Pharmaceutics and Pharmaceutical Technology - Science topic

Hallo all,

I would like to coat a tablet. I tried it with wax, which is dissolved in triglyceride, but the end product was too waxy! Could you pls give me suggestions?

Thanks in advance

Hallo,

I have a glucose syrup with sugar, I wann to mix them with heating up to 115 c. Then I have to cool it until 95 c and add another mix with stable temp. I use for that purpose a hot plate. My question is: how to control the temp of the mixture at 95 c during this process? Taking in our consideration that 95 c is the temp of the liquid not the surface of the hot plate.

Thanks in advance

Normally, a plant species need to have a scientific name as a prerequisite to be able to publish its newly discovered medicinal properties. However, in my situation, this specific plant has a common name widely known by the locals and lacks a scientific name. I'm curious if the publication of findings on an unidentified plant's medicinal properties is acceptable and justifiable?

I am a Ph.D. candidate at China Medical University. We are conducting a project to develop a methodological quality assessment tool for health economic evaluation alongside pragmatic clinical trials. We sincerely invite scholars who are interested in health economic evaluation to participate in this survey. Your insights and participation in this survey would be invaluable to this study. This survey does not take more than fifteen minutes of your time. If you would like to participate, please click on the link below: https://qualtricsxmyzlnhzhd5.qualtrics.com/jfe/form/SV_0BWiD2usi20hmui. This link will redirect to the Qualtrics platform. For questions, please contact me at 2022110055@cmu.edu.cn or songrm97@gmail.com. Thank you for your time and consideration. Song Ruomeng, Ph.D. candidate China Medical University, China

I am a newly hired microbiologist at a pharmaceutical factory that produces non-sterile drugs (cream, syrup, lotion). Since this is not my main specialty, I am learning some microbiology laboratory techniques by researching and experiencing, there is a subject I would like to consult.

I regularly analyze the purified water used in production, I use the membrane filtration method for this job. The problem is that I am not sure whether the media I use are suitable for this job, and the microbiology SOP files are missing on this subject, I need to update them.

As a result of my research in the relevant pharmacopoeias (EP, USP), I found that it is recommended to use R2A agar for microbiological analysis of purified water. However, I'm not sure that the contamination of purified water can only be measured with R2A agar, and even if I carried out this analysis with R2A alone, I don't know how to identify many microorganisms in one agar plate (E.coli, P. aeruginosa, S. aureus, Bacillus subtilis) that multiply afterwards. However, looking at the analysis notebook, the microbiologist hired before me used the following media to secure the job: TSA, SDA, MCA, MSA, CA, R2A. As it is known that except TSA and R2A, other agars are selective media for a specific type of bacteria, this approach seems correct, but is it normal to use so many media in practice? Can't this job be done with less?

Although this information is not given in detail in the pharmacopoeias. Apart from the information I gained, I also learned that each laboratory can create its own analysis method, but I don't have enough experience to create a method myself and I'm the only microbiologist in this factory. It would be very useful for me if microbiologists experienced in the pharmaceutical sector could give their valuable opinion on this subject, thank you.

https://www.igi-global.com/publish/call-for-papers/call-details/7275

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I have tried to dissolve the 0.286 gm indomethacin in 8 ml of Dmso [(100mM)] but it did not dissolve completely. I had put in a shaker overnight. then I incubated it at 75 C for 10 minutes and then sonicate for around 10 minutes but still, it did not dissolve.

and then i had disolve 71.56mg in 10 ml of ethyl alcohol [(20mM)] and still it did not disolve.

please suggest any idea????

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Hi Everyone

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Has anyone encountered a problem like this before? What procedures did you take to properly test the hypothesis? Any recommendation/advice is most welcome

Thank you :)

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Regards

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Hi,

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It is often required to use solid reagent for analytical analysis within their shelf-life period, however, some suppliers can't provide a specified expiry date (they provide sometimes only the release test date)?

my question then, is about how to process (set appropriate release test) in order to be conform to the quality of solid reagent?

A bacteria grew on macconkey, they were white and round colonies, oxidase negative, catalase positive, nonlactose fermenter but when I did gram staining it appeared as gram negative cocci sometimes in chains and others as a diplococci. It was isolated from xanthan gum powder used to manufacture drugs. Any idea what ir could be or what I can do to identify it?

Oh it also grew on Oxoids Brillance Salmonella agar forming pink colonies which also rules out salmonella the thing is that that agar has novobiocine and cefsulodine as antibiotics so that bacteria must be resistant to both at least at the concentrations in the agar, and the and gram staining gave the same result as the macconkey. Also before plating in both agars 10g of the xanthan gum were enriched on triptic soy broth for 24h at 37C

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Thank you

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Best wishes

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Hello everyone,

How can performed DOP test for return/exhaust HEPA filters in the clean room? Because it can not be done by scan method for the leak test.

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thanks.

Hello all 

I am working on drug molecule cilnidipine

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 i have tried following disso mediums but none of them show peak of my drug

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also can anyone tell me about authenticity of using methanolic buffer / solution as dissolution medium?

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Greetings

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I've been working on some lipid extraction analysis with QDa HPLC.

I start with some biological samples that are spiked with a different final concentrations of a lipid mix (consisted of few known lipids), thus to see what is the minimal concentration (and the recovery %) of the lipids that can be detected. In parallel, I use a freshly prepared calibration curve (0;0.5;1;2;4;6;8;10;20).

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Thanks in advance,

Margarita

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https://youtu.be/vl4sX8yYNC4

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Dear researchers,

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Best regards

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Thanks in advance!

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Hi All,

Thank you for all your support.

Thank you chandra mohan , Christian Janiesch and Ramin Sedaghat.

Looking for more published projects where students can get benefited by referring these documents.

Please share the docs directly into genotech.in@gmail.com or reply me here.

Regards,

Ranjan

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Our research project is the production of probiotic pills from native strains. What is the best method?...