Science method

Neoplasms - Science method

New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
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Colon tumors with deficient DNA mismatch repair (dMMR) are generally infiltrated by T cells more densely than tumors with proficient mismatch repair (pMMR). However, high numbers of tumor-infiltrating lymphocytes (TILs) are found in select pMMR tumors, and low numbers of TILs are seen in select dMMR tumors. In this study, we compared T-cell reperto...
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Pindborg tumor is a benign expansile and slow growing odontogenic tumor that occurs mainly in adulthood. Limited management data exist for its treatment in young patients. We report the case of a 5-year-old patient and provide recommendations for the care of pediatric patients diagnosed with this rare odontogenic tumor.
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Malignant proliferating pilar tumors are very rare adnexial lesions that can be confused with other skin neoplasms. The authors present four patients with malignant proliferating trichilemmal tumors located on the scalp. A review of the literature search for malignant proliferating pilar tumors and treatments was performed.
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Lipomas, although ubiquitous, are extremely uncommon in digital nerves. We present a 68-year-old male patient with right ring finger radial digital nerve intraneural lipoma. The tumor was enucleated preserving all the nerve fascicles. We present this case to highlight the rare occurrence of lipomas within a digital nerve.
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Beckwith–Wiedemann syndrome (BWS, OMIM # 130650) is an imprinting disorder, associated with overgrowth and increased risk of embryonal tumors. Patients carrying hypomethylation in the KCNQ1OT1:TSS DMR (11p15.5) show MLID (Multilocus Imprinting Disturbance) upon epimutations at other imprinted regions. Few cases of BWS MLID’s mothers with biallelic...
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Cancer is the leading cause of mortality worldwide. Regulator of calcineurin 1 (RCAN1), as a patent endogenous inhibitor of calcineurin, plays crucial roles in the pathogenesis of cancers. Except for hypopharyngeal and laryngopharynx cancer, high expression of RCAN1 inhibits tumor progression. Molecular antitumor functions of RCAN1 are largely depe...
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Background Hepatic epithelioid hemangioendothelioma (HEH) is extremely rare and the MRI features have never been investigated in a large group of patients. Methods A retrospective study was designed to review the MRI images of HEH patients. Two radiologists separately evaluated signal intensity (SI) on unenhanced imaging, morphological features, c...
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Background The aim of this study was to evaluate the role of F-18 FDG PET/CT imaging in the diagnosis of primary and metastatic adrenal tumors that originate from non-lung cancer primary tumors. Results F-18 FDG PET/CT images of patients (8 male and 6 female; mean: 55.36 ± 16.2 years old) who attended with the diagnosis of primary or adrenal metas...
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Background Distinguishing between a pituitary adenoma and a pituicytoma can be challenging. Hormonal changes in pituicytomas are uncommon, and the tumor's mass effect has triggered most symptoms. There were only two reported cases of pituicytoma with elevated hormonal levels in patients who presented with Cushing syndrome as of 2017. Case presenta...
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The aim of this observation was to report an exceptional association of xeroderma pigmentosum and rhabdoid renal tumor in a 7-year-old girl, diagnosed with imaging and treated by adjuvant chemotherapy.
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Cardiac hemangioma is a rare, benign primary tumor characterized by endothelial proliferation. While reports of cardiac hemangiomas demonstrating 18 F FDG avidity and other forms of hemangiomas showing 68 Ga Dotatate avidity have been published, we present a rare case of primary cardiac hemangioma demonstrating 68 Ga Dotatate avidity, mimicking a p...
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image In children with MPNs, clots are most common in those with JAK2 mutations and those with polycythemia vera
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We outline the features of the R package SparseSignatures and its application to determine the signatures contributing to mutation profiles of tumor samples. We describe installation details and illustrate a step-by-step approach to (1) prepare the data for signature analysis, (2) determine the optimal parameters, and (3) employ them to determine t...
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Cardiac inflammatory myofibroblastic tumor (IMT) is a rare benign tumor that occurs mainly in infants and children. We report a case of right atrial IMT in a 1‐month‐old girl with episodic cyanosis. Both echocardiography and cardiac computed tomography revealed a right atrial mass. The patient underwent a complete surgical resection of the mass and...
