Is it possible for states to make a similar trajectory to this other figure (SMC - possible)? The initial condition of my simulation was x1 = 1 and x2 = 2, with the controller acting as a regulator. When I apply a step-type reference signal (r = 2) to state x1, in half the simulation time, the behavior of the states is shown in the third figure (SMC - reference). My doubt is due to the "turn" of the trajectory of the states, apparently they cross the sliding surface but do not start sliding on the first pass.
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Firstly, your doubt can be cleared by the following tutorial i.e., "Reachability: Attaining sliding manifold in finite time" [1].
For beginner, there are need to clear some basics about [2]
(a) Reaching phase
(b) Sliding motion
(c) And Theorems related to both (a) and (b) for better understanding.
Note: Part (a) is for clearing the doubt (as you asked above ).
Suppose that if the initial conditions are very near about origin i.e. x1(0)=0.1, x2(0)=0.1, then what will be happened?
So, the phase trajectories are interrelated to all the factors (type of the dynamics, constants of the switching surface/manifolds, gains of the controller) for getting desire response.
Reference:
[2] Slotine, J. J. E., & Li, W. (1991). Applied nonlinear control (Vol. 199, No. 1). Englewood Cliffs, NJ: Prentice hall.
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Why a teacher should be seen as a leader.
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knowledge
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I am interested to see the impact of Renewable Energy Sources on the frequency regulation on a smart grid. Any recommended references and papers?
Thanks!
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Proposed this papers:
DOI: 10.1109/TIA.2020.3024350
DOI: 10.1007/s12652-020-02260-z
DOI: 10.1016/j.ijepes.2021.106814
DOI: 10.1016/j.jestch.2019.03.007
DOI: 10.1109/TIE.2020.2984419
DOI: 10.1016/j.isatra.2020.12.026
DOI: 10.1016/j.epsr.2021.107339
Best regards.
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I am looking for applied work in regulation using ABM (Agent Based Modeling), someone has suggestions?
thx a lot
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Maybe this will help you. Take a look:
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Indian Govt. is planning to introduce regulated crypto-currency. Does it not violate the real essence of cryptocurrency which itself is decentalized?
Crypto-currecy in real sense is decentralized which means that there is no regulatory body who governs the entire system. Does " Regulated crypto-currency" doesn't violate this structure.
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Dear Dr. Ashish Seth it's the contradictory process of its ideology.
They said it is decentralized but they want to control it.
The moral of the story is there is a need to set the universal rule for cryptocurrency transactions and then realise the system globally.
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I'm planning to do a bit of action research at home.
I have access to a child of 13 who challenged me on why I restricted his time on his online game. I suggested it was because children of his age did not have the capacity to regulate themselves when playing online games. He challenged me on that.
I'm looking for any literature on this.
I have found studies regarding access to sugar for children and the impact of restricted diets leading to more of a fixation on sugar or food.
I'm going to trial it for two weeks where he has access to the PS4 from 7am to 8.30pm each day, 9.30pm on non school days. My question is whether the child will be able to regulate their own intake of Fortnite over that two-week period.
I am going to build in some provisos regarding attendance at school but one week will be a usual school holiday. I'm going to take hourly observations to see how much time he spends online, gaming, outside with friends etc.
Any comments or know of any research which has looked into this already?
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Interesting topic.
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I've done three treatment groups of RNA-SEQ, one group is Normal, the second is alcohol-withdrawal, the third one is alcohol-withdrawal injected with Drug-A. I want to find the genes and pathways that are regulated by DrugA, so which two groups I should compare with, withdrawal vs Drug-A or Normal vs drugA, or Normal vs withdrawal?
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How you define normal group.
Is it the group with alcohol in take or is it a group not taking alcohol. First you have to specify that.
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I'm looking for information on how chemicals and mixtures are regulated in Canada. I have found that the hazardous products regulations (HPR) specify the criteria for hazard classification and that the Canadian Environmental Protection Act (CEPA) gives a definition of "toxic substances" according to the risk posed by the substance or group of substances. As far as I understood, toxic substances are added to a list and risk management measures can be considered. Does it mean that the classification, for instance as carcinogen, does not imply directly a regulation? What about mixtures and alloys?
Thanks for any information and examples you may provide!
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Concerning pesticides in Canada, they are under regulatory responsability of three levels of jurisdiction, i.e. federal, provincial, municipal.
See pdf attached and the following link:
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I am trying to locate the promoter of Rop gene on this plasmid. Is Rop co-expressed with TetR?
