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Psychiatry - Science topic

Psychiatry are which mind is that?
Questions related to Psychiatry
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Initially, the individual appeared to be intellectually gifted and possibly on the autism spectrum. It has become evident that she whispers for an unknown reason, while others are around, without apparent realization that she is doing it. Occasionally, she will hold her hand in front of her mouth while whispering. It may be a sentence or a 30 second speech. One time, she spoke normally to a companion, then whispered, then spoke normally again. It happens more often when she is tired. Are you familiar with this phenomena? Are there any thoughts other than schizophrenia? Thank you.
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Hai. I observed this with a normal person when he is in difficulty and trying to solve a problem, he whispers to himself like talking to his inner-self in a "loud" for an answer.
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I have been researching this for many years and studied psychotherapy in both London University and Middlesex. I have many papers on here and elsewhere, which examine the subject, I believe, thoroughly.
My conclusion:
A discipline of opinion with a concentration on 'identity'. The drugs, which became a speciality of mine, I consider extremely dangerous; dangers that are ignored by the profession.
Psychiatry gets immense credibility from its connection to medicine (of course), an extremely and excessively powerful institution, but also to the drug companies.
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Abeyemi,
If you can get your energy together sufficiently to read on, most of the psychotropic drugs over the past 40 years are now on dangerous drugs list or warnings that they can cause depression and anxiety. Do your research!
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Pasricha, Satwant K. “Relevance of para-psychology in psychiatric practice.” Indian journal of psychiatry vol. 53,1 (2011): 4-8. doi:10.4103/0019-5545.75544
In my own words, possibly reading minds, possible afterlife and probability.
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Parapsychology encompasses several specific areas, including:
  1. Extrasensory Perception (ESP): Study of phenomena like telepathy, clairvoyance, and precognition.
  2. Psychokinesis (PK): Investigation of the ability to influence physical objects or events with the mind.
  3. Survival Research: Exploration of consciousness after death, including near-death experiences and reincarnation.
  4. Mediumship: Study of communication with spirits or the deceased through mediums.
  5. Ghosts and Hauntings: Investigation of paranormal activity and experiences related to ghosts.
  6. Anomalous Cognition: Research into phenomena that challenge conventional understandings of perception and cognition.
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It’s real to notice that with important use of social médias with huge number of people connected to internet since this last decade, it has been noticed an increase in the number of citizens having thier mentale health state deteriorated due to what they follow on social media on dailly basis.
And this linked to the fact that, those eho turn to become media influencers for the majorité do not spread real life and real facts. They profit of the virtual aspect to pretend irrealistitic affirmations, thus inducing the most fragile to
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How probably is autism an evolutionary adaptation to computerized environment requiring less of certain skills but, more of others?
Very high is the probability that autism is an evolutionary adaptation to a computerized environment requiring different skills. Especially because, at least in children, autism correlates with testosterone. Plus, certain autistics outperform the general population with computers. Lastly, autism correlates with lacking skills less computerised, such as tennis and socialization.
Work Cited
Moller , Ralph. “Autism and Testosterone: Everything You Should Know.” Above & Beyond ABA Therapy, 18 Sept. 2023, www.abtaba.com/blog/autism-and-testosterone. "There is evidence to suggest that there may be a link between autism and testosterone. Research has shown that children with autism tend to have higher levels of testosterone in their bodies than children without autism."
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For Screen Autism, maybe this may align, but generally one has to carefully consider the pros and cons of technology in autistic children.
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Following the publication of our article in Lancet Psychiatry, with the collective support of amazing minds, we're planning to establish a Task Force dedicated to creating a standardized protocol for eMHPSS (electronic Mental Health and Psychosocial Support Services).
We're calling out to NGOs, foundations, agencies, academic institutions, and individual experts interested in contributing to this vital initiative.
If you're keen to get involved and get recognized. Please express your interest by sending a message or email to darya.rostam@koyauniversity.org
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Great work.
Interested to collaborate with you.
Regards,
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Since in Psychiatry , treatment is done through counselling and medicines are prescribed according to it, my question is what would be the most appropriate study design in the subject of psychiatry.
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The nature of the study design (cross-sectional or clinical trial) depends on the research question being asked and the methodology used to investigate it, rather than on the practice of counseling itself.
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I am leaning towards a different construction of personality than that in psychology and psychiatry, believing both are top down and dependent on artificial notions. I have recently read East of Eden by Steinbeck and Sanctuary by William Faulkner and the description of psychopathology in both, a description not evident before although itemised. It goes without saying that this is complex but there is far more proof for this idea than genuine evidence for psychiatry.
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Yes. Culture does construct personality, with respect to autopoIlses (interaction between environment, biological system and self-control).
_______
Until you make the unconscious conscious, it will direct your life and you will call it fate.
C.G. Jung
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I struggle with neurology as producing genuine insights into human mental health, apart from those areas of possible degradation. Senility, affects on memory, brain damage, or areas where thinking-feelings affect interaction.
While the brain cannot be isolated but can be seen only in relation to the external world the investigation into the brain outside of these factors cannot possibly be justified.
Justifications are sought.
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Classical Science as a whole is a creation of what we belief. This means that Classical Science, as a whole, shows how we function. That is how Classical Science is an inverted image of our own being; in part.
It means that everything you do and experience adds to our understanding of Life.All disagreements with others exemplifies the interest of personal perspective.Differences in experience add to the variety in collective knowledge. Healing is the restoration of integrity of integration of information, in a living being.We can apply the same approach to revive’ our understanding of “science”, a ’rebirth’.It is a fundamental change in ‘axiomatic’ scientific understanding, a “Paradigm Shift”. It is about the inclusion of freedom of choice, involvement, in science.
Modern Medicine is based on Classical Science. Classical Medicine needs more than just the new classical relativistic quantum field models of science. Science regarded the scientist as a (classical) outsider with a (relativistic) event horizon, separated by a (quantum) leap from true involvement. Health Care addresses the experience of Life. Life differs fundamentally from ‘dead matter’.
Possible gateways Stanley Wilkin for better medicine and health care:
  • Update Classical Medicine from classical science through relativity and probability theory to the now emerging field theory of science.
  • Integrate the time-tested methods of healing from all cultures in New Science; combining experience with life involvement with insight into matter.
  • Bringing Science to Life (Integrating Traditional Health Care with New Science)
  • Healing Health Care (Integrating the result with Classical Medicine).
  • Traditional Health Care can help science understand the role of involvement.
  • Modern physics (New Science) can help Traditional Health Care explain how we can restore the integration of information and matter in our living being.
__________
The physician should not treat the disease but the patient who is suffering from it. Moses Maimonides
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  1. I have purchased a commercial grade EEG machine, for a reasonable price, in order to perform a study for my project. How familiar are you with less sophisticated EEG equipment? To what extent would using a simple EEG headband affect the credibility of the data collected, given it only having four electrodes, placed on the forehead?
  2. What is the generalised process of interpreting EEG data? I understand how to employ certain mathematical concepts for interpretation (such as time frequency distributions (TFD), fast Fourier transforms (FFD), eigenvector methods (EM), and wavelet transforms (WT)), but when applying these strategies, how can I link the findings to neurology?
  3. What available resources are there that I could use? Such as medical journals or otherwise, to cite in my research, relevant to the field of neurology, psychiatry, autism, and meditation?
  4. What is your understanding of the influence meditation has on certain neurological structures?
  5. What is your understanding of the neurological variance between autistic and neurotypical individuals?
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They are very compassionate, once who are afflicted. Ive read the DSM. And observed some. You may hear Pico Iyer, an Indian ethnic who was asked on this available on Youtube. These are the main offmainstream ideas I can contribute. Thanks.
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I am wondering which term is more appropriate for use in titles when discussing a group within a larger category: 'among' or 'in'?
For example:
'Prevalence of sleep disorders among children with autism'
'Prevalence of sleep disorders in children with autism'
Could you explain the difference between using 'among' and 'in' in such contexts and advise which option is more suitable for title usage?
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Both "among" and "in" can be appropriate in titles when discussing a group within a larger category, but the choice depends on the specific context and emphasis of the title. Here's a brief overview of the optimal usage for each term:
Among:
Use "among" when you want to emphasize the idea of being part of a larger group or set, but not necessarily confined to it. This term suggests that the group you're referring to is integrated or exists within a broader context.
Example title: "Patterns of Communication Among Adolescents in Urban Schools"
In:
Use "in" when you want to emphasize the idea of being contained or located within a specific category or context. This term suggests a more specific or bounded relationship between the group and the larger category.
Example title: "Factors Affecting Academic Achievement in Students with Disabilities"
In summary, consider the nuances of meaning and emphasis you want to convey in your title when choosing between "among" and "in." If you want to highlight the group's integration within a larger context, use "among." If you want to emphasize their specific location or relationship within a category, use "in."
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Dear Researchers,
Anatolian Journal of Mental Health (AMH) is an academic/scientific journal which has started publication in 2024. The journal aims to be settled in high-level international indexes in a short time with its expert editorial team.
The journal accepts articles related to mental health subjects from in Medicine, Nursing, Midwifery, Social Work, Psychology, Sociology, Physiotherapy and Rehabilitation, Ergotherapy, Nutrition and Dietetics, Emergency Aid and Disaster Management, Child Development, Language and Speech Therapy, Health Management, Educational Sciences etc.
