Psoriasis - Science topic

Capsule Summary Generalised pustular psoriasis is one of the severe dermatological disorders. The use of biologics in psoriatic patients with end‐stage renal disease is rare, and the safety information on biologics treatment in such patients is limited. Here, we reported the first case of flare‐up in a generalised pustular psoriasis patient under h...

Nail-fold capillaroscopy (NFC) has emerged as a pivotal non-invasive imaging technique crucial for diagnosing and monitoring collagen vascular diseases and various related conditions. This review provides a comprehensive overview of NFC, encapsulating its historical evolution, principles, techniques, parameters for analysis, indications and clinica...

Since its first publication in 1998, the 5-item World Health Organization Well-being index, WHO-5, has become one of the most widely used questionnaires to assess subjective psychological well-being. To perform a systematic review of the WHO-5 questionnaire, with a focus on its use across various disease areas and patient populations. Studies repor...

Diaper area dermatitis encompasses a group of diseases with diverse etiologies and very similar clinical presentations, making their analysis sometimes complex. Among them is diaper psoriasis, a characteristic presentation in infants and young children. In this article, we conducted a review of the current literature available on diaper psoriasis,...

Chronotherapy, the science of administering treatments in synchrony with circadian rhythms, has emerged as a promising strategy to enhance therapeutic efficacy and minimize adverse effects. Circadian rhythms govern numerous physiological processes, including immune regulation, hormone secretion, and skin barrier function. In dermatology, the skin d...

Background Clinically coded long COVID cases in electronic health records are incomplete, despite reports of rising cases of long COVID. Aim To determine patient characteristics associated with clinically coded long COVID. Design & setting With the approval of NHS England, we conducted a cohort study using electronic health records within the Ope...

This summary-of-research article presents the findings of a post hoc analysis comparing immunogenicity across the VOLTAIRE trials program, originally published in BMJ Open. Adalimumab-adbm (Cyltezo®) is approved by the US Food and Drug Administration as an interchangeable biosimilar to the adalimumab reference product (RP; Humira®). In this analysi...

Psoriasis body surface area (BSA) of 10% or more has been a major criterion for determining systemic therapy eligibility. However, patients with BSA < 10% and even ≤ 3% may have high disease burden and difficulties accessing biologics. To assess psoriasis burden among patients with BSA ≤ 10%, this study characterized patient-reported outcomes (PROs...

Transplantation of adipose-derived mesenchymal stromal/stem cells (ASCs) has successfully alleviated the severity of psoriasis. Although several therapeutic mechanisms of mesenchymal stromal/stem cells (MSCs) for psoriasis have been elucidated using the imiquimod (IMQ)-induced psoriasis-like dermatitis model, the effects of MSC transplantation on p...

Using clinically relevant animal models, we have recently demonstrated that the anticonvulsant primidone (Liskantin ® ), approved by the FDA for the treatment of various forms of epilepsy, can effectively block RIPK1 enzymatic activity, which mediates cell death, and consequently prevent RIPK1 cytotoxicity and associated inflammatory responses. Bas...

This study was conducted to fulfill the FDA requirement for the designation of adalimumab-fkjp, an FDA-approved biosimilar, as an ‘interchangeable’ biosimilar to the reference adalimumab. The primary objective was to evaluate the interchangeability of adalimumab-fkjp (low concentration, 40 mg/0.8 mL) with reference adalimumab (high concentration, 4...

Background Tapinarof, a novel topical aryl hydrocarbon receptor (AhR) modulator, has demonstrated promising therapeutic efficacy in the treatment of plaque psoriasis. However, its comprehensive safety profile in real-world settings remains underexplored. Objective To assess the post-marketing safety of Tapinarof using data from the FDA Adverse Eve...

Spondyloarthritis refers to a group of inflammatory rheumatic diseases characterized by shared clinical features, such as inflammatory involvement of the axial skeleton, a specific pattern of peripheral joint involvement (usually asymmetric mono- or oligoarthritis, predominantly involving the lower extremities), enthesitis, and dactylitis. Common e...

Neutrophils are the first cells among the innate and adaptive immune cells, which quickly react to infections, injuries, and disease. Neutrophils have a wide range of antimicrobial proteins that are secreted from the cell through the NETosis process. Neutrophil extracellular traps (NETs) are intricate formations composed of chromatin decondensed an...

