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This paper discusses the use of the terms symbols, symbolism, and symbolling in the archaeological literature. The lack of definition and any grounding in cognitive theory makes identifying prehistoric symbols and symbolling more art than science. A multiplicity of claims from the literature highlights the tendency to claim almost any form from any...
Article
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There have been multiple published phylogenetic analyses of platyrrhine primates (New World monkeys) using both morphological and molecular data, but relatively few that have integrated both types of data into a total evidence approach. Here, we present phylogenetic analyses of recent and fossil platyrrhines, based on a total evidence data set of 4...
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Sapajus libidinosus is a New World primate belonging to the Cebidae family that lives in the caatinga and cerrado, which are known Brazilian biomes. It is currently classified as near threatened, almost endangered, by the main animal protection organizations. Knowledge of biochemistry, the C-reactive protein, and the proteinogram are important for...
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Lumbar interbody fusion (IF) is a common procedure to obtain fusion of the spine by replacement of the intervertebral disc with a cage. Optimization of spinal cages is ongoing to reduce complications such as a pseudoarthrosis and subsidence of the cage. IF animal models (primate, dog, pig, goat and sheep) remain important to assess implant effectiv...
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Macroautophagy/autophagy initiated by STING1 (stimulator of interferon response cGAMP interactor 1) is actively involved in viral infection; and it is known that interferon-inducible guanylate-binding proteins (GBPs) exploit autophagy to defend the host against bacterial infection. Here we showed that in the tree shrew (Tupaia belangeri), a close r...
Chapter
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Theater sind Maschinen des Erscheinens. Und Theatermaschinen, die erscheinen lassen, verbergen sich selbst und bezeugen sich in ihren Effekten. Das teilen sie mit den Machinationen, wie Intrigen bis ins 19. Jahrhundert hießen. Sie widerstreiten dem Primat der dramatischen Handlung und ermöglichen in Verbindung mit Musik und anderen Illuminationen T...
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The current study was designed to predict why human primates often behave unfairly (equity aversion) by not exhibiting equity preference (the ability to equally distribute outcomes 1:1 among participants). Parallel to humans, besides inequity aversion, lab monkeys such as kin of long-tailed macaques (Macaca fascicularis) also demonstrate equity ave...
Article
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Humans and non-human primates can flexibly switch between different arbitrary mappings from sensation to action to solve a cognitive task. It has remained unknown how the brain implements such flexible sensory-motor mapping rules. Here, we uncovered a dynamic reconfiguration of task-specific correlated variability between sensory and motor brain re...
Preprint
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Non-human primates (NHPs) have become key for translational research in noninvasive brain stimulation (NIBS). However, in order to create comparable stimulation conditions to humans it is vital to evaluate and match electric fields across species. Numerical models to simulate electric fields are an important tool for experimental planning in NHPs a...
Article
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Vaccine hesitancy and the occurrence of elusive variants necessitate further treatment options for coronavirus disease 2019 (COVID-19). Accumulated evidence indicates that clinically used hypertensive drugs, angiotensin receptor blockers (ARBs), may benefit patients by mitigating disease severity and/or viral propagation. However, current clinical...
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An essential step in restricting HIV infectivity by the antiviral factor APOBEC3G is its incorporation into progeny virions via binding to HIV RNA. However, the mechanism of APOBEC3G capturing viral RNA is unknown. Here, we report crystal structures of a primate APOBEC3G bound to different types of RNAs, revealing that APOBEC3G specifically recogni...
Article
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In the new hierarchy of space created by the Greek Revolution, Nafplio acquired a prominent position and soon replaced Tripolitsa as the preeminent administrative center of the fledgling state. Declared by law as the seat of the administration in September 1823, Nafplio was a stronghold during the incessant infighting that characterized the Greek s...
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White-footed tamarin (Saguinus leucopus) is an endemic primate of Colombia. This species is under threat and categorized as vulnerable by International Union for Conservation of Nature (IUCN). This species has omnivorous habits consuming mainly soft fruits and insects. In this report, an event of predation by this primate on a chick of the American...
