Science topic
Reactive Oxygen Species - Science topic
Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.
Publications related to Reactive Oxygen Species (10,000)
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Neutrophils are key components of the immune system and play a significant role in the tumour microenvironment (TME) of breast cancer. These cells can undergo polarization into two distinct phenotypes: N1 and N2 neutrophils. N1 neutrophils are typically associated with antitumor immunity, characterized by the production of pro-inflammatory cytokine...
_______________________________________________________________________________________________________________ Endothelial dysfunction is a significant complication in patients with both sickle cell disease (SCD) and human immunodeficiency virus (HIV) infection, contributing to increased morbidity and mortality. In SCD, chronic hemolysis leads to...
Peaks in the mass loss rate (MLR) curve derived from thermogravimetric analysis (TGA) are commonly used to infer the pyrolysis rates of solid fuels. While the main peaks are often modelled, smaller MLR fluctuations are typically neglected, leading to discrepancies between models and experiments. The impact of these small fluctuations on key simulat...
The proliferation of microplastics (μP) in aquatic environments poses a significant threat to ecosystem health, with repercussions extending to aquatic organisms and potentially to human health. In this study, we investigated the efficacy of a novel biosurfactant-microplastic (BSμP) hybrid in reducing in vivo green bio-toxicity of microplastics (μP...
Maize (Zea mays L.) is a vital crop worldwide, serving as a cornerstone for food security, livestock feed, and biofuel production. However, its cultivation is increasingly jeopardized by environmental challenges, notably soil salinization, which severely constrains growth, yield, and quality. To combat salinity stress, maize employs an array of ada...
Photocatalytic antibiotic degradation is an energy‐efficient and environmentally friendly approach with the potential for large‐scale application but is severely constrained by the lack of efficient and stable catalysts to produce reactive oxygen species (ROS). This research introduces a charge‐ordered 3D Fe3S4‐PUF composite integrated into a custo...
Traditional ophthalmic formulations are characterized by low bioavailability, short intraocular retention time, strong irritation, and failure to achieve the expected therapeutic effect due to the special physiological structure of the eye and the existence of many barriers. Microneedle drug delivery is a novel transdermal drug delivery modality. R...
Cu(II), Mn(II) and Ag(I) complexes incorporating bridging dicarboxylate and 1,10-phenanthroline ligands have exhibited anti-cancer potential with significant in vitro and in vivo cytotoxic efficacies. Our study focuses on regulated cell death process of apoptosis as a mode of action of the anti-cancer activity by the complexes. Cytotoxicity screeni...
Photothermocatalytic cellulose steam reforming has emerged as a sustainable strategy in balancing energy conservation and efficiency; the paramount stumbling block in its industrial application is the excessive byproducts and rapid deactivation due to vigorous reaction. This study substantiates how doping La³⁺ in ceria loaded with nickel nanopartic...
![a) Reaction optimization for propylene oxide. [a] Deviations from the...](publication/389551021/figure/fig1/AS:11431281316814783@1742230848986/a-Reaction-optimization-for-propylene-oxide-a-Deviations-from-the-standard-conditions_Q320.jpg)
The selective autoxidation for the synthesis of valuable oxygenates has provoked keen interest from both academic and industrial sectors. Although the generation of reactive oxygen species via oxygen attack on C─H bonds near ester linkages is well‐established, research into aliphatic ester oxidation has primarily focused on combustion, neglecting t...
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common enzymatic disorder. This situation leads to an increase in reactive oxygen species (ROS) within the body, causing tissue damage and hemolytic anemia. COVID-19 affects individuals differently, with those with chronic conditions at a higher risk of experiencing a more severe outcome. Thi...
NOXO1 (NADPH Oxidase Organizer 1) is a key regulatory subunit of the NADPH oxidase complex, primarily involved in the production of reactive oxygen species (ROS). It plays an essential role in cellular signaling, immune response, and oxidative stress-related disorders. Dysregulation of NOXO1 is linked to various diseases, including cancer, inflamma...
Evaluating SLAM algorithms is critical in determining their performance and suitability for specific applications. This paper introduces a novel benchmark framework for quantitatively assessing the quality of occupancy grid maps produced by 2D laser-based SLAM algorithms, including Gmapping, Hector SLAM, and Cartographer. The framework consists of...