Background Patients' quality of life is greatly impacted by psoriasis, a prevalent chronic inflammatory skin condition that is frequently linked to a number of systemic disorders. Recent research shows that obesity is a major risk factor for psoriasis. Since Relative Fat Mass (RFM), an innovative way to measure obesity, offers a more precise estima...

Aim Only limited data is available on the benefit of brodalumab 210 mg, an IL-17 receptor A antagonist, on patient-reported outcomes (PROs) in different psoriasis severity groups under real-world-evidence (RWE) conditions. Methods LIBERO, a prospective, multicenter, 12- and 52-weeks (W) non-interventional study on brodalumab in adult patients with...

Patients with autoimmune diseases are susceptible to developing a second autoimmune disorder. Psoriasis, a common autoimmune disease, frequently occurs alongside other autoimmune conditions in some individuals. We report the case of a young female patient diagnosed with plaque psoriasis, initially treated with secukinumab, and achieved complete ski...

Psoriasis is a common inflammatory skin disease with a complex pathogenesis consisting of genetic factors, immune dysfunction and environmental background. In adults, psoriasis is strongly associated with a higher risk of developing metabolic abnormalities; however, data in children are inconclusive. Metabolic syndrome (MetS) is a group of conditio...

Linear psoriasiform eruptions in children are diagnostically challenging, particularly when they follow Blaschko’s lines. The main differential diagnosis includes inflammatory linear verrucous epidermal nevus (ILVEN) and linear psoriasis (LP), a rare mosaic variant. We describe the case of a 5-year-old boy with extensive unilateral lesions clinical...

Background: Psoriasis is a persistent, inflammatory skin condition characterized by distinct clinical and histological features. The disease is linked to systemic inflammation and immune system dysregulation. High Mobility Group Box 1 (HMGB1) is one of the innate immunity components that have been implicated in disease development and severity. Obj...

The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor involved in the regulation of many pathophysiological processes. Among these, immune system modulation, as well as regulation of skin homeostasis and inflammation, make it a promising target for psoriasis therapy. Tapinarof, an AhR agonist recently approved for psoriasis...

Background This study focuses on rare immune-mediated psoriasis induced by anti-PD-L1 drugs. Given that its clinical features have not been fully defined, the aim is to clarify the clinical manifestations, treatment, and outcomes of anti-PD-L1-induced psoriasis. Methods We performed a retrospective analysis of psoriasis cases induced by anti-PD-L1...

Psoriasis is a systemic immune‐mediated disorder involving multiple signalling pathways. Recent attempts to treat psoriasis involve monoclonal antibodies that block different inflammatory pathways. The monoclonal antibody Adalimumab (ADM) is one of the biologics that block the inflammatory cascade of TNF‐alpha. We previously demonstrated the involv...

Glucagon-like peptide 1 receptor agonists (GLP-1RAs) and dipeptidyl peptidase 4 inhibitors (DPP-4is) are well-established agents for type 2 diabetes mellitus (T2DM) management. Ongoing research has provided data on their both beneficial and adverse effects on the skin. For instance, GLP-1RAs have exhibited therapeutic benefits in psoriasis, while D...

Background Sexual health is fundamental to overall health and wellbeing. When a person has one or more immune–mediated inflammatory diseases (IMIDs), their sexual health may be undermined. Aim To investigate how intimacy and sexual health were affected in patients with IMIDs and to generate knowledge on their disease-related difficulties and their...

Dermatology diseases index fourth edition is first largest and most updated index of skin diseases in the world containing more than 5500 names ,and this index not just index so read to discover https://www.mediafire.com/folder/4sir5u7xu9rs2/Index New diseases in dermatology literature had been added in the last index edition june 2025👇👇 ✨sparke...

Protein kinase CK2 has emerged as a pivotal regulator of cellular processes involved in skin homeostasis, including cell proliferation, differentiation and inflammatory response regulation. In fact, CK2 activity dysregulation is implicated in the pathogenesis of different skin diseases, such as psoriasis, cancer and inflammatory dermatoses. CK2 ove...