Article
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Finding sleeping sites is important for the fitness of many mammal species. Like most nonhuman primates, Madagascar's mouse lemurs (genus: Microcebus) are thought to exclusively use arboreal sleeping sites. The rufous mouse lemurs (Microcebus rufus) in Ranomafana National Park (southeastern Madagascar) have always been documented to sleep in either...
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Background The On–Off, or long flash, full field electroretinogram (ERG) separates retinal responses to flash onset and offset. Depending on degree of dark-adaptation and stimulus strength the On and Off ERG can be shaped by rod and cone photoreceptors and postreceptoral cells, including ON and OFF bipolar cells. Interspecies differences have been...
Article
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Viruses have evolved diverse mechanisms to antagonize host immunity such as direct inhibition and relocalization of cellular APOBEC3B (A3B) by the ribonucleotide reductase (RNR) of Epstein-Barr virus. Here, we investigate the mechanistic conservation and evolutionary origin of this innate immune counteraction strategy. First, we find that human gam...
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Introduction The microcephaly is a rare and severe disease probably under purifying selection due to the reduction of human brain-size. In contrast, the brain-size enlargement is most probably driven by positive selection, in light of this critical phenotypical innovation during primates and human evolution. Thus, microcephaly-related genes were ex...
Article
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Increased brain size in humans and other primates is hypothesized to confer cognitive benefits but brings costs associated with growing and maintaining energetically expensive neural tissue. Previous studies have argued that changes in either diet or levels of sociality led to shifts in brain size, but results were equivocal. Here we test these hyp...
Article
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The human vaginal microbiota has a central role in the regulation of the female reproductive tract (FRT) inflammation. Indeed, on one hand an optimal environment leading to a protection against sexually transmitted infections (STI) is associated with a high proportion of Lactobacillus spp. (eubiosis). On the other hand, a more diverse microbiota wi...
Article
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Interleukin-18 (IL-18) can effectively activate natural killer (NK) cells and induce large concentrations of interferon-γ (IFN-γ). In healthy humans, IL-18 binding protein (IL-18BP) can inhibit the binding of IL-18 to IL-18R and counteract the biological action of IL-18 due to its high concentration and high affinity, thus preventing the production...
Chapter
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Theater sind Maschinen des Erscheinens. Und Theatermaschinen, die erscheinen lassen, verbergen sich selbst und bezeugen sich in ihren Effekten. Das teilen sie mit den Machinationen, wie Intrigen bis ins 19. Jahrhundert hießen. Sie widerstreiten dem Primat der dramatischen Handlung und ermöglichen in Verbindung mit Musik und anderen Illuminationen T...
Article
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Some persistent infections provide a level of immunity that protects against reinfection with the same pathogen, a process referred to as concomitant immunity. To explore the phenomenon of concomitant immunity during Mycobacterium tuberculosis infection, we utilized HostSim, a previously published virtual host model of the immune response following...
Article
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Epilepsy has been extensively studied as a common neurological disease. Efforts have been made on rodent and other animal models to reveal the pathogenic mechanisms of epilepsy and develop new drugs for treatment. However, the features of current epilepsy models cannot fully mimic different types of epilepsy in humans, hence non-human primate model...
Article
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Background Non-B DNA conformations are molecular structures that do not follow the canonical DNA double helix. Mutagenetic instability in nuclear and mitochondrial DNA (mtDNA) genomes has been associated with simple non-B DNA conformations, as hairpins or more complex structures, as G-quadruplexes. One of these structures is Structure A, a cloverle...
Chapter
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Theater sind Maschinen des Erscheinens. Und Theatermaschinen, die erscheinen lassen, verbergen sich selbst und bezeugen sich in ihren Effekten. Das teilen sie mit den Machinationen, wie Intrigen bis ins 19. Jahrhundert hießen. Sie widerstreiten dem Primat der dramatischen Handlung und ermöglichen in Verbindung mit Musik und anderen Illuminationen T...
Chapter
Full-text available
Theater sind Maschinen des Erscheinens. Und Theatermaschinen, die erscheinen lassen, verbergen sich selbst und bezeugen sich in ihren Effekten. Das teilen sie mit den Machinationen, wie Intrigen bis ins 19. Jahrhundert hießen. Sie widerstreiten dem Primat der dramatischen Handlung und ermöglichen in Verbindung mit Musik und anderen Illuminationen T...