I want to extract the ori and rop to put in another plasmid to get a copy number ~20.
I also looked at addgene https://blog.addgene.org/plasmid-101-origin-of-replication . They mentioned a pColE1 with ~20-25 copies but I actually didn't find this plasmid. not sure about whether it is this one: https://benchling.com/s/seq-9zEdeLxgNETJ8VfFbDTB
I've looked they are both the ColE1 family, does it mean they both regulated with similar mechanism with Rop?
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The mechanism of replication of pMB1 (the parent to pBR322) and ColE1 should be essentially the same, and yes the link you provided is to ColE1. There are a few different ColE1 variants which have been studied but they are essentially identical with regard to plasmid replication. These are natural plasmids and not normally used directly for cloning purposes since they do not carry an antibiotic resistance gene. However some cloning vectors were created using ColE1 origin regions.
Why don't you take a plasmid that is known to have lower copy number and just move the the part of your plasmid that is important (gene of interest or expression cassette) directly into it?
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Hello !
Concerning the dissolution testing, I don't understand why we work in NON-SINK conditions when we doing development (for example if I test the solubility of my active ingredient) and in SINK conditions when we have to do regulation...
Thanks!
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Very good question. What I believe is , during development , we check the time vs release profile upto a period of 120mins max for IR tablets. We compare it with RLD , also subjected to same condition as that of the test and try to understand how far or how close our test product is from the RLD by comparing the release profiles. So our main intention in development is to understand how close or far is our test formulation from RLD, hence maintaining sink condition is not necessary, as without sink condition our purpose is served. I hope this helps.
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Hello, I am wondering whether there is any legal regulation about the duration of the non-compete agreement between influencers and advertisers or not. It is well-known that It is not uncommon for an influencer to work with other companies. Some companies may offer the same or similar products or services. It is crucial for the parties to discuss the exclusivity. If the company requires the influencer to be exclusive, they may require a non-compete agreement. Definitely, this noncompetition should continue during the main agreement. Nonetheless, is there any legal regulation which can indicate that the duration of the noncompetition might be extended after the expiration of the main agreement?
Thanks in advance.
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The regulations on non competes can vary by jurisdiction. Check your jusrisdiction/state laws. Considering this is a newer field, i think getting professional advice is necessary.
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Is there any database that can provide me with information on how a particular gene is regulated (for example, names of transcription factors)
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awo! great, thanks
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Hi All friends , Environmental Impact have high effect , How are fish farms regulated to minimize that ?
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Hello !
Concerning the dissolution testing, I don't understand why we work in NON-SINK conditions when doing development (for example if I test the solubility of my active ingredient) and in SINK conditions when we have to do regulation...
Thanks !
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As far as I understand, drug molecules can be dispersed in accumulated clusters at concentrations above the point where the drug is able to be molecularly dispersed (ie dissolved). This accumulation can lead to stability of the clusters that falsely increase the perceived solubility, depending on method of measurement of solubility. This is particularly present if the method of quantification is the addition of aliquots of drug until a perceived saturation point.
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i tried to extract globulin from oat bran by using 5% Nacl, but failed to get considerable amount of globulin.
The globulin yield from 100g, was less than 0.5 g.while reference artical claimed more than 70 % yield.
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it is not a subject that I am interested in.
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Good day experts,
I am currently designing a research project where my partners and I are investigating the difference in effectiveness of thermal regulation in a highly color variable ectotherm species. We wish to investigate how much of a difference coloration causes in the absorption and reflection of broad spectrum- and UV-light.
We are looking for a method that can be applied in a field situation with relatively high accuracy.
Are there anyone here who can point me in the right direction? Or do you know someone I should be talking to?
Cheers
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Hello Joe; In the 1960s through the mid -1970s studies in temp regulation in reptiles and amphibians were rapidly developing. Bayard Brattstrom, Ken Nagy and others published a number of papers. Some of the data was referred to as "beer can" data. They would put a thermistor in a water-filled beer can (readily available at the field sites) and watch the rates of temp change in various, biologically realistic situations. Nagy made accurate models of animals and followed similar protocols. If you aren't familiar with that ancient stuff, you might enjoy looking it up. You can contact Bayard at bayard@hughes.net Enjoy!! Jim Des Lauriers
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Hello!
I would like to know if it's possible to do continuous absorbance readings within a CO2 incubator to regulate the CO2 concentration.
I will be working with some fastidious bacteria that require CO2 to grow and some of the work requires to do some growth curves (OD600 vs time).
