Science topic

Pulmonology - Science topic

A group dedicated to lung related issues
Filters
All publications are displayed by default. Use this filter to view only publications with full-texts.
Publications related to Pulmonology (9,745)
Sorted by most recent
Article
Full-text available
Chronic obstructive pulmonary disease (COPD) is a debilitating medical condition often accompanied by multiple chronic conditions. COPD is more frequent among older adults and affects both genders. The aim of the current cross-sectional survey was to characterize chronic comorbidities stratified by gender and age among patients with COPD under the...
Article
Full-text available
Background and Objectives: Chronic thromboembolic pulmonary hypertension (CTEPH) has a high mortality. The treatment of CTEPH could be balloon pulmonary angioplasty (BPA), medical (MT) or pulmonary endarterectomy (PEA). This study aims to assess the clinical characteristics of CTEPH patients, surgically or medically treated, in a pulmonology referr...
Article
Full-text available
Introduction: Chronic obstructive pulmonary disease (COPD) is a disease of respiratory airflow obstruction. There are >80 tools to measure various aspects of COPD patients’ well‑being. This study aimed to evaluate the reliability and consistency of CAT and clinical COPD questionnaire (CCQ) and their correlation with St. George respiratory questionn...
Article
Full-text available
Introduction Obstructive sleep apnea syndrome (OSAS) and asthma are two diseases with a high epidemiological impact that may often coexist. Both diseases have underlying pathogenic mechanisms (chronic inflammation, genetic predisposition, etc.); it is still unclear whether or not their coexistence is due to a specific pathophysiological factor. In...
Article
Full-text available
Background There is significant variability in the performance and outcomes of invasive medical procedures such as percutaneous coronary intervention, endoscopy, and bronchoscopy. Peer evaluation is a common mechanism for assessment of clinician performance and care quality, and may be ideally suited for the evaluation of medical procedures. We the...
Article
Full-text available
Background Airspace disease as seen on chest X-rays is an important point in triage for patients initially presenting to the emergency department with suspected COVID-19 infection. The purpose of this study is to evaluate a previously trained interpretable deep learning algorithm for the diagnosis and prognosis of COVID-19 pneumonia from chest X-ra...
Article
Full-text available
Background The prognostic value of mixed venous oxygen tension (PvO2) at pulmonary hypertension diagnosis treated with selective pulmonary vasodilators remains unclear. This study sought to investigate the association of PvO2 with long-term prognosis in pulmonary arterial hypertension (PAH) and medically treated chronic thromboembolic pulmonary hyp...
Article
Full-text available
The COVID-19 pandemic offers a unique context and opportunity to investigate changes in healthcare professional perceptions towards the adoption of novel medical technologies, such as point-of-care technologies (POCTs). POCTs are a nascent technology that has experienced rapid growth as a result of COVID-19 due to their ability to increase healthca...
Article
Full-text available
Aim. To study the dynamics and pattern of publications in Russian on post-COVID-19 syndrome (PCS) in order to assess the completeness of information and identify medical specialties with its most active investigation in Russia. Material and methods . The search for publications was carried out in the database of the largest digital scientific libra...
Article
Full-text available
Acute bronchiolitis is a common disease of infants affecting the small airways. Rarely, acute bronchiolitis may occur in adolescents and adults. Here, we present four unrelated adolescent patients with severe clinical presentation and unique CT imaging with extensive tree-in-bud pattern, representing a rare clinical phenotype of acute diffuse panbr...
Article
Full-text available
Background Patients still receive non-beneficial treatments when nearing the end of life. Advance care planning (ACP) interventions have shown to positively influence compliance with end of life wishes. Hospital physicians seem to miss opportunities to engage in ACP, whereas patients visiting the outpatient clinic usually have one or more chronic c...