Article
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Comprehensive integration of structural and functional connectivity data is required to model brain functions accurately. While resources for studying the structural connectivity of non-human primate brains already exist, their integration with functional connectivity data has remained unavailable. Here we present a comprehensive resource that inte...
Chapter
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Theater sind Maschinen des Erscheinens. Und Theatermaschinen, die erscheinen lassen, verbergen sich selbst und bezeugen sich in ihren Effekten. Das teilen sie mit den Machinationen, wie Intrigen bis ins 19. Jahrhundert hießen. Sie widerstreiten dem Primat der dramatischen Handlung und ermöglichen in Verbindung mit Musik und anderen Illuminationen T...
Chapter
Full-text available
Theater sind Maschinen des Erscheinens. Und Theatermaschinen, die erscheinen lassen, verbergen sich selbst und bezeugen sich in ihren Effekten. Das teilen sie mit den Machinationen, wie Intrigen bis ins 19. Jahrhundert hießen. Sie widerstreiten dem Primat der dramatischen Handlung und ermöglichen in Verbindung mit Musik und anderen Illuminationen T...
Article
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The development of antiretroviral therapy (ART) has been effective in suppressing HIV replication. However, severe drug toxicities due to the therapy and its failure in targeting the integrated proviral genome have led to the introduction of a new paradigm of gene-based therapies. With its effective inhibition and high precision, clustered regularl...
Chapter
Full-text available
Theater sind Maschinen des Erscheinens. Und Theatermaschinen, die erscheinen lassen, verbergen sich selbst und bezeugen sich in ihren Effekten. Das teilen sie mit den Machinationen, wie Intrigen bis ins 19. Jahrhundert hießen. Sie widerstreiten dem Primat der dramatischen Handlung und ermöglichen in Verbindung mit Musik und anderen Illuminationen T...
Chapter
Full-text available
Theater sind Maschinen des Erscheinens. Und Theatermaschinen, die erscheinen lassen, verbergen sich selbst und bezeugen sich in ihren Effekten. Das teilen sie mit den Machinationen, wie Intrigen bis ins 19. Jahrhundert hießen. Sie widerstreiten dem Primat der dramatischen Handlung und ermöglichen in Verbindung mit Musik und anderen Illuminationen T...
Article
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Toxoplasma gondii infection in healthy animals is often asymptomatic. However, some species with little history of contact with the parasite, such as marsupials and New World primates, present high mortality rates after infection. Despite its potential conservation concern, T. gondii infection in insectivorous bats has received little attention, an...
Article
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It is technically challenging to generate large doses of regulatory T cells (Tregs) engineered to express a chimeric antigen receptor (CAR) in non-human primates (NHP). Here, we have optimized the manufacturing of CAR Tregs by stringent sorting of Tregs, stimulation by artificial antigen-presenting cells, transduction by simian tropic lentiviral ve...
Chapter
Full-text available
Theater sind Maschinen des Erscheinens. Und Theatermaschinen, die erscheinen lassen, verbergen sich selbst und bezeugen sich in ihren Effekten. Das teilen sie mit den Machinationen, wie Intrigen bis ins 19. Jahrhundert hießen. Sie widerstreiten dem Primat der dramatischen Handlung und ermöglichen in Verbindung mit Musik und anderen Illuminationen T...
Article
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Human longevity has increased dramatically during the past century. More than 20% of the 9 billion population of the world will exceed the age of 60 in 2050. Since the last three decades, some interventions and many preclinical studies have been found to show slowing aging and increasing the healthy lifespan of organisms from yeast, flies, rodents...
Article
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The evolution of human right-handedness has been intensively debated for decades. Manual lateralization patterns in non-human primates have the potential to elucidate evolutionary determinants of human handedness, but restricted species samples and inconsistent methodologies have so far limited comparative phylogenetic studies. By combining origina...
Chapter
Full-text available
Theater sind Maschinen des Erscheinens. Und Theatermaschinen, die erscheinen lassen, verbergen sich selbst und bezeugen sich in ihren Effekten. Das teilen sie mit den Machinationen, wie Intrigen bis ins 19. Jahrhundert hießen. Sie widerstreiten dem Primat der dramatischen Handlung und ermöglichen in Verbindung mit Musik und anderen Illuminationen T...