I already have an EPOCH 2 microplate reader (Biotek) and we should be getting a ICO CO2 incubator (Memmert) soon, with a modification that allows cables to pass through one of the sides of the incubator.
Can I make this two equipments work together?
Am I doomed to buy a more expensive microplate reader with built in gas control unit?
Thanks in advance!
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Dear Juan,
I am using a similar setting where I have a imaging system set inside a culture chamber to maintain temperature CO2 and humidity levels ( I am recording cells in culture).
It work fine BUT there are crucial points to consider:
1) CO2 won't have any impact on the reader
2) Temperature won't affect your reader providing that your reader can work at said temperature (check the specification such as operating temperature)
3) Humidity will damage your reader !
The machine I use is sealed and has a specific device inside which prevent building up of humidity inside the system to protect the contacts and electronics (dessicate the air).
IF you are using a dry incubator it's fine, if you are having a water reservoir in your incubator then you will have some issues with your plate reader unless it is fitted with a similar humidity prevention system.
good luck
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Dear colleagues, please for your information. Which year formally through legislation regulates inclusive education in your country.
You can also send me links to posts.
Thanks in advance!
Julia Doncheva
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Dear prof. Proloy Barua Thank you for the information, it is very valuable to me. I know very little about education in your country. Thank you one more time!
All the best: Julia Doncheva
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Has anyone ever tried to deliver CO2 with a CGA 300 regulator? I know that a CGA 320 regulator is standard for CO2. The issue is that I currently do not have any free CGA 320 regulators. I also noticed that the threads for the CGA 300 and 320 are the same size, as shown here: https://www.concoa.com/cgachart.html . Moreover, the cylinder pressure of a 50-LB CO2 tank is ~860psi, which is well within the max pressure for the first stage of a CGA 300 regulator. The only difference I see is that inner thread of a CGA 300 is tapered, whereas the inner thread of a CGA 320 is flat. What is the worst that can happen? A catastrophic regulator failure and explosion, obviously. However, it would seem that is unlikely if the max pressure of the CGA 300 is less than the cylinder pressure and if the threads perfectly overlay. What do you think?
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Brian Karl Richards , I respect what you are saying. Here is the issue: In the lab space that I inherited, there were already two CGA 540 oxygen regulators connected to CGA 320 carbon dioxide tanks. We have observed no leaks or regulator failures in three months, and again these regulators were in use on these and similar cylinders for years before I arrived. I am a newbie on this, having always relied on house-supplied gas lines. I noted that my predecessor had used a shortcut, so I wondered if another shortcut were also possible.
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Globally, late payment to construction contractors remain a lingering commercial issue in the construction industry. The problem is exacerbated by array of factors; with huge negative consequences on contractors and other supply chain in the sector (The National Audit Office (NAO) 2018). Recent statistic reveals that there has been substantial increase from 18% to 27% in the number of late-payment cases in the UK construction industry; with over £30 billion of unpaid invoices to Small and Medium-Sized (SMEs) contractors alone. Moreover, 82% of the total unpaid invoices were monies owed to subcontractors by different tiers of construction clients.
Standard forms of contract and various payment regulations exist to checkmate chronic late payments issues that is deep-rooted in the construction sector. Yet, there is hardly evidence or case law that suggest punitive measures against clients that are involved in unfair payment practices. For example, various payment laws such as the Payment Services Regulations 2017, the Late Payment of Commercial Debts Regulation (2013), The Small Business, Enterprise and Employment Act (2015) and the Public Contract Regulation (2015), etc clearly criminalises defaulters of payment laws.
Conversely, victims of unfair payment practices are often reluctant to seek legal redress; though payment regulations clear stipulate punitive measures against unfair payment practices. Perhaps, withholding payment from contractors is not a financial crime; but a mere industry strategy that benefits both perpetrators and victims. Yet, research that seek to explain the relationship between misconduct (criminality) and business strategy underpinning lingering late payments quandary in the construction sector are scarce.
Thus, the research question: Is late payment to construction contractors a financial crime or magnificent commercial strategy?
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Hi Ian Ross,
Thanks for your detail analysis and contribution to my question. The issue of late payment to contractors remain a chronic issues that requires indepth study.
I am curremtly writing a paper on this subject and I will like to seek your option on issues arising from this subject.
I will reach out to you very soon.
Once again, thanks
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Hello dear colleagues and experts!
When developing a model of a wind generator, I faced the problem of adjusting the PI controller for the pitch angle. I read a lot of articles, but the PI regulator failed ...