Background Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) not only regulates cholesterol metabolism and cardiovascular disorder but also modifies inflammatory response and autoimmunity. Objective This study investigated the relation of PCSK9 to clinical features and treatment outcomes in psoriasis patients. Methods One hundred and five pso...

Objectives To investigate the prevalence of psoriasis in SLE using a Swedish regional cohort and a nationwide cohort from the National Patient Register (NPR). Furthermore, we compared clinical features between patients with and without comorbid psoriasis. Methods In total, 351 patients diagnosed with SLE based on the 1982 American College of Rheum...

Secukinumab has been widely applied in adults for the treatment of plaque psoriasis and psoriatic arthritis. However, there remains a knowledge gap in the dosing of secukinumab for pediatric patients with plaque psoriasis. This study aims to investigate the dosing regimen for pediatric patients aged 2 years and older. A physiologically based pharma...

Metformin, a well-established, first-line therapy for type 2 diabetes mellitus, is still gaining interest for its potential applications beyond glycaemic control. In addition to its insulin-sensitising effects, metformin exhibits anti-inflammatory, antioxidant, anti-proliferative, and immunomodulatory properties, rendering it a promising candidate...

Background Psoriatic disease (PsD) is a chronic immune-mediated condition with substantial humanistic burden. Despite guidelines emphasizing patient awareness for effective management, many individuals remain uninformed about its systemic nature and associated comorbidities. Aim This study assessed PsD patient awareness in the Gulf region using th...

Dermatology encompasses a broad range of conditions, ranging from single-gene disorders to common complex disorders characterised by polygenic risk factors like psoriasis and atopic dermatitis. For clinicians, understanding the genetic basis of these conditions is essential for accurate diagnosis, effective management, and appropriate genetic couns...

SARS-CoV-2 infection has been associated with increased autoimmune disease risk. Past studies have not aligned regarding the most prevalent autoimmune diseases after infection, however. Furthermore, the relationship between infection severity and new autoimmune disease risk has not been well examined. We used RECOVER’s electronic health record (EHR...

Introduction: Chronic dermatoses significantly affect patients’ lives, and global burden of skin diseases represents important public health challenge worldwide, with the phenomenon of a tendency towards increasing level of dermatological pathology.Methods: In the last two decades, there has been a significant breakthrough in improving methods and...

Psoriasis, a chronic inflammatory skin disease, poses significant diagnostic challenges due to its heterogeneous clinical manifestations and overlap with other dermatological conditions. The inconsistencies in diagnostic standards and variability in disease presentation further exacerbate the controversy surrounding the diagnosis of psoriasis. Rece...

Psoriasis is a chronic inflammatory skin disorder that is triggered by immune-mediated, genetic, and environmental factors. Moxifloxacin is a fluoroquinolone antibiotic with extended non-expected anti-inflammatory and immune-modulating effects. This study aims to investigate the possible influence of two different concentrations of moxifloxacin emu...

Epidermal keratinocytes are a major source of antimicrobial peptides and proteins. RNase 7 (R7) exhibits antimicrobial and immunomodulatory activities and is upregulated in the lesional skin of atopic dermatitis and psoriasis patients. Here, we performed mRNA microarray analysis to study the influence of R7 on gene expression in human keratinocytes...

Tryptophol (TOH) is an aromatic alcohol, a natural compound, which is produced by various microorganisms. TOH has been reported to have sleep-inducing effects, anti-microbial activities as well as immunoregulatory properties. While TOH was shown to suppress proinflammatory cytokine production in a variety of cell types, in vivo evidence supporting...

Nailfold videocapillaroscopy (NVC) is a non-invasive method for the visualization of nailfold capillaries. Recent advancements in imaging technology have enhanced the resolution and accuracy of capillaroscopic assessment, making nailfold capillaroscopy an essential tool for evaluating microvascular changes. Various alterations in the microcirculati...

Loss-of-function variants in MDA5, a key sensor of double-stranded RNA from viruses and retroelements, have been associated with protection from type 1 diabetes (T1D) in genome-wide association studies (GWAS). MDA5 loss-of-function variants have also been reported to increase the risk of inflammatory bowel disease (IBD). Whether these associations...