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Purpose History of keratinocyte carcinoma (KC) has been associated with survival following the diagnosis of a second primary malignancy (SPM), with the direction of the association varying by cancer type. Research is needed to elucidate the role of other key factors in this association. Methods A retrospective cohort study was conducted among pati...
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Pancreaticoduodenectomyis a major and challenging operation, carrying a significant risk of morbidity and mortality. Today, surgical resection of localized tumor remains the only potentially curative option available for periampullary tumors patients
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Meningiomas are the most common intracranial primary tumor in adults. Surgery is the predominant therapeutic modality for symptomatic meningiomas. Although the majority of meningiomas are benign, there exists a subset of meningiomas that are clinically aggressive. Recent advances in genetics and epigenetics have uncovered molecular alterations that...
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This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s12943-018-0783-3.
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El LNH representa el 26 % de los tumores en los pacientes inmunodeprimidos; constituye la segunda neoplasia más frecuente después del sarcoma de Kaposi en estos pacientes, en donde la afectación cardíaca por el linfoma es un hecho excepcional, siendo 10 a 40 veces más frecuente la invasión secundaria del corazón que la primaria. Existen pocos casos...
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Los tumores cardiacos primarios representan el 0.2% de todas las neoplasias, siendo benignos el 75%, encontrando a los mixomas cardiacos como los más frecuentes, presentándose en adultos entre 30 a 50 años de edad, prevaleciendo en mujeres. Suelen ser únicos y su localización habitual es en aurícula izquierda en un 83%, pudiéndose encontrar en cual...
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Primary mesenteric gastrointestinal stromal tumours are un common neoplasms. These mesenchymal tumours present with nonspecific clinical features. We are reporting a case of large primary mesenteric gastrointestinal tumour with an unusual presentation as acute abdomen.
Preprint
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A coherent model of smittium donation to polio virus is fledged. While a small fragment was shown to initial research arm, the method is expected to larger intercepts as multi viral taxid inquiry. Further, the observed segment is very useful to structural template as enteric specific pathogenesis. In general, this model follows earlier, more primit...
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Juvenile ossifying fibromas (JOFs) of the jaws are uncommon benign fibro-osseous tumors affecting children under 15 years of age. Based on histological criteria, JOFs have been classified into psammomatoid and trabecular. Their aggressiveness, added to their high tendency to recur, provokes real diagnostic and therapeutic challenges for the dental...
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Adenomatoidodontogenic tumor (AOT) is a relatively rare, benign, hamartomatous, and cystic odontogenic neoplasm that was first described more than a century ago. The lesion still continues to intrigue experts with its varied histomorphology and controversies regarding its development. The present article describes threecases of AOT with an unusual...
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Giant epidermal cysts, which have a diameter of ≥5 cm, have rarely been reported. Giant epidermal cysts that have multiple lobules are referred to as multilocular giant epidermal cysts. This study aims to establish the epidemiological characteristics and statistically determine the significance of lobulation in giant epidermal cysts. Data on 19 pat...
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Hemangiomas of the oral cavity are uncommon but have a predilection for the tongue. Although the majority of lingual hemangomas are superficial, certain lesions can affect the deep tongue or even the entire tongue. They're called hamartomas rather than genuine neoplasms. Author presents a case of haemangioma of the anterior 2/3 rd of the tongue inv...
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This Special Issue focused on the current understanding of signaling pathways as well as genetic and epigenetic features involved in the pathogenesis of brain tumors and other nervous system tumors, with emphasis on the development of novel therapeutic approaches aimed at improving the current standard of care [...]
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Treating pancreatic cancers are always challenging to oncologists. Pancreatic tumors are very difficult to treat. Pancreatic cancers spread very fast, have high mortality rates and patients die very quickly. Outcomes for advanced metastatic stage IV pancreatic cancer are poor (less than 3 %). New research showed that it is possible to reduce aggres...
