Psychiatry - Science topic

Hello,

I would love to receive some recommendations from experts in regards to the topic, whether there are valid findings in research on biological markers for anxiety disorders. I am trying to gain some stable insight and be able to argue in favor of the notion, that no anxiety disorder "comes from a malfunction/sickness of the brain".

Thank you in advance!

Best

Ivo

The relevance of the Microbiota-Gut-Brain axis to Alzheimer’s and neurodegenerative diseases needs extensive analysis. The various articles indicate that there are various questions with relevance to microbiota-gut-brain axis that are relevant to the pathology, pathogenesis and treatment of neurodegnerative diseases.Several mechanistic studies are required to determine the underlying mechanisms for effective and safe probiotic treatment for AD and probiotic benefits remain to determined. The relevance of gut dysbiosis may induce inflammatory responses that may be the cause of the induction of the pathogenesis of AD and relevance of diet (unhealthy diets), probiotics and gut microbiota should be carefully assessed. The meta-analysis studies indicate that probiotics reduce inflammation and oxidative stress and enhances cognition in AD and MCI individuals. The effects of different types of probiotics on amyloid formation and deposition needs to be evaluated and probiotic mixture therapy may be unsafe. The safety of probiotic therapy for AD patients require investigation with relevance to neuron reprogramming and programmed cell death in AD. The risk of unsafe microbiota and probiotic use may lead to the inactivation of the anti-aging gene Sirtuin 1 and the generation of uncontrolled short chain fatty acid release that promote amyloid beta plaque formation.

The concerns with relevance to the induction of dyslipidemia and the role of safety of diet-microbiota-brain axis should be carefully assessed with relevance to the cholesterol-AD connections. The prebiotic, symbiotic and probiotic formulations should be carefully assessed for bacterial composition and living microorganisms such as gram negative and positive. The release of bacterial lipopolysaccharides (LPS) from gram negative bacteria needs to be controlled and the content of gram negative bacteria carefully assessed in these prebiotic, symbiotic and probiotic formulations. Unhealthy diets contain end products such as LPS and diets should be carefully assessed for LPS contents since LPS has been associated with the inactivation of Sirtuin 1. The gut microbiota based therapy is in progress and the relevance to the treatment of brain diseases such as AD is limited. The benefits, limitations and safety of gut microbiota and probiotics on Alzheimer’s disease needs to be placed under systematic review with relevance to dietary regulation and postbiotic supplementation that have the implications for amyloidosis and neurodegeneration. The role of probiotic therapies to create a health gut environment by balancing bacterial populations may require the activation of the anti-aging gene Sirtuin 1 to reverse the pathogenesis of Alzheimer’s disease. The literature indicates that yogurt is a prime source for probiotics and provide a healthy balance of live bacteria to provide health benefits to individuals in various countries of the world. However a recent article indicates that within 12 hours yoghurt can grow gram negative bacteria. The gram negative bacteria in yoghurt depending on daily or weekly intake can generate high levels of plasma LPS with relevance to prebiotic, synbiotic and probiotic quality products and ill health. Yoghurt products may need to be assessed for gram negative bacteria populations and LPS to determine the quality control of these products for international communities.

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A. Marzban A, Rahmanian V, Marzban A, Ramezani Siakhulak F. The Role of Probiotics in Improving Alzheimer's Disease. JNFS. 2022; 7 (2) :136-138.

B. de Rijke TJ, Doting MHE, van Hemert S, De Deyn PP, van Munster BC, Harmsen HJM, Sommer IEC. A Systematic Review on the Effects of Different Types of Probiotics in Animal Alzheimer's Disease Studies. Front Psychiatry. 2022 Apr 27;13:879491.

C. Guo L, Xu J, Du Y, Wu W, Nie W, Zhang D, Luo Y, Lu H, Lei M, Xiao S, Liu J. Effects of gut microbiota and probiotics on Alzheimer's disease. Transl Neurosci. 2021 Dec 27;12(1):573-580.

D. Ji HF, Shen L. Probiotics as potential therapeutic options for Alzheimer's disease. Appl Microbiol Biotechnol. 2021 Oct;105(20):7721-7730.

E. D’Argenio V, Sarnataro D (2021) Probiotics, prebiotics and their role in Alzheimer’s disease. Neural Regen Res 16(9):1768-1769.

F. Bonfili L, Cuccioloni M, Gong C, Cecarini V, Spina M, Zheng Y, Angeletti M, Eleuteri AM. Gut microbiota modulation in Alzheimer's disease: Focus on lipid metabolism. Clin Nutr. 2022 Mar;41(3):698-708.

G. Naomi, R.; Embong, H.; Othman, F.; Ghazi, H.F.; Maruthey, N.; Bahari, H. Probiotics for Alzheimer’s Disease: A Systematic Review. Nutrients 2022, 14, 20.