Subjects;
Diagnosis of mental illnesses/problems,
Treatment of mental illnesses/problems,
Care of mental illnesses/problems,
Rehabilitation of mental illnesses/problems,
Protection from mental illnesses/problems,
Improving mental health and
Maintenance of mental health
In this context, we kindly request you to be a part of our process and to contribute with an article for publication in our upcoming issue for the Anatolian Journal of Mental Health (AMH).
Research Article/ Review/Case Reports/Mini Review/Book Review/Commentary Articles etc., are welcome for possible publication in first issue in July 2024.
You can kindly submit your articles through our online submission system. There is NO PUBLICATION FEES or APC.
Thank you for your time and consideration in this matter.
We look forward to receiving your submission.
Don't hesitate to get in touch.
Best Regards.
Anatolian Journal of Mental Health
Editor-in-Chief
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Wishing you Veysel Kaplan success !
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هل يوجد فرق بين الأخصائي النفسي العيادي والطبيب النفسي؟
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Psychiatrists are medical doctors who are specialized in mental and behavioral disorders and they treat the patients with medications and behavioral therapy. On the other hand most of the psychologist are not medical doctors and they treat the patients with behavioral therapy counselling etc
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Dear researchers,
I trust this message finds you well. I am currently engaged in research exploring the applications of deep learning algorithms in neurodevelopmental disorders. In order to enrich my understanding and address queries that may arise, I am seeking occasional guidance from a #psychologist or #psychiatrist.
Would any of you be able to assist me in connecting with someone in this field who could offer insights or answer questions?
Your assistance in this matter would be invaluable to me. Thank you for considering my request.
Warm regards,
Sohrab
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Could you be more specific in your question? Perhaps with an example or two of the kinds of research questions you seek to investigate.
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Are psychology & psychiatry locally & socially scientific but worldwide being unscientific ?
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Psychiatry can be questioned, with respect to the scientific method and also political implications, like mental policing and drug prescription.
Psychology has a solid scientific foundation, since Wilhelm Wundt and his Leipzig laboratory.
Medicine needs psychology, because many pathologies of humans cannot be attacked by one-dimensional physical treatments, i.e. healing requires deeper approaches, which include behavioral approaches.
________
In this sense, science grows by combination with auxiliary science:
Math by logic (e.g. Gödel, Jv Neumann).
Engineering by technology (e..g. AI tools, but also problem-solving).
Economics by sociology (e.g. political economy, statistics).
Medicine by psychology (e.g. physiology of behavior).
___________
The sciences do not try to explain, they hardly even try to interpret, they mainly make models. By a model is meant a mathematical construct which, with the addition of certain verbal interpretations, describes observed phenomena.
Jv Neumann
_______
Conclusion:
Personally Sinan Ibaguner I do consider psychiatry not as a science,
but as a sort of mental police.
As example (but no more limited to a political entity):
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Franz Fanon died in 1961 aged 36. A philosopher and psychiatrist he was one of the first, and still most important, black thinkers in the western world. He helped establish militancy as a means of extracting African states from colonialism. He advocated violence and may thereby be held responsible for terrorism. Race for him was 'not fixed but a means of an unequal ordering of people in a demeaning way.' Nevertheless, he was interested in Western slavery and racism and not that of other cultures, such as Islam, thereby for me missing the complete picture and creating cognitive bias, even dissonance. His call for decolonisation otherwise has been influential and remains so but again is fixated on certain kinds of colonialism.
His thinking created the splitting off of sexual difference as a process of discrimination creating the extreme sexual identification of today.
As a psychiatrist he pointed to civil and social trauma, something I agree with, rather than the internal manifestation of traditional psychiatry, the area of 'white, privileged, middle class boys and girls in suits.' (My phrasing) That trauma for me is being treated by the very group causing it.
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Good to get two such informed answers so quickly.
Nevertheless, the limited perception of colonialism needs to be addressed. Can I ask, Brajesh, freedom fighters where and for what, especially giving African countries acceptance of Russian dominance? Many African countries were not fought over but given their independence within a time scheme. But colonialism is not just about control by another country but cultural impress that makes irrelevant a native culture, for example. For many African societies nakedness carried symbolic importance but was suppressed by monotheism.
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Affective computing has the following main objectives: (i) to recognize human behaviors and emotions; and (ii) consider emotional aspects in the design of computer systems.
Several solutions using Machine Learning have been developed to recognize feelings and emotions and to predict mood disorders and mental problems, such as depression, anxiety, schizophrenia, bipolarity, among others. These solutions have used various social media, sensors, and even incorporated some methods of psychology.
  1. Considering state of the art in Affective Computing. What do you find to be the roadmap for years to come?
  2. What we have to novelty, and what possible search paths?
  3. How much can computer science provide support for experts (psychologists and psychiatrists) in human behavior analysis?
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1. Emotion Recognition:
2. Behavior Analysis:
3. Contextual Understanding:
4. Personalization and Adaptation:
5. Human-Computer Interaction:
6. Ethical and Privacy Considerations:
7. Real-World Applications:
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Psychology, according to Wundt, drew on definitions of human nature as distinct from prior religious interpretation, that human beings are neither bad nor good. Although thereby not conditioned or inhabited by supernatural forces they are driven by the forces within and of their environments.
Psychiatry believes mental illness is determined or pre-determined, and that even when environment plays a part people react to the environment in pre-determined ways. People can and do claim that psychiatry is a science because it can be measured. I believe this is suspect!
The role played by drugs in psychiatry is seen by some as evidence of its scientific basis, as drugs belong to science and fit the claims of medicine for almost three hundred years. Drugs will suppress so the good they do, combined with their addictive nature, is suspect. Or do you consider otherwise? Again the effects of drugs are subject to measuring, or are they? Psychiatry predetermines human nature but is the categorisation of human beings reliable?
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Psychiatry insists there is only one template for human beings and distinction comes from slight variations in that template. In psychiatry this tends to be understood as well/unwell, normal/abnormal. Isn't normality an undefined state?
Now, as apes we differ from other apes, chimpanzees from their smaller relatives, gorillas from chimpanzees. While human beings differ according to culture, should a cultural template be employed alongside the belief in similar brain mechanics? Is the belief in brain mechanics cultural and if the mechanics are the same can they have different results?
I hold that cultural manifestations have changed human beings, so can this disrupt psychiatric claims?
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Dear Sir,
On belfalf of the others Editors-in-chief of Jornal Brasileiro de Psiquiatria, we would like to know how can we update the page (https://www.researchgate.net/journal/Jornal-Brasileiro-de-Psiquiatria-0047-2085).
Best regards,
Marcia Cristina Nascimento Dourado
Editor-in-chief
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You have to be logged in to ResearchGate as the person who created the page, I guess. If this person is no longer available, you need to negotiate with RG. However, it's peculiar that RG hasn't updated the journal contents in the last decade.
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Does the large number of comorbidities in current mental illness suggest that the current classification of illness is problematic? What diagnostic classification criteria do psychiatrists need to identify and treat disorders?
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Our project: Quantifying Mental health/// is based on mood science and the pathological chronification of moods as, for example, represented in the Plutchik’s Wheel of Emotions, dear Cai Jinping This approach works by ontological engineering, forensic simulation and key AI technologies.
cc
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The "Goldwater Rule" is a guideline that pertains to the ethical standards of mental health professionals, particularly psychiatrists, when it comes to making public statements about the mental health of public figures, such as politicians. It is named after Senator Barry Goldwater, who ran for President of the United States in 1964. During that campaign, a magazine published a survey of psychiatrists assessing Goldwater's mental health without a proper evaluation. This raised ethical concerns and led to the development of the Goldwater Rule.
The Goldwater Rule is a part of the American Psychiatric Association's (APA) ethical guidelines, specifically in its "Principles of Medical Ethics" related to the field of psychiatry. The rule states that it is unethical for psychiatrists to offer professional opinions on the mental health of individuals they have not personally evaluated or obtained consent to discuss. This includes public figures whose mental health status becomes a topic of public interest.
The principle behind the Goldwater Rule is to maintain the integrity of the psychiatric profession, protect patient confidentiality, and avoid making speculative or potentially harmful statements about an individual's mental health without proper evaluation. Public statements made by mental health professionals without direct assessment could be misinformed, stigmatizing, and politically biased.
It's important to note that the Goldwater Rule is specific to psychiatrists and mental health professionals governed by the American Psychiatric Association's ethical guidelines. Other mental health professionals may have their own ethical guidelines related to making public statements about individuals they have not personally evaluated.
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This rule is derived from the golden rule, that says that do to others or treat others the way you would like to be treated.
Water gold rule states that one should avoid anything that could cause harm or conflict.
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SO WHAT ARE THE JOBS WITH HIGHEST SUICIDE RATES?
1. Medical Doctors 2. Dentists 3. Police Officers 4. Veterinarians 5. Financial Services 6. Real Estate Agents 7. Electricians 8. Lawyers 9. Farmers 10. Pharmacists
Each year in the U.S., roughly 300 - 400 physicians die by suicide;
.
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Prof Stephen David Edwards is correct in my opinion, normally women are more empathic an compassionate. Therefore mind has gender as I wrote the article below: 18TH CENTURY ENGLISH PHILOSOPHER MARY WOLLSTONECRAFT'S FALSE CLAIM THAT "MIND HAS NO GENDER"
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Hello all,
We are looking for colleagues to conduct studies on to find out the psychological consequences of natural disasters on women and adolescent samples.
We aim to make the researches comprehensive and internationally collaborative project, particularly by soliciting contributions from researchers in different disciplines of mental health field.
