Panax - Science topic

The study aims to determine the effects of natural dietary supplements on endurance performance for weightlifter athletes, therefor, prepared capsule consisting of blended ratio from the powders of probiotics, wheat germ, dandelion, ginseng root, moringa seeds, taurine, spirulina, fenugreek sprout, carob fruit, doum fruit, buckthorn fruit, whey pro...

Background The heart, as the body's blood-pumping organ, is extremely sensitive to changes in oxygen levels. Myocardial injury caused by hypoxia is a challenging issue, and there are currently no definitive specific drugs available for its treatment. Ginsenoside Rg5, one of the main rare saponins in ginseng, has shown significant efficacy in treati...

Single‐atom nanozymes (SAzymes) offer exceptional promise as next‐generation substitutes for natural enzymes due to its superior catalytic performance. However, single active sites of SAzymes have predominantly been limited to mimicking a monofunctional enzymatic activity, which hinders their adaptability in complex biological systems. Herein, an i...

Background Ginseng (Panax ginseng C. A. Meyer) herb itself and its derived preparations (e.g. Shenmai injection) are often prescribed for cancer patients as Traditional Chinese Medicines clinically in China. Ginsenosides Rh2 and Rg3 are two of main active components of ginseng. They have significant cytotoxic effect against non-small cell lung canc...

Background Ginsenoside Rd (G-Rd), found in Panax species, has shown therapeutic potential against metabolism-associated fatty liver disease (MAFLD), but its mechanism has not been well elucidated. This study investigated the key mechanisms of G-Rd in modulating the gut microbiome and lipid peroxidation-mediated ferroptosis pathway in MAFLD. Method...

Endophytic actinomycetes of medicinal plants have recently been in focus for developing novel antimicrobial compounds to combat multidrug-resistant pathogens. In this study, we isolated and characterised endophytic actinomycetes of Panax sokpayensis rhizome traditionally used as medicine in Sikkim-Himalayan region and assessed their antimicrobial a...

The roots of Panax ginseng , commonly known as ginseng, have been widely used worldwide for treating various diseases and general health maintenance. Due to its natural origin, extensive historical uses, and the accumulation of scientific evidence from clinical studies in humans, ginseng is widely regarded as safe. This review aims to summarize cli...

Eleutherococcus senticosus, a unique herb with significant medicinal and ecological importance, has remained largely unexplored regarding its mitochondrial genome. This research details the complete assembly and annotation of the E. senticosus mitogenome, achieved using a hybrid sequencing strategy that integrates data from Illumina short-read and...

Panax ginseng sprouts (GSs) have attracted attention as functional resources due to their short cultivation time and enriched ginsenoside content. This study aimed to evaluate the bioactivities of GSs cultivated using kelp fermentates (KF) as a nutrient solution under a smart-farming system. Ginsenoside-enriched extract (FGE), its water-soluble sap...

Phellodendron chinense Schneid, a traditional Chinese medicinal herb, has been widely utilized in the treatment of various diseases. In an effort to discover new bioactive compounds, the present study conducted a systematic isolation of chemical constituents from this medical plant, which led to the isolation of a new limonoid named pheldronone (1)...

Syringaresinol (SYR) is a dietary lignan largely known for its therapeutic effects. Thus, our present review provides an overview of the natural sources and chemistry of this molecule and discusses its biological and pharmacological properties. Indeed, SYR is widely distributed in the plant kingdom and has been reported in 87 species distributed ov...

Panax ginseng (PG) is a medicinal plant used for many years to treat many diseases. The current study aimed to investigate the possible prophylactic and therapeutic effects of PG extract on doxorubicin (DOX)-induced testicular toxicity in rats. 32 adult male Sprague–Dawley rats (200–250 g) were used in the experiment. The experimental groups were d...

Hypertension (HTN), a major global health concern and the primary cause of cardiovascular disease (CVD) death is expected to impact 29% of all adults by 2025. Hypertension (HTN) is a multifactorial condition, arising from the complex interaction of hereditary, environmental, and physiological variables that contribute to elevated systolic and diast...

Ginseng phytochemicals have attracted considerable attention for their potential therapeutic applications in bone-related diseases including osteosarcoma, osteoporosis, and osteoarthritis. Recent research has highlighted the promising effects of ginsenosides and polysaccharides from ginseng by studying multi-target effects and combination therapies...

American ginseng (Panax quinquefolius L.) exhibits multiple pharmacological properties, including anti‐inflammatory, antioxidant, and neuroprotective effects. In 2023, it was officially approved as a dual‐purpose substance for both medicinal and food applications, establishing it as a scientifically validated ingredient for functional foods and hea...