H. Arora K, Green M, Prakash S. The Microbiome and Alzheimer's Disease: Potential and Limitations of Prebiotic, Synbiotic, and Probiotic Formulations. Front Bioeng Biotechnol. 2020 Dec 14;8:537847. doi: 10.3389/fbioe.2020.537847.

I. Peterson CT. Dysfunction of the Microbiota-Gut-Brain Axis in Neurodegenerative Disease: The Promise of Therapeutic Modulation With Prebiotics, Medicinal Herbs, Probiotics, and Synbiotics. J Evid Based Integr Med. 2020 Jan-Dec;25:2515690X20957225.

J. Kincaid HJ, Nagpal R, Yadav H. Diet-Microbiota-Brain Axis in Alzheimer's Disease. Ann Nutr Metab. 2021;77 Suppl 2:21-27. doi: 10.1159/000515700.

K. Alessio Vittorio Colombo Rebecca Katie Sadler Gemma Llovera Vikramjeet Singh Stefan Roth Steffanie Heindl Laura Sebastian Monasor Aswin Verhoeven Finn Peters Samira Parhizkar Frits Kamp Mercedes Gomez de Aguero Andrew J MacPherson Edith Winkler Jochen Herms Corinne Benakis Martin Dichgans Harald Steiner Martin Giera Christian Haass Sabina Tahirovic Arthur Liesz. (2021) Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition. eLife 10:e59826.

L. Anti-Aging Genes Improve Appetite Regulation and Reverse Cell Senescence and Apoptosis in Global Populations. Advances in Aging Research, 2016, 5, 9-26

M. Appetite Regulation and the Peripheral Sink Amyloid beta Clearance Pathway in Diabetes and Alzheimer’s Disease. Top 10 Commentaries in Alzheimer’s Disease (e-book). 2019;2:1-11. www.avidscience.com

N. Single Gene Inactivation with Implications to Diabetes and Multiple Organ Dysfunction Syndrome. J Clin Epigenet. Vol. 3 No. 3:24.

O. Sirtuin 1, a Diagnostic Protein Marker and its Relevance to Chronic Disease and Therapeutic Drug Interventions”. EC Pharmacology and Toxicology 6.4 (2018): 209-215.

P. Nutritional diets accelerate amyloid beta metabolism and prevent the induction of chronic diseases and Alzheimer’s disease. Photon ebooks. 2015.

Q. Wassenaar TM, Zimmermann K. Lipopolysaccharides in Food, Food Supplements, and Probiotics: Should We be Worried? Eur J Microbiol Immunol (Bp). 2018 Aug 21;8(3):63-69.

R. The Future of Genomic Medicine Involves the Maintenance of Sirtuin 1 in Global Populations. Int J Mol Biol . 2017. 2(1): 00013.

S. Bacterial Lipopolysaccharides and Neuron Toxicity in Neurodegenerative Diseases. Neurology Research and Surgery. 2018; 1(1): 1-3.

T. C.J. Hervert, N.H. Martin, K.J. Boor, M. Wiedmann. Survival and detection of coliforms, Enterobacteriaceae, and gram-negative bacteria in Greek yogurt, Journal of Dairy Science, Volume 100, Issue 2, 2017, Pages 950-960.

U. Fisberg M, Machado R. History of yogurt and current patterns of consumption. Nutr Rev. 2015 Aug;73 Suppl 1:4-7.

In which trimester i.e. 1st or 2nd or 3rd, the mean score was higher on Revised Pregnancy Distress Questionnaire (NuPDQ) 17 items, references to the previous researches ?

Corporal punishment, violent communication, humiliation...by parents and teachers.

Is International Journal of Psychiatry Research (ISSN 2641-4317, Impact Factor: 0.65) good journal?

Which are the most widely used rating scales for anxiety and depression in the setting of an outpatient psychiatry clinic?

Should I use HAM-A and HAM-D, or BAI and BDI?

Which would be most widely used in the UK? I'd be interested to know if preferences/recommendations are different elsewhere?

Also, would you recommend anything more specific for older adult patients?

COVID-19 is changing the social life of all people. Jumping out of the personal aspect, how does it affect the family as a whole.

Family is regarded as the fundamental structure of the society, will COVID-19 changes the future family structure, unit and model?

How is it affecting gender issues too?

Besides, why is domestic violence increasing? Is psychology and psychiatry playing a role?

reference:

[1] Campbell AM. An increasing risk of family violence during the Covid-19 pandemic: Strengthening community collaborations to save lives.

Forensic Science International: Reports vol. 2 (2020): 100089.

https://doi.org/10.1016/j.fsir.2020.100089

[2]COVID-19: Reducing the risk of infection might increase the risk of intimate partner violence

EClinicalMedicine

https://doi.org/10.1016/j.eclinm.2020.100348

[3]The pandemic paradox: The consequences of COVID‐19 on domestic violence

J Clin Nurs

Dear friends!

