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Patenting - Science topic

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I have been granted four patents so far. I wish to work on getting more and more patents. But I am getting any idea to go for it. I seek your help and suggestions to work on my next patentable idea. I will surely include your name, if I register your idea.
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If I have an idea for a patent I will get the patent myself. Why would I want to give it to someone I don't know?
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Hello everyone,
I'm currently facing a decision between patenting 'xyz' invention and publishing my findings in a research paper. Both options have their apparent advantages and disadvantages, and making the right choice seems crucial for my career and the dissemination of my work.
I would greatly appreciate it if you could share your experiences:
  • What factors did you consider when making a similar decision between patenting and publishing?
  • Can you share any personal experience or lessons learned from either patenting your invention or opting to publish your research article?
  • How has your choice impacted your professional trajectory or the advancement of your research?
  • Are there specific considerations in certain fields or industries that one should be aware of when making this decision?
Your responses would be very helpful to me. Thank you in advance for your kind responses.
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It depends what you want to do with the invention.
Publishing before you have a patent can create prior art, that makes it challenging to secure a patent. Working with a Patent Agent can help you identify if your invention is novel, and non-obvious.
Publishing your work can help to ensure others do not patent something that might prevent you from using your work if a future patent is filed on the invention.
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If we design proteins like tetrabody or triabody with unique binding sites in silico without further wet lab validation can we patent that structure and procedure?
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This is something that should be discussed with a patent attorney or agent in the specific jurisdiction which you aim to submit the patent. An article that covers the particulars of protein sequences and patents can be found in link [1].
Also, even if the sequence is not patentable, its process of "construction" may be and the particular tools could also be patentable, if they are unique, novel and non obvious.
Reference:
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Please will you send me links to anything you have come across that relates to the questions of : (i) can/should AI-derived work be IPR protected? and
(ii) can/should an AI be seen as creative to the extent that IPR come into play?
Yes, DABUS, but I haven't seen everything over DABUS, so please send it (preferably downloadable).
(iii) there are Masters and PhD theses, and publications thereof out there - please send them in.
I take IPR and patentability seriously - look at my publications. This is a request for help to find more , not a Masters' student's request that you do her work for her. If, like a certain German PhD student, you have finished, but not yet submitted, just tell me and I will keep YOUR insights private until you publish.
My name is Julian Cockbain, and for the last two decades my primary concern has been 'just what should the state protect, if anything, in relation to immaterial 'things''?
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My view is that, at this point in the evolution of AI and machine learning, the derivative work is not patent eligible. if you take a look at my argument in [1]. The main point in the article is that currently, at most, AI could get a non obviousness rejection since the work can be traced to a recombination of existing elements. I build up my argument from a mathematical viewpoint and the implications for a challenge to AI inventiveness would have to be resolved by providing evidence through a discovery process. The discovery would revolve around providing further support of creativeness and autonomy.
If you want to, you can message me and we can discuss it in-depth.
References
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We are working on an automatic self-tracking solar panel (it's patentable work). If anyone is interested in collaborating, please let me know.
NB: Image added for reachability, it's not the real work.
#patent #patents #research #solarenergy #solarpv #self #tracking #trackingsystems #trackingsolutions #trackingsolutions
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Can you explain how the collaboration will be organized and carried out.
For example, if one has a design then one can send you the design where you review it, implement it and test it and give feed back to the designer such that one finally get a professional two axis tracking system.
Then the design will be patented in common with you at your university.
What is the period of this project?
Are you working also on new encapsulation technologies for solar panels?
Please inform me as I have interest in such collaboration.
Best wishes
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What are challenges to patent a research work?
Exactly what points consider before patenting?
- Criteria, Eligible to Patenting or No?
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the first questions to make is why get a patent? Is there a commercial application for the work? Where is the commercial venture going to succeed in terms of geographical region?
After that the next question to answer is on whether the work qualifies for a patent.This varies from jurisdiction to jurisdiction so where is the commercial venture going to succeed answer is imperative.
For example in the US jurisdiction the criteria that it needs to be an invention and not a natural process is essential. Has this invention been used, described anywhere in the world? Have you searched exhaustively to determine this originality?
After you answer these questions positively towards establishing that you have a unique invention then you can proceed with considering a patent. I strongly suggest that you contact an IP professional at this stage to get further advise.