Doping of non‐metallic elements is considered a promising strategy for metal oxide catalysts modification in alkane oxidative dehydrogenation (ODH). It can avoid over‐oxidation of alkane and improve product selectivity. Regulating electronic properties of oxygen species on cerium oxide (CeO2) surface is effective for cyclohexane ODH to cyclohexene....
The scientific evidence for the medical application of thoron, an isotope of radon, remains to be insufficient internationally. In addition, the ICRP reported that thoron progeny nuclides show higher radiobiological effects than radon progeny nuclides. For this reason, we outlined some of the research results that we have so far reported the biolog...
This project integrates self-training robots with IMU-based navigation, developed with ESP32 and ROS 2 off-board computation for adaptive locomotion enhancement. Gesture-based robots, the norm in the field, are not adaptive, especially on rough terrain. With reinforcement learning (RL) techniques such as Q-learning and an MPU-6050 IMU and HC-SR04 u...
Reactive oxygen species (ROS) are widely considered key to pathogenesis in chronic metabolic disease. Consequently, much attention is rightly focused on minimising oxidative damage. However, for ROS production to be most effectively modulated, it is crucial to first appreciate that ROS do not solely function as pathological mediators. There are >90...
Ischemic stroke is one of the major causes of disability and mortality in the aged people. A better understanding of the pathology, mechanism, diagnosis and treatment of stroke might have important practical implications for patient clinical management, especially for aged patients. Affected by cerebral ischemia, neurons are not capable of maintain...
The internationalization process helps firms accumulate business knowledge and experience; however, firms also enjoy the benefit of decreasing risk due to diversification. The Taiwanese food industry has encountered some difficulties in internationalization, including insufficient production capacity, high tariffs, the lack of long-term planning by...
Benign prostatic hyperplasia (BPH) is a common urological condition affecting aging men, characterized by the non-malignant enlargement of the prostate gland, which often leads to lower urinary tract symptoms (LUTS). While hormonal changes and age are recognized as primary risk factors, the roles of chronic inflammation and oxidative stress in the...
Exposure to diesel exhaust particles (DEPs), which are major constituents of urban air pollution, is associated with adverse health outcomes. Previous studies have shown that DEPs enhance the expression of pro-inflammatory cytokines and immune responses. However, few studies have focused on genomic variants that regulate DEP-induced signaling. Here...
This paper aims to address sensor-related challenges in simultaneous localization and mapping (SLAM) systems, specifically within the open-source Google Cartographer project, which implements graph-based SLAM. The primary problem tackled is the adaptability and functionality of SLAM systems in diverse robotic applications. To solve this, we develop...
Devil Facial Tumour Diseases (DFTD), threatening Tasmanian devils, consist of two distinct transmissible cancers, DFT1 and DFT2, with differing origins and geographic spread. We investigated the metabolic differences between DFT1 and DFT2, examining cell viability, metabolic outputs, and bulk gene expression. Using both DFT1 and DFT2 cell lines and...
Redox (reduction–oxidation) imbalance is a physiological feature regulated by a well-maintained equilibrium between reactive oxygen species (ROS) and oxidative stress (OS), the defense system of the body (antioxidant enzymes). The redox system comprises regulated levels of ROS in the cells, tissues and the overall organ system. The levels of ROS ar...
This study investigated the influence of carbon quantum dot (CQD) deposition onto ZrO2 nanoparticles with respect to photocatalysis and sonocatalysis using methyl orange (MO) degradation as a model dye. The synthesized composites demonstrated enhanced catalytic activity compared to pristine ZrO2, with a 0.1% mass fraction of CQDs, achieving the hig...
Copper exposure poses potential detrimental effects on both public and ecosystem health. Spermidine, an antioxidant, has shown promise in reducing oxidative stress and inflammation within the liver. However, its specific role in mitigating copper‐induced hepatic cuproptosis and disturbances in copper metabolism remains unexplored. Consequently, thi...
Cooperative perception enabled by Vehicle-to-Everything (V2X) communication holds significant promise for enhancing the perception capabilities of autonomous vehicles, allowing them to overcome occlusions and extend their field of view. However, existing research predominantly relies on simulated environments or static datasets, leaving the feasibi...
The BRILLO (Bartending robot for interactive long-lasting operations) project aims to create an autonomous robotic bartender that can interact with customers while accomplishing its bartending tasks. In such a scenario, people’s novelty effect connected to the use of an attractive technology is destined to wear off and, consequently, negatively aff...