Article
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Laser-induced hypertension in nonhuman primates is used to mimic human glaucoma, the leading cause of irreversible blindness. In this protocol, we detail steps for laser-induced ocular hypertension in nonhuman primates by laser photocoagulation of the trabecular meshwork and subsequent intracameral injection. We further describe recording and evalu...
Article
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Purpose: To examine the ocular changes in accommodation, wavefront aberrations, and dynamic range of focus (DROF) after laser scleral microporation (LSM) for treating presbyopia. Methods: Four presbyopic aged cynomolgus macaques (>13 years; n = 8 eyes) were included. All eyes received LSM with erbium: yttrium-aluminum-garnet laser. Spherical equ...
Chapter
Full-text available
Theater sind Maschinen des Erscheinens. Und Theatermaschinen, die erscheinen lassen, verbergen sich selbst und bezeugen sich in ihren Effekten. Das teilen sie mit den Machinationen, wie Intrigen bis ins 19. Jahrhundert hießen. Sie widerstreiten dem Primat der dramatischen Handlung und ermöglichen in Verbindung mit Musik und anderen Illuminationen T...
Chapter
Full-text available
Theater sind Maschinen des Erscheinens. Und Theatermaschinen, die erscheinen lassen, verbergen sich selbst und bezeugen sich in ihren Effekten. Das teilen sie mit den Machinationen, wie Intrigen bis ins 19. Jahrhundert hießen. Sie widerstreiten dem Primat der dramatischen Handlung und ermöglichen in Verbindung mit Musik und anderen Illuminationen T...
Chapter
Full-text available
Theater sind Maschinen des Erscheinens. Und Theatermaschinen, die erscheinen lassen, verbergen sich selbst und bezeugen sich in ihren Effekten. Das teilen sie mit den Machinationen, wie Intrigen bis ins 19. Jahrhundert hießen. Sie widerstreiten dem Primat der dramatischen Handlung und ermöglichen in Verbindung mit Musik und anderen Illuminationen T...
Article
Full-text available
Second-generation COVID-19 vaccines could contribute to establish protective immunity against SARS-CoV-2 and its emerging variants. We developed COH04S1, a synthetic multiantigen modified vaccinia Ankara-based SARS-CoV-2 vaccine that co-expresses spike and nucleocapsid antigens. Here, we report COH04S1 vaccine efficacy in animal models. We demonstr...
Article
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Social gaze has received much attention in social cognition research in both human and non-human animals. Gaze following appears to be a central skill for acquiring social information, such as the location of food and predators, but can also draw attention to important social interactions, which in turn promotes the evolution of more complex socio-...
Chapter
Full-text available
Theater sind Maschinen des Erscheinens. Und Theatermaschinen, die erscheinen lassen, verbergen sich selbst und bezeugen sich in ihren Effekten. Das teilen sie mit den Machinationen, wie Intrigen bis ins 19. Jahrhundert hießen. Sie widerstreiten dem Primat der dramatischen Handlung und ermöglichen in Verbindung mit Musik und anderen Illuminationen T...
Article
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How human language evolved remains one of the most intriguing questions in science, and different approaches have been used to tackle this question. A recent hypothesis, the Interaction Engine Hypothesis, postulates that language was made possible through the special capacity for social interaction involving different social cognitive skills (e.g.,...
Chapter
Full-text available
Theater sind Maschinen des Erscheinens. Und Theatermaschinen, die erscheinen lassen, verbergen sich selbst und bezeugen sich in ihren Effekten. Das teilen sie mit den Machinationen, wie Intrigen bis ins 19. Jahrhundert hießen. Sie widerstreiten dem Primat der dramatischen Handlung und ermöglichen in Verbindung mit Musik und anderen Illuminationen T...
Article
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Close contacts of individuals with pulmonary tuberculosis are at risk for tuberculosis infection and the development of active tuberculosis. In current contact investigations, immunologic tests (the tuberculin skin test and interferon-gamma release assay) and chest X-ray examinations are used to dichotomize contacts with Mycobacterium tuberculosis...