I hope you had a wonderful Christmas. Im very much interested in teaching and I would like to ask your views on a highly ( to me at least) interesting topic. There are probably as many methods of teaching methods as there are lecturers but here are a few types accepted in literature.

Which one do you use and why?

Best wishes Henrik

Are there any hospitals that are working on a multidisciplinary team approach for involuntary movements in the orofacial region such as oromandibular dystonia?

I mean, the multidisciplinary team approach is a collaboration between medical specialists (neurologists, neurosurgeons, psychiatrists, otolaryngologists) and dental specialists (dentists, oral surgeons, prosthodontists) for diagnosis and treatment.

My lab is looking for a reliable, valid measure of pain for our nonprofit-funded phase 1 clinical trial. We were originally considering the Brief Pain Inventory (BPI) but the paywall (~400) is a bit higher than anticipated. Has anyone had luck with other pain measures similar to the BPI but is either free or more budget-friendly? I did see the McGill Pain Questionnaire, but this appears to require a fee as well (still waiting to hear what that fee will be).

We are looking for a scale that reports both acute and more chronic pain, ideally including history of pain medication/treatment effectiveness. Hence, some of the scales that initially come to mind (e.g., visual analogue scale, numerical rating scale) don't seem like the best fit.

Any help would be appreciated, many thanks!

David

Hi. We have a case report manuscript that we are ready to submit for publication. Since it's a case report, there aren't many journals where to send it. We are between two journals: a traditional journal in the field that has an impact factor of 2.7, and a Frontiers journal with an impact factor of 4.2.

What do you think it's best in this case? To submit the manuscript to a lower-impact but traditional journal, or to a higher-impact but Frontiers journal?

Thanks for your suggestions!

Heroin abusers are associated with accelerated aging and neurodegenerative disease. The cellular effects of heroin is possibly linked to mitochondrial apoptosis. The risk of uncontrolled heroin consumption may lead to multiple organ disease syndrome and the risk of death. Heroin addicts have altered immune system and core body temperature defects that may lead to chronic disease. Heroin addicts may have an increase risk for stroke and intraparenchymal hemorrhage. The inactivation of the anti-aging gene Sirtuin 1 is associated with accelerated aging, stroke and neurodegenerative disease. Sirutin 1 is important to core body temperature and immune reactions that is linked to neurodegenerative disease. Heroin may inhibit Sirtuin 1 and accelerate mitochondrial apoptois with relevance to multiple organ disease syndrome. Sirtuin 1 regulates telomerase that is critical to biological aging. Exercise and mindfulness decompression therapy that can improve the social anxiety level of heroin withdrawal patients and may involve the activation of Sirtuin 1. Nutritional diets that activate Sirtuin 1 may be critical to prevent the accelerated aging and neurodegenerative disease in heroin abusers and addicts.

RELEVANT REFERENCES:

1. Gordon L.F. Cheng, Tatia M.C. Lee. Chapter 95 - Accelerated Aging in Heroin Abusers: Readdressing a Clinical Anecdote Using Telomerase and Neuroimaging. Neuropathology of Drug Addictions and Substance Misuse. 2016. Pages 1012-1022.

2. Cheng, G., Zeng, H., Leung, MK. et al. Heroin abuse accelerates biological aging: a novel insight from telomerase and brain imaging interaction. Transl Psychiatry 3, e260 (2013).

3. Zaki NG, Osman A, Moustafa H, Saad AH. Alterations of immune functions in heroin addicts. Egypt J Immunol. 2006;13(1):153-71.

4. Bola RA, Kiyatkin EA. Brain temperature effects of intravenous heroin: State dependency, environmental modulation, and the effects of dose. Neuropharmacology. 2017;126:271-280.

5. Eugene A. Kiyatkin, Roy A. Wise. Brain and Body Hyperthermia Associated with Heroin Self-Administration in Rats. Journal of Neuroscience 1 February 2002, 22 (3) 1072-1080.

6. Kovacs GG, Horvath MC, Majtenyi K, Lutz MI, Hurd YL, Keller E. Heroin abuse exaggerates age-related deposition of hyperphosphorylated tau and p62-positive inclusions. Neurobiol Aging. 2015;36(11):3100-3107.

7. Zhu M, Xu Y, Wang H, Shen Z, Xie Z, Chen F, Gao Y, Chen X, Zhang Y, Wu Q, Li X, Yu J, Luo H, Wang K. Heroin Abuse Results in Shifted RNA Expression to Neurodegenerative Diseases and Attenuation of TNFα Signaling Pathway. Sci Rep. 2018 Jun 18;8(1):9231.

8. Cunha-Oliveira T, Rego AC, Garrido J, Borges F, Macedo T, Oliveira CR. Street heroin induces mitochondrial dysfunction and apoptosis in rat cortical neurons. J Neurochem. 2007 Apr;101(2):543-54.