Therefore, we welcome those who are interested in joining the project. We kindly request you to share your interest and suggestions related to the topic.
Please drop me message. I'll turn back as soon as possible.
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Collaborative studies on the psychological effects of earthquakes could significantly contribute to understanding the mental health challenges faced by survivors. It is essential to explore the prevalence of post-traumatic stress disorder (PTSD) and other mental health issues in those affected by earthquakes, as well as identifying effective coping strategies and resilience factors. By fostering collaboration among professionals in the mental health field, such as psychologists and psychotherapists, valuable insights can be gained to develop targeted interventions and support systems for individuals and communities dealing with the aftermath of earthquakes. These studies may also pave the way for implementing preventive measures and enhancing disaster preparedness to mitigate the long-term psychological impacts of seismic events.
I am more than willing to be part of this study.
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Relative to neuroscience in general, medical research in neurology and psychiatry are far less tolerant of theory and speculation (as reflected in the bottom-up approach taken by most prestigious journals, for example).
In your opinion, does this warrant some type of paradigm shift, or is the status quo as should be? Why?
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our Litiginous society has "evolved" with Big Pharma producing a plethora of "alternative facts" backed by profit and legal penalties.
A version of the truth is reported on every medicinal package in the fine print listing disclaimers which include a form of magical thinking that if we are aware of how the medicines are bad, then they can be good.
this helps nobody but big pharma, and it ensures that the psychiatric field is entangled with best practices that are not at all good.
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A question that will debate and controversy...
Anxiety and Depression are only subjects of Psychiatry and Psychology?
What do you think Dear colleagues?
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Anxiety typically involves excessive worry, fear, and unease about future events or circumstances. It often manifests as physical symptoms like rapid heartbeat, restlessness, and difficulty concentrating. Whereas: Depression, on the other hand, is characterized by persistent feelings of sadness, hopelessness, and a loss of interest in activities. It can lead to changes in appetite, sleep disturbances, low energy, and thoughts of self-harm.
Moreover, anxiety focuses on apprehension and excessive worry, depression centers around a pervasive sense of sadness and disinterest in life.
However, it's important to note that both conditions can have overlapping symptoms and may require professional help for diagnosis and treatment.
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A human is an ability to eat, to walk, to memorize, to think, to rightly express your moods. Then he goes to work as electrician, musician, physicicist, physician, etc. All these human  activity is generated by human society, government.
WHERE IS A PURE MAN? Do we think about ourselves (our memory, thinking, why do we live, why do we do such action, etc) frequently? NOT AT ALL! We immersed in highly complicated "whirlpool" оf self-preservation of ourselves, our children, our parents, our relatives, our MONEYS, etc. Our self-preservation is  so complicated that we have no time to think on other subjects. So we are ants, we get commands and we just execute it. That is essence if our life - we do what we do not understand but we are in hurry to make it on time! All it is a comedy.
Besides Shakespeare`s phrase "all the world is a theater" I say all the world is comedy.
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Lo de automatico sobra…
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Evolutionary psychiatry attempts to explain and examine the development and prevalence of psychiatric disorders through the lens of evolutionary and adaptationist theories. In this edited volume, leading international evolutionary scholars present a variety of Darwinian perspectives that will encourage readers to consider 'why' as well as 'how' mental disorders arise. Using insights from comparative animal evolution, ethology, anthropology, culture, philosophy and other humanities, evolutionary thinking helps us to re-evaluate psychiatric epidemiology, genetics, biochemistry and psychology. It seeks explanations for persistent heritable traits shaped by selection and other evolutionary processes, and reviews traits and disorders using phylogenetic history and insights from the neurosciences as well as the effects of the modern environment. By bridging the gap between social and biological approaches to psychiatry, and encouraging bringing the evolutionary perspective into mainstream psychiatry, this book will help to inspire new avenues of research into the causation and treatment of mental disorders.
A copy of the reference could be requested on:
See also:
Deleted research item The research item mentioned here has been deleted
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1. Does consciousness exist?
2. If so, what is Consciousness and what are its nature and mechanisms?
3. I personally think consciousness is the subjective [and metaphysical] being that (if exists) feels and experiences the cognitive procedures (at least the explicit ones). I think that at some ambiguous abstract and fuzzy border (on an inward metaphysical continuum), cognition ends and consciousness begins. Or maybe cognition does not end, but consciousness is added to it. I don't know if my opinion is correct. What are potential overlaps and differences between consciousness and cognition?
4. Do Freudian "Unconscious mind" or "Subconscious mind" [or their modern counterpart, the hidden observer] have a place in consciousness models? I personally believe these items as well are a part of that "subjective being" (which experiences cognitive procedures); therefore they as well are a part of consciousness. However, in this case we would have unconscious consciousness, which sounds (at least superficially) self-contradictory. But numerous practices indicate the existence of such more hidden layers to consciousness. What do you think about something like an "unconscious consciousness"?
5. What is the nature of Altered States of Consciousness?
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Jerry waese
Thank you very much I have my own views & in this line I have expressed my publication which have been appreciated by well many for which I have no comment .
For your contribution I respect you .
Thanks
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hey give me your suggestions and refer me a studies related to this topic
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Define the purpose and objectives of the test: Start by defining the goals of the script concordance test. What specific knowledge, skills, or attitudes do you want to assess in BSc nursing students in the psychiatry department? What are the learning outcomes you expect to achieve with this test?
Identify the key concepts to assess: Review the curriculum and identify the key concepts, topics, and skills that are relevant to the psychiatry department. This will help you define the scope of the test and select the appropriate cases and scenarios to use.
Develop the cases and scenarios: Develop a set of cases and scenarios that reflect the real-world challenges that BSc nursing students may encounter in their clinical practice. Each case should include a brief vignette or clinical scenario, followed by a set of questions that require the students to interpret, evaluate, or apply the information in the scenario.
Define the scoring system: Develop a scoring system that reflects the complexity and relevance of the questions. Consider using a three-point or five-point scale to evaluate the accuracy, completeness, and relevance of the students' responses.
Pilot test the tool: Before implementing the script concordance test, pilot test the tool with a small group of students and faculty members. This will help you identify any potential issues or weaknesses in the tool, and make necessary revisions.
Implement and evaluate the tool: Once you have finalized the tool, implement it in the classroom or clinical setting. Evaluate the results and use the feedback to improve the tool and the teaching and learning process.
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During my clinical life as MD, psychiatrically I deduced that "Almost 99 % of declared child-geniuses are due to both parents are rich & borderline/schizophrenic so their child(ren) is/are genious for them forcing these children even get masters and PhD degrees in unreliable way in unaccredited institutes while at teen ages." These borderline/schizophrenic parents must be seriously treated psychiatric clinics otherwise they can ruin not just their lives but also their children severely ! Prodigiousness in childhood in music or in arts are possible, I have no doubt in that at all, but not masters (MA/MS) &/or doctorates (PhD) at chilhood !
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The type of children who are claimed to graduate from some universities (?), with an isolated self education and getting doctorates etc at the age of 10-15 years are of course not normal! Rather they get such fancy diplomas by the influence of their parents who have considerable personality disorders.
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Why and how is this kind of long-term potentiation (LTP) possible?
Is LTP even needed for all sorts of synaptic plasticity and long-term memory formation?
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Longer version:
Long-term potentiation (LTP which is necessary for synaptic plasticity and long-term memory formation) needs repeats and reinforcement of the engrams to be triggered.
However, apparently everybody automatically "absorbs" a lot of information immediately and also permanently, even without needing any extra effort (at least any conscious effort), which seems to be needed for LTP to happen. Everyone seems to have this ability, although it is even stronger in those with better memories.
People simply "learn" many things once; and many of those learned items remain there for a pretty long duration, and in many cases even for the rest of their lives. This seems to happen without any repeats, at least without any apparent or conscious efforts to remember or re-remember those memories. This is the case for a lot of semantic information (especially the information of interest or importance to the person) as well as a large portion of the contents of episodic memory.
Why and how is this kind of LTP possible?
Perhaps attention plays a major role here, e.g., being interesting and important automatically triggers LTP without a further need for repeats.
But such effortless long-term memorization happens also in the case of a lot of semantic information or autobiographical events that are not inherently interesting or significant to the person.
Is LTP even needed for all sorts of synaptic plasticity and long-term memory formation?
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I apologize for any confusion my previous response may have caused. Let me clarify:
There is evidence that some synapses are stronger than others, and that synaptic strength can change over time through a process known as synaptic plasticity, which includes long-term potentiation (LTP) and long-term depression (LTD). These changes in synaptic strength are thought to be important for learning and memory.
However, it is not clear that any single axon-branch to dendrite mini-synapse involved in memory formation is larger or stronger than any other one in general. The strength of a synapse is determined by a variety of factors, including the amount of neurotransmitter released, the number and sensitivity of receptors on the postsynaptic membrane, and the properties of the presynaptic and postsynaptic neurons themselves. These factors can vary widely from synapse to synapse, even within the same neural circuit.
So, while there may be differences in synaptic strength between individual synapses, it is not accurate to say that any single synapse is always larger or stronger than any other one, or that the strength of a synapse is solely determined by its size. The idea of synaptic weighting and LTP/LTD remains an important and valid concept in the field of neuroscience.
On the other hand, I am also, among other things, a philosopher, a clinical psychologist and a theoretical physicist. I tend to look at commonly accepted definitions and paradigms from many different perspectives.