Chapter
Full-text available
Theater sind Maschinen des Erscheinens. Und Theatermaschinen, die erscheinen lassen, verbergen sich selbst und bezeugen sich in ihren Effekten. Das teilen sie mit den Machinationen, wie Intrigen bis ins 19. Jahrhundert hießen. Sie widerstreiten dem Primat der dramatischen Handlung und ermöglichen in Verbindung mit Musik und anderen Illuminationen T...
Article
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Adjuvants enhance the magnitude and the durability of the immune response to vaccines. However, there is a paucity of comparative studies on the nature of the immune responses stimulated by leading adjuvant candidates. In this study, we compared five clinically relevant adjuvants in mice—alum, AS03 (a squalene-based adjuvant supplemented with α-toc...
Article
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Cases of parallel or recurrent gene fusions in evolution as well as in genetic disease and cancer are difficult to explain, because unlike point mutations, they can require the repetition of a similar configuration of multiple breakpoints rather than the repetition of a single point mutation. The used-together-fused-together hypothesis holds that g...
Article
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The "voice areas" in the superior temporal cortex have been identified in both humans and non-human primates as selective to conspecific vocalizations only (i.e., expressed by members of our own species), suggesting its old evolutionary roots across the primate lineage. With respect to non-human primate species, it remains unclear whether the liste...
Article
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Transplantation is an effective approach for treating end-stage organ failure. There has been a long-standing interest in xenotransplantation as a means of increasing the number of available organs. In the past decade, there has been tremendous progress in xenotransplantation accelerated by the development of rapid gene-editing tools and immunosupp...
Article
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Tití gris (Saguinus leucopus) es un primate endémico de Colombia, categorizado como vulnerable (VU) según la Unión Internacional para la Conservación de la Naturaleza (UICN). La especie posee hábitos omnívoros y se caracteriza por el consumo de frutos blandos e insectos. En esta nota, reportamos un evento de depredación de este primate sobre un pol...
Article
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Without clinical efficacy data, vaccine protective effect may be extrapolated from animals to humans using an immunologic marker that correlates with protection in animals. This immunobridging approach was used for the two-dose Ebola vaccine regimen Ad26.ZEBOV, MVA-BN-Filo. Ebola virus (EBOV) glycoprotein binding antibody data obtained from 764 vac...
Article
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Human monkeypox, caused by monkeypox virus, has spread unprecedentedly to more than 100 countries since May 2022. Here we summarized the epidemiology of monkeypox through a literature review and elucidated the risks and elimination strategies of this outbreak mainly based on the summarized epidemiology. We demonstrated that monkeypox virus became m...
Article
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In the early 1970s, urbanisation shifted towards counterurbanisation in most developed countries. In contrast, there is little evidence that developing countries will experience counterurbanisation due to the complexity of their historical, economic, and social conditions. To examine the transition process, Geyer and Kontuly (1993) introduced diffe...
Article
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One of the most distributed primate species in Gunung Palung National Park is the long-tailed monkey (Macaca fascicularis). This study aims to determine habitat characteristics, daily activities, use of habitat as a source of food by long-tailed monkeys, and potential use of habitat by long-tailed monkeys in Gunung Palung National Park as a source...
Article
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In 2017–2019, Brazil recorded its most severe outbreak of yellow fever due to the spread of the virus (YFV) in the country’s southeast. Here, we investigated mosquito fauna and the spatial distribution of species in a primatology center in the Atlantic Forest bioregion in Rio de Janeiro state to evaluate the risk of YFV transmission in distinct env...
Article
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The emergence of the novel henipavirus, Langya virus, received global attention earlier this month after the virus sickened over three dozen people in China. There is heightened concern henipaviruses as respiratory pathogens could spark another pandemic, most notably the deadly Nipah virus (NiV). NiV causes near annual outbreaks in Bangladesh and I...
Preprint
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Neutrophils are the most abundant cell type in airways of tuberculosis patients. Recent investigations reported induction of neutrophil extracellular traps (NETs) during Mycobacterium tuberculosis ( Mtb ) infection, however, the molecular regulation and impact of NETosis on Mtb pathogenesis is unknown. We find that in response to Mtb infection in n...