Adrenal insufficiency is a condition marked by insufficient adrenal hormone production, leading to fatigue, hypotension, and metabolic imbalances. Conventional treatment mainly involves hormone replacement therapy, but increasing interest in complementary medicine has highlighted adaptogenic herbs as potential therapeutic options. Adaptogens such a...

Depression is a psychological disorder with significant global impact. It is widely hypothesized that this disorder is associated with neuroinflammation, which disrupts neural homeostasis through various pathways. This study aims to investigate the effective compounds and mechanisms of Black Ginseng under forest (BG) in combating neuroinflammation....

Ischemic stroke remains a leading cause of mortality and long-term disability worldwide, despite advancements in acute intervention and rehabilitation strategies. Traditional, Complementary, and Integrative Medicine (TCIM) systems; including herbal medicine, acupuncture, and mind-body interventions are increasingly being explored as adjunct therapi...

Diabetes mellitus (DM) is a multifactorial metabolic disorder characterized by chronic hyperglycemia and systemic metabolic dysregulation. Although ginsenosides, the primary bioactive components of Panax ginseng Meyer, exhibit regulatory effects on glucose and lipid metabolism, their precise mechanisms and key targets in DM remain incompletely unde...

Shenling Baizhu San (SLBZS) is a formulation of traditional Chinese medicine (TCM) recorded in the Song Dynasty medical book Taiping Huimin Heji Jufang (AD 1078–1085). It comprises eleven herbs: Ginseng Radix Et Rhizoma, Atractylodis Macrocephalae Rhizoma, Poria, Dioscoreae Rhizoma, Nelumbinis Semen, Coicis Semen, Lablab Semen Album, Amomi Fructus,...

Soil‐available silicon (SAS) and soil moisture (SM) contents are critical parameters for crop growth; however, traditional detection methods are time‐consuming and inefficient. This study aimed to develop a non‐destructive testing method using hyperspectral imaging (HSI) technology for the rapid and real‐time detection of SAS and SM in ginseng soil...

Eleuthero root extract (also known as Siberian ginseng) is an herbal supplement derived from the root of Eleutherococcus senticosus, a shrub native to north eastern China, Japan, Russia, particularly Siberia. Eleuthero has been used for over 2,000 years in traditional medicine, particularly in Chinese and Russian healing systems. American and Asian...

Eleuthero root extract (also known as Siberian ginseng) is an herbal supplement derived from the root of Eleutherococcus senticosus , a shrub native to north eastern China, Japan, Russia, particularly Siberia. Eleuthero has been used for over 2,000 years in traditional medicine, particularly in Chinese and Russian healing systems. American and Asia...

Ginsenoside compound K (CK) exhibits valuable pharmacological activity and has potential applications in the development of antitumor and immunity‐enhancing drugs. As a metabolite of ginsenosides in the gut, ginsenoside CK is generally considered a kind of non‐natural ginsenoside that cannot be synthesized in Panax species. In this study, necessary...

Ginseng (Panax ginseng C. A. Meyer) adventitious roots (ARs) were cultured with various nutritional factors to determine optimal conditions of macro and microelements for root biomass in solid medium and a flask. Growth characteristics, including the number of lateral roots per explant, length of lateral roots, fresh weight and dry weight, were tes...

The traditional Chinese herbal medicine Panax ginseng can optimize physical health and is anticipated to be a valuable resource for investigating anti‐aging therapies. This study investigated the anti‐aging effects of red ginseng aqueous extract (RG) and white ginseng aqueous extract (WG). Network pharmacology forecasted that the key mechanisms of...

30 Interspecific interactions including plant-plant, plant-microbe, and plant-insect interactions are 31 the important elements to drive the positive plant-soil feedback for maintaining ecosystem stability 32 in biodiversity ecosystems. Yet, the role of diversified foliar pathogens in biodiversity system in 33 influencing the plant-soil feedback (P...

The mTOR signaling pathway has a main role in integrating extracellular and intracellular signals, acting as a key regulator of proliferation, growth, metabolism, and survival. Research conducted over the past 10 years has revealed that the mTOR pathway is activated in numerous cellular processes, including angiogenesis, tumor formation, adipogenes...

Callus induction is one of the most important techniques in plant-based industries. Important features in the use of callus induction are the maintenance of pluripotency and the proliferation of cells. Although the importance of callus induction is also understood in ginseng, there are no studies on the genetic modules associated with callus induct...

Panax quinquefolius L., with a history of over 300 years in traditional Chinese medicine, is notably rich in ginsenosides—its primary bioactive components. Although our previous study found that biochar application could enhance the content of ginsenoside Re, Rg and other contents in P. quinquefolius, its effect on the overall secondary metabolism...

