Science topic

Musculoskeletal System - Science topic

The MUSCLES, bones (BONE AND BONES), and CARTILAGE of the body.
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Publications related to Musculoskeletal System (10,000)
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Article
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Dear Colleagues, The rapid effects of the COVID-19 pandemic on the musculoskeletal system are a result of physical and mental inactivity caused by environmental factors such as social distancing and isolation from nature. The COVID-19 pandemic presents a significant challenge for all organizations. Biological agents may affect occupational safety...
Article
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Background Porphyria cutanea tarda (PCT) is a skin disorder caused by a defect in the liver enzyme uroporphyrinogen decarboxylase and is associated with hepatitis C virus infection, high alcohol intake, smoking and iron overload. Data on the long-term morbidity of PCT is lacking. Methods We conducted a nationwide matched cohort study over a 24-yea...
Article
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Sestrins (Sesns), highly conserved stress-inducible metabolic proteins, are known to protect organisms against various noxious stimuli including DNA damage, oxidative stress, starvation, endoplasmic reticulum (ER) stress, and hypoxia. Sesns regulate metabolism mainly through activation of the key energy sensor AMP-dependent protein kinase (AMPK) an...
Article
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Introduction The World Health Organization describes chiropractic as a health profession that treats the musculoskeletal system and the effects of that system on the function of the nervous system and general health. Notwithstanding such descriptions, scope of practice remains a contentious issue in Australia chiropractic with various authors defin...
Article
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Disability and distress caused by chronic low back pain (LBP) lacking clear pathoanatomical explanations cause huge problems both for patients and society. A subgroup of patients has Modic changes (MC), identifiable by MRI as vertebral bone marrow lesions. The cause of such changes and their relationship to pain are not yet understood. We explored...
Article
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Background Ceroid lipofuscinoses neuronal 6 (CLN6) disease belongs to the neuronal ceroid lipofuscinoses (NCLs), complex and genetically heterogeneous disorders with wide geographical and phenotypic variation. The first clinical signs usually appear between 18 months and 8 years, but examples of later-onset have also been reported. Common manifesta...
Article
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Hydatid disease continues to be a significant health problem in under developed and developing parts of the world where farming and agriculture is common but no veterinary control exists. It is also encountered in developed communities where it is common in the immigrants or in people with a history of travel to endemic areas. Hydatid disease of th...
Article
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Escobar syndrome is a rare, autosomal recessive disorder that affects the musculoskeletal system and the skin. Mutations in the CHRNG and TPM2 genes are associated with this pathology. In this study, we conducted a clinical and genetic investigation of five patients and also explored via in silico and gene expression analysis their phenotypic varia...
Article
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Dissection in anatomy teaching is key in medicine; however, a debate is underway about whether it complements well a modern curriculum in the digital era. We aimed to determine whether a short add-on dissection practise facilitates learning of the gross anatomy relative to studying it with just prosection, plastic models, and digital 3D atlases. We...
Article
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Purpose of Review In this review, we discuss the mechanism of action of gabapentinoids and the potential consequences of long-term treatment with these drugs on the musculoskeletal system. Recent Findings Gabapentinoids, such as gabapentin (GBP) and pregabalin (PGB) were designed as antiepileptic reagents and are now commonly used as first-line tr...
Article
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Background Mobility deficits have been identified as an independent risk factor for hospital readmission for adults ≥65 years. Despite evidence indicating how determinants additively influence and predict mobility, no hospital-to-home care transition models comprehensively assess all seven mobility determinants, cognitive, financial, environmental,...
Preprint
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It is known that specimen collection followed by histopathological workup is the core of evidence-based medical therapy of musculoskeletal tumors. There exist many controversies about how a biopsy should be performed. While some centers recommend minimal invasive biopsy procedures, mostly the core needle biopsy (CNB), others prefer the incisional b...
Article
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Osteomyelitis, or bone infection, is a major complication of accidental trauma or surgical procedures involving the musculoskeletal system. Staphylococcus aureus is the most frequently isolated pathogen in osteomyelitis and triggers significant bone loss. Hypoxia-inducible factor (HIF) signaling has been implicated in antibacterial immune responses...