9. Intraparenchymal hemorrhage after heroin use. American Journal of Emergency Medicine. American Journal of Emergency Medicine 33 (2015) 1109.e3–1109.e4

10. Feng G, Luo Q, Guo E, et al. Multiple organ dysfunction syndrome, an unusual complication of heroin intoxication: a case report and review of literature. Int J Clin Exp Pathol. 2015;8(9):11826-11830.

11. Pu H, Wang X, Zhang J, et al. Cerebellar neuronal apoptosis in heroin-addicted rats and its molecular mechanism. Int J Clin Exp Pathol. 2015;8(7):8260-8267. Published 2015 Jul 1.

12. Anti-Aging Genes Improve Appetite Regulation and Reverse Cell Senescence and Apoptosis in Global Populations. Advances in Aging Research, 2016, 5, 9-26

13. Single Gene Inactivation with Implications to Diabetes and Multiple Organ Dysfunction Syndrome. J Clin Epigenet. (2017) Vol. 3 No. 3:24.

14. Regulation of Core Body Temperature and the Immune System Determines Species Longevity. Curr Updates Gerontol. (2017) 1: 6.1.

15. Early Diagnosis and Nutritional Treatment stabilizes Neuropsychiatric Disorders. Global Journal of Medical Research. 2018;1(1):1-7.

16. Palacios JA, Herranz D, De Bonis ML, Velasco S, Serrano M, Blasco MA. SIRT1 contributes to telomere maintenance and augments global homologous recombination. J Cell Biol. 2010 Dec 27;191(7):1299-313.

17. Nutrition Therapy Regulates Caffeine Metabolism with Relevance to NAFLD and Induction of Type 3 Diabetes. J Diabetes Metab Disord. 2017; 4: 019.

18. Sirtuin 1, a Diagnostic Protein Marker and its Relevance to Chronic Disease and Therapeutic Drug Interventions”. EC Pharmacology and Toxicology 6.4 (2018): 209-215.

19. The Global Obesity Epidemic is Related to Stroke, Dementia and Alzheimer’s disease. JSM Alzheimer’s Dis Related Dementia. 2014;1(2): 1010.

20. A Randomized Controlled Trial of Mindfulness Decompression Therapy and Aerobic Exercise in the Treatment of Social Anxiety in Heroin Addicts. Addiction Research and Adolescent Behaviour. 2021.

Would it harm if an MDD patient receives TMS sessions 6 days a week instead of 5?

On a different note, is it required for the patient to receive 5 sessions in a row, or a patient could have TMS sessions simply 5 days a week in any order. Thanking you in advance.

Any research paper or review that discuss pharmacological treatments for voice and speech disturbances that occur as a result of anxiety? For example stuttering, weak/trembling voice, etc.. as a result of anxiety? Any pharmacological that can address the vocal cords and breathing that can resolve this problem?

Hello,

This is clinical research in computational psychiatry involving the identification of biomarkers. I am thinking about Frontiers Computational Psychiatry, JAMA Psychiatry, and European Psychiatry. I would appreciate any other recommendations!

Many thanks,

Akshay Patel

There is a protective role of estradiol against fear overexpression during the recall of fear memories, but why are anxiety disorders more common in females?

In the current pandemic situation, it is not possible to completely avoid a psychiatric patient carrying COVID-19 or being directly symptomatic. In addition, medical priority is to help anyone. How is your psychiatric clinic prepared for this situation? What is the experience of Italian psychiatrists or psychiatrists from other countries of the world (China, European states?)

COVID-19 infection is currently superior to any mental disorder, but what is your management of an acute psychiatric patient with a positive epidemiological history or clinical symptoms? I am very curious about your opinions, comments and observations.

The drug vinpocetine is currently being promoted in Slovakia by certain pharmaceutical company for use in psychiatry. Vinpocetine has a rich history and is mainly used to improve cognitive function after vascular insults/pathology of brain. Does anyone have experience with it in the treatment of cognitive impairment within psychiatry, or in any other indication? Is there any strong clinical reason to resurrect this drug, so to speak? Does it make sense to give it for cognitive symptoms, e.g. in patients with affective disorders? Does it make sense to combine it with ginkgo biloba extract? What are your experiences?

I'm a community Pharmacist and I'm interested in writing, especially writing scientific papers. I'm offering my help and assistance in case you need a hand with your current research. My areas of interest: Pharmacotherapy, psychology, neurology, psychiatry. So send me a message in case you need help.

I guess there must be some data collected regarding Covid and related to the field of psychology/psychiatry, considering its psychological impact. It might be gathered from the patients, family members or the society at large, either a public or private collection. Does anybody have any idea on how to access such data for research purposes?

In the last years a lot of studies and meta-analyses have been published in music therapy. But in the light of the current "crisis of confidence" a lot of questions arose. Respecting the publication of Fanelli (D. Fanelli: „Positive“ Results Increase Down the Hierarchy of the Sciences. PLOS one. 2010, 5 (4) e10068.) one question is about the high rate of positive results in psychology, clinical medicine and psychiatry. Therefor our intention is to find studies with negative results in the field of music therapy. Help from the community would be great.