A hallmark of aging is the progressive decline in resilience to stress and mitochondrial activity. As mitochondrial function decreases with aging, mitochondrial DNA (mtDNA) is shed under apoptotic stress, resulting in a persistent low-level of sterile inflammation (called inflammaging) that induces the aging program. In response to inflammaging, th...

OBJECTIVE: To evaluate the economy of Pan Long Qi Tablets compared with Bone-setting Qi Li Tablets in the treatment of fractures. METHODS: A retrospective study was conducted to collect medical records of 6,654 fracture patients from more than 20 hospitals in China from July 2021 to September 2023, which were divided into 3,706 cases in the experim...

Glioblastoma (GBM) is a highly aggressive brain tumor and is relatively common among malignant brain tumors in adults. Its rapid proliferation and significant invasiveness make its treatment one of the major challenges in brain tumor research. Panaxadiol, a compound extracted from ginseng roots, has been found to have significant therapeutic effect...

The ginsenoside compound K (CK) is a derivative that demonstrates exceptional bioactivity and has been proven to possess significant health benefits. However, the predominant ginsenosides present in ginseng can undergo enzymatic hydrolysis or microbial fermentation, leading to the biotransformation of CK through cleavage of the attached sugar moiet...

Rare ginsenosides, known for their significant pharmacological effects, are found in only trace amounts in natural ginseng, making it necessary to produce them through transformation processes. In this study, ginsenoside Re was chemically transformed into 30 rare ginsenosides using a novel heterogeneous catalyst HSiW@MeSi in aqueous methanol soluti...

Background The disruption of renal cell homeostasis caused by aging has attracted considerable attention. A traditional Chinese medicine, ginseng, is a potential drug for treating aging-related diseases. The study investigates the effect and mechanism of ginsenoside Rg1, an active component of ginseng, on renal aging and injury. Materials and meth...

Ginseng growth is susceptible to environmental stresses, particularly the frequent occurrence of low temperatures and water fluctuations in spring in Northeast China, which often lead to a decline in medicinal yield and quality. This study systematically analyzed the physiological response characteristics and variation patterns of active components...

Type 2 diabetes mellitus (T2DM), a chronic condition commonly observed in adults, particularly among the elderly, is characterized by a dysfunctional insulin response that impairs blood glucose regulation, resulting in persistent hyperglycemia. Ginseng, a medicinal plant with significant economic value and a longstanding history of therapeutic use...

Introduction A study on the soil microecological mechanisms influencing the growth vigor and saponin accumulation of mountainous forest cultivated ginseng (MFCG) under various forest types. Methods Using MFCG from different forest types as experimental material, the correlation and functional analysis of MFCG growth vigor, ginseng saponin content,...

This study aims to evaluate the pharmacological potential and standardize the bioactive compounds of Ngoc Linh Ginseng (Panax vietnamensis) as a candidate phytopharmaceutical. The study was conducted throughout 2024 using a multidisciplinary approach, including ultrasonic extraction, chemical analysis, and pharmacological tests. Samples were collec...

Background: Ginseng soluble dietary fiber (GSDF) has been shown to have good physicochemical properties; however, its in vivo benefits in obesity are yet to be fully elucidated. Methods: To explore this, C57BL/6J obese mice were given metformin hydrochloride and different doses of GSDF for 60 days. The levels of blood lipids and inflammatory factor...

Plants have played a key role in natural therapies for centuries, and their impact on the nervous system and the treatment of neurological disorders is of growing interest to scientists. Modern research confirms that plant substances can modulate neurotransmitters, reduce oxidative stress and support cognitive functions. Like humans, dogs also resp...

During ginseng selection, marketing promotion, and sales, it is imperative to expeditiously differentiate the overall quality grades, identify the geographic traces and determine the growth ages. This facilitates the selection of the most appropriate quality grade for each product, thereby ensuring the most efficacious marketing strategy. In this s...

Protopanaxadiol-type ginsenosides, the major bioactive components of Panax ginseng, exhibit diverse pharmacological activities, but suffer from low oral bioavailability due to poor water solubility and membrane permeability. Enzymatic deglycosylation has emerged as an effective strategy to enhance their therapeutic potential; however, most glucosid...

Administration of high-dose fermented ginseng powder (2.385 mg/g) resulted in a reduction in body weight and an improvement in blood biochemical parameters in high-fat diet (HFD)-fed mice. Significant reductions in lipid droplet size were observed in both liver and epididymal adipose tissues. Western blot analysis showed increased protein levels of...