Note: I noticed that you are a research associate at a Sant Gadge Baba Amravati University. Please make sure that you check with the University's technology transfer office on proper procedure if conducted during the normal course of your work.
Hope this helps
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Can a published research work be patented?
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Yes
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Please suggest some papers/reports on the changes in the policy with respect to patenting of computer software in India. Does it have any implications as to why the IT services companies (mostly MNCs) are mainly patenting only at the USPTO?
Why are foreign MNCs keen on doing R&D in computer software in India?
Please suggest papers that discuss Patent Policies in the Indian IT Services Industry.
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Most patent investment strategies depend on the possible market returns for the investment. The U.S. is one of the main consumers of technology so it is strategically advantageous to invest in patenting in the US. The second and third are Japan and the EU making it the patent triangle.
India is a source of talent and therefore it is also strategically advantageous to do the R&D there.
Hope this helps
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What does mean of this sentence (plants produce bioactive compounds of new or known structure which can be used as model compounds for semi-synthesis to synthesis patentable entities of higher activity and/or lower toxicity?
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Simply, it means, all kind of plants produce certain chemical compounds, which have a biological activity may it be not yet observed or already had been observed their chemical structure. After extracting one of them from the plant, researchers may change their structure by a chemical modification and obtain new compound which may have different biological activity than the initial one. In that case new compound is called semi-synthesized compound, which based obtained on the modification of natural compound. The compound may be object for protecting of intellectual property if it is not yet known for scientific society. The modification is used for reducing side effects (including toxicity) of known biological active compound or increasing its specific activity. In both cases, usually, the index of effectiveness of the biological active compound is increased.
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Patenting an work or Idea
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Dear Professor Hudedmani,
The Patents Act, 1970 is the main legislation about intellectual property of India. The Chapter II of this Act prohibits patenting ideas, as can be seen from the fact that the law provides that they aren't patentable "the mere discovery of a scientific principle or the formulation of an abstract theory (...)".
More informations see: http://www.ipindia.nic.in/
I added the text of the Patents Act, 1970.
Best regards,
Professor Thiago Pires
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Dear colleagues, currently I run an academic project dealing with rational discovery of novel antagonists of one of the GPCRs. I performed a hierarchical virtual screening of few libraries (some comprising natural compounds, others - synthetic), and selected few dozens for the evaluation in a cell-based system. In the tests, some compounds showed promising results, and now I am wondering how can I check the newness/patentability of their molecular scaffolds. Have no idea where to start. Are there any specific services for these? Or maybe you can suggest some helpful literature on this topic?
Thanks for any suggestions!
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You can use Chemical Abstract Services like Scifinder, Reaxys, STN on the web, SPRESI (Scientific Chemical Databases) and many more. Chemical Abstract Services keep track of all synthesized compounds.
Ofcourse, there are other online tools also like Chemspider, E-molecule, Chemexpert, Pub chem compound and many more.
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I want to find out the difference between inventorship and authorship and at what level is a technical solution to a problem patentable.
Dose the procedure of obtaining a patent differ in countries?
Am primarily interested in the standard procedures involved not necessarily the steps in the commercial benefit from the invention.
You sincere response would be highly appreciated.
Thanks
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In brief, A patent gives its owner some rights, while the inventor, is not necessarily the owner of a patent.
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In which cases is it better to deal with national authorities and on the other hand, in which cases is it more suitable to fill the regional priority patent application.
What is your opinion about this patent strategy?
I would really appreciate your experiences worldwide.
Thanks!
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Thank you for sharing your experience with the USPTO, EPO, WIPO and EPO. I can only confirm this view based on my own experience.
However, I do not think my previous approach was non-business. On the contrary, if I have a great invention and I need strong protection in many countries, I have a lot of possibilities to achieve it. The timing of entry into the national and / or regional phases is quite important and should be in line with the business affiliation to which the application relates.
One option is to submit a national priority application and then you have 12 months to decide where to go. If you need more time for decision-making, you can use the PCT filing application where you can extend this time to enter the national phases for 30 months from the priority date. Another option is to enter directly into the national phases where I am applying for protection during the twelve months. Alternatively, enter the EPO, successfully terminate the procedure and then only validate in the EPC member countries.
The cost of such a patent procedure is difficult to predict and varies according to the number of countries in which protection is sought, and also by authorities you are trying to achieve it.
In this case, I think that, in order to save money during patent proceedings with national and regional authorities, it is advisable to think about where I can get a positive and quality preliminary survey. As a result, it can simplify further patent proceedings and thus reduce the costs of both the patent attorney and the utility fees.
