Science topic
Pain - Science topic
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Questions related to Pain
An experimental therapy using pills filled with live microorganisms — similar to those found in a healthy human gut — is showing encouraging results in reducing chronic pain. In clinical trials, patients suffering from fibromyalgia, endometriosis, and related conditions reported substantial pain relief after receiving these microbial supplements.
The idea stems from a 2019 discovery that the gut microbiomes of women with fibromyalgia differ significantly from those of healthy individuals. Early findings suggest these microbial therapies may influence key chemical signals involved in pain perception, opening new possibilities for treating complex pain conditions through the gut–brain axis.
- This sparked a question among scientists: could restoring a balanced gut microbiome with microbes from healthy donors reduce pain and fatigue? and
- Could rebalancing the microbiome rewrite how we treat pain?
Sources:
Nature: Gut Microbes and Pain Perception
Nature: Microbiome Therapy for Pain
Nature: Chronic Pain and Gut Health
Hello!
I am a PhD student and I am looking for EEG/MEG open datasets in which pain or temperature stimuli were applied.
Ideally I would like to have both healthy controls and patients (chronic pain, fibromyalgia), and it is ok for me to have access to both resting state conditions and event-related paradigms.
Can you help me? Thank you!
Our study introduces a novel two-stage AI framework that detects and localises pain using Electrodermal Activity (EDA) signals. We developed Multi-Domain Binary Patterns (MDBP) to extract hidden patterns from EDA signals, achieving 77.9% accuracy in pain detection and 69.67% in pain localisation. This work could pave the way for non-verbal pain assessment.
What other biosignals do you think could enhance pain recognition? Additionally, are there other publicly available physiological signal datasets for pain research that could help validate AI-based pain assessment models?
Read more about our work here: A Two-Stage Architecture for Identifying and Locating the Source of Pain Using Novel Multi-Domain Binary Patterns of EDA. (DOI:10.1016/j.bspc.2024.107454)
Does the nerve need to be completely damaged, or can pain arise from stress or even slight damage to the nerve?
Pain increases at 75 degrees flexion and when working with stability exercises.
Dear Colleagues who do pain-like behavioral assays, I have two questions: 1) what bedding do you use for housing your mice and 2) what are your normal, non-injured von Frey thresholds?
We published a study in Pain, 2016 showing that bedding material affects von Frey thresholds PMC4698037; and I remain curious what other labs use and what their von Frey thresholds average.
Thanks and best, Cheryl
With increasing age, the amount of toxins and corrosive substances and various types of waste in the body increases due to various reasons. At the same time the pollution of the mind also increases. Due to the accumulation of pain one after another in the mind, at one time it exceeds the limit of endurance. Various types of physical pain and problems arise from depression and mental pain. Numerous microorganisms are constantly destroying our body. Then the body is gradually damaged by various types of rays and substances from the environment. As it goes on, the body gradually loses its ability to repair the damage. As a result of all this, the condition that occurs in a person is called old age.
Hello, dear RG community.
Personally, I have found Xarray to be excruciatingly slow, especially for big datasets and nonstandard operations (like a custom filtering function). The only suggestion how to speed up the things that I have found on the Internet is to use numpy. When I adjusted my code accordingly (i.e., used numpy), I laughed so hard because I had to convert almost every single piece of Xarray-based code to a numpy-based code. Still, the remnants of the Xarray-based code kept slowing me down. I went ahead and wrote a crazy piece of code combining Dask and Xarray and numpy and, finally, increased the speed to some acceptable magnitude. That was such a pain.
Pandas, of course, are essentially the same speed-wise. And I couldn't find anything else to handle named arrays in Python other than Xarray or Pandas (I work with multidimensional arrays, so I need Xarray anyway).
I read the docs for Xarray. The authors say the reason for Xarray is to be able to work with multidimensional arrays. I can't fully comprehend that. Why not just add this functionality to Pandas? I could understand if they started such big of a project for some big idea, but just add multidimensional functionality that should've better been added to Pandas to spare users time learning two different data bases seems like not a good justification to me. To say nothing that Xarray has ended up being as slow as Pandas.
I think that a good justification for starting a new data base project for Python is to make it really fast first and foremost. I think a new data base project that will follow numpy example must be started: when the code base is written in lightning-fast C/C++ and then Python wrappers are added on top of that.
I am wondering if anybody is aware of such an effort. If so, when should we expect the release?
Thank you in advance.
Ivan
I want to choose a resarch topic regarding enzyme inhibition. So I did my research and found out most of the diseases that originate from enzymes were actually caused by the "deficiency" of enzymes, not the "activity". For the sake of my reaserch, I want to find troublesome enzymes (such as ACHE) that their high activity causes problems in body or metabolism. What are the examples of it?
Hi, I'm a graduate student, college of nursing, chungnam national university in Daejeon.
The topic of my thesis is "Quality Assessment of Tools for Evaluating Acute Postoperative Pain." I have conducted a quality assessment of pain evaluation tools based on the COSMIN guidelines for the quality of measurement tools. I have a few questions regarding this process.
- The COSMIN guidelines for PROM quality assessment are specifically for self-reported measurement tools. Is it appropriate to apply these guidelines to pain evaluation tools, which include not only self-reported measures but also observational tools used by healthcare professionals that consider behavioral indicators and physiological measures?