Please help with setting it up and getting characteristics
Thank you very much in advance!
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IF you use simulink, In PID box there are "PID tuner", by clicking on it the PID tuner open and you can set the PID parameters for your system.
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What do you think about the balance between exploring widely different designs vs. local optimization at different levels of biology (genomics, transcriptomics, proteomics, anatomy, etc.)? Which levels are more or less modular or plastic?
In the endocrine system, for example, one feels that having tropic hormones (i.e., those controlling the release of other signaling hormones at other glands) may offer a finer and perhaps more robust regulation, compared to a being where all hormones were non-tropic. However, the anatomic location of elements in these networks is not trivial. For example, in the renin-angiotensin-aldosterone system, renin is produced in the kidney, and aldosterone eventually exerts its effects in the kidney as well. However, the intermediate step by angiotensin-converting enzyme (ACE) mainly occurs in the lungs, which could introduce a delay in the regulation.
Do we have good explanations for the sites of production and action of different hormones in the body? Are there common principles to be learned as optimized by evolution in this respect? Or are happenstances/contingent evolution stronger determinants?
Thank you for sharing your thoughts!
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  • hello, in fact I encountered problems during the simulation of the fuzzy regulator applied to the asynchronous machine. I replaced the PI regulator of the vector control with the fuzzy regulator, I made all the settings but the simulation does not work. I ask for help to carry out the simulation.
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Oussama Gherouat I exported the fis file but the simulation does not work. The problem is that if I only simulate the fuzzy controller it works but if I replace the PI regulator with the fuzzy regulator it doesn't work
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tail regulator operation condition effect on down stream water level and rating curve of barrages and dams
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I been wondering if genes when stable transfected become regulated by the cell, or if the gene is constitutively express and translated and the protein previously made is degraded at a slower rate which allows protein accumulation. I have been wondering these since there need to reach an equilibrium in either case for the transfected gene (and the subsequent protein) and not to become toxic to the cell. I hope someone could direct me to a paper that explains this.
I ask this question because if a protein is inhibited by post-translational modification and is perpetually recycle (meaning the older protein is being ubiquitinated as new transcript are giving rise to new proteins) this means that the proteins are technically always active. However, if the transfected stable gene is regulated somehow, means that protein reaches a limit and all in time will become inhibited by this hypothetical post-translational modification. Then if the protein in question is naturally being regulated in transcription factors specifically present in certain cell lines (myeloid for example), but not in others. This could mean that the protein would not have activity in non-myeloid cells even if it's express since there is no way to activated unless other proteins that could undo the previous modification are also supplied.
I am thinking correctly, or this is just crazy talk?
Thank you, and stay safe
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Stable transfection can integrate the transfected DNA into the cell genome and transform it into the offspring that is passed on to the cell, thereby realizing the long-term introduction of foreign DNA into the cell and achieving continuous expression. Whether there is a change in degradation needs to consider whether the gene is related to the protein degradation pathway
learn more about transfection, please visit https://transfection.bocsci.com/
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Hi, I have a question if anyone can answer. I have identified two co-factors for my transcription factor. But the mass spec data seems insignificant. Now I want to find if some other co-factors are involved in regulating my transcription factor? So, how can I do this? Should I cut my gel band at different molecular weight or should I go for ChIP-seq to determine their binding complex?
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Do you have any idea what these other co-factors might be? if not ChIP-seq would not really be possible if you don't know the protein of interest for the cofactor. At that point I would think about trying other methods.
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If each cell in our face were to undergo just one more cell division, we would be considered horribly malformed. If each cell in our arms underwent just one more round of cell division, we could tie our shoelaces without bending over. Our arms are generally the same size on both sides of the body. How is cell division so tightly regulated?
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Dear Mian,
Cyclins are a peculiar breed of protein that impersonates a significant performance. Cyclins give some chemical signals by which one cell communicates with the other cells. The signals produced by cyclins (proteins) allow the cells to behave as switches. With this attribute, the cell comes to know, that when they have to divide or when not... Or, Another thing we can say is that The appearance of unnatural telomeres limits the division of cells further.
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Hello,
I have performed WB analysis and qPCR analysis to analyze the protein level and the rispective gene relative expression of mTOR, GBA1, LC3 genes in brain of mutant mice.
I observed a significant downregulation of all these genes in the mutant mouse compared to WT mice, but no alterations in the protein quantity. Moreover, I did the same for LAMP2 protein and transcripts levels. LAMP2 protein levels were increased, which its mRNA levels were downregulated.