Purpose Epidermal growth factor receptor inhibitors (EGFRIs) and immune checkpoint inhibitors (ICIs) show promising efficacy in colorectal cancer and head and neck squamous cell carcinoma therapy, especially in combination. However, given the many cutaneous adverse effects (CAE) associated with each, there is concern for overlap and exacerbation of...

Achievement of stringent outcomes (e.g., ≥ 90% improvement from baseline in Eczema Area and Severity Index [EASI 90] or minimal-to-no itch on the Worst Pruritus Numerical Rating Scale [WP-NRS 0/1]) is associated with a substantial improvement in quality of life among patients with atopic dermatitis (AD). Using stringent outcomes, we evaluated the e...

Zusammenfassung Das klassische Anwendungsgebiet der Dermatoskopie ist die Unterscheidung und korrekte Klassifizierung unterschiedlicher gut- und bösartiger Hauttumoren (melanozytär und nichtmelanozytär). In der letzten Dekade sind zahlreiche weitere Indikationen hinzugekommen, sodass die Dermatoskopie mittlerweile auch regelhaft in der allgemeinen...

Background: awareness that psoriasis is more than 'skin deep' and that it has important systemic manifestations that are shared with other chronic inflammatory been looking for a reliable laboratory technique to evaluate the severity and progression of psoriasis for a very long time. The current clinical choice of method for determining the severit...

Objective To describe the psoriatic phenotype associated with psoriatic arthritis (PsA) Methods Based on the previously published PURE 4 validation study, this work aims to describe the sociodemographic and clinical characteristics, as well as the PURE-4 questionnaire outcomes, of psoriasis patients who completed the study. It compares those diagn...

Abstract: Artificial intelligence (AI) is rapidly transforming diagnostic approaches in different fields of medical sciences, demonstrating an emerging potential to revolutionize dermatopathology due to its capacity to process large amounts of data in the shortest possible time, both for diagnosis and research purposes. Different AI models have bee...

Studies evaluating the long-term comparative efficacy between biologic therapies for psoriatic arthritis (PsA) are scarce. Two biologic therapies, guselkumab and secukinumab, were evaluated up to 52 weeks in a mixed patient population (biologic-naïve and biologic-experienced patients). An unanchored matching-adjusted indirect comparison (MAIC) was...

Psoriasis is a chronic, inflammatory skin disease characterised by increased oxidative stress, the overproliferation of keratinocytes, the accumulation of inflammatory mediators, and a damaged skin barrier. Although a number of therapeutic options are available, well-tolerated and patient-friendly treatments over the long term remain a challenge. T...

Paradoxical psoriasis is a rare but increasingly recognized adverse effect of anti-TNF-α therapy, characterized by the onset or exacerbation of psoriatic lesions in patients treated for other immune-mediated conditions. We report the case of a 47-year-old woman with chronic plaque psoriasis who developed severe generalized pustular psoriasis (GPP)...

Psoriasis is an autoimmune disease in which hereditary and environmental factors play a key influence, with an estimated global prevalence of 2–5%. Furthermore, available treatment methods are linked to both an unflattering visual look and toxicities, resulting in poor patient compliance over time. The potential for nanotechnology-based drug delive...

Introducción. La psoriasis pediátrica tiene una prevalencia del 0,5 al 4,1 %. Es más frecuente en el sexo femenino y predomina su variante vulgar o en placa. Se ha relacionado con comorbilidades como la obesidad y el síndrome metabólico, e incluso, con antecedentes familiares de psoriasis.Objetivo. Describir las características epidemiológicas y cl...

Guselkumab, a selective interleukin-23 (IL-23) inhibitor, has emerged as a promising biologic therapy for the management of patients with moderate-to-severe Crohn’s disease (CD) and has been recently approved for its treatment. Unlike conventional therapies, guselkumab offers a different mechanism of action by selectively inhibiting IL-23, a key cy...

For patients with psoriasis, psoriatic arthritis can be a painful comorbid condition that is often undiagnosed. It is therefore essential that more research is done to understand which treatments for psoriasis relieve both dermatologic and joint symptoms. This analysis aimed to compare the effects of deucravacitinib vs. placebo or apremilast on joi...