Contamination of inanimate surfaces with microorganisms is considered one of the routes for transmission of pathogens, which is a matter of concern not only in healthcare-related facilities, but also in public areas. Durable antimicrobial coatings have emerged as the one of most promising strategies for reducing the accumulation of microorganisms o...
Birds have higher plasma glucose concentrations but lower cancer prevalence than other vertebrates. However, this inverse relationship between glucose and cancer may not hold within vertebrate groups. Given that diet affects blood sugar levels, and carnivores have higher cancer risk than herbivores, we also examined whether diet correlates with pla...
Copper is a trace element indispensable for cellular physiology, integral to cellular redox balance, and a constituent of enzyme active sites, thereby playing a pivotal role in cellular physiological function. Concerning the pathogenesis of Alzheimer’s disease (AD), the homeostatic balance of copper is perturbed both intracellularly and extracellul...
Aging and degenerative diseases are characterized by the progressive decline in cellular, tissue, and organ function, resulting in a significant reduction in quality of life and posing major medical challenges. This highlights the urgent need to elucidate the underlying mechanisms and to develop innovative therapeutic approaches. In this study, we...
Organic luminophores have found extensive applications in cellular and in vivo fluorescence imaging. However, their efficacy is often hindered by formidable challenges, including a low signal‐to‐noise ratio (SNR), susceptibility to false‐positive signals, limited tissue penetration depth, and autofluorescence arising from non‐negligible background...
Long-term treatment with glucocorticoids significantly impacts bone health, with glucocorticoid-induced osteoporosis (GIOP) being the most prevalent consequence. Previous studies have established that Atractylenolide I (Atr I) possesses anti-inflammatory, antioxidant and anti-tumor properties, however, its specific effects on osteoclastogenesis and...
Hepatoblastoma (HB) is a rare but predominant liver cancer in children, with few treatment choices in advanced stages. YWHAE is closely related to several human diseases and acts as a molecular scaffold for malignant transformation. However, whether YWHAE promotes HB development remains unknown. Conducting RNA and m⁶A sequencing on HB tissues, we f...
Oxidative stress has been found to burden dialysis patients relying on artificial kidney membranes. If the artificial kidney membrane itself had a higher antioxidant capacity, scavenging the reactive oxygen species generated during dialysis may be possible. However, no means to compare the antioxidant capacity of the membranes is currently availabl...
An investigation of the mtDNA haplogroup in 96 Taiwanese women with diminished ovarian response (DOR) and normal ovarian response (NOR) showed that only the haplogroup R is less likely to experience DOR than other mtDNA haplogroups. When analyzing the relationship between age and mitochondria-related markers (mtDNA copy number, ROS levels, and telo...
Introduction
Ovarian cancer is a malignant tumor that arises in the female reproductive system and is associated with a very high mortality rate. This is primarily due to the highly invasive nature of metastasis and recurrence. Transforming the immune environment from an immunosuppressive state to an anti-tumor state through the phenotypic transfor...
Ensuring food quality and safety according to stringent global standards requires analytical procedures that are accurate, cost‐effective, and efficient. This present innovative high‐throughput microrobots designed for the detection of antioxidants in food samples. These microrobots consist of photocatalytic bismuth subcarbonate anchored on silica‐...
Maintaining microbiota balance and enhancing the antioxidant performance of nanozyme‐based probiotic systems are crucial for effective inflammatory bowel disease (IBD) therapy. Despite significant advancements, developing a green and safe coating technology that functionalizes probiotics with nanozymes while preserving the activity of both componen...
![Mean values in [min] of the parameters T max ROS, ET 50 MPO, and ET 50...](publication/389765475/figure/tbl1/AS:11431281315245151@1741771653398/Mean-values-in-min-of-the-parameters-T-max-ROS-ET-50-MPO-and-ET-50-NETosis-n-for_Q320.jpg)
This study examines how different concentrations of arginine vasopressin (AVP) and its preservative chlorobutanol (ClB) impact the immune functions of human polymorphonuclear neutrophils (PMNs), which are crucial in the immune response, particularly in sepsis. Using a model to simulate the physiological, sepsis-related, and therapeutic AVP levels i...
