Science topic

Physiological Adaptation - Science topic

The non-genetic biological changes of an organism in response to challenges in its ENVIRONMENT.
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" In stark contrast to classical theory, the total heritable variance in a trait can be larger than the phenotypic variance in the trait, Var(TBV) > Var(P)..... In that case, a population contains a heritable variance which is greater than the observed phenotypic variance. Social interactions, therefore, result in hidden heritable variation ".( In book : Julius van der Werf et al. 2009 Adaptation and Fitness in Animal Populations - Page 116 )
Can Piter Bijama's sentence in the book be interpreted in this way: If in the formula heritability, genetic variance is greater than phenotypic variance, the heritability would be greater than one.!
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I agree with Rafat's view. I may add absence of sex linked effects, additive x additive interactions,epistasis and highly uniform prevalence of environmental interactions this minimising total phenotypic variance in the denominator ratio. Small SAMPLE SIZEstudied and unreliable standard error of h2 value are the major reasons for this situation to happen
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Hello everyone
Please, based on the research and experience you have gained, please answer the following question.
"What are the best modalities for low and high -both- physiological responses to resistance training in rats?"
Thank you
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There is no "best" modality. You have limited options. Weighted wheel running is probably your best option. In this setup, you use a rodent running wheel and resistance is provided by hanging a strap with weight over the wheel. The degree of resistance is controlled by the amount of weight hung from the strap. The more the weight, the greater the friction applied by the strap to the wheel. An alternative would be to use steep uphill running on a rodent treadmill. The exercise in both of these setups is not pure resistance training. They also provide an aerobic training component. Training effects will be primarily to the plantarflexor and knee extensor muscle groups.
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Adaptations correspond to physiological ranges (reaction norms, somatic adaptations). According to the theory of facilitated variation, such dynamic physiological restorations of the phenotype in response of variable environmental conditions are the outcome of genetic constraints (e.g. plasticity and robustness of developmental pathways). Therefore, when somatic adaptation occurs, exposing the phenotype to different selective conditions, physiological ranges can be "easily" shifted (i.e. their evolutionary shift is facilitated) by mutation, or genetic reassortments from the existing variability in the population (Baldwinian evolution). In other words, one of the key characteristics of adaptations would be their evolvability, or to say this with the words of Gould and Vrba (1982), "cooptability for fitness". Evolvability can thus be strongly conserved at the level of core molecular processes. Adaptations would then be selected to be both physiologically adaptable, i.e. to function in "a range of ways" in response to changed conditions ("dynamic restoration" or somatic adaptation), and to be evolvable. In other words, the "cooptability for fitness" would be under selection.
In my view, this idea implies that all adaptations at the organismal level should be partly selected to be "preaptations" (sensu Gould and Vrba 1982, Paleobiology), i.e. structures that retain the potential to enhance fitness (adaptive function) in variable conditions. Gould (2002, the structure of evolutionary theory) suggested that this selection should act at higher hierarchical level (species selection). However, the fact that adaptations that are selected in specific conditions are also selected to be physiologically modifiable, or to function in “a range of ways”, would make them likely to have fitness-increasing effects (aptations) that are not those they were selected for during their historical genesis, i.e. to become exaptations. Could this be a bet-hedging strategy also selected at organismal level?
That is, exaptations would also have a non-random origin (contra Gould & Vrba 1982), while this does not rule out the possibility of non-aptations as a possible source of exaptations. In this scenario, exaptations from nonaptations (spandrels s.s.) would be less frequent than exaptations from previous adaptations. Note also that the measurable adaptations are a subset of the extant ones, due to the overall scarcity of available historical data.
I will often modify my comments.
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Gianluca,
Thanks for the feedback. My comments below:
1. Pluralism in the MS just means acknowledging measured contributions of the main evolutionary forces: selection, drift, gene flow and mutation.
But there is no mention of mechanisms for the origin of mutation and their spread through populations without selection, drift, or gene flow.
2. Either a structure has an effect on the fitness of the organism, then being either maladaptive or adaptive, or it hasn't, thus being non(ad)aptive. In the latter case, it just does not have any function (neutral).
If you wish to define function that way.