What do you think are the most important psychological disorders associated with COVID-19?

While I have many reads on a number of papers there are two I've written concerning the history of psychiatry and the LGBT commmunity whicxh are never read.* The topic is clearly represented in the title of the papers, yet, there are never any reads on either of these papers. Can anyone offer a possible explanation why this is so and a way to rectify this situation? Surely it can't be for lack of interest. Many thanks, Bill

*I have double checked to make sure these papers are part of my collected papers...

I suspect this may encourage relatively limited research into the importance of trauma- and stressor-related disorders.

What are the factors that predispose patients to treatment-resistant depression?

What are the advances that predict antidepressant treatment response for depression?

Two articles about prediction of antidepressant treatment response by using artificial intelligence technology and machine learning algorithms:

As often in medicine animals are ( SADLY) used in experiments .A new study of mice shows there are important links between human and mouse minds in how they function -- and malfunction. Researchers at Washington University School of Medicine in St. Louis devised a rigorous approach to study how hallucinations are produced in the brain, providing a promising entry point to the development of much-needed new therapies for schizophrenia.

The study that was published in the journal Science, lays out a way to probe the biological roots of a defining symptom of psychosis: hallucinations. The researchers trained people and mice to complete a computer-based task that induced them to hear imaginary sounds. By analyzing performance of the task, the researchers were able to objectively measure hallucination-like events in people and mice.

This approach allowed them to study the neural circuits underlying hallucinations, potentially fully opening up the study of mental illness to the kind of scientific studies that have been fruitful for diseases of other parts of the body. My concern is that despite the positives and even if there are similarities, can a study like this be of great value when it comes to humans who has a fundamentally different cognitive ability and brain structure? I agree that we can see tendencies and the study gives an insight, however can this ever fully be transferred to humans? also see other risks as well as grave ethical concerns that applies with all experiments on animals. What are your thoughts?

Best wishes

Henrik

There are multiple views ranging from inbuilt societal norms to not being seen as a lucrative field. How can the current scenario be changed and also made sure that medical graduates in India atleast have requisite competency to atleast manage patients? (in a country with 1 per 100000 psychiatrist)

Hello and regards, our study investigates the relationship between latent toxoplasmosis and psychiatric and psychological mental disorders. It is part of my research (Ashkan Latifi, postgraduate student of psychology at University of Tehran- Iran) in partial fulfilment of the requirements of my master’s degree. By filling in this questionnaire, you have been of great help to me and to those with toxoplasmosis. In addition, by optionally sharing your email with me, you allow me to inform you of any possible toxoplasmosis-associated psychological/psychiatric problems in you under the supervision of two professors of University of Tehran (Dr. Abbas Rahiminezhad, psychologist and Dr. Reza Rostami, psychiatrist) for free. You can participate in this study if you have latent toxoplasmosis (other than congenital toxoplasmosis) and are at least 18 years old. The approximate response time to the questionnaire is ten to fifteen minutes. Thank you in advance for your participation in this research.

Link to the questionnaire: https://docs.google.com/forms/d/1Qvu3J0MuXz56r1d1dZtpWBYHKUmXDByx_3eQ37LRsg0/viewform?edit_requested=true

Just curious about knowing if some fellow researchers have had lived the same experience I do during research work.

At quite frequent period I am completely cognitively exhausted. At the point of not being able to work at all and being unable to even think about what is my research concepts.

It's quite terrifying since I cannot switch back to non exhausted mode. Trying to read any paper will take several hour and left me confused about if anything I read made sense.

Then I eventually go back to normal cognitive mode and can make up my mind.

The triangular theory of love by Sternberg, characterises love in an interpersonal relationship using three different dimensions: intimacy, passion, and commitment.According to this theory different stages and types of love can be categorised by different combinations of these three elements. My question is this: does this model fully capture the essense of what we call love. Can love not also have other attributes, we can have feelings of love towards a person without having either commitment, passion or intimacy, some people are asexual for example and lack commitment, others such as teenagers lack the understanding of what love is. Do you agree with this theory or do you like me see problems associated with such a sharp division of element of human affects. Best wishes Henrik

Dear friends

There are a few theories on child development. I have always been interested in the teaching of Piaget but recently I thought alot about this subject since I became a father. My question is, which theory do you think best describes the development of a child and the developmental stages it goes trough. Your thoughts?

Best wishes Henrik

It is well known that mammals like horses and dogs develop psychiatry conditions such as depression. What are the other mental health conditions do the animals develop?

                                           Francis J Dunne , FRCPsych, Consultant Psychiatrist 

Psychiatry is arguably the least scientific, most dogmatic and most contentious of all medical disciplines.  Many argue it is not a medical discipline at all except, and most contentiously of all in the way it employs pharmaceutical interventions.