Background Interleukin (IL)‐23p19 and IL‐17 inhibitors have demonstrated high efficacy for psoriasis in randomized controlled trials, though real‐world data, particularly for risankizumab (IL‐23p19 inhibitor) and brodalumab (IL‐17 receptor (IL‐17R) inhibitor), is limited. Objectives To assess drug survival of IL‐23p19 and IL‐17 inhibitors compared...

Background and Objectives: Psoriasis and atopic dermatitis (AD) are immune-mediated inflammatory diseases traditionally viewed as distinct. However, a subset of patients may present with overlapping features, leading to diagnostic and therapeutic challenges. This study aims to characterize the clinical, histopathological, and therapeutic features o...

Tralokinumab, a human IgG4 monoclonal antibody that inhibits the IL-13 pathway, is approved for the treatment of atopic dermatitis. However, real-world data are lacking and are needed to inform its efficacy and safety in broader populations. This retrospective study reviewed the Eczema Area and Severity Index (EASI) and Dermatology Life Quality Ind...

INTRODUÇÃO: As doenças dermatológicas afetam significativamente a qualidade de vida, impactando o bem-estar físico, emocional e social. Condições como psoríase e acne geram estigma, ansiedade e isolamento. É crucial adotar abordagens terapêuticas integradas, que incluam suporte psicológico e social. METODOLOGIA: Este estudo é uma revisão integrativ...

Tildrakizumab is an anti-interleukin-23 p19 monoclonal antibody approved in several countries to treat adult patients with moderate-to-severe plaque psoriasis who are candidates for phototherapy or systemic therapy. Limited data are available on tildrakizumab treatment patterns in clinical practice. The Canadian tildrakizumab patient support progra...

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder, which primarily affects the gut, but is not restricted to the intestinal tract. IBD is result of a complex interplay between a dysfunctional host immune response and environmental triggers. Extraintestinal manifestations (EIMs) are frequently observed in patients with IBD. The aim...

Psoriasis (Pso) and atopic dermatitis (AD) are chronic inflammatory skin diseases with distinct but also shared immunological features. Assessment of the feasibility of high content immunohistochemistry to identify distinct immune responses in skin biopsies from patients with chronic inflammatory skin diseases. While principal component analysis (P...

At the “Genetics and Physiology: Past, Present, Future” (IGPH2025) conference, Aidar Dairov — a researcher at the Stem Cell Laboratory of the National Center for Biotechnology and a second-year PhD student at L.N. Gumilyov Eurasian National University — presented a poster titled: “Study of the therapeutic effect of cytokine-preconditioned mesenchym...

A psoríase é uma doença inflamatória crônica da pele, de natureza autoimune e multifatorial, que compromete a qualidade de vida dos pacientes e exige abordagens terapêuticas cada vez mais eficazes. Com o avanço das terapias biológicas, o foco passou a ser o bloqueio seletivo de citocinas envolvidas na inflamação, especialmente a interleucina 17. O...

The Psoriasis Area and Severity Index (PASI) is widely used to evaluate psoriatic disease activity in clinical settings; however, its limitations hinder its practicality in routine use. The Simple-Measure for Assessing Psoriasis Severity (S-MAPA) has emerged as a promising tool addressing these limitations, providing a more feasible approach for as...

Nanotechnology is widely recognised as one of the most important advances in science from the last decades. Its numerous applications and rapidly expanding demand have led the way for innovative approaches to the synthesis of nanomaterials of higher quality. Green synthesis of silver nanoparticles (AgNPs) using the Dimor-phocalyx glabellus (Sny. Tr...

A psoríase é uma condição crônica que afeta não somente a pele, mas também a saúde mental e a qualidade de vida dos pacientes acometidos. Estudos têm demonstrado a relevância das intervenções psicológicas, como a Terapia Cognitivo-Comportamental (TCC) e práticas de mindfulness (atenção plena), no manejo da doença. Este trabalho visa revisar a liter...

Sirenomelia is a rare congenital malformation affecting multiple organ systems. The phenotypic feature is fusion of the lower extremities. We hereby present a case of sirenomelia diagnosed at an ultrasound at 12 weeks gestation. The pregnant nulliparous woman had a history of bypass surgery and a BMI of 46. The father was treated with methotrexate...