In this way, patent agents should provide their services.
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Universities and other public research organizations are increasingly protecting their inventions – from genetic inventions to software – helping raise additional funding for research and spurring new start ups. The rise in university patenting has occurred against a broader policy framework aimed at fostering a greater interaction between public research and industry in order to increase the social and private returns from public support to R&D. The general strengthening of intellectual property protection world-wide as well as the passage of legislation aimed at improving technology transfer are additional factors that have facilitated the expansion of patenting in academia in OECD countries.
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Dear Usharani,
thanks for your remark. Not many scientists are used to report the potential invention in time before they plan to publish it. The dire fact is that most of the time the space left for the TTO to prepare a patent application before the thing gets published is rather limited. The resulting patent application may then not be optimal from the point of view of coverage and potential future follow up patents.
As I mentioned previously, you are free to file with a Patent and Trademark office of your choice, including the USPTO. The US Provisional Application might give you the necessary wiggle space to prepare well thought through filing later and still have your fling date before publishing the research.
And yes, good patent is as good as a good paper, thus might be used to document your scientific proves. I'd guess the use of patents to document the scientific achievements should even be actively promoted and encouraged.
Patents of course might be cited in papers (but most scientists do not even care about including patents in their literature search), but more importantly, the scientific papers are frequently quoted in patents.
Should your paper been cited in a patent, this may serve to document your science has also practical applications.
Unfortunately, even if your paper is cited in many patents, this will not change your h-factor a bit. This is because patents are not scanned either by the Web of Science or by most other citation engines. In fact it seems there even is no reasonable tool out there to obtain the paper-in-patent citations, with the exception of one brave experiment by U. Illinois. You can try Google to get your paper-in-patents citation rate, though it may turn out quite cumbersome. Should anyone be aware of anything better, I'd be glad to hear.
Rgds
Michal
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Generally, academic researchers focus on publishing on public journals while company researchers are more interested in patenting. Sometimes, it is hard to choose between publishing your good results on a journal and applying for a patent. It takes a couple of years or longer to get your results patented. Obviously, it's much quicker to publish your results in a good journal. A journal paper is important to a researcher, and an invention patent often means more. The question is how to choose properly between publishing and patenting?
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Seek quality advice from experienced professors that has published in both. If your research is unique, ground breaking and content is worth waiting for a long time then a patent is definitely worth going for. However, if time frame is of consideration or paper isn't academically and intellectually ready for patent then go for journal publication. Also define your aim. Industry employers usually place high value on patent publications.
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Warm wishes,
To all my dear and respected teachers & sirs,
                           I am Md Rafiuddin, Pharm.D(2010-2016) from Osmania University, Hyderabad, India. I have derived a mathematical formula in biochemistry to calculate turn over number (TON) of an enzyme in my intermediate in 2008. I wanted to know whether I can patent it or I have to just securely publish it in some biochemistry journals. According to Indian Patent Act Section 3(k) - "A mathematical, or business method or a computer programme or algorithms are not inventions and hence not patentable."
                                    Any suggestions or guidance from seniors in this regard is highly appreciable.
Thanks and Regards
Md Rafiuddin
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 As Eugene Yang said, scientific principles are not patentable. Only any process / method of making something something is patentable subject to fulfilling Novelty and Obviousness criteria.
The process or method of making or manufacturing enzyme by using your formula is patentavle. you can go for that
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Why are there two patents with same title same inventors and different patent number in one country?
For example: Jacobs Jr., William R. US patents:
6300061 =>Mycobacterial species-specific reporter mycobacteriophages
6225066 => Mycobacterial species-specific reporter mycobacteriophages
What is the differences between these documents technically?
Thank you
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Each patent is for 1 invention only. The later patent is called a divisional. Typically the description is identical for such patents or applications. Both may have the same description but protect different scope of invention. If you look at claim 1 for both patents you will see the differences 
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Currently the technology of gene editing CRISP-Cas9 is being addressed in counts over the matter who owns the patents. As a result progress by making use of this technology may be hampered. Similarly, we have seen in the past patent claims on PCR, DNA sequences, proteins and research antibodies. Such claims also have an adverse effect since research on the subjects become more expensive by royalties for the patents in place.
Where should the border be between waived royalties for research purposes and commercial exploitation when an invention is used at larger scale? Should be redefine the term invention for patent claims and should we bar discoveries existing in nature from patent claims?