Article
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The role of biomechanical stress and trauma in the initiation of inflammation of the joints and periarticular structures in psoriatic arthritis (PA) is currently not fully understood. Soft tissues and joints are the target for constant biomechanical stress and microtrauma, leading to inflammation. There is an opinion that this inflammation in PA is...
Conference Paper
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Introduction: Pigmentary mosaicism is a term that describes varied patterns of pigmentation in the skin caused by genetic heterogeneity of the skin cells with an altered ability to produce melanin. In a substantial number of cases, pigmentary mosaicism is observed alongside extracutaneous abnormalities typically involving the central nervous system...
Article
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Versatile strategies have been developed to construct electrospun fiber-based drug delivery systems for tissue regeneration and cancer therapy. We first introduce the construction of electrospun fiber scaffolds and their various structures, as well as various commonly used types of drugs. Then, we discuss some representative strategies for controll...
Article
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Background: Henoch-Schönlein purpura (HSP) is a common systemic vasculitis in children, involving the skin, musculoskeletal system, gastrointestinal tract and kidneys. Some studies in children have shown possible risk factors linked with the development and severity of HSP Nephritis (HSPN). The aim of this study was to research predicting factors...
Article
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Background: Complaints of arm, neck, and shoulders (CANS) is a common problem among patients whose work involves computer use, but often ignored most importantly by the physicians partly due to not being able to appreciate the importance of taking a careful detailed occupational history of exposure to a repetitive activity involving upper arms. Met...
Article
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Rheumatoid arthritis (RA) is a chronic inflammatory disease caused by numerous genetic and environmental factors leading to musculoskeletal system pain. RA may damage other tissues and organs, causing complications that severely reduce patients’ quality of life. According to the World Health Organization (WHO), over 1.71 billion individuals worldwi...
Article
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Hydatid cyst is a zoonosis located most commonly in the liver and lungs and is frequently encountered in our country. Its localization in the musculoskeletal system is quite rare and the diagnosis is difficult due to the nonspecific symptoms of the patients. In this article, a case of hydatid cyst located in the left vastus medialis muscle in a 60-...
Article
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Magnesium (Mg)-based implants were extensively developed and tested to improve the shortages of traditional hard metal implants. Unlike the nail, screw, and plate, pure Mg wire is rarely applied in the musculoskeletal system because of its poor mechanical properties. Therefore, we developed the magnesium–zinc–gadolinium (ZG21) alloy wire, which pre...
Article
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Purpose of Review Chemotherapy drugs combat tumor cells and reduce metastasis. However, a significant side effect of some chemotherapy strategies is loss of skeletal muscle and bone. In cancer patients, maintenance of lean tissue is a positive prognostic indicator of outcomes and helps to minimize the toxicity associated with chemotherapy. Bone-mus...
Article
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Humans perform dexterous and highly dynamic movements like throwing, running, hitting or jumping by adjusting the dynamic characteristics of their musculoskeletal system. While the human muscle stiffness varies across different tasks, adjustable stiffness ensures the safety, saves energy, and provides comfort of to the human while maintaining perfo...
Article
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Robotic manipulators are expected to enhance humans’ ability to grasp and manipulate objects. Soft materials offer innovative opportunities to develop robotic manipulators that are inherently compliant, physically robust, and interact safely with humans. Herein, a soft‐material‐based musculoskeletal module is reported. Inspired by the human shoulde...
Article
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Tendons are essential components of the musculoskeletal system that links the skeletal muscle to the skeleton. This dense connective tissue exhibits great plasticity. Therefore, research on the influence of types of exercise, including acute and long-term training, on the structural and mechanical properties of tendons in athletic and sedentary pop...
Article
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Choroba zwyrodnieniowa stawów jest najczęściej występującą chorobą narządu ruchu, postępującą, obejmującą w pierwszej kolejności powierzchnie stawowe. Zwyrodnienia wywołują u pacjentów bol i sztywność stawów, co prowadzi do utrudnienia życia codziennego oraz negatywnie wpływa na komfort psychofizyczny chorego. Celem pracy była ocena wpływu dwutygod...