Methotrexate has a broad range of applications in various autoimmune and proliferative dermatological conditions, primarily in inflammatory dermatoses such as psoriasis. While its main mechanism of action involves cytotoxic effects via the folic acid cycle, it also stands out for its anti-inflam-matory and immunomodulatory properties by affecting t...

The study aimed to review preclinical studies of mesenchymal stem cells and their exosomes for psoriasis treatment and summarize their mechanisms of action.

This study aimed to review the literature on the prevalence, incidence, and gender- and age-related distribution of psoriasis across different countries and racial groups, with a particular focus on Kazakhstan, in order to identify gaps in epidemiology data.

Objective Individuals with psoriasis are related to a significantly increased risk of cardiovascular diseases (CVDs), the major cause of death among psoriasis patients. Prompt diagnosis and intervention of CVDs can effectively retard the progression of the disease. This study developed and validated the CVDs diagnostic prediction model for psoriasi...

The aim of this study is to evaluate the real-world safety of brodalumab by analyzing adverse events (AEs) associated with the drug. The AE reports related to brodalumab from the FAERS database from 2017 Q1 to 2023 Q4 were collected. Subsequently, we employed four disproportionality analysis methods to identify positive signals among AEs associated...

Psoriasis is a chronic inflammatory skin disease driven by complex epigenetic-immunological interactions. Although some immunological mechanisms have been characterized, the primary initiating factor of psoriasis remains elusive. The discovery of non-coding RNAs and their role as gene expression regulators has revealed their critical involvement in...

Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disorder known for its diverse clinical manifestations and potential for overlap with other connective tissue diseases. While overlap syndromes involving conditions such as rheumatoid arthritis (RA) and Sjögren’s syndrome (SS) are well established, the coexistence of SLE and pso...

Introdução: A psoríase é uma doença imuno-inflamatória crônica que afeta 3% da população mundial. Durante a gestação e lactação, tem um curso imprevisível e com relatos de agravamentos. Desse modo, imunobiológicos tornam-se opção terapêutica. Objetivo: Avaliar a segurança do uso de imunobiológicos para tratamento da psoríase em gestantes e lactante...

Psoriasis is a chronic immune-mediated disease with significant systemic implications. Tildrakizumab, an IL-23p19 inhibitor, has demonstrated efficacy in moderate-to-severe plaque psoriasis. Higher doses may be beneficial for patients with elevated body weight or greater disease burden. This study evaluates the effectiveness of tildrakizumab 200 mg...

Vulvar dermatological conditions, including lichen sclerosus, lichen planus, psoriasis, and eczema, often have autoimmune components influencing their pathophysiology and treatment responses. Patients with systemic autoimmune comorbidities frequently exhibit altered responses to standard therapies, suggesting a complex interplay between local and s...

The Rosaceae family, comprising over 3000 species, has been extensively investigated for its therapeutic potential, particularly in dermatological applications. Skin illnesses have become in recent years a serious burden worldwide, with more than 3 billion individuals of all ages affected by a skin condition. This review focuses on approximately 50...

Network meta-analysis (NMA) combines evidence from multiple trials comparing treatment options for the same condition. The method derives its name from a graphical representation of the data where nodes are treatments, and edges represent comparisons between treatments in trials. However, edges in this graph are limited to pairwise comparisons and...

Psoriasis, a chronic immune-mediated dermatological disorder, significantly impacts patients' quality of life, particularly in its moderate to severe forms. The advent of biologic therapies, specifically monoclonal antibodies (mAbs), has revolutionized the treatment landscape. This article provides an in-depth analysis of the efficacy, safety, and...

Psoriasis vulgaris and psoriatic arthritis are common diseases that can lead to considerable impairment of quality of life. The coexistence of alopecia universalis and psoriasis may suppose a therapeutic challenge. We report a 31‐year‐old female patient with alopecia universalis, psoriasis vulgaris and psoriatic arthritis. The patient exhibited a r...

Background Ixekizumab, a monoclonal antibody targeting IL-17A, is approved for psoriasis (PsO) and psoriatic arthritis (PsA). While clinical trials demonstrate its efficacy, real-world safety insights remain critical due to limitations in detecting rare or delayed adverse events (AEs). Methods This study analyzed 28,889 ixekizumab-associated AE re...