I worked as a neuroscientist for 2 years at the Medical University of Wrocław, I previously studied neuroscience at Duke University. I did not find answers to my questions. On the one hand, we are looking for something, while on the other hand, our accepted definitions and paradigms often lead us to contradictions.
What interests me are noumena (things in themselves). I look for them in everything, although they can be a difficulty in typically technical discussions. Nevertheless - I cannot believe in any theory, concept or description if I do not find assumptions deep enough in them. The foundations are often fragile.
Neuroscience is one of my favourite disciplines of knowledge, but I nevertheless think that its foundations are not clear enough. I think the same about theoretical physics.
Hence, I warn you that what I write may be risky at times, but I take part in this discussion because I myself very much want to understand and be able to reflect further.
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What is this curious non-updatable mega memory? Does it have any scientific terms?
What are its causes and mechanisms?
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Explanation:
I have had the honor of witnessing very rare people who have some strange forms of mega memory: They effortlessly, automatically, and immediately memorize many difficult things such as phone numbers or their difficult and comprehensive books, etc. And they retain those easily captured memories for a very very long time (a couple of decades at least), without any smallest effort or reinforcement. Not to mention that they record or remember almost everything else (semantic or episodic) quite easily, and also with a lot of details. Furthermore, they are very very accurate in recalling those items. For example, they can serve as pretty reliable living phone books; or for example, they are extremely awesome at medicine, etc.
But when I am talking about "strange", I don't mean their super-human ability to easily capture such vast amounts of information for such long durations and recall them accurately.
Their super-human ability is of course strange. But the even stranger part of their memory is that once it is captured, it cannot be updated or revised easily. For example, if they misunderstand something the first time, it will take perhaps 10 or 20 attempts over days or weeks for their colleagues to remind them of the mistake and ask them to correct their misunderstanding.
It is like that once their memory is formed the very first time, it is set in stone. It is absorbed very efficiently and strongly, and at the same time, not much prone to future updates.
What is this curious non-updatable mega memory? Does it have any scientific terms?
What are its causes and mechanisms?
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The type of memory you are describing is often referred to as highly superior autobiographical memory (HSAM) or hyperthymesia. Individuals with HSAM have the ability to recall detailed and specific information about events from their own life, as well as information from other domains, with exceptional accuracy and vividness. They often report that these memories come to mind involuntarily, without any conscious effort to retrieve them.
The inability to update or revise memories in individuals with HSAM may be related to the way their memories are stored and retrieved. Research suggests that individuals with HSAM have highly efficient and reliable retrieval processes, which allow them to access memories quickly and accurately. However, this efficiency may come at the cost of flexibility and updating, as memories may become so strongly encoded that they are resistant to change.
The causes and mechanisms underlying HSAM are not yet fully understood. Some research has suggested that HSAM may be related to differences in brain structure or function, such as increased connectivity between certain brain regions involved in memory processing. However, more research is needed to fully understand the underlying neural mechanisms of HSAM.
It's important to note that HSAM is a rare phenomenon, and not everyone with exceptional memory abilities has HSAM. While memory abilities can be enhanced through various techniques and strategies, the type of memory observed in individuals with HSAM appears to be a unique and innate ability.
I know a bit more about this from autopsy as well. I was also diagnosed with autism spectrum disorder as a child.
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In most contexts, the terms alternative medicine, complementary medicine, integrative medicine, holistic medicine, natural medicine, and unconventional medicine are almost synonymous.
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Yes. Naturopathy and phytopharmacology, for example, make great sense, especially as balancing treatments and therapies.
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Hi all!
Does anyone use endophenotypes for research purposes? I found very interesting papers explaining the value of endophenotypes (mostly in psychiatry), but I think the concept is perfectly applicable to any medical condition. Unfortunately, I can't find a methodological paper explaining the process of constructing an endophenotype.
Is there a formal statistical/methodological approach to do this? or more than the process of making them, is there an evidence-based process to probe their suitability?
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endophenotypes are insidious genotypical signs that doosnt seen pehnotypically but van be detectable via laboratory and /or radioliogic fingins which have not implicated by clinical manifestations
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Corporal punishment, violent communication, humiliation...by parents and teachers.
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Violence towards children never lead to good results
Adults who suffered violence in childhood usually abuse others around them
Talking and explaining and discussing a bad behavior and explaining serious consequences would be much better understood and internalized much more than an aggressive approach.
Also violence infront of other poeple will definitely be modelled by the abused child with peer groups or as an adult.
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Hello,
Is there anybody happy to be the reviewer of my paper (Frontiers in Psychiatry) on smoking frequency and life satisfaction and test whether self-rated health serves as a mediator between this association? I am happy to review back if your manuscript needs a reviewer. Please leave me your name, email address, and institution if you are interested.
Regards,
Wesley
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Yes, why not? You can add me as reviewer. brain26091986@gmail.com
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Hello,
I would love to receive some recommendations from experts in regards to the topic, whether there are valid findings in research on biological markers for anxiety disorders. I am trying to gain some stable insight and be able to argue in favor of the notion, that no anxiety disorder "comes from a malfunction/sickness of the brain".
Thank you in advance!
Best
Ivo
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The relevance of the Microbiota-Gut-Brain axis to Alzheimer’s and neurodegenerative diseases needs extensive analysis. The various articles indicate that there are various questions with relevance to microbiota-gut-brain axis that are relevant to the pathology, pathogenesis and treatment of neurodegnerative diseases.Several mechanistic studies are required to determine the underlying mechanisms for effective and safe probiotic treatment for AD and probiotic benefits remain to determined. The relevance of gut dysbiosis may induce inflammatory responses that may be the cause of the induction of the pathogenesis of AD and relevance of diet (unhealthy diets), probiotics and gut microbiota should be carefully assessed. The meta-analysis studies indicate that probiotics reduce inflammation and oxidative stress and enhances cognition in AD and MCI individuals. The effects of different types of probiotics on amyloid formation and deposition needs to be evaluated and probiotic mixture therapy may be unsafe. The safety of probiotic therapy for AD patients require investigation with relevance to neuron reprogramming and programmed cell death in AD. The risk of unsafe microbiota and probiotic use may lead to the inactivation of the anti-aging gene Sirtuin 1 and the generation of uncontrolled short chain fatty acid release that promote amyloid beta plaque formation.
The concerns with relevance to the induction of dyslipidemia and the role of safety of diet-microbiota-brain axis should be carefully assessed with relevance to the cholesterol-AD connections. The prebiotic, symbiotic and probiotic formulations should be carefully assessed for bacterial composition and living microorganisms such as gram negative and positive. The release of bacterial lipopolysaccharides (LPS) from gram negative bacteria needs to be controlled and the content of gram negative bacteria carefully assessed in these prebiotic, symbiotic and probiotic formulations. Unhealthy diets contain end products such as LPS and diets should be carefully assessed for LPS contents since LPS has been associated with the inactivation of Sirtuin 1. The gut microbiota based therapy is in progress and the relevance to the treatment of brain diseases such as AD is limited. The benefits, limitations and safety of gut microbiota and probiotics on Alzheimer’s disease needs to be placed under systematic review with relevance to dietary regulation and postbiotic supplementation that have the implications for amyloidosis and neurodegeneration. The role of probiotic therapies to create a health gut environment by balancing bacterial populations may require the activation of the anti-aging gene Sirtuin 1 to reverse the pathogenesis of Alzheimer’s disease. The literature indicates that yogurt is a prime source for probiotics and provide a healthy balance of live bacteria to provide health benefits to individuals in various countries of the world. However a recent article indicates that within 12 hours yoghurt can grow gram negative bacteria. The gram negative bacteria in yoghurt depending on daily or weekly intake can generate high levels of plasma LPS with relevance to prebiotic, synbiotic and probiotic quality products and ill health. Yoghurt products may need to be assessed for gram negative bacteria populations and LPS to determine the quality control of these products for international communities.
📷
RELEVANT REFERENCES:
A. Marzban A, Rahmanian V, Marzban A, Ramezani Siakhulak F. The Role of Probiotics in Improving Alzheimer's Disease. JNFS. 2022; 7 (2) :136-138.
B. de Rijke TJ, Doting MHE, van Hemert S, De Deyn PP, van Munster BC, Harmsen HJM, Sommer IEC. A Systematic Review on the Effects of Different Types of Probiotics in Animal Alzheimer's Disease Studies. Front Psychiatry. 2022 Apr 27;13:879491.
C. Guo L, Xu J, Du Y, Wu W, Nie W, Zhang D, Luo Y, Lu H, Lei M, Xiao S, Liu J. Effects of gut microbiota and probiotics on Alzheimer's disease. Transl Neurosci. 2021 Dec 27;12(1):573-580.
D. Ji HF, Shen L. Probiotics as potential therapeutic options for Alzheimer's disease. Appl Microbiol Biotechnol. 2021 Oct;105(20):7721-7730.
E. D’Argenio V, Sarnataro D (2021) Probiotics, prebiotics and their role in Alzheimer’s disease. Neural Regen Res 16(9):1768-1769.
F. Bonfili L, Cuccioloni M, Gong C, Cecarini V, Spina M, Zheng Y, Angeletti M, Eleuteri AM. Gut microbiota modulation in Alzheimer's disease: Focus on lipid metabolism. Clin Nutr. 2022 Mar;41(3):698-708.