Is it time it was re-thought and reclassified? 

In the aftermath of the 1918 Spanish Flu pandemic there was a marked increase in incidence in psychological and psychiatric illness incidence. These conditions now often referred to generically as post-viral syndrome increased hospital admissions and treatment of mental health disorders in the years following the outbreak in 1918.

Population studies in countries that did not take part in World War One seem to indicate that the possible post war melancholy could be ruled out as a confounder as this increased incidence was seen in all countries affected by the flu that had been non-combattants in WW1.

Could there be a lasting and chronic element to all SARS type respiratory disorders?

SARS genome sequences have been detected in the brain of earlier SARS autopsies with LM, EM, and with real-time RT-PCR. The signals were confined to the cytoplasm of numerous neurons in the hypothalamus and cortex. Oedema and scattered red degeneration of the neurons was identified in the brains of 80% of the confirmed cases of SARS examined.

SARS viral sequences and pathologic changes have not been found in the brains of unconfirmed cases or control cases.

We may have a longer lasting health care problem that will affect those 'recovered' from Covid-19 for some years to come.

Hi,

I am interested in semantic dementia and I am looking for database/repository of narrative speech transcripts of patients suffering from semantic dementia, or conversations with patients with semantic dementia.

I have found very short ones such as here

but I am looking for larger databases, whatever the language is

Thanks a lot,

Josselin Houenou (Mondor Univ. Hospital, Psychiatry Dept, Créteil, France)

Nearly 50,000 died of opioid overdose during 2018. What I want is, textbook or research paper that go deeper into these numbers and analyze them. Like, were all deaths attributed to overdose due to addiction or some of them were due to medication error, iatrogenic in other words? Maybe 1000 died due to iatrogenic opioid overdose? So, instead of listing 50,000, I want analysis, deep analysis of this number?

Currently we have 8 psychiatrists, and 9 nurses. Referrals come from GP's/NP's for medication review, diagnosis request, or consultation. Problem is that some doc's want to follow with client and have had clients since 2007!

I am looking for a board certified psychiatrist with specialty in sleep medicine and addiction medicine? Any referrals?

As per the reports, the UK’s leading psychiatrist predicts impact will be felt for years after pandemic ends.

Are feelings of emptiness commonly experienced even within non-clinical populations? If so, are these experiences less salient due to a lack of personal awareness about the problem? Or, are people reluctant to disclose this feeling due to societal stigma?

In other words, is emptiness a major problem in modern society, and, if so, why is it so inconspicuous?

Hello

I am researching the appropriate cut-off point measurement for the five anxiety scales in cancer patients.

But I can not draw an overall Roc curve with SPSS for all scales.

How can I draw this curve like the example below?

I have a case report from psychiatry, which i want to publish. Kindly help me!

Dear Psychiatrist, what would be the mental condition of a normal person with positive COVD-19 when he is not taken admission in any hospital ?

Hello

Evidence suggest that technical knowledge and accessibility both for patient and therapist are essential to the effectiveness of tele-psychiatric treatment. The questions as I see it arises when discussing patient characteristics.

Do anyone have experience with what kind of patient characteristics modulates positive effects of web-based or tele-psychiatric treatment, particularly videoconferencing, for

patients with psychiatric diseases?

The literature regarding gender and the distribution of personality traits ( Big five personality traits model as a reference,; McCrae & Costa) are pretty clear. Women score higher on traits such as agreeableness and openness for example. There are some examples in the literature regarding why there is a difference between men and women in terms of personality traits. However how does sociological factors such as the influence asserted by the individuals belonging to social group, ethnic group, culture etc. Can we say that women across the spectrum are more agreeable or open and men are less agreeable according the the big five personality traits model (McCrae & Costa 1985 etc) or are there other markers that also influence out traits...can it be that in some cultures women are less agreeable than men for example or do you think the big five model and the distribution of traits in terms of a gender perspective is universal? Are there any identifiable research gaps in your view? Best wishes Henrik

Dear all,

I want to analayze the inattentiveness level in ADHD patients and compare the current score with the score of 6 months before now. I do not have any score of inattentiveness level of 6 months before now. If I ask the patient or the patients close relative to state or fill out a questionnare about inattentiveness level of 6 months before now( stating their behaviour of 6 months earlier), will the results be reliable? Will the comparison stay out of bias?

In your personal experience,How do you manage your life and make a balance between work, family and other related sections!?:)

I would be thrilled to have your points!

What is your take?

I often hear from friends negative things about academia, its boring, not connected to reality etc. I have been on and off in academia for 25 years but for the most part I have been in the real world, running businesses and working as a business consultant. I can still feel that in academia there is at least in my field a theoretical knowledge but still people doesn't understand how the real world operates. After university I felt like I knew everything, I knew Kotler backwards and forwards and all the theories..it felt like any way but when I started my first business (during my university years) I felt like I had to relearn everything. This lack of connection to reality was a problem for me and it is something I hear a lot for other business people. "Academics know nothing! ",one friend said and he has a Phd! Perhaps this illustrates the problem?