3. Exaptations (shifts of function from either an adaptation or a nonaptation) are real stuff, not dreams.
Not so sure about that.
4. Gene duplications, pseudogenes and genetic shifts of functions are the results of historical events, not dreams.
Sure, but the dreaming comes in when people invoke ‘selective pressures’ or other such without any evidence.
5. Bird feathers are …the end result of a historical process made of contingencies and interactions between biological systems and environments:
true of anything (and anyway, a feature is really two feathers in one)
6. Gould ….. aimed to contrast adaptationism by reinforcing structuralist themes, which seems quite the opposite of what you're saying.
OK. Although I think he just further muddied the waters of Darwinian evolution. But that is just a personal opinion.
Cheers, John
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I would expect my negative control not to produce bands as there is no DNA to migrate towards the anode. However, the components of the negative control includes the loading which like DNA has a negative charge, will it not migrate towards the anodes producing bands as well?
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I agree,
DNA contamination in your negative control is the most reasonable justification. The reagents must be contaminated with DNA template (in such a case you must discard them) or maybe it was just a pippeting error. Think about what you did and fix it for next runs
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I will be assessing the production of carbon dioxide in Puff Adders, and am trying my best to avoid glass or plexiglass. Are there any suitable ones? Many of the papers I have read typically leave out the specific details of what their respirometer chambers were made from.
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See E. Don Stevens (1992) "Use of plastic materials in oxygen-measuring systems" in Journal of Applied Physiology
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Many athletes become injured early on in their introduction to a sport do to total immersion of the activities without the time needed to physiologically adapt to the stresses caused by the particular sport they have chosen to participate in. Bone remodeling is essential to the sport of running and many other sports that need structural reinforcement by the musculoskeletal system. Long term injuries can develop due to adverse events at an early age. Health/wellness is in a nurse's interest for their clients.
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Proper orientation and inculcation of self discipline into the athletes are of fundamental importance as these would help to check their level carefulness and
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Mesembryanthemum crystallinum is a prostrate succulent plant native to Africa, Sinai and southern Europe, and naturalized in North America, South America and Australia. I need the detailed internal processes behind the physiological adaptations seen in it.
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Physiological adaptation, due to its extreme stress tolerance, drought and high salinity resistance, and its ability to shift from C3 photosynthesis to CAM in response to environmental stresses or as part of its developmental programme. At present minor attention has been paid to elevated light and UV rays effects on ice plant metabolism and its adaptation. Young ice plants have been exposed to 5 W m -2 UV-B light (3 to 9 kJ m -2 d -1 UV-B BE ) for 10 – 30 min. On the next day leaves and roots have been collected, frozen and used for determination of total contents of osmolytes, chlorophyll, polyamines and free amino acid composition. A decrease in chlorophyll and net CO2 assimilation gave evidence that ice plant had high sensitivity to UV-B irradiation. The absence of proline in leaves accompanied with other modifications in free amino acids composition in both leaves and roots, the slight stimulation of polyamine biosynthesis as well as the lack of cadaverine in roots could be considered as indications for the damage of ice plants due to the poor metabolic adaptation to stress caused by UV-B irradiation.
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Overbreathing resulting in Hypocapnia - reduced carbon dioxide in the body and out breath - accompanies threat. When threat is prolonged it results in the individual moving beyond their tolerance or anxiety and resulting fight, flight or fold responses. 
Reducing CO2 tightens arterioles resulting in the shunting of blood into large arteries, enabling the flight response to proceed. Similar physiological mechanisms move blood supply away from the cerebral cortex to the deep mid-bearing areas controlling emotions.
These are adapted responses and accompanied - if threat is prolonged - by respiratory alkalosis (Henderson - Hasselbalcht equation) and via the Bohr Effect a reduction of available oxygen to tissues which affects limbic system regulation via autonomic, HPA, axis, immune, and neuro-peptide mechanisms.  
How robust and consistent has the effects of Hypocapnia been in preparing us to respond to threat? 