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Introdução: O câncer de mama é o tipo de neoplasia com maior incidência e mortalidade na população feminina no mundo. Observa-se aumento da incidência do câncer de mama e redução da mortalidade associados à detecção precoce. Objetivo: Analisar indicadores de rastreamento de câncer de mama a partir dos registros de mamografias realizadas em mulheres...
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The cancer microenvironment, or tumor microenvironment (TME), describes the non-cancerous cells present in the tumor, such as fibroblasts, immune cells, and cells that comprise the blood vessels and proteins produced by all of the cells present in the tumor that support the growth of the cancer cells [...]
Presentation
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In Nigeria, ovarian cancer is the deadliest gynaecologic malignancy and the second highest cause of cancer death in women. Because overall survival remains low, new drugs targeting Wnt/-catenin are needed.
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Background: The objective of this study was to elucidate the association between neoplastic progression and somatic copy number alterations (SCNAs) occurring within the same colorectal cancer (CRC) tumor. Methods: We investigated SCNAs to identify the progression from a high-grade intramucosal lesion (HGIL) to an invasive front lesion (IFL), via...
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Epithelioid sarcoma (ES) is a rare, clinically polymorphic tumor that afflicts the dermal and subcutaneous region of distal extremity of young adults. In the distal extremity, the involvement of pubic and inguinal region is very rare. We present a case of an epithelioid sarcoma of the pubic region, which was managed, with a combination of upfront s...
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z Giriş ve Amaç: Küçük hücreli akciğer kanseri (KHAK) tüm akciğer kanserlerinin yaklaşık %15'ini oluşturmaktadır. Küçük hücreli akciğer kanserinde prognoz; yeni kemoterapotik ajanların kullanılması, radyoterapi (RT) tekniklerinin gelişmesi ve profilaktik kraniyal ışınlamanın (PKI) eklenmesi ile tedavi sonuçları iyileşmesine rağmen halen kötüdür. Ak...
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Although the implementation of surgery has reduced the mortality of breast cancer, postoperative recurrence is still an important problem bothering patients. DCE-GMRI can not only clearly display the morphological characteristics of breast lesions but also dynamically observe the blood perfusion of the lesions. On account of this, we explored the p...
Preprint
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In this paper, we consider a multispecies variant of the porous media equation used in cancer modelling. Here each species represents a different cell population e.g. healthy cells versus tumor cells. The density of each population solves a continuity equation where the velocity field is given by a pressure gradient that is induced by the total cel...
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Aging induces a series of immune related changes, which is called immunosenescence, playing important roles in many age-related diseases, especially neurodegenerative diseases, tumors, cardiovascular diseases, autoimmune diseases and coronavirus disease 2019(COVID-19). However, the mechanism of immunosenescence, the association with aging and succe...
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DermatoFibroSarcoma Protuberans (DFSP) is a rare recurrent fibrohistiocytic tumor. Because of the rarity of the disease, non‐specific presentation and lack of immunohistochemistry (IHC), its diagnosis is often delayed and prompt treatment is deferred, which can lead to complications such as recurrence and metastasis. Given the limitation of availab...
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Purpose Repeat sentinel lymph node biopsy (rSLNB) has been suggested for axillary staging in clinically node-negative (cN0) patients with ipsilateral breast tumor recurrence (IBTR). Although rSLNB is technically feasible in this group of patients, the clinical value has not been established. We aimed to assess the added value of rSLNB in cN0 patien...
Preprint
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The dynamics between healthy and malignant cells at the avascular stage of growth is described by a set of chemical reactions representing the populations of both types of cells. We obtain a generalization of the logistic-Gompertz dynamics and study the consequences in terms of the properties of tumor growth associated with the Warburg effect, mito...
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Purpose Free flap reconstructions following head and neck tumor resection are known to involve more than 50% rate of complications and other adverse events and up to 50% mortality during a 5-year follow-up. We aimed to examine the difference in the long-term quality of life (QoL) between the 2-year and 5-year assessments after free flap surgery for...
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In this study, we present an extremely rare case of thoracic spinal glomangioma located at the thoracic T7–8 level in the foraminal region, mimicking a schwannoma tumor, in a 65-year-old female patient who was admitted to our clinic with a 6-month history of back pain and weakness in legs.