I guess it is the same in many fields..academia is seen as dry and not connected to the real world. What can be done about this or can anything be done? How do you view your education in relation to your working life? Do you feel your education was relevant? For me...not so much. Later I started to teach and do research but I still have this feeling. How do you feel about academia and the real world? Is academia part of the world we live in or just some "other place"..your thoughts?

Best wishes Henrik

The big five personality trait model ( McCrae & Costa) describes 5 bipolar dimensions of personality. The model received some criticism but is still generally accepted and perhaps it is the only descriptive model of personality that is "widely" accepted. What do you think are the strengths and weaknesses of this model? Is it complete or not? If not, what is missing?

Best wishes Henrik

Dear colleagues, as part of an underway systematic review into the efficacy of nicotine replacement therapy on levels of agitation among psychiatric inpatients, for completeness, co-authors and I are looking for recommendations of papers related to this topic. Any suggestions would be sincerely appreciated. Please see PROSPERO registration for further details; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=158871

Patient diagnosed with intractable major depression. Olanzapine treatment caused severe drug-induced Parkinsonian symptoms. Olanzapine discontinued 18 months ago and patient recovered from DIP. What alternative medication would you recommend?

I am a Brazilian psychiatrist with a master degree in preventive medicine. This year I will coordinate an academic ambulatory for medical students. I would like to teach deprescribing in psychiatry. The students are in the final year of medicine degree, and they will spend one month in this ambulatory. The ambulatory is part of a primary care setting which don’t have psychiatrists or other specialists. So, my major difficult is how to select patients? Which patients would benefit of this approach? Anyone has previous experience or suggestion??

Thank you!

Prudent prescribing of antimicrobial drugs to hospital inpatients may reduce the incidence of antimicrobial drug resistance and healthcare-associated infection. Despite strenuous efforts to control antimicrobial drug use and promote optimal prescribing, practitioners continue to prescribe excessively; it is estimated that up to 50% of antimicrobial drug use in hospitals is inappropriate. Antibiotics have several drug-drug interactions (DDIs) with psychotropic drugs (mainly antidepressants, antiepileptics, antipsychotics), which can lead to adverse events, treatment failure and significantly rise the costs of treatment. 

I'm currently trying to learn how to use network analysis, as this method of analysis is increasingly used in psychiatry and psychology research. But as the question suggests, I'm very much a frog in the well regarding this topic. When looking for sources online, most would suggest about "use WCGNA", "use r-package," "use bayesian program," or other similar measures.

However, if I look at a glance, most of the tools are mainly used for good visualization. As long as we can define centralized nodes, know the value of r for each two nodes, differentiating direct/indirect correlation, and draw the lines with thickness corresponding to r-value, we should be able to make network analysis without a program.

Is it wrong? Is there any good resources to learn from scratch?

Affective computing has the following main objectives: (i) to recognize human behaviors and emotions; and (ii) consider emotional aspects in the design of computer systems.

Several solutions using Machine Learning have been developed to recognize feelings and emotions and to predict mood disorders and mental problems, such as depression, anxiety, schizophrenia, bipolarity, among others. These solutions have used various social media, sensors, and even incorporated some methods of psychology.

Dear colleagues and other scholars,

I'm a psychiatry resident currently working on a review about BPSD management. However, one thing I haven't understood is: "Why is it that researcher and clinicians group BPSD as if it was a single entity?"

Given the varied symptoms of BPSD, is it logical to group it as a single syndrome just because it's happening along with dementia? Or does it have a well-established psychopathology to justify the grouping?

Does anyone have a good reference regarding this issue?

What does it even mean? Are you suffering from Empathy Deficit Disorder (EDD)?

COVID-19 has pull people apart from each other. Social distancing is the main way to prevent spreading of infection. Tele-medicine, once used for rural area remote healthcare model, is the emerging new way of practice under COVID-19.

Different specialties have different practicing needs, what difficulties do you encounter on applying tele-medicine under COVID-19 in your specialty? Will tele-medicine totally uproot the usual face-to-face room consultation of medical practitioners? And becoming the new service model?

What is your view?

Some references:

Virtually Perfect? Telemedicine for Covid-19

NEJM

DOI: 10.1056/NEJMp2003539

Covid-19 and Health Care’s Digital Revolution

NEJM

DOI: 10.1056/NEJMp2005835

Telemedicine in the Era of COVID-19

The Journal of Allergy and Clinical Immunology: In Practice

DOI: 10.1016/j.jaip.2020.03.008

Keep Calm and Log On: Telemedicine for COVID-19 Pandemic Response.