In pursuing sustainable environmental solutions, the concept of ‘waste to treasure’ has emerged as a promising approach. In this study, a new process is proposed to combine solid copper slag with hydrogen peroxide (H2O2) to remove nitrogen oxides (NOx) from acidic exhaust gases, thus effectively utilizing waste materials. Firstly, different smeltin...
This research aims to explore whether Berbamine (BBM) can mitigate tissue damage in mice resulting from hind limb muscle ischemia-reperfusion by scavenging lipid ROS and inhibiting p65 nuclear translocation. The hind limb ischemia-reperfusion (IR) injury model in mice was employed. Forty-eight mice (n = 12 per group) were randomly allocated into fo...
Background
Sarcopenia and obesity, two prevalent health conditions, often coexist and exacerbate each other’s impact, increasing the risk of chronic diseases and mortality. This dual condition is termed “sarcopenic obesity.” The correlation between oxidative stress (OS) and sarcopenia or obesity was established, and the oxidative balance score (OBS...
Effective chemical catalysts can artificially control intracellular metabolism. However, in conventional catalytic chemistry, activity and cytotoxicity have a trade-off relationship; thus, driving catalysts in living cells remains challenging. To overcome this critical issue at the interface between catalytic chemistry and biology, we developed cel...
To extend the shelf life of button mushrooms, the optimal fumigation doses for hydrogen gas treatment were screened through sensory evaluation, combined with browning index and weight loss rate in this study. Then, using H2 fumigation combined with polyethylene film packaging as a control, changes in the sensory quality, reactive oxygen species, br...
Pancreatic cancer stands as one of the most aggressive and deadly malignancies, characterized by a limited array of treatment options and unfavorable patient outcomes. Recent strides in the realm of nanotechnology have introduced advanced approaches to increase the delivery of anti-cancer agents and intensify their effectiveness. The lipid-based na...
Oxidative stress, resulting from an imbalance between reactive oxygen species (ROS) production and antioxidant defenses, plays a crucial role in tumor development. Tumor cells often experience elevated oxidative stress due to rapid proliferation and unstable metabolism, leading to DNA damage. The enzyme 8-oxoguanine DNA glycosidase (OGG1) is centra...
Nitrate signaling coordinates the expression of a broad range of genes involved in nitrate uptake, transport, and assimilation, playing a crucial role in plant growth and development. Notably, nitrate signaling interacts extensively with various messenger molecules, including phytohormones, calcium ions (Ca ²⁺ ), reactive oxygen species (ROS), pept...
Cataracts are a leading cause of visual impairment and blindness worldwide, primarily affecting the elderly population. Oxidative stress has been identified as a major contributor to cataract formation, leading to the oxidation of lens proteins and structural changes in the lens. Antioxidant defense mechanisms play a crucial role in preventing and...
Recently, oxidative stress and inflammatory responses have been shown to directly impact tumor growth and the tumor microenvironment (TME). However, more research is necessary to fully understand the relationship between oxidative stress and inflammatory responses and colorectal cancer (CRC).
The FindCluster algorithm was used to extract CRC Single...
Currently, multidrug-resistant (MDR) pathogens are becoming a human and economic burden worldwide and have posed a grave threat to public health. In this case, mild-temperature photothermal therapy (PTT) has become a promising alternative to conventional antibiotics because it has the characteristics of minimally invasive property, targeted destruc...
Diabetes, also known as oxidative-stress disorder, is a global health issue
characterized by damage of enzymes, cellular machinery and also increased
insulin resistance due to oxidative stress. Enhanced oxidative stress
pathways appears to be deleterious leading to morbidity and mortality
associated with diabetes. Antioxidants of plant origin has b...
Cell death is a crucial mechanism through which cells respond to damage and stress, thereby maintaining homeostasis. Cell death pathways include both caspase-dependent and caspase-independent mechanisms, such as apoptosis, necrosis, autophagy, and ferroptosis. The recent discovery of oxeiptosis identifies a unique form of ROS-mediated, caspase-inde...
Paraquat (1,10-dimethyl-4,40-dipyridinium chloride),is an effective herbicide used for crop protection. Several cases of acute paraquat induced poisoning are reported across globe. Toxicity mechanism involves production of harmful Reactive oxygen species (ROS) which causes systemic damage. In present study we tried to study the harmful effect of pa...