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Hi Everyone:
Saw this question bit late hence thought of adding into it.
Mere discovery of a scientific principle or the formulation of an abstract theory cannot be patented but application of the said principle and / or theory resulting into a novel process / product capable of industrial application could be protected under patent.
DNA sequences per se are not patent-able unless the same codes for a functional protein which evidences the innovation within it.  
Best
Shaklain Khurshid
Indian Patent Agent
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Each hiPS line technically meets patent requirements: proper subject matter, novelty, nonobviousness, utility, and proper disclosure, but since these elements are constantly in flux in the courts regarding biological material, I wonder if anybody has had success?
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You can not achieve a protection for cell line such as. In patent application you have to prove the effect of your invention. You could achieve protection on new way of cultivation or production or usage of this cell line for treatment of ... . The most popular system in  achievement the patent protection called "problem and solution". You have some problem and your invention offers a solution.  
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What are the claims in patenting? How can I know about originality of my idea/product before filing for patenting?
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Vishal,
A utility patent consists of three or four main parts, the abstract, the drawings, the specification, and the claims.
The abstract summarizes the idea and is a one paragraph description that can be easily referenced to assess a patent.
The specification is where the inventor teaches the world what their idea is, how it works, and why it is better than the other ideas (and novel).
The drawings are a graphical aid to explaining the idea.  Some patents have no drawings, for example chemical formula patents.
The claims are a word description of what your idea consists of.  The claims are the most important part of the patent, because the define what the idea is.
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I wonder if there is any quickest or easiest method available to determine the FTO of any invention? Say X is added to system Y and considered a member of Z family, is this OK to consider X under FTO even though Family Z is already patented? Thanks in advance for your feedback. Kind Regards, Abdullah Kafi 
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X is an independent entity so one should not be confused between FTO and patent grant. What does it mean ? Simply stated X can be granted, provided one proves novelty and inventively vs prior art. But this patent, although being granted, at the commercial exploitation stage, can "walk on the toes" of other patents (Y, Z). The FTO allows then to define to which extent X will walk on the toes and what are the risks ? To which extent your patent X, being commercially exploited, would infringe patent Y and family Z ? If so what is the strategy ? Shall you license with patent Y or Z owners ? Or shall you consider that risk of being litigated is so low that no need to sign a licence ?  
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Hi, can someone please provide reasons as to why the current system of patenting of pharmaceutical products are ethically sustainable?
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In my view, 'sustainable' refers to a process that can be carried out indefinitely, that is, there is an unlimited supply of raw materials and energy to supply the process. So the phrase 'ethically sustainable' is interesting because ethics doesn't usually deal with such quantities. It refers more to the social judgements that guide the behaviour of individuals and societies. So, are you asking whether societies are simply prepared to allow the present system of pharmaceutical patenting to continue? I  would imagine that the system has been created by governments on the advice of the pharmaceutical companies, so I would be very surprised if they were to turn round and suddenly admit that their systems were unethical and needed changing.
But governments are in a bind, too, because it can cost the best part of a $1billion to  research, develop, test, refine, retest and finally qualify some drug for human use. Who's going to pay for this unless the company has an effective patent? Should the taxpayer simply underwrite ALL pharmaceutical developments past a certain stage in return for a much more limited patent system? It's not an easy issue!
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Being an inventor or budding inventor, an individual might have lots of questions in mind.. Such as..how to obtain patent for my invention? Is my invention patentable? Can I file patent by myself? etc. There must be certain basic guidelines that are already known to the patent practitioners to help the inventors. Inputs are invited  for helping the inventors and scientist how to apply and protect intellectual property.
also if some patent guides/mentors or agents are available..
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Aman,
I will try to answer each of the questions in your post:
1) How to obtain patent for my invention?
Each country has specific rules and criteria that you must meet in order to get a patent in that country. There are also special procedures such as the Patent Cooperation Treaty (PCT) which allows you to file in multiple countries 148 countries http://www.wipo.int/pct/en/ . I would strongly advise  professional advice in this matter.
2) Is my invention patentable?
Each country has different standards to meet. For example non-obviousness (US) and Inventive step(UK) are guided by different case law that may make the process more stringent in a specific area(for example, software) within that country. Seeking professional help in this regard
3) Can I file patent by myself?