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Thanks Monique, I have also found the following references that support the hypothesis that in sustained anxiety and panic attack disorder breath regulation is disturbed before the somatic symptoms develop: 
Respiratory Dysregulation in Anxiety – Comprehensive Article by Frank H. Wilhelm of Stanford University Richard Gevirtz California School of Professional Psychology—San Diego and Walton T. Roth Professor ‘’Respiration is a key physiological system affecting a variety of physical processes that can act as a critical link between mind and body’’
Alicia Meuret and Co-Researchers show in their research and another U tube clip how at least an hour before the client experiences a panic attack the breathing style becomes over breathing with falling carbon dioxide levels. Treatment supported by this research showd that restoring carbon dioxide levels is an effective treatment.
Link: Out-of-the-blue panic attacks aren't without warning; data show ...
With good wishes, 
David 
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Looking to know how important it is to identify the dominant or non dominant leg in muscle biopsy and protein expression. Will appreciate very much your help and guide. Best Wishes.
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This is tough problem because to answer it one has to have the ability to do multiple sampling, i.e, take tissue from different muscles at distal or proximal levels for the limb considered dominant and its contralateral one. Alternatively, a non-invasive technique would need to be applied. In tennis players, selected areas of the ulna or radius in the dominant arm might have up to twice the Bone Mineral Content (BMC). This question could be answered thanks to DEXA or other non-invasive radiographic techniques. But for muscle protein is more challenging. - I think this is an interesting question that could be first approached in an animal model assuming limb dominance is found in experimental animals and such dominance is not mainly related to CNS neurological skill but rather and as in tennis players, to the structure or mass of the limb. Thus, multiple tissue sampling could be done as it is the gold standard technique and it could be compared to imaging and non-invasive techniques. 
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Interesting!
Do you think the difference in effect sizes between cross-sectional and longitudinal analyses may point to underlying adaptation processes?
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Sandra:
I think the reasons are complex, and likely there are several things going on at the same time.
Zapf, Dormann & Frese (1996) made a similar point to yours that people can adapt to stressors at work, suggesting that it can be helpful to study people newly hired into a job. But there are other things likely going on too. For example, correlations from cross-sectional self-report studies are sometimes higher than in longitudinal studies because of the possibility of shared biases due to occasion factors. Spector, Chen & O'Connell (2000) found evidence that mood at the time of the survey might affect responses. A third alternative is that the workplace is dynamic and stressors change. Thus measuring stressors and strains at the same time is a better indicator of their connection than measuring them over time because by the time you assess strains, the stressors have changed. But evidence for an accumulative effect over time comes from a recent meta-analysis by Ford et al. (2014) concerning lags in stress research. What they found is that the strength of relationships between stressors and strains is curvilinear, and that the peak is around 3 years.
Ford, M. T., Matthews, R. A., Wooldridge, J. D., Mishra, V., Kakar, U. M., & Strahan, S. R. (2014). How do occupational stressor-strain effects vary with time? A review and meta-analysis of the relevance of time lags in longitudinal studies. Work & Stress, 28(1), 9-30. doi: 10.1080/02678373.2013.877096
Spector, P. E., Chen, P. Y., & O'Connell, B. J. (2000). A longitudinal study of relations between job stressors and job strains while controlling for prior negative affectivity and strains. Journal of Applied Psychology, 85(2), 211-218. doi: http://dx.doi.org/10.1037/0021-9010.85.2.211
Zapf, D., Dormann, C., & Frese, M. (1996). Longitudinal studies in organizational stress research: A review of the literature with reference to methodological issues. Journal of Occupational Health Psychology, 1, 145-169.
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Not only vultures, ostriches and many other birds that live in hot habitats also have dark feathers. Considering their extremely hot habitat and there are not many objects with such a dark color, why do they have black feathers?
Black colors can absorb sunlight better than other colors so that it can increase body temperature (like in penguins). Besides that, it's hard to camouflage since black color is easily seen in their habitats, which mostly light-brown colored.
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This is actually a pretty old question in thermal biology. Another version of the problem is "why are beetles in the Namib desert black?" Most of the animal physiology textbooks should give substantial insight as a starting point. Withers (1992) "Comparative Animal Physiology" is my usual starting point.