Lactic acid bacteria (LAB) are gaining increasing attention as functional ingredients in the cosmetic industry, particularly those derived from natural plant sources. Although various LAB strains have been widely applied in cosmetic formulations, studies investigating the effects of naturally derived LAB on the skin remain limited. In this study, w...

The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is a multiprotein complex that plays a crucial role in the innate immune system by responding to microbial infections and cellular damage. However, its dysregulated activation is implicated in the development and progression of metabolic diseases, including cryopyrin-associ...

Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by the abnormal deposition of amyloid-beta (Aβ) peptides and neurofibrillary tangles (NFTs). Ginsenosides, the primary active constituents in ginseng, exhibit potential in combating AD. In our previous work, the ginsenoside SumI was demonstrated to have superior anti-AD...

Ginsenosides, the primary bioactive constituents of ginseng, are recognized for its potential to mitigate cognitive deficits associated with neurodegenerative conditions. Nevertheless, its molecular targets within cerebral tissues remain to be elucidated. First, cellular thermal shift assay (CETSA) combined with liquid chromatography mass spectrome...

Cancer, also known as malignant tumors, is formed due to abnormal mutations and the proliferation of human cells. Cancer cells not only demonstrate accelerated proliferation but also show robust invasive and metastatic potential, disseminating from a primary affected region of the body to multiple areas and potentially culminating in organ dysfunct...

Astragalus and ginseng, esteemed as traditional Chinese herbal medicines, have demonstrated the ability to bolster physical health and enhance the immune function of organisms. In this study, the effects of a dietary astragalus–ginseng mixture on the growth performance, intestinal health, and nonspecific immunity of yellow catfish (Pelteobagrus ful...

Herbs are plants that have compounds that are beneficial to the human body, especially in sports and fitness. Fitness is the body's ability to perform activities without excessive fatigue and still have energy for other activities. There are several influencing factors, including genetic, gender, age, exercise, fat composition, and smoking. This sy...

The ATP-binding cassette (ABC) transporter family is one of the largest and oldest protein families and encodes a class of transmembrane transporter proteins that transport substances in living organisms. Panax ginseng is a traditional Chinese herbal medicine, and its main active ingredient is ginsenoside, a secondary metabolite. Transportation and...

North American ginseng (NAG) has received increasing attention as an alternative medicine for the treatment of diabetes. Extract of the NAG root has been reported to possess antidiabetic properties, but the underlying mechanisms for such effects have not been identified. Here we investigated the effects of NAG root extract on type 1 and 2 diabetes...

Background/Objectives: Hyperlipidemia (HLP) encompasses a spectrum of poorly understood lipid metabolism disorders that are frequently overlooked or misdiagnosed, potentially leading to multiple complications. While the gut microbiota has been implicated in HLP pathogenesis, the causal relationships and molecular mechanisms remain elusive. This stu...

The current investigation aimed to determine if Panax ginseng might shield male rabbit liver against stannous chloride (SnCl₂)-induced liver damage. 20 rabbits were randomly divided into 4 equal-sized groups comprising 5 rabbits each. The first group (control) was given the same amount of corn oil only. The effects of P. ginseng (100 mg per kg of b...

Ginsenosides are triterpenoid saponins found in Panax ginseng. They are well known for their health benefits, including antioxidant, anticancer, and antidiabetic effects, along with their support for cardiovascular and neurological function. Our previous study showed that cultivating Panax ginseng in tissue culture successfully led to its rapid gro...

The main root, reed head, and fibrous root are three different main edible medicinal parts of ginseng (Panax ginseng C. A. Meyer). When processed into ginseng products, such as ginseng powder, they exhibit similar colors and odors, easily confused in market circulation. However, there are differences in their pharmacological activity and clinical i...

Background Senotherapeutics, agents targeting cellular senescence, have recently shown great promise in anti-aging applications by removing senescent cells or attenuating the senescence-associated secretory phenotype (SASP). Ginseng and its bioactive component, ginsenosides, are widely recognized in Asia for their anti-aging effects. In this study,...

Cistanche deserticola Y. C. Ma (C. deserticola), a holoparasitic desert plant traditionally revered as “desert ginseng”, has emerged as a versatile resource with significant applications in both medicinal and dietary contexts. This comprehensive review systematically explores its bioactive constituents, including phenylethanol glycosides (PhGs), ir...

Objectives Ensuring quality and authenticity of traditional medicines is crucial, particularly for multi-ingredient formulations like commercial Chinese polyherbal preparations (CCPPs). This study aims to authenticate Renshen Jianpi Wan (RSJPW), a classical CCPP composed of 11 prescribed botanical drugs, using DNA metabarcoding to overcome challeng...