- According to the COSMIN guidelines, the first step is the risk of bias assessment for individual studies. The guidelines state that there is no need to assess other measurement properties if content validity and structural validity are not reported in the individual studies. If most of the extracted studies do not report these validities, is it meaningful to proceed with the COSMIN quality assessment steps?
- For individual studies that do not report most of the measurement properties, would it be acceptable to conduct a COSMIN quality assessment only for the studies focused on tool development and validity based on the researcher's discretion, and for other studies using the tool, analyze only the number of studies reporting reliability and validity without conducting a COSMIN quality assessment?
- If there are multiple individual studies applying the same tool, should each study be assessed for quality separately according to the COSMIN guidelines, or should the assessment focus on the tool itself across multiple studies?
Thank you.
A researcher always have plainful, instead of joyful, experience when they reflecting of their action taken. I, as an autoethnographer, came across of this journey, and the result is fruitful.
Any similar experience to share?
In line with the work of affective neuroscientist Jaak Panksepp and social neuroscientists Naomi Eisenberger and Matthew Lieberman, the "pain" that humans experience due to social injury (actual or threatened damage to essential social bonds via separation, loss, rejection, exclusion, abandonment, ostracism, discrimination, neglect, abuse, insult, humiliation, and so on) is generated by much the same neural mechanisms responsible for physical pain and injury. Panksepp was, as far as I can determine, the first to theorize that this "social pain" system "piggybacked" off the physical pain system at some point in our evolutionary past. My question is: when, approximately, in mammalian, primate, or hominin evolution did social pain evolve from the preexisting physical pain system (the nervous system, nociception, endogenous opioids, pain avoidance behavior, learning, etc), which, according to modern research dates back at least to our fish ancestors, some 450 million years ago? Obviously, before social pain could evolve, a species must have become "social," in the sense that its survival and/or reproductive fitness would be compromised if its bonds with social conspecifics were either threatened or actually damaged or broken. When do you think that first occurred, and why?
- Scrambler therapy (ST) is a novel method for treating pain by electro-stimulation and reorganizing the brain's pain centre with the principle of neuroplasticity, first described by Giuseppe Marineo in 2003.
- Interferential therapy (IF) is an alternating medium-frequency current with amplitude modulation at a low frequency, which reduces pain according to gate control theory.
inflammatory response can attacked immune system and effect on healthy cells in your body by mistake, causing inflammation (painful swelling) in the affected parts of the body. as well as joints. how cytokine like il-37 act as anti inflammatory react with RA and upregulated the inflammation?
Meta-analysis is a statistical method used to combine and analyze the results of multiple independent studies on a particular topic, to provide a more comprehensive and reliable assessment of the evidence. In the context of treatment approaches for pain management, a meta-analysis can be conducted to synthesize the findings from various studies that have investigated the effectiveness of different interventions for alleviating pain.
I want to use the Visual Analog Scale for Anxiety (VAS-A) in my DNP project. I know the VAS for pain is public domain, however, I have been unable to find whether the VAS-A is also public domain. Does anyone know whether I need to get permission to use the VAS-A in my research and if so where I can get permission? Thanks!
Marma points are one of the fundamental concepts of Ayurveda. Detail about each and every marma is elaborated in the 6th Chapter of Sharir Sthana of Susuta Samhita. However, in this chapter, these are to be saved from injury or while making an incision. knowledge of Marma is said to be half the knowledge of surgery. Primarily Marma massage or Marma therapy was practised mostly in the southern part of India, but now it is practised across India. Many good results are also reported via the same therapy. Though many articles are been published, certain queries like the one quoted in question still remain unanswered. I request all the learned scholars to throw some light of wisdom
Can AI address medical practice “pain points,” providing more efficient and efficacious care while de-escalating physician burnout?
The patient is 4 days postpartum after a physiological delivery. Complaints of unbearable pain in the perineum and lumbar pain. There were minor internal tears. On examination, there is no inflammation, no swelling. Pain relief with ketoprofen is of little help. Can you please advise how to anaesthetise or partially relieve the pain?
Working on a paper in which i analyze the language of pain in fiction from India and Dominican Republic.
When the article was uploaded, an incorrect version was used - and it pains me to see reader traffic grow on a wrong version of the document. Please guide me on how to remove it, so I can replace it with the correct version.
A common feeling in the skin or below the skin- tissues . Pain arises due to a force applied beyond our tolerance externally or internally through any ingrowth inside. Illness is just getting rid of pain / reduction in temperature in our body.
I am currently doing research for a topic about Financing of Private Universities in Nigeria: Pains & Gain. I will need help towards this topic and I looking forward to getting some help. Thank you
Most of the people are suffering from more or less mental distress and depression in the present difficult times. Many times our mental pain turns into physical pain. A large part of various pains in the body is due to mental pain, mental poison and mental stress.
Many a times, we are unable to get well even after various treatments to get rid of physical pain due to not understanding this fact.
If it is seen that the pain of the body is also increasing when the mental turmoil increases, then it must be understood that the pain and suffering of the mind has manifested as the pain and suffering of the body.
Among these physical ailments, one of them is abdominal pain and problems. When the pain of the mind manifests in the form of abdominal pain or inflammation with various problems, it is called IBS. Irritative bowel syndrome.