Periodontitis, a common dental illness, causes periodontal tissue inflammation and irreversible bone loss, inevitably resulting in tooth loss. Hyperhomocysteinaemia (HHcy), defined as blood total homocysteine (Hcy) levels greater than 15 µmol/L, is linked to increased cardiovascular disease risk. Mounting evidence indicates a connection between HHc...
![Analysis of cell proliferation and viability in low [Na⁺] (a) Cell...](publication/389677189/figure/fig1/AS:11431281314574054@1741453221070/Analysis-of-cell-proliferation-and-viability-in-low-Na-a-Cell-proliferation-of-ACHN_Q320.jpg)
![Analysis of cell invasion in low [Na⁺] Cell invasion of ACHN and Caki-1...](publication/389677189/figure/fig2/AS:11431281314546041@1741453221544/Analysis-of-cell-invasion-in-low-Na-Cell-invasion-of-ACHN-and-Caki-1-was-assessed-by_Q320.jpg)
![Analysis of cell migration in low [Na⁺] (a, b) Cell migration of ACHN...](publication/389677189/figure/fig3/AS:11431281314499728@1741453222185/Analysis-of-cell-migration-in-low-Na-a-b-Cell-migration-of-ACHN-and-Caki-1-was_Q320.jpg)
![Analysis of oxidative stress in low [Na⁺] (a, b) Reactive oxidative...](publication/389677189/figure/fig5/AS:11431281314564912@1741453223027/Analysis-of-oxidative-stress-in-low-Na-a-b-Reactive-oxidative-species-ROS_Q320.jpg)
Hyponatremia is the most common electrolyte disorder in cancer patients and is associated with a worse outcome. This finding has also been reported in patients with metastatic renal cell carcinoma (mRCC). We have previously demonstrated that low extracellular sodium concentrations ([Na⁺]) increase cell proliferation and invasion in several human ca...
Background: Hyperglycemic changes in the cellular biological properties of retinal pigment epithelium cells are involved in the pathophysiology of diabetic retinopathy (DR). To assess the effects of the new anti-diabetic agent imeglimin (Ime) on DR, the pharmacological effects of Ime and those of metformin (Met) in combination with the PPARα agonis...
Cerebral ischemia–reperfusion (CIRI) represents a complex disease entity that encompasses multiple pathways. The occurrence of CIRI induces cerebral infarction, accompanied by brain tissue necrosis and focal neuronal impairment. Previous studies have demonstrated that ferroptosis, a specific cell death pathway implicated in CIRI, plays a crucial ro...
Radiotherapy resistance is a major cause of recurrence and metastasis in colorectal cancer (CRC). We established radiotherapy‐resistant cell lines to explore the molecular mechanisms of radiotherapy resistance in CRC. HT29 and HCT116 cells were subjected to repeated irradiation at 2 Gy to establish these lines. CCK‐8 assay, colony formation, and xe...
A high-performance Fe–N co-doped carbon-based catalyst was prepared to activate PMS by a one-step pyrolysis using ferbam, melamine and sucrose. The best catalyst Fe–N/C exhibited high catalytic activity against PMS at an ultra-low catalyst dosage (50 mg L⁻¹), and the TC decomposition rate reached 92.3% within 30 min. The results demonstrated that g...
Extracellular vesicles (EVs) could be involved in the onset of systemic sclerosis (SSc) through the modulation of vascular function. Anyway, available data are contradictory, and further investigation would be necessary to clarify this aspect. Here, we characterized circulating EVs isolated from SSc patients and evaluated their effects on human vas...
Seed priming is a simple, inexpensive, and effective pre-sowing technique that enables plants to better tolerate abiotic stresses, including high soil salinity, which is a major limiting factor in the establishment of halophytes for saline agriculture, as germinating seeds and early seedlings of many halophytes are sensitive compared to the mature...
Automating agricultural machinery presents a significant opportunity to lower costs and enhance efficiency in both current and future field operations. The detection and destruction of weeds in agricultural areas via robots can be given as an example of this process. Deep learning algorithms can accurately detect weeds in agricultural fields. Addit...
[Ru(bpy)3]2+ is a widely used molecular photosensitizer (PS) for light-driven reactions in combination with separate catalysts, although the PS alone is known to promote water oxidation under aqueous conditions. In...