Anyway, the crux of the thing is that black is a pretty good colour in both cold and hot environments, depending on the aim of the game. In the cold it's a very good colour for absorbing heat (hence basking in ectotherms is often facilitated by physiological darkening). The thing is, through, in hot conditions it's a very good colour to dump excess heat. Since black surfaces become so much warmer than the environment heat can easily transfer from the surface by convection or conduction. So the real question you're asking here is what's the evolutionary driver for the vultures in these hot environments? Are they aiming to absorb and retain heat, or are they aiming to dump it? And of course this depends on their altitude, because during high altitude soaring they probably want to retain heat, but at low altitude they probably want to dump it. Hence, for a vulture, black is probably the best colour they could be because they can play both ends off against the middle.
This is, of course, all my general speculation. If you read some general textbooks you should be able to see whether my broad understanding is correct. Also, if you read the paper attached by Dr Blount (and references therein) you'll get a more detailed understanding specific to birds, and of course the whole thing is flexible to the stressors of ecology and evolution, as suggested by Dr. Veroustraete. My caution here is that even a simple question like this often indicates complicated patterns, and that if you get trapped in to narrow a set of assumptions, such as "black is a good colour for cold environments" you can often miss powerful insights.
Anyway, I hope that helps. I've suddenly realised that this reads like a lecture, and I'm probably not qualified to give one. Cheers
Sean
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While recording skin temperatures from the medial anterior thigh/upper arm, increases in skin temperature were associated with orthostatic instability during LBNP exposure. How much pooled blood is needed to raise skin surface temperature by 0.5 degrees Celsius for example? Can you in fact determine venous pooling or vasomotor activity via skin temperature readings? Does anyone have any experience with this method? Is there a blood heat flux formula that anyone has used?
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It is difficult to measure venous return in man during action.Insufficient venous return is the main cause of inverse recovery among cotton textile workers in weaving room because of hundred percent humidity in the section because of process demand. Due to higher skin temperature and low venous return develops inverse recovery which causes occupational disease of cardiovascular system Increase skin temperature is not serious as long as core temperature is differ significantly.. PCG,CLI
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We know that an organism or species can adapt to environmental change or a novel environment. But this can happen due to one or a combination of several adaptive mechanisms. What are these mechanisms and what do we know them as? My current classification, based on reviewed literature, is genetics (evolution by natural selection), phenotypic plasticity, and behavioral adaptation.
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That's a great way of putting it Daniel. I think where I am making the distinction between natural selection, plasticity, behavior, epigenetics, etc, is the time-scale. Obviously natural selection will act at a rate consistent with population turnover, whereas plasticity can act in one or more instances in a single generation. Then in terms of behavior, a fish might cope with unfavorable conditions by physiological adaptation, through lowered metabolism or active avoidance of currents of excessive velocity or switching to different food sources. The latter might not require going through any long-term adaptive change that will significantly reflect on progeny or subsequent generations. It may just be a habitual change, that enables the organism to continue as it would in previous or alternate environments, assuming nothing else is placing a selective pressure on it.
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Dear Researchers,
I wish to know who the first in life.. whether male or female ?
I feel that males are adaptive form of females, where the males possess some of the female characters like chest and nipples. But how extend it can be evident that the males are adoptive form of females or vise-versa.
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There is a very simple answer to that: all embryos will develop into females - however - if TDF1 is expressed from the Y-chromosome, then a female embry will become a male embryo. There is plenty knowledge about this. TDF1 is "testicle determining factor 1". This transcription factor is driving all the male embryogenesis. Genetic males with defects in TDF1 will end with a complete female phenotype. Thus, man is not the adaptive form of woman, but a derivative.
with kind regards
Rolf
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I read some articles concerning the "Kamp activity", usually 7 or 10 days, with specific results. What about your experience?
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Adaptation levels on specific training:
1.) approximately 10 days, first improvments caused by better movement coordination and better technique without unnecessary movements
2.) aprox. 20 days, development of body energy systems, in endurance event great increase of glycogen storage, in power events hypertrophy of muscle fibers
3.) aprox. 30 days, better coordination and optimalization of human functional systems
4.) aprox. 40 days, structural changes in human body synchronization of human functional systems fully adaptation on specific training.
.... this is base model adaptation is a complex phenomenon it depend on type of specific training and intensity of training stimulus and so on....
.. so the answer is no, you can only improve technique and coordination there will be a small changes in body energy systems, but adaptation is possible after a longer period than 7-10 days.