G. Naomi, R.; Embong, H.; Othman, F.; Ghazi, H.F.; Maruthey, N.; Bahari, H. Probiotics for Alzheimer’s Disease: A Systematic Review. Nutrients 2022, 14, 20.
H. Arora K, Green M, Prakash S. The Microbiome and Alzheimer's Disease: Potential and Limitations of Prebiotic, Synbiotic, and Probiotic Formulations. Front Bioeng Biotechnol. 2020 Dec 14;8:537847. doi: 10.3389/fbioe.2020.537847.
I. Peterson CT. Dysfunction of the Microbiota-Gut-Brain Axis in Neurodegenerative Disease: The Promise of Therapeutic Modulation With Prebiotics, Medicinal Herbs, Probiotics, and Synbiotics. J Evid Based Integr Med. 2020 Jan-Dec;25:2515690X20957225.
J. Kincaid HJ, Nagpal R, Yadav H. Diet-Microbiota-Brain Axis in Alzheimer's Disease. Ann Nutr Metab. 2021;77 Suppl 2:21-27. doi: 10.1159/000515700.
K. Alessio Vittorio Colombo Rebecca Katie Sadler Gemma Llovera Vikramjeet Singh Stefan Roth Steffanie Heindl Laura Sebastian Monasor Aswin Verhoeven Finn Peters Samira Parhizkar Frits Kamp Mercedes Gomez de Aguero Andrew J MacPherson Edith Winkler Jochen Herms Corinne Benakis Martin Dichgans Harald Steiner Martin Giera Christian Haass Sabina Tahirovic Arthur Liesz. (2021) Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition. eLife 10:e59826.
L. Anti-Aging Genes Improve Appetite Regulation and Reverse Cell Senescence and Apoptosis in Global Populations. Advances in Aging Research, 2016, 5, 9-26
M. Appetite Regulation and the Peripheral Sink Amyloid beta Clearance Pathway in Diabetes and Alzheimer’s Disease. Top 10 Commentaries in Alzheimer’s Disease (e-book). 2019;2:1-11. www.avidscience.com
N. Single Gene Inactivation with Implications to Diabetes and Multiple Organ Dysfunction Syndrome. J Clin Epigenet. Vol. 3 No. 3:24.
O. Sirtuin 1, a Diagnostic Protein Marker and its Relevance to Chronic Disease and Therapeutic Drug Interventions”. EC Pharmacology and Toxicology 6.4 (2018): 209-215.
P. Nutritional diets accelerate amyloid beta metabolism and prevent the induction of chronic diseases and Alzheimer’s disease. Photon ebooks. 2015.
Q. Wassenaar TM, Zimmermann K. Lipopolysaccharides in Food, Food Supplements, and Probiotics: Should We be Worried? Eur J Microbiol Immunol (Bp). 2018 Aug 21;8(3):63-69.
R. The Future of Genomic Medicine Involves the Maintenance of Sirtuin 1 in Global Populations. Int J Mol Biol . 2017. 2(1): 00013.
S. Bacterial Lipopolysaccharides and Neuron Toxicity in Neurodegenerative Diseases. Neurology Research and Surgery. 2018; 1(1): 1-3.
T. C.J. Hervert, N.H. Martin, K.J. Boor, M. Wiedmann. Survival and detection of coliforms, Enterobacteriaceae, and gram-negative bacteria in Greek yogurt, Journal of Dairy Science, Volume 100, Issue 2, 2017, Pages 950-960.
U. Fisberg M, Machado R. History of yogurt and current patterns of consumption. Nutr Rev. 2015 Aug;73 Suppl 1:4-7.
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Answer
Gerobiotics: probiotics targeting fundamental aging processes
Gerobiotics: probiotics targeting fundamental aging processes (nih.gov)
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In which trimester i.e. 1st or 2nd or 3rd, the mean score was higher on Revised Pregnancy Distress Questionnaire (NuPDQ) 17 items, references to the previous researches ?
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Dear Dr :Atiq Ur Rehman
looking forward to read good answer and participation . thank you for this question .
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Is International Journal of Psychiatry Research (ISSN 2641-4317, Impact Factor: 0.65) good journal?
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Be careful, the Beall’s list consists of two lists, one is the so-called stand-alone journal list (https://beallslist.net/standalone-journals/) and indeed this journal is not listed. However, there is another list of potential predatory publishers (https://beallslist.net/). The journal “International Journal of Psychiatry Research” ISSN 2641-4317 is published by "SciVision Publishers", a publisher mentioned in the updated version of the Beall’s list (https://beallslist.net/#update). This is a red flag. But there are more:
-Fake impact factor since journal is not indexed in Clarivate’s SCIE/SSCI (which one can check here https://mjl.clarivate.com/home)
-Indexing info https://www.scivisionpub.com/journals/abstracting-and-indexing-international-journal-of-psychiatry-researchmentions CiteFactor, DRJI etc. all known examples of a misleading metrics (https://beallslist.net/misleading-metrics/) often used by predatory journals
-Contact info indicates that SciVision Publishers LLC is a Delaware Limited-Liability Company Jeffrey Beall once said “Also, many publishers create companies in the United States- state of Delaware and use a Delaware address to make it appear they are based in my country. Anyone can create a company registered in Delaware by visiting a website and paying a small fee. The registration companies allow those who create new companies to use their addresses. So, many predatory publishers who claim to be based in the U.S. are not”.
-I think 1200 USD is ridiculously high for a basically nonindexed journal https://www.scivisionpub.com/publication-charges
So, though it all looks misleadingly professional I would stay away from this one.
Best regards.
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Which are the most widely used rating scales for anxiety and depression in the setting of an outpatient psychiatry clinic?
Should I use HAM-A and HAM-D, or BAI and BDI?
Which would be most widely used in the UK? I'd be interested to know if preferences/recommendations are different elsewhere?
Also, would you recommend anything more specific for older adult patients?
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DASS 21
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COVID-19 is changing the social life of all people. Jumping out of the personal aspect, how does it affect the family as a whole.
Family is regarded as the fundamental structure of the society, will COVID-19 changes the future family structure, unit and model?
How is it affecting gender issues too?
Besides, why is domestic violence increasing? Is psychology and psychiatry playing a role?
reference:
[1] Campbell AM. An increasing risk of family violence during the Covid-19 pandemic: Strengthening community collaborations to save lives.
Forensic Science International: Reports vol. 2 (2020): 100089.
[2]COVID-19: Reducing the risk of infection might increase the risk of intimate partner violence
EClinicalMedicine
[3]The pandemic paradox: The consequences of COVID‐19 on domestic violence
J Clin Nurs
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Dear Dr Sunny Chi Lik Au . See the following useful RG link:
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Dear friends!
I hope you had a wonderful Christmas. Im very much interested in teaching and I would like to ask your views on a highly ( to me at least) interesting topic. There are probably as many methods of teaching methods as there are lecturers but here are a few types accepted in literature.
  • Teacher/lecturer-Centered
  • Student-Centered / Constructivist Approach.
  • Inquiry-Based Learning.
  • Flipped Classroom.
  • Cooperative Learning.
  • Personalised Education.
Which one do you use and why?
Best wishes Henrik
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Former USSR traditional lecturers with great academicians, undoubtedly those times won't be repeated anywhere, Prof. Henrik G.S. Arvidsson
Feliz Año & Best Regards.
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Are there any hospitals that are working on a multidisciplinary team approach for involuntary movements in the orofacial region such as oromandibular dystonia?
I mean, the multidisciplinary team approach is a collaboration between medical specialists (neurologists, neurosurgeons, psychiatrists, otolaryngologists) and dental specialists (dentists, oral surgeons, prosthodontists) for diagnosis and treatment.
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Dear Dr. Bhogaraju Anand,
Thank you very much for your valuable information. Unfortunately, it is unclear whether dental specialists participate in the diagnosis and treatment of movement disorders as a multidisciplinary team approach.
Vast majority of the literatures on oromandibular dystonia is published mainly by medical specialists such as neurologists. Although I think a collaboration between medical and dental specialists must be necessary for diagnosis and treatment, there are very few reports of collaboration with dental professionals.
Best regards,
Kazuya Yoshida
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My lab is looking for a reliable, valid measure of pain for our nonprofit-funded phase 1 clinical trial. We were originally considering the Brief Pain Inventory (BPI) but the paywall (~400) is a bit higher than anticipated. Has anyone had luck with other pain measures similar to the BPI but is either free or more budget-friendly? I did see the McGill Pain Questionnaire, but this appears to require a fee as well (still waiting to hear what that fee will be).
We are looking for a scale that reports both acute and more chronic pain, ideally including history of pain medication/treatment effectiveness. Hence, some of the scales that initially come to mind (e.g., visual analogue scale, numerical rating scale) don't seem like the best fit.
Any help would be appreciated, many thanks!
David
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Hello David,
Here are a couple of sources that might prove helpful for your search:
Good luck with your work.
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Hi. We have a case report manuscript that we are ready to submit for publication. Since it's a case report, there aren't many journals where to send it. We are between two journals: a traditional journal in the field that has an impact factor of 2.7, and a Frontiers journal with an impact factor of 4.2.
What do you think it's best in this case? To submit the manuscript to a lower-impact but traditional journal, or to a higher-impact but Frontiers journal?
Thanks for your suggestions!