Have anyone experienced this type of "compensation" mechanism between trascriptional regulation and protein levels?
Which kind of regulation can be responsible for this differences?
Thank you so much
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thank you Alejandro for the reply!
For mTOR, GBA1 and LAMP1, p<0.05
for LC3, p<0.01
about the first question, what do you mean by "dynamic range of the assay"?
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Is there any possibilities I do explanatory study between two variables above mentioned? The first variable, think tank capacity, measured using close-ended questionnaire. The other one, research impact on policy, measured using content analysis where policy document (law, regulation) as unit of analysis.
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Yes, it is very possible, but it is better to do two studies (an analysis of the content - and a survey of a specific audience) and study the effect of the content on the audience's answers, which increases the strength, sobriety and scientific credibility of the research.
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I work with Lorna Myers, PhD in the area of PNES. We are always looking for new ways to research this group. I think this questionnaire would be helpful for us in the area of understanding issues with emotional regulation.
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Emotion regulation, the ability to control emotional experiences and expressions, is essential for positive adaption across the lifespan. Individual and contextual factors contribute to emotion-regulation variance between and within different age groups. Individual factors include, for example, genetic dispositions and neurobiological vulnerabilities. Contextual factors involve opportunities to learn about and practice emotion regulation. In infancy and childhood, the family is especially important for assisting in regulating and teaching about emotions. During adolescence, physiological and socioemotional changes can contribute to transient instability in emotion regulation. Throughout adulthood, favorable average well-being trajectories co-occur with increases in pro-hedonic motivation. Emotion-regulation abilities are maintained into old age, but towards the end of life, stressors may overtax individuals' emotion-regulation capacity. This chapter reviews key developmental theories and empirical findings on emotion regulation in childhood, adolescence, and adulthood. It also highlights shortcomings and gaps in the available knowledge and points towards future research directions.
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I work with Lorna Myers, PhD in the area of PNES. We are always looking for new ways to research this group. I think this questionnaire would be helpful for us in the area of understanding issues with emotional regulation.
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The roots of emotional intelligence (EI) stem from the notion of social intelligence. Thorndike (in Intelligence and its uses. Harper’s Mag 140:227–335, 1920) regarded EI via the lens of social intelligence, stating that social intelligence is the capability to empathize with others and perform sensibly in human relationships (see Goleman in Working with emotional intelligence. Bantam Books, New York, 1998). Nonetheless, his opinions were not greatly welcomed until years later. Emotional thought was viewed to be in the domain of intelligence.
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How can parents make sure that their kids only view webpages provided by schools or other learning agencies without digressing to adult sites online or be misled by pop up adds (from google or other search engines) into viewing adult stuffs online. This is a major concern for parents that are not always around to regulate what their kids view online. What can be done to alleviate this problem?
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There are a number of software and firewall solutions that may be implemented to prevent such sites being visited. 'NetNanny' is one popular example.
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Dear colleagues,
I keep seeing certain researchers whom I unfollowed even whom I never followed. How can I regulate my feed not to see unwanted content?
Best
Ibrahim
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I found my way back into customization. On >Settings >Notifications, click on the word "Networks". Unclick the kinds of e-mails you don't want. "General Notices" also may need some unclicking. And sometimes on your home page, you may need to scroll down to Following on the right and unfollow some people that it auto-set as people you are following. For example, since I responded to your post, it may set one of us as following the other. :-)
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For example, if the regulation is allosteric or not. I did not find this information on PDB, protein human atlas, Kegg or BRENDA.. Do you know any database that can I find this information?
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effect the sediment on discharge amount of lateral canals lining or do not lining at start joining of head regulator which at time reduce the discharge of canals with stay water level is constant or increasing because of detention of water due to sediment.
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this effect on rating curve therefore must change the rating curve at all month or at before and after rising of sediment
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The knocking out of Gene A results in induced expression of another pathway. I want to find a link between KO phenotype and overexpressed pathways? I am new, so I am stuck at this point of how to create a link?
The GO analysis are heavily enriched with metabolic pathways (since KO gene and overexpressed pathways are metabolic-related). My understanding is that the KO gene may be the negative regulator of OE pathway, but the StringDB analysis did not bring anything.
I have created the network using GeneMania and then did Enrichment analysis, but all the terms are metabolism-related. Any help/hint in this regard is highly appreciated.