The only way to get rid of IBS is to repair the damage to the body and treat the inflammation as well as eliminate the cause of stress and emotional distress, or treat the mind.
AVN can be very well managed through Ayurveda Panchakarma modalities, the quality of life and range of movements drastically incrase with no pain. Eventhough the evidences that can be generated are very subjective in nature.
How can be this lacunae sorted by using any Objective parameters of Assesment to find the intrinsic change that is being brough about in this painful condition to remain healthy and painfree without any routine disturbances.
Deficiency is the cause of many diseases today. Many diseases are caused due to the deficiency of one or more of the essential elements of the body.
Inflammatory damage is behind this deficiency. Inflammation is caused by poisons or toxins. Toxins from parasites, germs, viruses, fungi etc. and poisons from metals, chemicals, plants, plastics and radiation etc. cause inflammation in different parts of the body.
Also mind-poison plays another major role. Frustration, turmoil, anger, tension, grief, sadness, depression and mental disorder cause inflammation in the body. Many times the mental irritation or pain of the mind is transformed into pain and inflammation of the body. Due to physical and mental trauma and emotional distress, toxins are secreted from the body's special endocrine glands and cause inflammation.
Proper treatment will be possible only if these deficiencies can be filled and the cause of inflammation along with inflammation can be removed in an evil-free manner. Palliative treatments that suppress disease or symptoms by medical professionals and traders are wreaking havoc on people. While curing one disease, these wrong treatment methods are giving rise to many diseases.
I have seen in many patients, the application of external medicine to cure a skin disease, which has suppressed that skin disease, and given rise to one or more other serious diseases. But in this corrupt society, if I leave the business perspective in the field of medicine and talk about the welfare of people, this society will become my absolute enemy.
Another important thing to mention in this context is, combining the best parts of various medical disciplines will create a superior medical science. If we can combine essences from the theories of scriptures like Ayurveda, Homeopathy, Acupuncture, etc. and modern medical systems, we can get a great medical science.
What VAS pain core is free to use and were can I find proof that it is free. Thanks
I have a panel data set and one variable called pain level (which has 4 categories: no, slight, moderate and severe). If I directly write the code of "tab painlevel", Stata will tell me the N (overall obs.) in these 4 categroies. However, if I want to know n (group obs.) in each pain level, what code should I choose?
Thanks!
Greetings, community!
I am mastering visceral pain experiments. We are looking for an easy way to detect visceral pain specific behavior in mice. I have found a couple of articles in which specific behaviors are counted:
- licking the abdomen
- stretching the abdomen
- abdominal retractions
- squashing of abdominen against the floor
I completely understand the meaning of all these terms, but I cannot recognize correct behavioral manifistation (besides licking -- it is relatively obvious).
Could anybody provide a video with examples of each of these behaviors? I have found only one image on ResearchGate about rats phenotypes, but it didin't help much.
When people feel emotional pain, the same areas of the brain get activated as when people feel physical pain: the anterior insula and the anterior cingulate cortex. In one study, these regions were activated when people experienced an experimental social rejection from peers.
It could be considered that when we accept there is pain and its not going to go away (eg. Chronic pain/loosing a person) could help managing it, just like when we consider that a person is dead who is close to your heart, then after some time people accept it and move on, its not that pain is not there but they manage to cope with it. Just like that if a person with chronic pain which is not going away with treatment (any kind), if accepts that its going to remain and have to manage it, then brain starts masking its effects by reducing the sensation in the anterior insula and the anterior cingulate cortex. And that might help patients having better life!
- Mental Health medication is only treated for mental illness with chemical component in human body. But do you agreed this is also alleviate the emotional pain level as well? if yes. why? if not - why not?
- If the dosage of mental health medication does not prescribe only according to client's physical index calculation but not based on illness response and behaviour , do you think the medication is only suppressed the patient's responsive system gradually. and he/she will not be able to made decision clearly . Or they will also can make better decision if he/she can be calm down the negative emotion per se?
What mediation model should I chose
Hypothesis: Pain Catastrophizing Mediating the effect of Psychological Flexibility on Physical Functioning in Patients with Chronic Pain over time
I have one measure before starting acceptance commitment therapy (in an RCT), 6 months after, 12 months after, and now years after.
Could I use a longitudinal meditation model to look at the relationship between pain catstrophising, psychological flexibility and physical functioning over time?
Is latent difference score mediation appropriate?
Thank for Anita Z Goldschmied'comment:
Thank you for the topic and for introducing him. I am very active and always have been, so I can't imagine a life without movement. That is probably why I cannot consider issues of order and sides here, facts and beliefs, but acknowledge how they affect and shape one another to emerge effects. In terms of application of theory, my regime combines running, HIT, weight lifting, dancing, mindfulness, walking and many more in perfect harmony, never in opposition or hierarchy but interconnected and complementing, just like a problem and its (temporary) solution that we all have to figure out ourselves. Although I would be cautious with this translation, I will finish with his sentence: "After 10 years of hard work, I created my own story to entertain everyone."
From "empty nose" patient to triathlon "iron man"
This is my story."After 10 years of hard work, I created my own story to entertain everyone."
Many people have experienced, first-hand the saying, " toothache is not a disease, it just hurts really badly ". Toothache can destroy a person if it lasts for many days. Fortunately, there are dentists who can handle the disease.
But do you know "empty nose syndrome" ?