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Routledge
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Heroin abusers are associated with accelerated aging and neurodegenerative disease. The cellular effects of heroin is possibly linked to mitochondrial apoptosis. The risk of uncontrolled heroin consumption may lead to multiple organ disease syndrome and the risk of death. Heroin addicts have altered immune system and core body temperature defects that may lead to chronic disease. Heroin addicts may have an increase risk for stroke and intraparenchymal hemorrhage. The inactivation of the anti-aging gene Sirtuin 1 is associated with accelerated aging, stroke and neurodegenerative disease. Sirutin 1 is important to core body temperature and immune reactions that is linked to neurodegenerative disease. Heroin may inhibit Sirtuin 1 and accelerate mitochondrial apoptois with relevance to multiple organ disease syndrome. Sirtuin 1 regulates telomerase that is critical to biological aging. Exercise and mindfulness decompression therapy that can improve the social anxiety level of heroin withdrawal patients and may involve the activation of Sirtuin 1. Nutritional diets that activate Sirtuin 1 may be critical to prevent the accelerated aging and neurodegenerative disease in heroin abusers and addicts.
THE DOSE OF HEROIN IN ADDICTS AND ABUSERS SHOULD BE CAREFULLY CONTROLLED TO PREVENT SIRTUIN 1 INHIBITION AND THE INDUCTION OF PROGRAMMED CELL DEATH.
RELEVANT REFERENCES:
1. Gordon L.F. Cheng, Tatia M.C. Lee. Chapter 95 - Accelerated Aging in Heroin Abusers: Readdressing a Clinical Anecdote Using Telomerase and Neuroimaging. Neuropathology of Drug Addictions and Substance Misuse. 2016. Pages 1012-1022.
2. Cheng, G., Zeng, H., Leung, MK. et al. Heroin abuse accelerates biological aging: a novel insight from telomerase and brain imaging interaction. Transl Psychiatry 3, e260 (2013).
3. Zaki NG, Osman A, Moustafa H, Saad AH. Alterations of immune functions in heroin addicts. Egypt J Immunol. 2006;13(1):153-71.
4. Bola RA, Kiyatkin EA. Brain temperature effects of intravenous heroin: State dependency, environmental modulation, and the effects of dose. Neuropharmacology. 2017;126:271-280.
5. Eugene A. Kiyatkin, Roy A. Wise. Brain and Body Hyperthermia Associated with Heroin Self-Administration in Rats. Journal of Neuroscience 1 February 2002, 22 (3) 1072-1080.
6. Kovacs GG, Horvath MC, Majtenyi K, Lutz MI, Hurd YL, Keller E. Heroin abuse exaggerates age-related deposition of hyperphosphorylated tau and p62-positive inclusions. Neurobiol Aging. 2015;36(11):3100-3107.
7. Zhu M, Xu Y, Wang H, Shen Z, Xie Z, Chen F, Gao Y, Chen X, Zhang Y, Wu Q, Li X, Yu J, Luo H, Wang K. Heroin Abuse Results in Shifted RNA Expression to Neurodegenerative Diseases and Attenuation of TNFα Signaling Pathway. Sci Rep. 2018 Jun 18;8(1):9231.
8. Cunha-Oliveira T, Rego AC, Garrido J, Borges F, Macedo T, Oliveira CR. Street heroin induces mitochondrial dysfunction and apoptosis in rat cortical neurons. J Neurochem. 2007 Apr;101(2):543-54.
9. Intraparenchymal hemorrhage after heroin use. American Journal of Emergency Medicine. American Journal of Emergency Medicine 33 (2015) 1109.e3–1109.e4
10. Feng G, Luo Q, Guo E, et al. Multiple organ dysfunction syndrome, an unusual complication of heroin intoxication: a case report and review of literature. Int J Clin Exp Pathol. 2015;8(9):11826-11830.
11. Pu H, Wang X, Zhang J, et al. Cerebellar neuronal apoptosis in heroin-addicted rats and its molecular mechanism. Int J Clin Exp Pathol. 2015;8(7):8260-8267. Published 2015 Jul 1.
12. Anti-Aging Genes Improve Appetite Regulation and Reverse Cell Senescence and Apoptosis in Global Populations. Advances in Aging Research, 2016, 5, 9-26
13. Single Gene Inactivation with Implications to Diabetes and Multiple Organ Dysfunction Syndrome. J Clin Epigenet. (2017) Vol. 3 No. 3:24.
14. Regulation of Core Body Temperature and the Immune System Determines Species Longevity. Curr Updates Gerontol. (2017) 1: 6.1.
15. Early Diagnosis and Nutritional Treatment stabilizes Neuropsychiatric Disorders. Global Journal of Medical Research. 2018;1(1):1-7.
16. Palacios JA, Herranz D, De Bonis ML, Velasco S, Serrano M, Blasco MA. SIRT1 contributes to telomere maintenance and augments global homologous recombination. J Cell Biol. 2010 Dec 27;191(7):1299-313.
17. Nutrition Therapy Regulates Caffeine Metabolism with Relevance to NAFLD and Induction of Type 3 Diabetes. J Diabetes Metab Disord. 2017; 4: 019.
18. Sirtuin 1, a Diagnostic Protein Marker and its Relevance to Chronic Disease and Therapeutic Drug Interventions”. EC Pharmacology and Toxicology 6.4 (2018): 209-215.
19. The Global Obesity Epidemic is Related to Stroke, Dementia and Alzheimer’s disease. JSM Alzheimer’s Dis Related Dementia. 2014;1(2): 1010.
20. A Randomized Controlled Trial of Mindfulness Decompression Therapy and Aerobic Exercise in the Treatment of Social Anxiety in Heroin Addicts. Addiction Research and Adolescent Behaviour. 2021.
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Morphines, in general, are known to enhance the expression of SIRT1 (see 10.1016/j.neulet.2020.135599). I would be surprised to see that diacetylmorphine inhibits SIRT1. Perhaps overexpression of SIRT1 leads to adverse consequences.
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Would it harm if an MDD patient receives TMS sessions 6 days a week instead of 5?
On a different note, is it required for the patient to receive 5 sessions in a row, or a patient could have TMS sessions simply 5 days a week in any order. Thanking you in advance.
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Some references:
Lefaucheur JP, Aleman A, Baeken C, Benninger DH, Brunelin J, Di Lazzaro V, Filipović SR, Grefkes C, Hasan A, Hummel FC, Jääskeläinen SK, Langguth B, Leocani L, Londero A, Nardone R, Nguyen JP, Nyffeler T, Oliveira-Maia AJ, Oliviero A, Padberg F, Palm U, Paulus W, Poulet E, Quartarone A, Rachid F, Rektorová I, Rossi S, Sahlsten H, Schecklmann M, Szekely D, Ziemann U. Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): An update (2014-2018). Clin Neurophysiol. 2020 Feb;131(2):474-528. doi: 10.1016/j.clinph.2019.11.002
Yang LL, Zhao D, Kong LL, Sun YQ, Wang ZY, Gao YY, Li N, Lu L, Shi L, Wang XY, Wang YM. High-frequency repetitive transcranial magnetic stimulation (rTMS) improves neurocognitive function in bipolar disorder. J Affect Disord. 2019 Mar 1;246:851-856. doi: 10.1016/j.jad.2018.12.102. Epub 2018 Dec 25. PMID: 30795490.
Buchholtz PE, Ashkanian M, Hjerrild S, Hauptmann LK, Devantier TA, Jensen P, Wissing S, Thorgaard MV, Bjerager L, Lund J, Alrø AJ, Speed MS, Brund RBK, Videbech P. Low-frequency rTMS inhibits the anti-depressive effect of ECT. A pilot study. Acta Neuropsychiatr. 2020 Dec;32(6):328-338. doi: 10.1017/neu.2020.
Chou YH, Ton That V, Sundman M. A systematic review and meta-analysis of rTMS effects on cognitive enhancement in mild cognitive impairment and Alzheimer's disease. Neurobiol Aging. 2020 Feb;86:1-10. doi: 10.1016/j.neurobiolaging.2019.08.020
Kaur M, Michael JA, Fitzgibbon BM, Hoy KE, Fitzgerald PB. Low-frequency rTMS is better tolerated than high-frequency rTMS in healthy people: Empirical evidence from a single session study. J Psychiatr Res. 2019 Jun;113:79-82. doi: 10.1016/j.jpsychires.2019.03.015
Ribeiro JA, Marinho FVC, Rocha K, Magalhães F, Baptista AF, Velasques B, Ribeiro P, Cagy M, Bastos VH, Gupta D, Teixeira S. Low-frequency rTMS in the superior parietal cortex affects the working memory in horizontal axis during the spatial task performance. Neurol Sci. 2018 Mar;39(3):527-532. doi: 10.1007/s10072-017-3243-8.
Lefaucheur JP. Transcranial magnetic stimulation. Handb Clin Neurol. 2019;160:559-580. doi: 10.1016/B978-0-444-64032-1.00037-0
Zhang H, Sollmann N, Castrillón G, Kurcyus K, Meyer B, Zimmer C, Krieg SM. Intranetwork and Internetwork Effects of Navigated Transcranial Magnetic Stimulation Using Low- and High-Frequency Pulse Application to the Dorsolateral Prefrontal Cortex: A Combined rTMS-fMRI Approach. J Clin Neurophysiol. 2020 Mar;37(2):131-139. doi: 10.1097/WNP.0000000000000528
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Any research paper or review that discuss pharmacological treatments for voice and speech disturbances that occur as a result of anxiety? For example stuttering, weak/trembling voice, etc.. as a result of anxiety? Any pharmacological that can address the vocal cords and breathing that can resolve this problem?