Article
Full-text available
Objective: To determine the frequency of pulmonary hypertension among patients with idiopathic pulmonary fibrosis using echocardiography, presenting to the Pulmonology Department of a tertiary care hospital. Methodology: This cross-sectional study was conducted on a sample size of 130 patients (aged 50-80 years) with idiopathic pulmonary fibrosis p...
Article
Full-text available
Artificial intelligence processes are increasingly being used in emergency medicine, notably for supporting clinical decisions and potentially improving healthcare services. This study investigated demographics, coagulation tests, and biochemical markers routinely used for patients seen in the Emergency Department (ED) concerning hospitalization. T...
Article
Full-text available
Background. Coagulation disorders, endothelial dysfunction, immobility and dehydration contribute to deep vein thrombosis (DVT) and pulmonary embolism (PE) in COViD-19 patients. While the prevalence of PE accompanying COViD-19 is high, the number of studies on its long-term effects is limited in literature. Objectives. We expanded this process and...
Article
Full-text available
Objective: To determine the accurate ability to diagnose the pleural fluid GeneXpert MTB/RIF assessment in the suspected pleural tuberculosis patients considered as gold standard the pleural biopsy. Materials & Methods: This study was a validation cross-sectional survey and it was conducted in the pulmonology department of Pakistan Institute of Med...
Article
Full-text available
Thick, viscous respiratory secretions are a major pathogenic feature of COVID-19, but the composition and physical properties of these secretions are poorly understood. We characterized the composition and rheological properties (i.e., resistance to flow) of respiratory secretions collected from intubated COVID-19 patients. We found the percentages...
Article
Full-text available
Propofol-based sedation provides faster recovery than midazolam-based regimens with similar safety and comfort during video flexible bronchoscope (VFB) procedures. Pulmonologist-administered propofol “balanced” analgosedation (PAP-BAS) is still debated in Italy. In this real-life study, PAP-BAS safety and comfort during VFB procedures were investig...
Article
Full-text available
Según la encuesta nacional de salud de España del año 2017, el 22,1% de los habitantes entre 15-64 años se consideran fumadores diarios, correspondiendo un 25,6% a hombres y un 18,8% a mujeres, y siendo exfumadores un 32,2% de los hombres y un 18,02% de las mujeres. Aunque es bien conocido que el tabaquismo es un factor de riesgo para el desarrollo...
Article
Full-text available
Bronchopulmonary dysplasia (BPD) is one of the most common health complications of premature birth. Corticosteroids are commonly used for treatment of BPD, but their use is challenging due to variability in treatment response. Previous pharmacometabolomics study has established patterns of metabolite levels with response to dexamethasone. We obtain...
Article
Full-text available
Journal archives are invaluable resources to the scientific community. The Journal of Bangladesh College of Physicians and Surgeons (JBCPS) is one of the leading biomedical journals in Bangladesh. The objectives of the present review were to have an overview to the all published articles in the JBCPS and to identify remarkable articles for republic...
Article
Full-text available
BACKGROUND Pneumoscrotum is a rare clinical occurrence in which air accumulates in the scrotum. The origin of air is primarily from trauma, but spontaneous pneumoscrotum can develop from gastrointestinal or pulmonary sources. Physical examination of pneumoscrotum typically includes crepitus of the perineal region and scrotal swelling and associated...
Article
Full-text available
The present study sought to determine how changes during the coronavirus disease 2019 (COVID-19) pandemic affected asthma metrics in a majority African American pediatric population at a pediatric pulmonology clinic in a community hospital in New York. Methods This is a retrospective, pre-post, comparative cross-sectional study that included chil...
Article
Full-text available
Objective To outline a consensus designed process for triaging and managing patients with Post COVID syndrome at the Mayo Clinic. Patients and Methods We convened a central multidisciplinary team including members from General Internal Medicine, Occupational Medicine, Physical Medicine & Rehabilitation, Psychology, Allergy and Immunology, Infectio...
Article
Full-text available
The COVID-19 pandemic crisis, among so many social, economic and health problems, also brought new opportunities. The potential of telemedicine to improve health outcomes had already been recognised in the last decades, but the pandemic crisis has accelerated the digital revolution. In 2020, a rapid increase in the use of remote consultations occur...