It is a kind of breathing pain, called an incurable illness, and the doctor who was as effective as god, bringing the dying back to life, is helpless treating it.
Now, let me tell you that there is a patient with 27 years medical history of
"empty nose syndrome”. At that time, 27 years ago, he lost a large tooth and for many years experienced double torture with trauma of the body and spirit because of the disease and has experienced the feeling like the heart has cracked open and his tendons have pulled out. Because of the extreme pain he once let himself fall into the emotions of sorrow and despair; living was no better than dying. It was 20 years after the operation that he learned that the disease he was fighting against was actually a " incurable disease " Fortunately, he is a surgeon who likes sports since he was a child. He is also an optimistic activist and a practitioner of positive psychology. After seeking medical advice so many times, his treatment failed and his emotion dropped into hopelessness. He learned from the pain and did not complain about it to others. He regarded it as Heaven’s challenge to him....
2020.12.18
source:
What pain distribution would you expect, a C5 or C6?
A 9 .5 year-old boy complains of recurrent and frequent attach of bone pain for more than 3 months duration with increasing during the day, not at night, didn't awake him from sleep and increasing gradually during the day, which is undetermined, sometimes in the head, in the shaft of the thigh, or in the figures and uni or bilateral. his growth slightly above 95%. His complete blood picture with blood film shows normochromic normocytic with no anemia, no abnormal cells, and other cells quite normally. his Alkaline phosphatase blood sample is normal, his calcium blood level is normal, his Vit D level is normal, and his thyroid hormone, TSH< free T3, T4, is normal. his bone age x-ray matches age 11 years which is within normal.
Note 1- he has no sign of giantism.
2- no growth hormone analysis has been done yet.
3- very few secondary sexual characteristics appeared otherwise, genitalia normal?
What could be the possible diagnosis?
What are other investigations that should look for to reach the diagnosis?
What should do to relieve the pain as he is now continuously on acetaminophen ( paracetamol) which response partially to it?
The Medical Thermography group at Sao Paulo University's Neurology Department is looking for infrared medical thermography researchers for multicenter investigations. Pain, sport medicine, rehabilitation, public health, diabetes, breast, cardiovascular disease, surgery, healing, and mental problems are the key topics. Please contact with me.
This is part of a genomic research for ascertaining gene expression differences between patients in pain and pain-free patients following spinal surgeries.
I need to perform automatic deep learning (VGG) processing. I imported my images in the matlab environment but I can't find them for the rest of my work and since then it pains me.
Please I urge you do it for me with the steps:
- Import step
- Resizing step
- Normalization step
Respectfully
Thanks
I need to perform automatic deep learning (VGG) processing. I imported my images in the matlab environment but I can't find them for the rest of my work and since then it pains me.
Please I urge you do it for me with the steps:
- Import step
- Resizing step
- Normalization step
Respectfully
Thanks
I need to perform automatic deep learning (VGG) processing. I imported my images in the matlab environment but I can't find them for the rest of my work and since then it pains me.
Thanks
It seems that pain science is not included or neglected in public health topics. However, pain is a great concern among the public in developed and LMI countries. Do you think pain science should be prioritized in public health to deal with many pain patients?
experts opinions are needed on this
I have 3 variables that consist:
- Duration (< 2 hour [short], 3 hour [mid], > 3 hour [long]
- Body posture (1 [safe], 2 [small risk], 3 [middle risk], 4 [very high risk])
- Pain (1 [low], 2 [mid], 3 [high], 4 [very high])
I want to analyze the correlation between duration - pain and posture - pain. So I pretend that duration and posture are independent. Should I use chi-square or spearman? Thank you.
We have to examine the basic changes we need to adopt to match the pace of the competition. We have to focus on How to bring change, what kind of change, to what extent change is required.
There is a 2X2 experimental design. One factor is the group: patients vs controls. The other factor is the within-subject condition: pain ratings for self vs for others. The pain rating is acquired on a 7-point numerical scale. Of note, there are 10 trials in each condition, i.e., participants are required to rate their pain intensity for 10 pain-related images. Therefore, each participant completed 20 trials.
For data analysis, most of the papers using a similar experimental design applied a repeated-measures ANOVA. Firstly, the mean pain value of the 10 trials was calculated for each condition per subject. Then this mean value was treated as the DV and the repeated-measures ANOVA was conducted with the group (patients vs controls) as the between-subject factor and the condition (ratings for self vs others) as the within-subject factor.
My questions:
1. Is such a parametric ANOVA appropriate for the above experimental design if the sphericity assumption is satisfied?
2. Is it reasonable to calculate the mean of the pain ratings in each condition? Indeed, pain ratings on numerical scales are ordinal, and therefore nonparametric tests should be applied for such variables.
3. If non-parametric tests are applied for such a dataset, how to do? The median is calculated for each condition first and then how?
Many thanks and welcome for clarification and discussion.
Born with club feet which were corrected by means of plastering within the 6 months of age. Current age 67 years. Suffering feet and ankle pain for over 3.5 decades. Habitual of a routine post dinner walk for about 3-4 km everyday. No pain killers used. Pain is normally bearable but sometimes gets severe and is normally relieved to bearable limits by warm water bath / contrast bath. Recent podiatric/orthotic investigation suggesting Charcot Feet.
