Nitroglycerin - Science topic

Stabilization is made in the process of washings with water and sodium carbonate solutions. NG is quite safe in the emulsion with water, as it is after the synthesis and washings. When it separates it is much more dangerous and I wouldn't recommend storing for a prolonged period of time.

Dynamites have lower sensitivity because NG content is low and the ester is absorbed in other solid ingredients. However, it doesn't mean they have a long shelf life, they are meant to be used soon after the production.

Hello Mr.Grice

Some good leaving groups like tosylate ,tms ,.. are good.(base on reported works)

But halids are relatively inert in some reactions .

Use of I as leaving group in allylic position is a Conventional method but problem is cost.

Nucleophilc replacement of NO3/X since Hughes & Ingold is Well known but other cations participation or catalysis is unkown...

Thank you Sajjad. You provided me with some effective leads.

Package with desiccants.

Ramin Farajpour

Headache following nitroglycerine is common finding in most hypertensive patients specially in migraine cases. Somatriptan is used in this cases... I want to know the efficacy of somatriptan in this type of headache and also other treatment suggestion for decreasing it.

There are several aspects that I would like to comment upon:

1. You cannot treat hypertension-NTG linked headache or hypertension-NTG-migraine properly without understanding the mechanism (see attached file).

2. Sumatriptan is cautioned in hypertensive cases or in clinical situations with established or suspected cardiovascular risk.

3. Hypertension should be treated primarily.

4. Beta-blockers should be used for predominantly systolic hypertension, despite the International recommendations (see attached file).

5. For emergencies, metoclopramide might be a better option -- caution: side-effects (see attached file).

Best wishes,

New Delhi

08 March 2016

orcid.org/0000-0002-6770-5916

You do not have right to treat these patients. This situation cannot be solved by the answer to a multiple showiest question. How did you get into that situation

I do not know a gold standard. However, we were using ilomedin (iloprost) intravenously in increasing concentration during right heart cath to assess a response on TPG/PVR before listing patients for cardiac transplantation. If they respond well and TPG decreases during iloprost infusion the patient could be listed. Yet, I know from other centres who treat patients with bosentan p.o. for 6 month before they are re-evaluated for heart transplantation