The short answer is yes. The long answer is that it depends on how much time are you willing to invest on getting familiarized with patent procedures. if you are thinking of patenting in the US you can start by using as reference the book patent it yourself (http://www.nolo.com/products/patent-it-yourself-pat.html). Most people stop here but it is not enough. The book will provide enough background so that you can tackle the following references:
by Robert C. Faber
4) Any Patent help in India (Protection of Intellectual Property)? I have reached out to several IP agents and attorneys in India. If you want to I can forward the information offline(though I have only had talks with them on potential patenting of my work in India).
Although I am not a lawyer(and all actions that you take should be consulted with one), I am currently developing research and commercial software in this area and will gladly offer whatever advise I can.
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The realisation of employee innovative performance and output varies in the literature. A popular measure is the patent. However, in the context on a long ideation funnel where 3000 ideas are said to lead to 300 potential patents which may eventually result in  one commercial success,  (Stevens & Burley 1997), then patents would seriously underrepresent the deep and rich ideation cauldron that feeds innovative output. Further, patents record "substantially new" process or product developments,  and not the small incremental "shopfloor innovations" that are more pervasive and occurring daily in firms (Axtell et al 2000). In that context, what other measures would be suitable for capturing and reflecting innovative output at the individual employee level in firms
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In many firms, the key driver for operational excellence is "transformation through innovation”.
I found an interesting article written by Soren Kaplan entitled "How To Measure Innovation (To Get Real Results)" 
According to McKinsey, more than 70% of corporate leaders tout innovation as a top three business priority, but only 22% set innovation performance metrics.
One reason why that innovation metric gap exists is because there’s no set formula for what fuels innovation. What works for one company might be too fuzzy for the next. That said, there are a few things you can measure in order to figure out how innovative your company's culture is—it's the first step in figuring out how to reshape that environment and start promoting new behaviors.
Leadership
Percent of new innovations that come from external sources like crowdsourcing or open innovation
Percent of funding for game changers versus small tweaks to existing products or services
Percent of senior executive time focused on the future versus on daily operations
Employees
Number of ideas turned into patents by employees
Number of ideas turned into innovation experiments by employees
Number of teams that submit projects for innovation awards
Percentage of employees trained in the innovation process
Customers
Number of ideas submitted by customers through "open innovation" programs
Number of new product or service ideas that come from mining social networks
Number of customers that help test and refine new ideas
Regards
Zoheir
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Claim Mapping Tools
Claim Charting Tools
Chemical Data Mining Tools
Markush structure Mining Tools
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Depends what analysis you want to do... have a look at www.lens.org which has some interesting analysis tools.
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We have developed technological products and would like to make some patents. However, the costs are very high. We are searching for partners or angel investors interested in sensors such as ion selective electrodes for samples of biological interest. We have also a project of a isepenmeter whose patent already is written, but it was not submitted.
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You need to put together the money to file a decent priority patent application, probably about 1-3 K EU, drafted by a competent patent attorney (not me, I'm under a non-compete). After that you can look for partners/investors/purchasors. Don't rely on a 'home-made' (i.e. self-drafted) patent application - it usually only takes a few minutes to work out how to 'steal' such inventions without infringing - remember patent attorneys are paid to find ways past competitors' cases as well as to protect their clients cases. There is no mercy.
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I have to decide in what countries I have to present a patent. The patent is related to an industrial system to be used in infrastructures.
The patent office is a register office where you claim that you are the first inventor of an invention.
Some people write that now the patents are not presented in every country in the World and if you present it in 4-5 countries, it is considered a global one. It is recommended a country in Europe, USA, Japan or Korea and other in South America or Spain (in Spanish language).
I only say that it would be better that only exists a register for every area (perhaps Europe, South America, North America, Africa and Asia) and that every country have its own agency but uploading the patents to an only one register per area.
Of course I will upload the patent here in Researchgate.
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There are a number of aspects which you need to consider.
First of all, it is not entirely clear to me from your questoins as to whether you have already filed a patent application as a first filing or not. If you have done so, than the Paris Convention allows to file a so-called subsequent patent applications within 12 months from the first filing date. These subsequent patent applications can claim the filing date of the earlier patent application as so-called priority date, which is the relevant date for determining the relevant prior art.
In deciding which countries you want to keep open the possibility of having a granted patent right, indeed you can consider filing an international patent application under the Patent Cooperation Treaty, as suggested by Fernando Torres. This internation application postpones costs and a decision on the actual countries with one and a half years. After that period a decision must be taken, in which countries/regions you want to continue with applying for a patent.