Coelenterazine (CTZ) is a common substrate of marine luciferases upon emission of bioluminescence (BL) in living organisms. Because CTZ works as a “luminophore” in the process of BL emission, the chemical modification has been centered for improving the optical properties of BL. In this review, we showcase recent advances in CTZ designs with unique...
Background
Stem canker of Zanthoxylum bungeanum is a destructive forest disease, caused by Fusarium zanthoxyli, poses a serious threat to the cultivation of Z. bungeanum. The lack of research on effector proteins in F. zanthoxyli has severely limited our understanding of the molecular interactions between F. zanthoxyli and Z. bungeanum, resulting i...
Regulated cell death (RCD) is considered a vital process in cancer therapy, determining treatment outcomes and facilitating the eradication of cancer cells. As an emerging type of RCD, PANoptosis features excellent antineoplastic effects due to its combination of death modes, including pyroptosis, apoptosis, and necroptosis. In this work, anion‐cat...
Breast cancer is one of the most common cancer types worldwide. It can potentially be treated with peptide therapy rather than chemotherapy and radiotherapy due to the adverse effects associated with the current treatments. Peptides are small units of proteins that do not induce an immune response.
Purpose
Thus, these biomaterials can be used to t...
The design of smart photoelectrodes capable of stimulating the localized production of reactive oxygen species (ROS) on demand is of great interest for redox medicine therapies. In this work, poly(3-hexylthiophene)...
Bacteria adapt to changes in their natural environment through a network of stress responses that enable themto alter their gene expression to survive in the presence of stressors, including antibiotics. These stress responsescan be specific to the type of stress and the general stress response can be induced in parallel as a backup mech-anism. In...
Mercuric chloride is a well-known environmental toxicant that induces genotoxic stress in human cells, leading to DNA damage and chromosomal aberrations. This study aimed to elucidate the dose-dependent effects of ascorbic acid on mitigating genotoxic damage in human blood cells exposed to mercuric chloride. Isolated human peripheral blood cells we...
Streptococcus suis is an important zoonotic pathogen that threatens human and pig health. During infection, the host can impose oxidative stress to resist pathogen invasion. Resistance to oxidative toxicity is an important factor for pathogens. Glutathione synthesis contributes to reactive oxygen species (ROS) detoxification in bacterial cells. Lit...
Antimicrobial photodynamic therapy (aPDT) utilizing light, oxygen, a photosensitizer and nitroreductase to enact cell death via the production of reactive oxygen species (ROS).
Nanozyme‐based immunogenic cell death (ICD) inducers that effectively induce a strong immune response via enzyme‐like process have attracted great attention, but how to ensure controllable active sites and maximize site utilization remains a problem. Here, we report a structurally well‐defined and highly functional single‐site copper(I) nanomodulat...
Glioma is the most aggressive form of brain cancer. Photodynamic therapy (PDT) has emerged as a promising treatment method for glioma; however, its efficacy is often hindered by the blood–brain barrier (BBB) and the need for precise tumor cell targeting. In the present study, a facile strategy is found to enhance the penetration of the BBB and the...
Acute kidney injury (AKI) is a common side effect of acetaminophen (APAP) overdose. Dihydromyricetin (DHM) is the most abundant flavonoid in rattan tea, which has a wide range of pharmacological effects. In the current study, APAP-induced AKI models were established both in vivo and in vitro. The results showed that DHM pretreatment remarkably alle...
Gastrointestinal cancers including esophageal squamous cell carcinoma (ESCC), gastric cancer (GC), and colorectal cancer (CRC) are common and highly lethal types of cancer worldwide. Metabolic reprogramming plays a critical role in cancer progression and involves metabolic processes such as glucose and lipid metabolism. Fatty acid oxidation (FAO) h...
Robots are essential for carrying out tasks, for example, in a nuclear industry, where direct human involvement is limited. However, present-day nuclear robots are not versatile due to limited autonomy and higher costs. This research presents a merely teleoperated DexterTM nuclear robot’s transformation into an autonomous manipulator for nuclear so...
Marine macroalgae (commonly known as seaweeds), a rich yet underexplored resource, have emerged as a promising source of bioactive compounds with potent antioxidant properties. While oxidative stress is a critical factor in the pathogenesis of numerous chronic diseases, including neurodegenerative disorders, cardiovascular conditions, and cancer, m...