Hi! What is the difference between Complex Regional Pain Syndrome and regular pain? I am aware of the various symptoms. However, from a cellular standpoint, what is the difference? Any specific receptors/proteins involved? The muscarinic receptors? Thank you!!
Assume that there are m number of patients. Each patient records his/her pain level in an ordinal scale (from "not at all" to "excruciating") at t_i time point fro i=1,2,...,n_i. Suppose that we want to know whether patients are improving with respect to time or not. Is there any existing literature to test that?
Hi everyone,
we use this stimulation electrode together with a Digitimer for pain stimulation in an experiment. We got them from another lab, but the first one broke and we just have a limited amount, so I am looking for some more of them, but did not succeed so far. Does anyone know or has an idea where to get more of them?
Thanks a lot!
(The cables originally looked a little bit different. I stabilized them to last longer)
I performed an AChE inhibition assay using a spectrophotometer with a wavelength 412 nm. In my study, I'm using plant extract which is Ulam Raja as AChE inhibitor. And I want to know why absorbance for negative control is higher than absorbance for the test sample with plant extract?
What I understand about this reaction is in negative control, AChE will hydrolyse substrate Acetylthiocholine Iodide and formed thiocholine as product detected by DTNB. This means that high thiocholine formed will increase the concentration thus, the absorbance also increase. For sample absorbance that contain plant extract as AChE inhibitor, it will inhibit AChE from hydrolyse Acetylcholine Iodide and DTNB will detect less amount of thiocholine thus, the absorbance for sample test is lower than negative control. It's mean that higher concentration of plant will result in low thiocholine production and the absorbance becomes lower. Is it correct? sorry for my grammar error I hope you can understand what I try to explain
I performed an AChE inhibition assay using a spectrophotometer with a wavelength 420 nm. In my study, I'm using plant extract which is Ulam Raja as AChE inhibitor. And I want to know why absorbance for negative control/ test sample is decrease or increase in spectrophotometer. What happen in the process
I’m curious if a newer theory on pain exists or whether we are still attempting to understand the theory fully in order to prove/disprove its correlation.
I understand it was a theory and required research to prove, however I’m not sure how a theory is proved if the medical establishment doesn’t still can’t successfully prevent or reverse the condition. Confirmation of a theory should balance recovery, reversal and management of pain through research studies, not simply pharmacological and pain management. We have severe chronic illnesses that fall distinctly in pain theory territory, for instance fibromyalgia a disease that has been coined “invisible“, abuses ones own body but can’t be tested or resolved and isn’t classified as an autoimmune condition. Yet the common information given to patients is we don’t understand fibromyalgia, nor how to reverse the condition. Some treatments are available to manage individual side effects of illness, generally consisting of seeing multiple disciplinary medical fields.
Central Sensitization Syndrome perhaps is a foundational stone in the theory. However I find it inconceivable with the advent of scientific medical research advancements (funded as part of the covid 19 pandemic), that this disease can continue to be discounted as a type of pandemic of various origins, given it often has certain known triggers ie infectious disease, PTSD And various other illness classifications.
I have been treating this patient for 20 years. She is 80 years old now. In the past 10 years her degenerative scoliosis (DS) has progressively worsened. We did xrays before starting the combination of lumbosacral Flexion/Distraction (Cox Technic) and Fascial Plane Therapy. Her scoliotis improved almost 13.5 degrees. Her pain improved (NPS) 6-8/10 to 1-2/10. I cannot find anything in the literature, non-surgically, to compare this to.
Dear research community, we need your help. We are conducting a systematic and narrative review on conditioned pain https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021266688.. If you know of any report or paper (published or unpublished) on the topic, please contact sahaj.kang@ugent.be
I am auditing pain score outcomes in a pain clinic and need to hopefully show that the score on discharge is significantly better than on admission for most patients - I am not sure which test to use for this as my stats is pretty rusty. I always thought T-test was for two different groups with different interventions...
Thanks!
Hi,
does anybody have information that can share about pain recognition in bats?
Citable sources will be especially appreciated.
Thank you
Javier
-Calculating the effect of a treatment-
I have the mean+- SD for both pre and post treatment
A 35 years- old man without comorbidities presents an epigastrium severe pain that irradiates for back (3 years). He denies use of alcohol, hypertrigliciredemia, abuse of drugs, hypercalcemia, pancreatic cancer or cholelithiasis. She realized several exams as CT where was observed tail pancreatic mass with 4 X 3 cm of diameter without as wirsung dilatation as calcifications, this finding was also observed in MRI. As ERCP as Cholangio MRI are normals.He realized echo-endoscopy that confirmed this mass, but discarded any finding of neoplasm. Biopsy was realized, showing at histopathology an absence of tumoral findings from pancreatic neoplasms. Only severe inflamation with large fibrosis and destruction of canalicules was observed. Auto-imune pancreatitis by either imuno-histochemical analysis or serical levels of igg4 and NAF was discarded.
This patient still presents severe pain in daily use of opioids. The question is: Is there a place for pancreatic resection in this setting?
Hello, I would like to ask from everyone's perspective what is the biological relevance and impact if the neurons that are being affected by an exogenous stimulus is (1) peptidergic or non-peptidergic neuron, (2) and their respective class of nerve fibers?
Currently, I am still consolidating and distinguishing these concepts because I think these are important research questions in molecular and cellular neuroscience projects.