Article
Full-text available
Purpose of Review This narrative review will focus on the role of the rheumatologist in evaluating patients with interstitial lung disease (ILD) without a defined rheumatic disease and will outline the current classification criteria for interstitial pneumonia with autoimmune features (IPAF) and describe what is known regarding IPAF pathobiology, n...
Article
Full-text available
Background: Post-COVID syndrome (PCS) is a complex, multisystem illness that may follow SARS-CoV-2/COVID-19 infection. As there is limited evidence for individual therapies and no singular treatment for PCS, guidelines endorse a multidisciplinary approach. This is a case report of a patient with PCS benefiting from a comprehensive approach includin...
Article
Full-text available
Chronic type 2 (T2) inflammatory diseases of the respiratory tract are characterized by mucus overproduction and disordered mucociliary function, which are largely attributed to the effects of IL-13 on common epithelial cell types (mucus secretory and ciliated cells). The role of rare cells in airway T2 inflammation is less clear, though tuft cells...
Article
Full-text available
Introduction: The chronic obstructive pulmonary disease assessment test (CAT) is a self-administered questionnaire that measures health-related quality of life. GOLD proposes using this questionnaire, since it provides thorough coverage of the impact of chronic obstructive pulmonary disease (COPD) on well-being. This questionnaire has been widely...
Article
Full-text available
Abstract Background Among patients hospitalized for severe pneumonia due to coronavirus disease (COVID-19), clinical stability and normal resting peripheral oxygen saturation (SpO2 ) levels are widely used as a discharge criterion after recovery. It is unknown whether a test to assess the functional exercise capacity, like a six-minute walk test (6...
Article
Full-text available
Nontuberculous mycobacteria (NTM) are an increasingly common cause of respiratory infection in people with cystic fibrosis (PwCF). Relative to those with no history of NTM infection (CF-NTMNEG), PwCF and a history of NTM infection (CF-NTMPOS) are more likely to develop severe lung disease and experience complications over the course of treatment. I...
Article
Full-text available
Studies have demonstrated the phenotypic heterogeneity of vascular endothelial cells (ECs) within a vascular bed; however, little is known about how distinct endothelial subpopulations in a particular organ respond to an inflammatory stimulus. We performed single cell RNA-sequencing of 35,973 lung ECs obtained during the baseline state as well as p...
Article
Full-text available
Background: Pulmonary physicians often face the dilemma of treating slow resolution pneumonia in-spite of using empirical antibiotics. Slow resolution pneumonia can be due to resistant strains, unusual and highly virulent organisms, inadequate antibiotic therapy, impaired host defenses, and co-morbidities. Objective: This study was conducted to ide...
Article
Full-text available
Constant exposure of the airways to inhaled pathogens requires efficient early immune responses protecting against infections. How bacteria on the epithelial surface are detected and first-line protective mechanisms are initiated are not well understood. We have recently shown that tracheal brush cells (BC) express functional taste receptors. Here...
Article
Full-text available
Background: A World Health organization estimated show that almost 10 million people effect from TB and almost 1.5 million people died from this disease in 2018. Pakistan is ranked 5 th in overall TB burden and ranked 4 th in drug resistance development of developing countries. About 510,000 case of TB arise every year in Pakistan and 15000 patient...
Article
Full-text available
Background Nutritional risk is associated with adverse clinical outcomes and is more prevalent among pulmonology patients than among patients in other departments. High-altitude environments can affect patients with chronic respiratory diseases, but evidence of the prevalence of nutritional risk among hospitalized patients with respiratory diseases...
Article
Full-text available
Aim: To assess the respiratory outcomes twelve weeks after the management with non-invasive positive pressure ventilation (NIPPV) in patients recovered from severe corona virus disease 2019 (COVID-19). Methodology: The cross-sectional analytical study was conducted in the Department of Pulmonology, Sir Ganga Ram Hospital Lahore between October 2020...