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Hi,
Here are few of the refeences:
Vasenina EE, Levin OS. Narushenie rechi i trevoga: mekhanizmy vzaimodeistviya i vozmozhnosti terapii [Speech disorders and anxiety: interaction mechanisms and therapy potential]. Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(4):136-144. Russian. doi: 10.17116/jnevro2020120041136
Lowe R, Menzies R, Onslow M, Packman A, O'Brian S. Speech and Anxiety Management With Persistent Stuttering: Current Status and Essential Research. J Speech Lang Hear Res. 2021 Jan 14;64(1):59-74. doi: 10.1044/2020_JSLHR-20-00144
Bergamaschi MM, Queiroz RH, Chagas MH, de Oliveira DC, De Martinis BS, Kapczinski F, Quevedo J, Roesler R, Schröder N, Nardi AE, Martín-Santos R, Hallak JE, Zuardi AW, Crippa JA. Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients. Neuropsychopharmacology. 2011 May;36(6):1219-26. doi: 10.1038/npp.2011.6
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Hello,
This is clinical research in computational psychiatry involving the identification of biomarkers. I am thinking about Frontiers Computational Psychiatry, JAMA Psychiatry, and European Psychiatry. I would appreciate any other recommendations!
Many thanks,
Akshay Patel
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Affirmative, Computational Psychiatry publishes original peer reviewed research articles that aim to understand psychiatric disorders through computational modeling.
Kind Regards
Qamar Ul Islam
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There is a protective role of estradiol against fear overexpression during the recall of fear memories, but why are anxiety disorders more common in females?
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I agree with all answers
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In the current pandemic situation, it is not possible to completely avoid a psychiatric patient carrying COVID-19 or being directly symptomatic. In addition, medical priority is to help anyone. How is your psychiatric clinic prepared for this situation? What is the experience of Italian psychiatrists or psychiatrists from other countries of the world (China, European states?)
COVID-19 infection is currently superior to any mental disorder, but what is your management of an acute psychiatric patient with a positive epidemiological history or clinical symptoms? I am very curious about your opinions, comments and observations.
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At a large hospital in Montreal (where my son works) many nurses have resigned and only a few doctors are remaining (most are taking a leave of absence, or a holiday, just to get out). The vaccine mandate (take vaccine or leave) has stripped this hospital of professionals rendering it useless. Who is going to treat patients?Maybe the administrators!
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The drug vinpocetine is currently being promoted in Slovakia by certain pharmaceutical company for use in psychiatry. Vinpocetine has a rich history and is mainly used to improve cognitive function after vascular insults/pathology of brain. Does anyone have experience with it in the treatment of cognitive impairment within psychiatry, or in any other indication? Is there any strong clinical reason to resurrect this drug, so to speak? Does it make sense to give it for cognitive symptoms, e.g. in patients with affective disorders? Does it make sense to combine it with ginkgo biloba extract? What are your experiences?
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I'm a community Pharmacist and I'm interested in writing, especially writing scientific papers. I'm offering my help and assistance in case you need a hand with your current research. My areas of interest: Pharmacotherapy, psychology, neurology, psychiatry. So send me a message in case you need help.
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I am interested...Kindly contact me after two weeks...
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I guess there must be some data collected regarding Covid and related to the field of psychology/psychiatry, considering its psychological impact. It might be gathered from the patients, family members or the society at large, either a public or private collection. Does anybody have any idea on how to access such data for research purposes?
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Dear Prof. Farhad Montazeri ,
For example, I saw of Lancet & Nature publications, just register, they will send updated data and research as you agreed to get updated - the ones you chose - to your email registered with them e.g.:
ABOUT THIS ALERT Access to article abstracts is open to all Alert recipients. Access to full-text articles is limited to subscribers who have activated their online access. Activate your online access to your subscriptions at (under elsevier):
@
the Lancet COVID-19 Resource Centre
@
Please add briefing@nature.com to your address book.
Enjoying this newsletter? You can use this form to recommend it* to a friend or colleague — thank you!
@
LitCovid is a curated literature hub for tracking up-to-date scientific information about the 2019 novel Coronavirus
@
Novel Coronavirus Information Center
Elsevier’s free health and medical research on the novel coronavirus (SARS-CoV-2) and COVID-19
@
COVID-19: Epidemiology, virology, and prevention
Hope I understand you correctly, dear Prof.
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Dear friends
There are a few theories on child development. I have always been interested in the teaching of Piaget but recently I thought alot about this subject since I became a father. My question is, which theory do you think best describes the development of a child and the developmental stages it goes trough. Your thoughts?
Best wishes Henrik
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Lawrence Kohlberg expanded on the earlier work of cognitive theorist Jean Piaget to explain the moral development of children, which he believed follows a series of stages. Kohlberg defined three levels of moral development: preconventional, conventional, and postconventional. Each level has two distinct stages.
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In the last years a lot of studies and meta-analyses have been published in music therapy. But in the light of the current "crisis of confidence" a lot of questions arose. Respecting the publication of Fanelli (D. Fanelli: „Positive“ Results Increase Down the Hierarchy of the Sciences. PLOS one. 2010, 5 (4) e10068.) one question is about the high rate of positive results in psychology, clinical medicine and psychiatry. Therefor our intention is to find studies with negative results in the field of music therapy. Help from the community would be great.
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Just some thoughts in case anyone else is still thinking about this.. it would be great to hear from anyone else who has observed negative wellbeing effects from music engagement.
I haven't seen much published data but I have heard of music therapy protocols that had to be abandoned early because it was quite clear that the participants were experiencing increased distress from the specific music. The music was created by a certified music therapist, but unfortunately was too direct in terms of the way it attempted to deal with the clinical issue and inadvertently made people feel worse. It was an unforeseen adverse effect, but unfortunately the appetite for reporting on this seems to be quite low.
I have also come across instances where music can trigger negative sensations for people with spinal cord injuries or damaged nerves. They can become physiologically over-sensitised to music and other sounds to the degree that it actually triggers painful sensations. Given that this is a physiological response it would occur regardless of whether the music was delivered by musicians or a music therapist. Typically individuals seem quite aware of the phenomenon themselves and often quickly decline from music intervention studies. This seems to be relatively rare, I have only seen it in clinical contexts, but have not seen systematic clinical evaluations on this. Nonetheless for this reason I always do safety checks now when I'm recruiting for music intervention studies and recommend that people discontinue listening if they feel any increases in discomfort.
I've also collected some data that indicates that people with musical anhedonia (people who do not experience pleasure as a result of music listening) do not appear to benefit to the same degree from music interventions as people who enjoy music. This would undermine the therapeutic benefits of music interventions, and should be considered and potentially controlled for in future research.
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What do you think are the most important psychological disorders associated with COVID-19?
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Los más comunes son depresión, estrés, miedo, ansiedad, desesperación, tristeza etc
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While I have many reads on a number of papers there are two I've written concerning the history of psychiatry and the LGBT commmunity whicxh are never read.* The topic is clearly represented in the title of the papers, yet, there are never any reads on either of these papers. Can anyone offer a possible explanation why this is so and a way to rectify this situation? Surely it can't be for lack of interest. Many thanks, Bill
*I have double checked to make sure these papers are part of my collected papers...
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His question starts from a premise that is not true, because what he says about "never reading two articles" is not true ... in fact I, although it is obvious that I am not a model of anything and for no one, I usually read more than one IF I SEEM INTERESTING and, in the same way, I have the immense fortune that they also read more than one article to me. Perhaps the "crux" of the matter lies in the interest of the articles in question, in that they are written in a pleasant way or not and, in short, that the Articles motivate potential readers to read them, since they are quite intelligent and selective and not masochistic.
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I suspect this may encourage relatively limited research into the importance of trauma- and stressor-related disorders.
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OF COURSE YES !!: In fact, the DSM -and the current DSM-5- catalog it as such; but the WHO International Classification of Diseases (ICD), currently the "11", TOO.
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What are the factors that predispose patients to treatment-resistant depression?
What are the advances that predict antidepressant treatment response for depression?
Two articles about prediction of antidepressant treatment response by using artificial intelligence technology and machine learning algorithms:
  • An electroencephalographic signature predicts antidepressant response in major depression (doi:10.1038/s41587-019-0397-3)
  • Brain regulation of emotional conflict predicts antidepressant treatment response for depression (doi:10.1038/s41562-019-0732-1)
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Because it depends on several causes:
-The type and intensity of such Depression
-The one that, in addition, there is also an Anxiety Chart (Mixed Depressive / Anxious Disorder)
-Whoever is male or female
-The type of Antidepressant used: An MAOI is not the same as a Tricyclic type, an SSRI or a Selective Serotonin and Noradrenaline Reuptake Inhibitor or Epinephrine (SSNRI)
-The one who receives a Combined Treatment with, in addition to Antidepressants, Psychotherapy, eminently Cognitive Behavioral.
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As often in medicine animals are ( SADLY) used in experiments .A new study of mice shows there are important links between human and mouse minds in how they function -- and malfunction. Researchers at Washington University School of Medicine in St. Louis devised a rigorous approach to study how hallucinations are produced in the brain, providing a promising entry point to the development of much-needed new therapies for schizophrenia.
The study that was published in the journal Science, lays out a way to probe the biological roots of a defining symptom of psychosis: hallucinations. The researchers trained people and mice to complete a computer-based task that induced them to hear imaginary sounds. By analyzing performance of the task, the researchers were able to objectively measure hallucination-like events in people and mice.