- I intend to do a quasi-experimental research, which compared a control group with an experimental group in which I apply an intervention to perform pain relief, comparing in both groups, pain levels before and after venous puncture
What should my sample size be?
In my last research, I investigate whether patients with musculoskeletal disorders had increased susceptibility to SARS-CoV2 infection or developed more severe forms of COVID-19; as well as whether COVID-19 affected the underlying disease.
Results showed that the frequency of COVID-19 was low and statistically nonsignificant, but that led to a worsening of the underlying disease.
What are your clinical impressions, ie do you have similar research results?
Dear All,
I am writing a meta analysis. My data from the studies only shows Pre: Mean (SD) Post: Mean (SD) for both treatment and condition. I want to summarize their findings.
I can calculate the difference of means and the SE. However, because they use different scales for the outcome 1-10, 1-21 or 1-40 (for pain), I think I need to transfer it to SMD. But How do I calculate that? And consequently how do I calculate the SE for each SMD per study because I need to provide that in RevMan for the generic inverse variance...
Lots of thanks!
I'm looking for co-authors
Are you a master's or doctoral student in psychology, behavioural sciences, social work, counseling psychology or a related discipline and would like to co-author a study on the depth of emotional pain? If so, let's examine this together.
Have you ever wondered why people self-harm when they are in discomfort or emotional pain? Some curse injury by cutting or burning their flesh, punching or hitting oneself. They do this to divert attention away from the pain or to distract the brain. Can you fathom burning your skin in order to relieve emotional pain? We won't be able to grasp why individuals do what they do or how to help them unless we understand the depth of emotional agony. It is simple to discuss bodily pains caused by injury or illness. Non-physical pain, on the other hand, is difficult to discuss, and instant treatment is impossible.
I need to understand the fibromyalgia tender points and the relation between each other, according to the concept " If they fire together, they wire together". But all what I found by searching was only their positions and some information about pain/ diagnosis/relief,...
So I need a help with any reference even if just an opinion about this issue. Thanks a lot.
16 year old female a known case of prematurity sequale with achilis tendon lengthening at age of 6
now presented with pain and numbness of left leg
by examination pyramidal sign all over
sensory impairement of ant thigh and leg
ncs show chronic tibial nerve injury
no history of trauma or infection
any suggestion?
Good morning all! I am hoping to create a graph similar to Melzack's pain graph comparing the scores of two groups on one scale (Please see attached). I am trying to find out what is the name of this type of diagram, and how to create one. I use SPSS and can work with Excel as well. Thank you!
My lab is looking for a reliable, valid measure of pain for our nonprofit-funded phase 1 clinical trial. We were originally considering the Brief Pain Inventory (BPI) but the paywall (~400) is a bit higher than anticipated. Has anyone had luck with other pain measures similar to the BPI but is either free or more budget-friendly? I did see the McGill Pain Questionnaire, but this appears to require a fee as well (still waiting to hear what that fee will be).
We are looking for a scale that reports both acute and more chronic pain, ideally including history of pain medication/treatment effectiveness. Hence, some of the scales that initially come to mind (e.g., visual analogue scale, numerical rating scale) don't seem like the best fit.
Any help would be appreciated, many thanks!
David
21-year-old female patient having shooting sciatic pain; stiffness in back; radiating pain through buttocks, hips, and legs; worsening pain with extended periods of sitting; some leg weakness. MRI demonstrates L5-S1 disc bulge with no nerve impingement. Diagnosed with degeneration of lumber intervertebral disc with degenerative disc disease and lumbar spondylosis. Surgery is not recommended, physical therapy not helping, cyclobenzaprine & other pain medication no longer working.
Backstory: "pulled" back in May of 2021 with excruciating, immobilizing pain. Got better in one week, pain is now constant.
(MRI & X-ray images included)
Hi all, regarding WOMAC scores, I note most are presented as a aggregate score out of 96. Where 96 means more pain. As confirmed here:
However, why is it here - this shows the opposite where high scores means less pain/normal?
Which score is correct and how does one convert to the other?
I have measured pain intensity using numerical pain intensity scale (NRS) in intervals of 30 min upto 6h for 4 groups. The NRS scale is from 0-10. Can anyone guide me on what statistical comparison can I use to compare the 4 groups?
Dear All
I am interested in publishing a text summarising the research on pain in neuropathic patients with CRPS (medical literature). The article summarizes the experience of pain management and pain use as a diagnostic indicator. Are you planning a publishing in this subject?
In many animal pain models, FCA (Freud's Complete Adjuvant) and carrageenan are injected (in the paw for instance) to induce an experimental immune response and then, assess inflammatory induced hyperalgesia. While carrageenan-induced hyperalgesia lasts a few days, FCA-induced hyperalgesia can last up to weeks using the same species and the same mode of administration.
What are the molecular mechanisms that drives such differences, knowing that CFA and carrageenan are different in nature (heat killed Mycobacterium tuberculosis and polysaccharide extracted from red seaweeds) ?
Dear RG members,
There is doubt that teaching/ learning online has become a pain in the neck worldwide. The gap is getting bigger and bigger. How to bridge such a gap? How would one overcome the barriers of online learning/teaching?
Regards,
I have watched a child crying loudly in pain, while collecting blood for testing. Can we develop a technique which can collect the blood or inject a medicine to children in a complete pain-free way ?