Article
Full-text available
Purpose: The objective of this study was to investigate the feasibility and pretest the effectiveness of an educational and telemonitoring program in a sample of Lebanese COPD patients to inform the design of a randomized study. Patients and methods: This study recruited a convenient sample of 15 patients from the pulmonology departments of four...
Article
Full-text available
The COVID-19 pandemic has revealed the high usefulness of telemedicine. To date, no uniform recommendations or diagnostic protocols for long-COVID patients have been developed. This article presents the preliminary results of the examination of patients after SARS-CoV-2 infection who were provided with medical telemonitoring devices in order to ove...
Article
Full-text available
Background Interstitial lung diseases (ILDs) include a variety of parenchymal lung diseases. The most common types of ILDs are idiopathic pulmonary fibrosis (IPF), autoimmune ILDs and hypersensitivity pneumonitis (HP). There is limited real world data on care patterns of patients with chronic fibrosing ILDs with a progressive phenotype other than I...
Article
Full-text available
Highly effective modulator therapies dramatically improve the prognosis for those with cystic fibrosis (CF). The triple combination of elexacaftor, tezacaftor, and ivacaftor (ETI) benefits many, but not all, of those with the most common F508del mutation in the CF transmembrane conductance regulator (CFTR). Here, we showed that poor sweat chloride...
Article
Full-text available
Introduction: The aim of this study was to survey the attitudes of internists, cardiologists, and pulmonologists regarding treatment or no treatment of isolated subsegmental pulmonary embolism (ISSPE) with anticoagulant drugs. Methods: Qualified physicians were asked to select their management options from a questionnaire that included a patient...
Article
Full-text available
The role of transbronchial lung biopsies (TBB) in the diagnostic workup of systemic inflammatory rheumatic disease-associated interstitial lung disease (SIRD-ILD) is unclear and TBB is not generally recommended. The study objective was to examine the utility of TBB to guide treatment in a population of patients with SIRD-ILD. All patients from the...
Article
Full-text available
Type 2 alveolar epithelial cells (AEC2s) function as progenitor cells in the lung. We have shown previously that failure of AEC2 regeneration results in progressive lung fibrosis in mice and is a cardinal feature of idiopathic pulmonary fibrosis (IPF). In this study, we identified a deficiency of a specific zinc transporter SLC39A8 (ZIP8) in AEC2s...
Article
Full-text available
Annual vaccination is fundamental for individual and group protection against seasonal influenza infection. International and Portuguese healthcare organizations have established influenza vaccination coverage rate (VCR) targets for risk groups, namely 75% in people ≥ 65 years old. The Vacinómetro® initiative has been monitoring influenza VCR among...
Article
Full-text available
Rationale and Objectives The burden of coronavirus disease 2019 (COVID-19) airspace opacities is time consuming and challenging to quantify on computed tomography. The purpose of this study was to evaluate the ability of a deep convolutional neural network (dCNN) to predict inpatient outcomes associated with COVID-19 pneumonia. Materials and Metho...
Article
Full-text available
The lung airways are constantly exposed to inhaled toxic substances, resulting in cellular damage that is repaired by local expansion of resident bronchiolar epithelial club cells. Disturbed bronchiolar epithelial damage repair lays at the core of many prevalent lung diseases including chronic obstructive pulmonary disease (COPD), asthma, pulmonary...
Article
Full-text available
Background: Impact factor (IF) is a quantitative tool designed to evaluate scientific journals’ excellence. There was an unprecedented upsurge in biomedical journals’ IF in 2020, perhaps contributed by the increased number of publications since the COVID-19 outbreak. We conducted a cross-sectional study (2018–2020) to analyze recent trends in stand...