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Hi Ayaz,
Yes rebuilding the networks using only the DEGs you are interested in pursuing plus your KO gene is a good start. In fact to built a fully connected network STRING/Reactome will need to add some genes in between your genes of interest, instead of disregarding those ones you could try to see the expression values of those genes to see if they were false negative possibly in your differential expression analysis and to see if biologically you find a possible mechanism of dysregulation due to your KO gene linked to the altered functionality of those genes and the connected ones.
Also with REACTOME as is more curated thus the number of interactions you will find is lower if you decrease to much the number of queried seeds you may end with nothing useful. In that case you may try to built first a functionality network, meaning your DEGs of interest plus the first level interactors of those ones, and then query all of them in REACTOME, and again re annotate those first level interactors with the expression levels to see if they could be slightly altered and following the same regulatory sense. Good luck. Kind regards, Mar
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Sometimes, it is not required chemical or nuclear weapons for mass destruction, and unsafe storage of chemicals such as Ammonium nitrate is good enough for the mass destruction. Massive damages at the Ports of Texas in 1947 and Beirut in 2020 are bitter examples of unsafe handling of chemicals such as ammonium nitrate.
Therefore, unsafe storage and handling of such chemicals within the boundaries of international ports should be regulated.
Since this is an international concern, I would like to discuss this matter with relevant experts.
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Thank you.
Do you think that the present international low is enough to handle these types of issues?
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Plastic which is rather problematic waste. It wil require prior consent by importing nations according Basel Convention s amendment but not between EU member states for example. EU also introduced broader regulation of 4 phthalates, DEHP (di(2-ethylhexyl)phthalate), DBP (dibutylphthalate), BBP (butylbenzylphthalate) and DIBP (di-isobutylphthalate) but didn t include some other also problematic phthalates. It regulates also some flame retardants like PBDEs but only to certain level which still allows deca-BDE to be recycled in new product for example. So my question whether it is enough and the regulation should not go further based on current scientific knowledge?
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Thank you all for your replies in this discussion. All your replies Anju Baroth , Akram Jassim Jawad , Abdelkader BOUAZIZ , Sarah Ozanova and Jindrich Petrlik are very valuable contributions to this discussion.
Ban for some additives reached global agreement under the Stockholm Convention. However this convention is focused on POPs. There are more additives like phthalates for which it doesn t seem they can reach criteria for POPs but they are also toxic. EU has banned some of them but they were replaced by another phthalates for many products. How to deal with these additives globally? It seems that even if phthalates were banned in EU they are still used in many other countries and it is almost impossible to control their use effectively. What do you think?
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Dear All Researcher,
Please help me, I need a questionnaire sample to analyse the impact of implementation of new regulation related to covid-19 to the company/organization.
I'm very thank you for your help.
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For a particular gene of interest, how can i find the coding RNA sequence and non-coding RNA sequences regulating the expression of this gene?
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You can use UCSC table browser for this.
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Emotional regulation is known to be .associated with Non-suicidal self-injury. In order to understand this phenomenon in a systemic context we are looking for measurement tools that evaluate emotions and their regulations from a systemic perspective. Any lead would be appreciated. Thanks in advance.
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This article may interest you:
file:///Users/scheung/Downloads/55-107-1-SM.pdf
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I tried but I could not find suitable one for my study.
Relationship Between Emotional Regulation and Attachment and
(Their) Differences in Collectivist and Individualist Cultures.
I used correlation for relationship.
but their differences in Collectivist and Individualist Cultures?
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What is your sample size?
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Global E-Commerce is growing fast, replacing traditional trade transactions. This is an issue for Governments, not having regulation mechanisms, as it causes tax revenue losses.
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Perhaps monitoring. There are so many companies i the market. Most of these are not authentic. So to keep everything OK there should be imposed more monitoring system in Ecommerce.
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DC current(or voltage) supply has to keep constant(DC) a current (or a voltage respectively) whatever the load ie evolution(AC) of the voltage (or the current respectively). This means that even DC, the supply has to react to any load fluctuation. So, this leads to an AC parameter, which is the bandwidth of this ability to compensate for fluctuations (?). have you any experience/example of power supply specifications showing the bandwidth of the regulations?
What happens, behind this bandwidths. What consequences on the biased (sensor, amplifier ...) system?
We have to design low noise current sources and we think about adding a passive current filter (with a parallel capacitor followed by a series inductor) to limit the noise bandwidth. Apart from the regulation stability, have you any recommendation/experience in such filtering. Assuming that a series inductor reacts to any currents fluctuation, we expect "passively" increase the regulation bandwidth, even if the active regulation is at the same time inhibited by this filter.