I'm a 4th year undergraduate in University Of Colombo School of Computing (UCSC) in Sri Lanka. I'm doing my final year research based on Taste and EEG data that is recorded of taste sensations. Where I was trying to find a public data set but couldn't find any. Does anyone know how can I find a EEG data set of Taste. Your responses and help will be much appreciated.
I have a small but significant relationship between pain scores and risk of a certain condition (R^2=0.057, p=0.039).
When I include age and gender as covariates, the model loses all significance (R^2=0.043, p=0.15).
This suggests to me that age and/or gender explain at least as much of the variance in pain scores that risk does.
However, when the univariate regressions just of age and gender show no relationship at all (age R^2=0.017, p=0.8, gender R^2=0.005, p=0.4)
I cant quite wrap my head around what the potential relationships between the covariates might be.
My long term study of patients with fibromyalgia and diffuse type 2 occupational overuse syndrome during use of sEMG biofeedback shows that there is a symptomatic difference in pain
during splinting of muscles causing deep ischemic pain and the release of muscle tension which brings about numbness, pins and needles and deep throbbing pain. I am looking for an objective measurement to verify this
Hello!
In cases where I want to evaluate an overall measure, how could I combine two means from the same group?
Example: I have pain VAS for lower back and VAS for hips. I want to know the overall pain VAS. How could I proceed?
Thank you,
I'm a 4th year undergraduate in University Of Colombo School of Computing (UCSC) in Sri Lanka. I'm doing my final year research based on Pain and EEG data that is recorded of pain. Where I was trying to find a public data set but couldn't find any. Does anyone know how can I find a EEG data set of Pain. Your responses and help will be much appreciated.
We are starting an investigation, in the field of physiotherapy, on the evaluation and clinic of pain.
We are interested in knowing which diagnostic evaluation scales are being evaluated.
We are also interested in knowing how to qualitatively assess pain: do you know interview protocols for patients with chronic pain?
We need your expertise/experience as a pain clinician, researcher or patient. We would like to hear your opinion about the learning of pain and others somatic sensations through this short survey https://limey.ugent.be/GHP272/index.php/263964?lang=en
Retraction is a pain in publishing: Opening a debate on this ever-evolving and a topic of wide concern.
What's the verdict on regional analgesia in breast surgery?
Is there any need to use it at all?
The 2018 Cochrane review concluded that synthesis of 18 RCTs favoured regional anaesthesia for the prevention of persistent pain three to 12 months after breast cancer surgery with an OR of 0.43 (95% CI 0.28 to 0.68, 1297 participants, low‐quality evidence).
However, the recent 11-year RCT published in the Lancet 2019 with 2132 patients across 13 hospitals internationally showed there was no difference in incisional pain:
Incisional pain was reported by 442 (52%) of 856 patients assigned to regional anaesthesia-analgesia and 456 (52%) of 872 patients allocated to general anaesthesia at 6 months, and by 239 (28%) of 854 patients and 232 (27%) of 852 patients, respectively, at 12 months (overall interim-adjusted odds ratio 1·00, 95% CI 0·85-1·17; p=0·99). Neuropathic breast pain did not differ by anaesthetic technique and was reported by 87 (10%) of 859 patients assigned to regional anaesthesia-analgesia and 89 (10%) of 870 patients allocated to general anaesthesia at 6 months, and by 57 (7%) of 857 patients and 57 (7%) of 854 patients, respectively, at 12 months.
If it doesn't reduce chronic post surgical pain, is there any point in using it?
(Note: these studies involved paravertebral regional analgesia)
Working in the sport and fitness industry since 20 years before studying in a post- graduate program on chronic non-cancer pain management (CNCP), questions raised up about potential therapeutic use of Androgen Anabolic Steroid (AAS).
If anybody knows if these sports enhancing performance agents (mostly known as sports doping agents) can help for CNCP relief ?
Since more than 20 years, mostly in the field of bodybuilding, I've been witness of devastating chronic pain syndrome such as Chronic Regional Pain Syndrome (CRPS), neuropathic pain and also MSK nociceptive somatic pain injuries happening on athletes. In a large proportion of injured subjects, those who continued to use supra-physiological dose of AAS seems to have a much better functionality than everyone else. I would add that the use of those doping agents allows the injured subjects with chronic pain to self-manage their pain condition a hundred times better than every other method, medication, muti-modal pain rehabilitation, regular HRT commonly used in chronic pain clinic and hospital. The users, or I would say, the abusers understand that a decade before now.
Looking what we have in the literature on that topic is fairly poor and limited. It seems to be a totally new spectrum of research in pain science, as on the ground AAS are often used for CNCP control.
Feel free to add your comments and impressions as in a brain storming reflexion. If anyone finds out publications on that topic please let me know. That research avenu is probably brand new, maybe cause of the toxicity and teratogen potentials of AAS ?
If anyone observed the same thing as I, just let me know.
JP
Is there any difference in efficacy and effectiveness of both vaccines of similar type.
Does anybody have a dataset from a posture intervention that would allow for a correlation coefficient to be calculated between change in posture and change in pain? Particularly interested in forward-head posture and tension-type headaches.