Article
Full-text available
Introduction: Bronchoscopic lung biopsy (BLB) is a widely used procedure. As the world's population is ageing, more BLBs are performed for older people with comorbidities. The aim of the study was to investigate if an older age is a risk factor for BLB related complications. Materials and methods: A prospective study at the Centre of Pulmonology...
Article
Full-text available
Neurofibromatosis type 1 is a genetic disease that leads to a specific collection of symptoms. Most patients over time develop cutaneous manifestations, which include neurofibromas, freckling, or even cafe-au-lait spots. In general, patients with NF1 have a shorter life expectancy than non-affected individuals. This report aims to present our patie...
Article
Full-text available
Background: Myofunctional therapy has been shown to be effective in treating sleep-disordered breathing. The elaboration of this protocol arises with the purpose of establishing a complete and common evaluation of sleep respiratory disorders from the point of view of the anatomy and functionality of the upper airway to guarantee the long-term treat...
Article
Full-text available
Background: The value of the soluble receptor for advanced glycation end-products (sRAGE) as a biomarker in COVID-19 is not well understood. We tested the association between plasma sRAGE and illness severity, viral burden, and clinical outcomes in non-mechanically ventilated hospitalized COVID-19 patients. Methods: Baseline sRAGE was measured a...
Article
Full-text available
Herpes zoster (HZ) is common in older adults with conditions such as chronic obstructive pulmonary disease (COPD). Effective prevention is available through vaccination, but HZ vaccine uptake remains incomplete. Using an online survey of people with self-reported COPD, ShiPPS assessed HZ risk awareness, HZ vaccine use and barriers, and the impact o...
Article
Full-text available
Introduction: Point-of-care ultrasound (POCUS), although commonly used in clinical practice, is not currently included in training programs for respiratory therapists (RTs). In fact, given its ubiquity and clinical utility, RTs in Ontario, Canada, are changing their mandate to incorporate POCUS into their daily patient assessment. Therefore, we co...
Preprint
Full-text available
Background: Post-COVID syndrome (PCS) is a complex, multisystem illness that may follow SARS-CoV-2/COVID-19 infection. As there is limited evidence for individual therapies and no singular treatment for PCS, guidelines endorse a multidisciplinary approach. This case describes a post-COVID patient benefiting from acupuncture within a comprehensive a...
Conference Paper
Full-text available
Hintergrund: Angebote im Rahmen der medizinisch-beruflich orientierten Rehabilitation (MBOR) sind inzwischen in vielen Kliniken Standard. Die Rahmenbedingungen hierfür sind im MBOR-Anforderungsprofil definiert. Während die Umsetzung der Anforderungen regelmäßig durch Visitationen überprüft wird, liegen wenig Informationen darüber vor, wie diese MBO...
Article
Full-text available
Objectives: Systemic sclerosis (SSc) is a dreadful autoimmune disease characterized by severe lung outcomes reducing life expectancy. Fra2TG mice offer the opportunity to decipher the relationships between the immune system and lung fibrosis. We herein investigated whether Fra2TG mice lung phenotype could result from an imbalance between the effec...
Article
Full-text available
Background Decreased physical activity significantly increases the probability of prevalent metabolic syndrome (MetS) with substantial impact on the expected course of COPD. Objective Our research aims to assess the metabolic consequences of chronic obstructive pulmonary disease (COPD) and evaluate the prevalence of MetS and its interrelations wit...
Article
Full-text available
The respiratory tract surface is protected from inhaled pathogens by a secreted layer of mucus rich in mucin glycoproteins. Abnormal mucus accumulation is a cardinal feature of chronic respiratory diseases but the relationship between mucus and pathogens during exacerbations is poorly understood. We identified elevations in airway MUC5AC and MUC5B...
Article
Full-text available
Background: COPA syndrome is a rare autoimmune disease, demonstrating an autosomal dominant inheritance pattern with variable penetration that occurs more frequently in females than males. This disease manifests in childhood as pulmonary hemorrhage, arthritis, and renal disease. Case: We present a case of obstetric management of a 20-year-old nu...