DOI: 10.12788/jhm.3419

‘Healing at a distance’—telemedicine and COVID-19

Public Money & Management

DOI: 10.1080/09540962.2020.1748855

The Role of Telehealth in Reducing the Mental Health Burden from COVID-19

Telemedicine and e-Health

DOI: 10.1089/tmj.2020.0068

In recent decades, the role of psychopharmacological treatment in psychiatry has become more and more central. Critical voices in this regard are increasing significantly

COVID-19 is in no doubt affecting every walks of life. Its impact towards every one and others' psychological and psychiatric health is significant, yet how should we quantify them?

Let's pull all related publications here for reference:

Understanding and Addressing Sources of Anxiety Among Health Care Professionals During the COVID-19 Pandemic

https://doi.org/10.1001/jama.2020.5893

The Mental Health Consequences of COVID-19 and Physical DistancingThe Need for Prevention and Early Intervention

https://doi.org/10.1001/jamainternmed.2020.1562

Under COVID-19, many human activities are suspended, public entertainment places are closed down. Football legends are almost fully cut off worldwide.

The targets for gambler to bet are less and less, no matter football, horse racing, boxing, bar ...

How do the psychiatric addictive gambler coping with their addiction under COVID-19?

In psychiatry, psycho therapy or behavioral modification is always used. Is COVID-19 helping these addictive gambler to run out of their obsession?

And more generally, would we expect anxious individuals to exhibit more or less prosocial behavior than their counterparts?

Adult ADHD is an organic neuropsychiatric disorder. Nearly 50 to 60 % of ADHD children suffer from Adult ADHD symptoms.

It is recently researched that prevalence of Adult ADHD is rising steeply.

Adult ADHD are a potentially significant threat to one and all. Because they are impulsive, unpredictable, unstoppable, mostly unaware of their mistakes or tendency of committing repeated errors and much more. They are very much accident prone due to fast driving tendency.

So I feel mist of the doctors other than psychiatrist ought to be aware of some details of Adult ADHD.

So floated this question to generate awareness.

Requesting all readers to give feedback or write their thoughts on the subject.

1. Does consciousness exist?

2. If so, what is Consciousness and what are its nature and mechanisms?

3. I personally think consciousness is the subjective [and metaphysical] being that (if exists) feels and experiences the cognitive procedures (at least the explicit ones). I think that at some ambiguous abstract and fuzzy border (on an inward metaphysical continuum), cognition ends and consciousness begins. Or maybe cognition does not end, but consciousness is added to it. I don't know if my opinion is correct. What are potential overlaps and differences between consciousness and cognition?

4. Do Freudian "Unconscious mind" or "Subconscious mind" [or their modern counterpart, the hidden observer] have a place in consciousness models? I personally believe these items as well are a part of that "subjective being" (which experiences cognitive procedures); therefore they as well are a part of consciousness. However, in this case we would have unconscious consciousness, which sounds (at least superficially) self-contradictory. But numerous practices indicate the existence of such more hidden layers to consciousness. What do you think about something like an "unconscious consciousness"?

5. What is the nature of Altered States of Consciousness?

Hamilton, M. A. X. (1959). The assessment of anxiety states by rating. British journal of medical psychology, 32(1), 50-55.

Hamilton, M. (1969). Diagnosis and rating of anxiety. Br J Psychiatry, 3(special issue), 76-79.

I would like to do research in the field of transdiagnostic psychiatry, specifically within the HiTOP framework. For that, I am looking for open-access datasets that include both clinical (e.g. PHQ-9) and non-clinical questionnaires (e.g. NEO-FFI, STAI-T). Does anyone know if there are any open-access datasets fitting my criteria?

Is anyone currently undertaking serious research into the psychological and group dynamic changes / damage which FGM may cause?

I know of one research finding

> Behrendt A, Moritz S. Posttraumatic stress disorder and memory problems after female genital mutilation. American Journal of Psychiatry 2005; 162:1000-1002

but there must surely be more recent work?

I'd like to learn about any / all such studies, anywhere, and am particularly interested in e.g. the ways FGM may itself alter responses to what might otherwise be effective interventions to bring this 'practice' to an end.

Many thanks,

Hilary

[hilary@hilaryburrage.com]

I need schizophrenic people's writings dataset for natural language processing, there are some work on social media contents through self disclosure ones, but I want clinical data in English.

Any help will be appreciated.

Due to the advancement in machine learning and it's application in psychiatry and clinical psychology, their is a need to understand the reliability of various programming software for predicting the prevalence of suicide and it's risk factors.

I was thinking on using the Zanarini Rating Scale for Borderline Personality Disorder (ZAN-BPD) but the self-report version has only 9 items (with dimensions being addressed with only 2 or 3 items) which is probably not methodologically appropriate. Any suggestions?

What do you think about so high accuracies reported in so many publications especially in medicine and psychiatry? Talking about overfitting and so frequent lack of internal and external validation, shouldn't we aim at some standardization prior to publication? It has a name: Unwarranted optimism in machine learning applications

Please share your thoughts about it.