Background/Objectives: Ginseng has been a traditional remedy for centuries, known for its diverse benefits such as anti-inflammation, antioxidant, bactericidal, fungicidal antidiabetic, and anticancer effects. This study employs a network pharmacology approach with molecular dynamics simulation to investigate the potential mechanisms through which...

Ginseng, a popular herb in traditional medicine, is commonly believed to possess therapeutic benefits including anti-inflammatory, anticancer, neuroprotective, and antioxidant effects. The popularity of the herb encourages overharvesting of the species’ wild populations, consequentially reducing genetic diversity and threatening their long-term via...

Endophytic flora serves a crucial function as a secondary line of defense against pathogen invasion in plants. To investigate the mechanisms underlying the relationship between changes in endophytic flora and ginseng root rot, exhumate beneficial endophytic bacteria, and explore biological management approaches for ginseng root rot. In this study,...

This review aims to systematically dissect the genetic regulatory mechanisms of plant secondary metabolites in the era of genomics, while comprehensively summarizing the progress and potential impact of genomics in plant secondary metabolism research. By integrating methodologies such as high-throughput sequencing, structural genomics, comparative...

Soil, as the foundation for the survival of understory ginseng, directly impacts its growth and development. However, studies focusing on the role of soil in determining the quality of understory ginseng are limited. This study examines the relationship between quality and yield of 5-, 9-, and 17-year-old understory ginseng and their soil microbiot...

As awareness of the link between diet and health grows, people are increasingly prioritizing functional foods that offer additional health benefits beyond basic nutrition. Ashwagandha, scientifically known as Withania somnifera (WS), is a perennial plant which belongs to the family Solanaceae, which grows abundantly in subtropical regions of the wo...

Background: Obesity is an important risk factor of intestinal inflammatory disease. This study aimed to evaluate the effects of Red ginseng extract powder (RGEP) and Red ginseng dietary fiber (RGDF) on the maintenance of immune and functional homeostasis in recovering obesity-induced impairment of intestinal immunity. Methods: Diet-induced obesity...

The interest in traditional meat being replaced by plant-based food has increased throughout the years. Some agricultural products, such as root crops, could be incorporated into alternative meat products due to the health benefits. However, relevant studies have discovered that some roots are considered allergen materials, necessitating further id...

Obesity-linked diabetes, also known as diabesity, is a growing global health concern characterized by insulin resistance, chronic inflammation, and oxidative stress. Oxidative stress plays a pivotal role in the pathogenesis of obesity-induced insulin resistance by disrupting cellular homeostasis, impairing pancreatic β-cell function, and promoting...

Ngoc Linh ginseng (Panax vietnamensis Ha et Grushv.) belonging to the family Araliaceae is one of the most economically and medicinally valuable endemic herbs in Vietnam owing to their pharmacological potentials. The microencapsulation of ginseng root extracts in the present study was investigated to develop Ngoc Linh ginseng microcapsules as novel...

Introduction and Purpose: Acne vulgaris, a chronic inflammatory skin condition, primarily affects adolescents and young adults, causing non-inflammatory and inflammatory lesions. Conventional treatments, including topical retinoids and systemic antibiotics, are effective but may lead to adverse effects, antimicrobial resistance, and high costs. The...

The emergence and spread of pathogens is one of agriculture's problems. Rhizopus stolonifer is the pathogen to be on the lookout for because it causes rhizopus loose rot disease. The pathogen must be dealt with immediately because it can result in losses of up to 40%. Integrated plant disease management (IPDM) is the approach being promoted. The ap...

Panax japonicus C. A. Mey. is a rare and endangered Class II important protected wild medicinal plant in China with a wide range of pharmacological activities. The development of the fruit is special, only the apical capitulum can develop into fruit normally, and the color trait changes during the maturation process showed a pattern from green to r...

Functional foods and herbal medicines have gained global demand due to their health benefits, which have led to increased consumer interest. Their contribution to health is associated to the existence of bioactive compounds with several pharmacological properties such as antidiabetic, antimicrobial, anticancer, and antiinflammatory activities etc....

This study explores the potential of ginseng-derived peptides (GPs) as multifunctional bioactive agents for skincare. Unlike previous research into ginseng saponins and polysaccharides, we identified that ginseng extracts containing water-soluble small molecules and polypeptides exhibit potent antioxidant, anti-inflammatory, and anti-aging properti...

Background Warfarin, a commonly used anticoagulant, interacts with medicinal plants, potentially complicating patient management. Clinical Decision Resources (CDRs) provide guidance on these interactions, but inconsistencies across resources may impact clinical decisions. This study aims to evaluate the consistency of interaction reports between wa...