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In most cases indeed passive post filtering (either RC for low currents or LC for high ) is the best option.
The voltage DC supplies are usually equipped with large output capacitor ( they are designed to be stable with such load). Then, that capacitor defines the transient behavior. Similarly, high current DC sources might be equipped with output inductor. However inductor only makes sense for rather high current sources, otherwise series resistor is used.
Important to note that some current sources are maintaining AVERAGE current - then they can be equipped with output capacitor too - and that makes usually very stable and low noise. Examples are current sources used for various filaments (heaters), Hall sensors, high precision electromagnets.
The noise measurement of high performance DC sources is b a bit tricky. One may look into e.g. :
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Legal regulation of records and archives management since the time of the Rzeczpospolita (1569-1795)
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However there are plenty of articles. If you write to my email, I can give you a few directions. Luciana.duranti@ubc.ca.
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The John Molson School of Business at Concordia University kindly invites contributions to the forthcoming edited book Beyond the 2ºC - Business and Policy Trajectories to Climate Change Adaptation to be published by Palgrave Macmillan and being considered for the “Palgrave Studies in Sustainable Business: In Association with Future Earth” book series.
ABOUT THE BOOK
Climate change mitigation, understood as an approach to reduce human-induced emissions, has taken centre stage in climate action debates and efforts in the last decades. Currently published reports and studies present scenarios under which we can limit the global temperature rise to a 2°C threshold. However, to stay within the 2°C threshold, we need to move towards net-negative global emissions. This would require mobilization on a global scale and improvements in our approaches to mitigating global warming. After passing the symbolic 400 parts per million (PPM) threshold of carbon dioxide equivalents (CO2-eq) in the atmosphere in 2016, recent studies have highlighted that the current emission trajectory can easily lead to concentrations of up to 1,000 PPM of CO2-eq – leading to an average global warming of up to 5.4°C by the end of this century.
While many governments, businesses and researchers like to believe that a mitigation-focused approach can keep the 2°C threshold within reach, this edited book intends to investigate the business and policy adaptation trajectories beyond what are currently understood to be some of the major tipping points in the climate system. In these scenarios, the planet will be on an accelerated path towards deforestation, biodiversity loss, erosion of inhabited and uninhabited coastal areas, and the possible disappearance of entire island states. These events will be coupled with the possible proliferation of disease, human migration, and increased conflicts over resources. This calls for academics, practitioners, and policymakers to shift their attention away from the almost exclusive focus on climate change mitigation, to also consider adaptation plans.
Beyond the 2ºC - Business and Policy Trajectories to Climate Change Adaptation is an edited collection that will review and critically analyze new and innovative business and policy approaches to climate change adaptation across different economic sectors and for different locations. The edited collection will aim to ignite an academic discussion regarding the necessary, and potentially urgent, adaption strategies that could address the risks induced by the fast-changing climate. The contributions should demonstrate how we can adapt to a world where fresh water is scarce, where extreme weather events are a daily reality, where global sea levels are up to 2.4 m higher than today, and where flooding and wildfires are no longer discrete events. The collection plans to evaluate the readiness of our businesses and policies to adapting to this “new” world and to explore strategies that move beyond the current incremental approaches.
CALL FOR CONTRIBUTIONS
Beyond the 2ºC - Business and Policy Trajectories to Climate Change Adaptation aims to explore and propose business and policy solutions for climate-induced economic, technical, and societal challenges.
The editors are accepting contributions by experts in both the academic and practitioner communities in business and policy, as well as related fields such as economics, management, development studies, finance, and entrepreneurship. The editors are inviting contributions that:
· Shed new light on our understanding of climate-related vulnerabilities and risks
· Explore innovative risk management procedures
· Present new and emerging processes for internalizing adaptation in existing business and policy approaches
· Identify new barriers to large scale and/or local climate change adaptation
· Introduce methodologies for mapping and understanding synergies and trade-offs in adaptation
· Investigate approaches to overcoming conflicts in business and policy adaptation trajectories
The editors are encouraging contributions that move beyond the current disciplinary divides and present novel interdisciplinary approaches, which use scenario building methodologies in their investigations and study the social, economic, environmental, and cultural dimensions of the complex adaptation trajectories. Moreover, the editors will also be accepting chapters that incorporate new concepts or tools beyond the academic fields of business administration and political science. These fields will include the natural and social sciences, which make connections to the business and policy. The editors also encourage contributions that move beyond carbon emissions to focus on emerging challenges and themes regarding adaptation, which includes health, wellbeing, air quality, waste, and biodiversity. In addition, chapters that use case studies or comparative studies (between different solutions, applications in different industries, or variations between regions) are strongly encouraged. Finally, considering the global nature of climate change and its multi-scale consequences, the editors invite authors to critically consider the scalar relevance – local, regional, national, and supranational levels – of their contributions.