This approach allowed them to study the neural circuits underlying hallucinations, potentially fully opening up the study of mental illness to the kind of scientific studies that have been fruitful for diseases of other parts of the body. My concern is that despite the positives and even if there are similarities, can a study like this be of great value when it comes to humans who has a fundamentally different cognitive ability and brain structure? I agree that we can see tendencies and the study gives an insight, however can this ever fully be transferred to humans? also see other risks as well as grave ethical concerns that applies with all experiments on animals. What are your thoughts?
Best wishes
Henrik
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The comparative study of living organisms is standard laboratory practice, e.g. the knowledge transfer of animal experiments to humans. Concerning psychiatry, this may be the human medicine par excellence, and I personally (and methodically) doubt that, in this case, the results of veterinary medicine can be applied to humans successfully.
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There are multiple views ranging from inbuilt societal norms to not being seen as a lucrative field. How can the current scenario be changed and also made sure that medical graduates in India atleast have requisite competency to atleast manage patients? (in a country with 1 per 100000 psychiatrist)
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To make a medical graduate competent enough to diagnose common mental illnesses and provide appropriate treatment in countries like India, the undergraduate psychiatry curriculum need to be strengthened more. Following suggestions may be useful.
1. Making psychiatry an independent and compulsory subject in undergraduate medical examination (MBBS).
2.Increasing the psychiatric posting and adopting competency-based medical education to teach psychiatry to the medical graduates.
3.Internship training needs to be more organized and rigorous.
The following article may be useful:
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Hello and regards, our study investigates the relationship between latent toxoplasmosis and psychiatric and psychological mental disorders. It is part of my research (Ashkan Latifi, postgraduate student of psychology at University of Tehran- Iran) in partial fulfilment of the requirements of my master’s degree. By filling in this questionnaire, you have been of great help to me and to those with toxoplasmosis. In addition, by optionally sharing your email with me, you allow me to inform you of any possible toxoplasmosis-associated psychological/psychiatric problems in you under the supervision of two professors of University of Tehran (Dr. Abbas Rahiminezhad, psychologist and Dr. Reza Rostami, psychiatrist) for free. You can participate in this study if you have latent toxoplasmosis (other than congenital toxoplasmosis) and are at least 18 years old. The approximate response time to the questionnaire is ten to fifteen minutes. Thank you in advance for your participation in this research.
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Sorry i don't have
I am sorry
Best regards
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Just curious about knowing if some fellow researchers have had lived the same experience I do during research work.
At quite frequent period I am completely cognitively exhausted. At the point of not being able to work at all and being unable to even think about what is my research concepts.
It's quite terrifying since I cannot switch back to non exhausted mode. Trying to read any paper will take several hour and left me confused about if anything I read made sense.
Then I eventually go back to normal cognitive mode and can make up my mind.
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Not medical advice, but Ive been taking a choline supplement, paired with a racetam supplement, and it helps me. Worth a look imho.
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The triangular theory of love by Sternberg, characterises love in an interpersonal relationship using three different dimensions: intimacy, passion, and commitment.According to this theory different stages and types of love can be categorised by different combinations of these three elements. My question is this: does this model fully capture the essense of what we call love. Can love not also have other attributes, we can have feelings of love towards a person without having either commitment, passion or intimacy, some people are asexual for example and lack commitment, others such as teenagers lack the understanding of what love is. Do you agree with this theory or do you like me see problems associated with such a sharp division of element of human affects. Best wishes Henrik
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For a complete answer to this interesting question (without any desire for prominence or any petulance) you can read some of my contributions here in "RG", specifically the article "Desire and love: the unfinished man" in which the two "Triangular Models" on Love and ways to evaluate and measure them:
-That of John Lee, from the University of Toronto, which offers us a wide typology of the ways of loving, thus –based on a questionnaire to measure falling in love– has established three primary types of love that are quite independent from each other: - EROS , LUDUS and STORGE, Identifying three “pure” combinations of these primary types: MANIA, PRAGMA and AGAPE.
-And, above all, that of Sternberg in his "Triangular Theory of Love" that considers three primary components: INTIMACY, PASSION and COMMITMENT, one in each vertex of the triangle, thus giving rise to 7 possibilities: INTIMACY: Like, friendship and affection without commitment or passion. ROMANTIC LOVE: Intimacy plus passion, with feelings of proximity and outbursts of passion. PASSION: Love at first sight, fickleness, mental and physical excitement. FATUO OR FALSE LOVE: Passion plus commitment, lightning engagement and wedding before intimacy develops, which usually leads to failure- COMMITMENT: Decision that one loves another person without intimacy or passion, it is an empty love or of convenience. COMPANION LOVE: Commitment plus intimacy, it is a solid but not romantic friendship.
As expected, in real life all these elements are mixed, with COMPLETE or CONSUMED LOVE being the one that combines intimacy, passion and commitment, in the center of the triangle.
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It is well known that mammals like horses and dogs develop psychiatry conditions such as depression. What are the other mental health conditions do the animals develop?
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According to animal psychologists, animals can suffer from various mental disorders, though not in quite the same ways as humans. Apart from depression, they can develop other mental health conditions such as activity anorexia, thin sow syndrome, pica, OCD, addiction, stress, stereotypies, etc.
Have a look at this article: https://pubmed.ncbi.nlm.nih.gov/11199284/
PMID: 11199284
PMCID: PMC6709740
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"Psychiatry is in decline and is becoming obsolete, a victim of its own psychobabble and increasingly mind-numbing research, understandable to the elite few".
                                           Francis J Dunne , FRCPsych, Consultant Psychiatrist 
Psychiatry is arguably the least scientific, most dogmatic and most contentious of all medical disciplines.  Many argue it is not a medical discipline at all except, and most contentiously of all in the way it employs pharmaceutical interventions.
Is it time it was re-thought and reclassified? 
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Although Psychiatry is in decline, there is no doubt that it is indeed one of the most important field of medicine. A lot might not agree, as they do not understand the importance of psychiatry. The more the world is developing, the more mental illnesses and problems arise. It is a deep science on its own to understand how the human mind, brain, and reasoning function, in relation to how these affects our day to day lives.
Not every mental problem can be solved be sitting and rendering advice. Not every form of addiction, can be broken by strong will. A lot of these problems are deeper than they appear. This is when the help of a psychiatrist is needed. Imaging techniques, administration of medications and series of follow up sections are administered to patients to restore normalcy.
Instead of psychiatry to be reconsidered as a medical course; lots of efforts should be put into training the future psychiatrist to understand their calling in the medical field. By increasing the width and depth of knowledge administered concerning psychiatry and other related courses.
We should always remember that there is a difference between a Guidance and Counselling practitioner, a Psychologist, a Religious and a Psychiatrist.
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In the aftermath of the 1918 Spanish Flu pandemic there was a marked increase in incidence in psychological and psychiatric illness incidence. These conditions now often referred to generically as post-viral syndrome increased hospital admissions and treatment of mental health disorders in the years following the outbreak in 1918.
Population studies in countries that did not take part in World War One seem to indicate that the possible post war melancholy could be ruled out as a confounder as this increased incidence was seen in all countries affected by the flu that had been non-combattants in WW1.
Could there be a lasting and chronic element to all SARS type respiratory disorders?
SARS genome sequences have been detected in the brain of earlier SARS autopsies with LM, EM, and with real-time RT-PCR. The signals were confined to the cytoplasm of numerous neurons in the hypothalamus and cortex. Oedema and scattered red degeneration of the neurons was identified in the brains of 80% of the confirmed cases of SARS examined.
SARS viral sequences and pathologic changes have not been found in the brains of unconfirmed cases or control cases.
We may have a longer lasting health care problem that will affect those 'recovered' from Covid-19 for some years to come.
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Of course: YES !!. The Covid-19 coronavirus is neurotrophic, but -in addition- it is generating thousands of behavioral and psychopathological disorders due to the infinity of biopsychosocial problems that it is generating ... not to mention the so-called "pandemic fatigue" that the entire population is suffering. in general because of the "anti-Covid control" measures (confinements, border closures and perimeter closures of cities, time controls, curfews, etc.) that are influencing a lot and changing our lifestyles ... phobias are skyrocketing. , paranoid and catastrophic ideations, Post-Traumatic Stress Disorders -PTSD-, sleep problems and disorders, over-stress, anxiety, depression, pathological grief for the deceased, problems of schooling and socialization of children and a long etcetera (without going any further far, the Separations and Conflicts of Couple have increased in the West by 135%).
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Hi,
I am interested in semantic dementia and I am looking for database/repository of narrative speech transcripts of patients suffering from semantic dementia, or conversations with patients with semantic dementia.
I have found very short ones such as here
but I am looking for larger databases, whatever the language is
Thanks a lot,
Josselin Houenou (Mondor Univ. Hospital, Psychiatry Dept, Créteil, France)
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hi Josselin
NCBI database
If you want help, I am at your service
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Nearly 50,000 died of opioid overdose during 2018. What I want is, textbook or research paper that go deeper into these numbers and analyze them. Like, were all deaths attributed to overdose due to addiction or some of them were due to medication error, iatrogenic in other words? Maybe 1000 died due to iatrogenic opioid overdose? So, instead of listing 50,000, I want analysis, deep analysis of this number?
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Currently we have 8 psychiatrists, and 9 nurses. Referrals come from GP's/NP's for medication review, diagnosis request, or consultation. Problem is that some doc's want to follow with client and have had clients since 2007!
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