More than ten ergot alkaloids comprising both natural and semi-synthetic products are used to treat various diseases1,2. The central C ring forms the core pharmacophore for ergot alkaloids, giving them structural similarity to neurotransmitters, thus enabling their modulation of neurotransmitter receptors³. The haem catalase chanoclavine synthase (...
Tissue necrosis is a devastating complication for many human diseases and injuries. Unfortunately, our understanding of necrosis and how it impacts surrounding healthy tissue – an essential consideration when developing effective methods to treat such injuries – has been limited by a lack of robust genetically tractable models. Our lab previously e...
This work demonstrates the antiferroptotic and cytotoxic effects of 2-aminomethyl phenothiazine (PTZ-NH2), and its alkyl derivative (PTZ-capryl) and mitochondria-targeted triphenylphosphonium conjugate (PTZ-TPP) on BT-474 cells, as well as their effects on isolated rat liver mitochondria. It was found that all studied compounds at 0.5 and 1 μM conc...
Head and neck cancer (HNC) is a genetically complex cancer type having treatment difficulties due to affecting multiple organs in complex anatomical sites. Radiotherapy resistance, chemotoxicity, post-surgery disability makes HNC treatment more complicated. Therefore, there is need to developed new treatment approaches. Nanoparticle-based therapies...
Introduction
Triple-negative breast cancer (TNBC) is known for its high malignancy, limited clinical treatment options, and poor chemotherapy outcomes. Although some advancements have been made using nanotechnology-based chemotherapy for TNBC treatment, the controlled and on-demand release of chemotherapeutic drugs at the tumor site remains a chall...
The impact of empagliflozin on OGD/R-induced ferroptosis in neurons is still unclear. This study aims to explore whether ferroptosis is associated with OGD/R-induced neuronal injury and the effect of empagliflozin on the ferroptosis effect of OGD/R-treated neurons. Western blotting, immunofluorescence, and RT-qPCR were used to detect the protein an...
Traumatic brain injury (TBI) disrupts oxygen homeostasis in the brain, leading to excessive reactive oxygen species (ROS) production and dysregulated antioxidant mechanisms, which fail to clear excess ROS. This ROS overload promotes the expression of pro-inflammatory genes, releasing cytokines and chemokines and creating a vicious “ROS-neuroinflamm...
Oxidative stress-induced photoreceptor cell death is closely associated with the etiology of age-related macular degeneration (AMD), and sodium iodate (SI) has been widely used as an oxidant stimulus in AMD models to induce retinal pigment epithelium (RPE) and photoreceptor cell death. However, the mechanism underlying SI-induced photoreceptor cell...
The COVID-19 pandemic had an unprecedented impact on all aspects of human activity worldwide, frequently resulting in post-acute sequelae and affecting multiple organ systems. The underlying mechanisms driving both acute and post-acute manifestations of COVID-19 are still poorly understood, warranting further investigation for new targets. The stud...
Residential stoves, commonly used for heating, are a significant source of emissions due to the harmful substances produced during biomass combustion, yet they remain largely unregulated. The use of catalytic systems presents a promising approach for mitigating these emissions. This study investigates the potential of Cu–Mg–Mn–Al and Co–Mg–Mn–Al mi...
Orthodontically induced inflammatory root resorption (OIIRR) poses a significant clinical challenge, as excessive orthodontic force shortens tooth longevity by impairing cementoblast‐mediated cementum mineralization and promoting root resorption. Cementoblasts, essential for mineralized cementum formation and resistance to resorption, exhibit alter...
CDC42 regulates neural morphology, differentiation, and injury and modifies oxidative stress and neural immune infiltration, but its effect on oxygen–glucose deprivation/reoxygenation (OGD/R)-induced neural injury has not been reported. Therefore, this study aimed to investigate the effects of CDC42 overexpression on neural injury and oxidative str...
Rain-on-snow (ROS) events are characterized by liquid precipitation or condensation onto snow surfaces that can lead to snowmelt and the formation of ice layers. ROS events can directly alter the physical structure and thermal properties of the snowpack, leading to rapid melting and runoff-induced flooding, reduced snow insulation, and permafrost d...
Nanotechnology offers innovative solutions for addressing the challenges posed by biofilm-forming bacteria, which are highly resistant to conventional antimicrobial therapies. This review explores the integration of pharmaceutical nanotechnology with antimicrobial peptides (AMPs) to enhance the treatment of biofilm-related infections. The use of va...