Piriformis syndrome (PS) is an elusive, benign medical condition. Patients usually complaint deep-seated gluteal pain with some aggravating and relieving factors. Regarding aggravating factors, prolonged sitting on the affected side, affected side lying, posture change - standing from sitting, forward bending, etc. are common, whereas walking relives pain somewhat, especially in chronic cases. In acute PS, patients have pain relieving posture finding difficulty, physicians also get confused it with more prevalent low back pain diagnosis, namely prolapsed lumbar intervertebral disc (PLID).
PS is a disorder of exclusion of clinical mimics and it has no definite cause; in literature, lumbar spinal stenosis, leg-length inequality, professional dancers, fibromyalgia, previous fall, blunt gluteal trauma, etc. are mentioned as its risk factors. Sporadic case reports and our recent systematic review addressed infective cause of piriformis muscle injury, where patients complain of clinical features unlike of PS. In piriformis muscle (PM) infection, patients report of persistent deep gluteal pain that doesn't change with posture, patients also have fever and raised laboratory inflammatory markers (raised WBC count, ESR & CRP). Moreover, there may be characteristic MRI changes in the deep-seated gluteal and pelvic structures including PM. Pain medications & PM stretching exercise don't help patient anyway, they need antimicrobials as well; when antibiotics don't work, surgical drainage of PM is required. Like in PS, intra-lesional steroid is contraindicated here. If piriformis pyomyositis is left undiagnosed and untreated precisely, life-threatening consequences may be the outcomes, hence we can consider the piriformis pyomyositis as the PM emergency.
What do you think?
Suggested reading :
1. Siddiq AB, Danny Clegg, Hasan SA, Rasker JJ. Extra-spinal sciatica and sciatica mimics – a scoping review. Korean J Pain 2020; 33:305-317.
2. Siddiq AB, Rasker JJ. Piriformis pyomyositis, a cause of piriformis syndrome – A systematic search and review. Clin Rheumatol 2019; 38:1811-1821.
Dear Community,
We are looking for an antibody that will bind to the outside of the tertiary structure of AChE. It must not bind to the inside of the tertiary structure of AChE.
So ideally, we need an antibody that meets the following criteria:
• reactivity for both rats and humans
• capable of working in an environment where proteins cannot be denatured
• capable of being used in vivo
• capable of binding to the outside of the 3D structure of AChE
In vivo use in this context does not imply that we intend to inject the antibody into an animal or human, but that we would like to bring it into contact with unfixed rat or human nerve tissue.
Assuming that we would get an antibody custom made: Is it possible to use the same antibody for both rat and human tissue?
Do you see any pitfalls in the experiment that we picture? We are mostly interested in the molecular feasibility.
Any help is highly appreciated!
I'm looking into a possible correlation of some types of chronic pain (those related to ptsd and mood disorders) correlating with balance issues, one-sided pain, or inner ear damage. Thanks for any help!
Hello, Everyone. Greetings of the day valuable members of the group. Hope you all are doing well.
I would start this conversation with this statement that, a researcher only knows the pain of another researcher and I believe we all are researchers because we all do research at some point in time. I hereby would like to seek your valuable response to a set of questions in connection to my Research. Kindly spare 5-10 minutes and share your opinions. If you can circulate among your friends, I would be glad to have their responses as well. Thanks a lot in advance. https://docs.google.com/forms/d/e/1FAIpQLSebnXJcW-18LcLkgyg65o11I-0yatIT3Ey3yMS4BGNE9KbTEA/viewform #research #sustainability
#circulareconomy #consumerbehavior #greeneconomy
Many clinicians have noted nonspecidfic pain modulating effects of injecting NACL0.9% or sterile water or another sterile solution which is considered inactive (used in the control group).
It is hypothesized that subcutaneous and intracutaneous injections modulate pain through:
1/ Dry needling effect: the effect of the needle which penetrates the skin and or muscle tissue such a 1A/ s the bleeding effect (blood contains platelets and growth factors), 1B/ triggerpoint effect when needling myofascial trigger points, 1C/ Gate control effect, 1D Effect on neuroinflammation, TRPV1 receptors,
2/ Volume effect: expansion of the extracellular space stimulates peripheral nerve endings
3/ Placebo effect (the placebo effect of an injection is bigger than a pil, but the effect seems to lessen after repeated sessions)
Pain is such sign/symptom that any patient can describe it as high or low although he/she have no pain.
I know there are many pain provocation MSK tests but patient can also express it as false.
Is there any tool to assess pain severity, which patient exactly have, not that patient describe?
My mother, aged 39, has chronic genetic pancreatitis since at least 15 years. She has known several episodes of severe pain and went through lots of surgery that were unsuccessfull. She had a total pancreactomy in may 2020 followed by months of non-pain. But it came back. Because of the surgery, she has, of course, diabetes. She has also gastroparesis but the doctors seem to think that it is not the origin of pain, althouth they are not sure. Her stomach swells before the arrival of pain, like a 6 months pregnant woman. She evaluates her pain at 10 at day and at 12 on the evening on a scale of 10. To relieve pain, she has lots of medicine like Tramadol and other morphine derivatives. The doctors are searching for the cause of the pain but they cannot find. Her life quality is diminished et she suffers a lot. If you have any leads or articles that could help my mother, I would be grateful.
If you can help me or share this post, it would be amazing. Thanks.
Delannoy Manon
Can anyone guide me on the pain areas in cloud computing where Operations Research techniques can be applied. Please guide me on this.
Regards,
JP