The submissions will be reviewed with an open mind and with a particular focus on the relevance of the chapter with respect to adapting to climate change and its consequences beyond the 2ºC threshold. The edited book will serve as an academic reference for senior undergraduate, graduate, and post-graduate scholars in the fields of business, public affairs, social science, environmental studies, and law across the globe. It will also function as a practical guide and a reference for emerging best practices on the topic of climate change adaptation for industry and business leaders, regulators, and policymakers around the world. Although the book can be used as a reference book in academic courses, it will not be specifically organized as a textbook.
POTENTIAL TOPICS FOR CHAPTERS
1. CLIMATE CHANGE HAZARDS AND THEIR MANAGEMENT
a. Understanding the hazards and their management
b. Technological hazards
c. Political hazards
d. Natural hazards (cyclones, floods, storms, floods, droughts)
e. Socio-economic risks
f. Human health risks
g. Planetary health and biodiversity risks
h. Geoengineering and climate management
i. Greenhouse gas management
ii. Solar radiation management
2. THE FUTURE OF FOSSIL FUELS AND EMISSIONS
a. Fossil fuel subsidies
b. Carbon pricing/carbon taxation
c. Biofuel and other alternative fuels
d. Renewable energy (wind, solar, geothermal)
e. The future of nuclear power (challenges and opportunities)
f. Battery electric vehicles (BEVs)
g. Hydrogen fuels
3. ADAPTING CITIES, URBAN SETTLEMENTS, AND CHANGES TO HUMAN BEHAVIOUR
a. Urban planning, urban design, and cities beyond the 2ºC
b. Waterfront settlements, island states, and other high-risk human settlements
c. Buildings and construction (design, materials, codes/standards/certifications, retrofitting)
d. Local modes of transportation (cars and other private transport, public transit, collective passenger transport, human-powered transport, etc.)
e. Intra-continental travel (rail, advanced trains and emerging technologies)
f. Inter-continental travel (aviation fuel, turbofan/turboprop engines, emissions and contrails, emerging technologies, etc.)
g. Global product transport and logistics
4. ADAPTING THE PRODUCTION AND CONSUMPTION PATTERNS
a. Agriculture, soil, and forests
i. Animal and marine farming
ii. Agriculture, agroforestry, reforestation
iii. Soil and its rehabilitation
b. Demand-side management
i. Incentive and financing programs
ii. Change and development in consumption patterns
iii. Consumer behaviour beyond a 2ºC warmer climate
c. Supply-side management
i. Change and development in production patterns
ii. Recycling, upcycling, reuse, and regeneration
iii. Closed-loop production models
iv. Living and biotic natural resources
v. Non-living natural resources (metals, minerals, and stone)
vi. Renewability of resources
d. New and emerging modes of production and consumption
5. FINANCING GLOBAL CLIMATE ADAPTATION
a. Microfinance (micro-credit, micro-insurance, risk, etc.)
b. Philanthropy and venture capital
c. ESG investment (trends, renewable energy investment, partnerships, water, etc.)
d. Climate finance (private climate finance, green funds, adaptation funds, the low carbon market, divestment, etc.)
e. Evaluating and managing the financial risks of adaptation
f. Natural capital accounting (efforts, innovations, and effects)
g. Financial policies
6. LIMITATION AND THE FUTURE OF CLIMATE ADAPTATION
a. The limits to climate change mitigation
b. Political and policy limits
c. Capital limits
d. Technological limits
e. Societal and cultural limits
IMPORTANT DATES
· Abstract and CV submission deadline – June 30th, 2020
· Selection of abstracts and notification to successful contributors – July 31st, 2020
· Full chapter submission – November 30th, 2020
· Revised chapter submission – February 28th, 2021
GUIDELINES FOR CONTRIBUTORS
Submissions should be written in English using a non-technical writing style. The contributions may include diagrams/illustrations in order to present data, or photographs/figures (all in black & white) to better illustrate the topic of discussion. Submitted chapters should be original and exclusively prepared for the present book. No part of the article should be published elsewhere. Chapters must not exceed 7,000 words (including all references, appendices, biographies, etc.), must use 1.5-line spacing and 12 pt. Times New Roman font, and must us