The country decision should be made on the basis of the commercial interests of the invention. Thus, countries where you intend to manufacture or market the invention, and countries where competitors manufacture or market similar products would be important. Additionally, some patent offices have a good reputation as regards there substantive examination of patents, such as Europe and the United States. If you are successful in getting a granted patent before these patent offices, then many other small patent offices are willing to follow their decisions.
Finally, note that there is no "global patent". A patent right is always a national right and only yields protection in the countries where a granted patent is actually in force.
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Sometimes it is said that you should not publish your work before applying for a patent. Is this true? Are there any Do's and Don'ts about patents?
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Three basic Criteria:
1) New: Should be completely different from prior art (should be published or disclosed ever anywhere!);
2) Non-obvious: Should be newer for the person Skilled in art as well as should be reproducible by person skilled in art;
3) Industrial Applicable: Should be useful to society/industry...
From these criteria you can definitely say that your work shouldn't published anywhere before you FILE a patent...
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Various classification systems exist and most have been designed so that each technical aspect of an invention to which a patent document relates can be used for classifying as a whole. These are too general to meet the needs and demands of specific technology areas. Is it efficient to search invention only using keywords? How often are patent classification codes used for patent search?
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Usually I use both, keywords and classes. For example, it's good to start with keyword search and when you find some relevant patent, then you can use its classes. If you use keywords and classes separately, you will receive different results. But you can always combine keywords and classes. What you need to bear in mind is that there are always some patent publications that are without classes. So if you use only classification search, then you may not discover all relevant patent documents. But if you use only keyword search, then you also will not find all relevant documents because of the language you use.
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I identified a novel drug compound that was patented for another bioactivity. Now I have identified another novel activity on same bioactive molecule. Is it patentable for this new biological activity?
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In Europe, the drug (X) already known for treating a disease (Y) but found useful to treat a different disease (Z) is patentable as 'X for use in the treatment of Z'. You can get a similar scope of protection (as a 'method of treatment' claim) in the US, and if the drug needs to be formulated in a different way, you can get a claim to the new composition. If all you have found is that drug X, known to treat disease Y, works by pathway A rather than pathway B (and is administered in the same way and in the same dosage), then you are in the realm of scientific papers rather than patents. Talk to a patent attorney in one of the major cities, if you ask nicely, they will probably give you 30 minutes free advice in order to find out whether you have a valuable invention (and of course to find out whether you can pay their fees). J
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Copyright or patent?
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Thanks for your reply.
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I want to patent my research. Can anyone provide me with some suggestions how I should start the procedures?
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Hi, I was working for an inventor in El Salvador, and I helped him to patent his invention. We begun from zero asking and reviewing articles about how to write, draw and follow the process of patenting. We hired a lawer that was a former examiner of the USPO and, at last, we could patent a ecological stove.
This article may help you.
Regards,
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I would like to know if the the patent number is assigned in chronological order with respect to the issue date. A reference would be really useful.
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Yes, US patent numbers are assigned in chronological order with respect to the issue date. The sequence beginning with "1" was established by Patent Act of 1836. The citation is Ch. 357, 5 Stat. 117 (July 4, 1836)
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When drafting a patent application for a compound portfolio and its therapeutic applications, which tools do you use to check for novelty-destroying prior art and for defining your patent claims? Sure, different databases are available. But which ones help you really to nail down the novelty-destroying prior art in a short time when checking say 500 exemplified compounds in your application draft? How do you make sure that the Markush claim you are going to apply for does not collide with any existing compounds?
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I am assuming this is a search for purposes of patentability only. Do the ~500 possible compounds have a common core structure? If so, I might start with a substructure search on the CAS Registry database. That should identify any compounds known to exist which have that core structure.
A manual search of the patent art is also useful. Chemical compound patents are classified based on structure, so that a search of the relevant subclasses is often feasible. In the case of ~500 compounds, it may be difficult unless the compounds are very similar. If not, we might request that the inventor identify a smaller number of compounds to serve as the basis of the manual search. We also do keyword searching on databases such as Derwent and Espacenet.
Another possible issue might be hypothetical compounds encompassed by Markush groups described in published patents. A search for Markush structures in the prior art can also be carried out on the MARPAT database. We also review Markush structures uncovered during a manual search to see if they cover the compounds at issue.