Article
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In recent years, the utility and efficiency of automated procedures for cognitive assessment in psychology and neuroscience have been demonstrated in non-human primates (NHP). This approach mimics conventional shaping principles of breaking down a final desired behavior into smaller components that can be trained in a staircase manner. When combine...
Article
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Retrotransposons are genetic elements with the ability to replicate in the genome using reverse transcriptase: they have been associated with the development of different biological structures, such as the Central Nervous System (CNS), and their high mutagenic potential has been linked to various diseases, including cancer and neurological disorder...
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Profiling of 5-hydroxymethylcytosine (5hmC) in the brain regions of rhesus monkey at different ages reveals accumulation and tissue-specific patterns of 5hmC with aging. Region-specific differentially hydroxymethylated regions (DhMRs) are involved in neuronal functions and signal transduction. These data suggest that 5hmC may be a key regulator of...
Preprint
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Working memory relies critically on the dorsolateral prefrontal cortex (dlPFC). Morphology and function of the dlPFC, and corresponding working memory performance, are affected early in the aging process. However, these effects are heterogeneous, with nearly half of aged individuals spared of working memory deficits. Translationally relevant model...
Article
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Ecosystems around the globe are facing irreversible impacts due to climate change, habitat destruction, hunting, and an ever‐increasing human population. Estimating densities of species across their geographical range helps us to understand natural variation and anthropogenic effects on species densities and to assess the effectiveness of existing...
Article
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Compared to other primates, humans are late bloomers, with exceptionally long childhood and adolescence. The extensive developmental period of humans is thought to facilitate the learning processes required for the growth and maturation of the complex human brain. During the first two and a half decades of life, the human brain is a construction si...
Article
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Sexual intercourse in the animal kingdom functions to enable reproduction. However, we now know that several species of non-human primates regularly engage in sex outside of the times when conception is possible. In addition, homosexual and immature sex are not as uncommon as were once believed. This suggests that sex also has important functions o...
Article
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Previous research on adaptive NK cells in rhesus macaques suffered from the lack of specific antibodies to differentiate between inhibitory CD94/NKG2A and stimulatory CD94/NKG2C heterodimeric receptors. Recently we reported an expansion of NKG2C receptor-encoding genes in rhesus macaques, but their expression and functional role on primary NK cells...
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The mitochondrial bc1 complex is a major source of mitochondrial superoxide. While bc1-generated superoxide plays a beneficial signaling role, excess production of superoxide lead to aging and degenerative diseases. The catalytic core of bc1 comprises three peptides -cytochrome b, Fe-S protein, and cytochrome c1. All three core peptides exhibit acc...
Article
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Tannins are a chemical defense mechanism of plants consumed by herbivores. Variations in salivary physicochemical characteristics such as pH, total protein concentration (TP), and presence of proline-rich proteins (PRPs) in animals have been reported as a mechanism to protect the oral cavity when consuming food with variations in pH and tannins. Va...
Article
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Evolution has honed predatory skills in the natural world where localizing and intercepting fast-moving prey is required. The current generation of robotic systems mimics these biological systems using deep learning. High-speed processing of the camera frames using convolutional neural networks (CNN) (frame pipeline) on such constrained aerial edge...
Article
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Tamarins, small Neotropical primates of the genera Saguinus and Leontocebus, have a mainly frugivorous-faunivorous diet. While consuming the pulp of a high diversity of fruit species, they also swallow seeds and void them intact, thus acting as seed dispersers. Here we compare different aspects of the seed dispersal ecology of tamarins with that of...
Preprint
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Chronic exposure to the Cyanobacteria biotoxin Beta-methylamino-L-alanine (BMAA) has been associated with development of a sporadic form of ALS called Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex (ALS/PDC), as observed within certain Indigenous populations of Guam and Japan. Studies in primate models and cell culture have supported t...
Article
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Aging is accompanied by a host of social and biological changes that correlate with behavior, cognitive health and susceptibility to neurodegenerative disease. To understand trajectories of brain aging in a primate, we generated a multiregion bulk (N = 527 samples) and single-nucleus (N = 24 samples) brain transcriptional dataset encompassing 15 br...
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