Article
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Whole body vibration (WBV) is well known to exert beneficial effects on multiple tissues, improving synaptic transmission, muscle mass, bone quality, and reducing anxiety and depressive behavior. However, the underlying molecular mechanisms are not yet fully understood, and organs and tissues may respond differently to the vibratory stimulus depend...
Article
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The primary objective was to learn the extent that muscle function, mobility, and self-reported health decline following incident diabetes, stroke, lung problem, and heart problems. A secondary objective was to measure subsequent recovery following the incident events. A longitudinal panel study of the natural history of four major chronic diseases...
Experiment Findings
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Lyme disease is an abundantly present vector-born disease, with nearly 400,000 new cases in the U.S. diagnosed each year. While treatment with antibiotics is effective, if the disease goes unnoticed and unchecked it can lead to lifelong damage to the nervous and musculoskeletal system. Hence, it is critical to detect the disease as early as possibl...
Article
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Musculoskeletal research deals with the effects of the orthopedic treatment of pathologies on the biomechanics of the affected areas and on the musculoskeletal system [...]
Article
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Systemic lupus erythematosus (SLE) involves dysregulation of the immune system, consequently affecting multiple organ systems, including the cardiovascular, neuropsychiatric, renal, and musculoskeletal systems. Optic neuritis and intracranial hypertension are conditions that rarely occur in SLE, and their coexistence has not been reported to date....
Article
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Background: The global pandemic of SARS-CoV-2, or COVID-19 continues to attack all human systems. Although COVID-19 is a respiratory disease, various extra-pulmonary manifestations, including musculoskeletal and neuropathies/myopathies was reported. This study aimed to investigates the long-term impacts of COVID-19 infection on physical health, cap...
Article
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Purpose of Review Headache disorders are often accompanied by associated symptoms involving organ systems other than the central and peripheral nervous system, including the integumentary, cardiovascular, and musculoskeletal system. However, skin changes or conditions are not commonly associated with headache disorders. Recognition of possible etio...
Article
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Echinococcosis (hydatidosis) remains a crucial public health concern in areas of endemicity including South Sudan. It affects mostly liver and lungs but rarely musculoskeletal system. A female, aged 75 years, presented to Kapoeta State Hospital, with a three years’ history of a painless mass on her back, gradual onset. There was no history of traum...
Article
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Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a new class of antidiabetic drugs, acting by inhibiting the reabsorption of glucose in the kidneys. They turned out to improve cardiovascular and renal outcomes not only in patients with type 2 diabetes but also in nondiabetic patients. At present, they are more and more widely used in patients...
Article
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Functional electrical stimulation (FES) can be used to restore motor function to people with paralysis caused by spinal cord injuries (SCIs). However, chronically-paralyzed FES-stimulated muscles can fatigue quickly, which may decrease FES controller performance. In this work, we explored the feasibility of using deep neural network (DNN) controlle...
Preprint
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Biological aging of human organ systems reflects the interplay of age, chronic disease, lifestyle and genetic risk. Using longitudinal organ imaging and physiological phenotypes from the UK Biobank, we establish normative models of biological age for 7 body (cardiovascular, pulmonary, musculoskeletal, immune, renal, hepatic and metabolic) and 3 bra...
Preprint
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Background How obesity earlier in life impacts upon mobility dysfunctions in late life is not well understood. Pernicious effects of excess weight on the musculoskeletal system and mobility dysfunctions are well-recognized. However, increasingly more data support the link of obesity to overall motor defects that are regulated in the brain. Objecti...
Article
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The rhythm and tempo of music has a beneficial impact on a person's desire to perform in unison movements. They can calm or excite the human nervous system and have a beneficial effect on the overall physical condition of the person. Regular fitness classes help to improve the mental and physical performance of students. Types and forms of fitness...
Article
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A case report of an 11-year-old boy with a de novo variant in NOTCH2 and clinical features characteristic of Hajdu-Cheney syndrome is reported, with acroosteolysis of the distal phalanges of the feet and hands, generalized osteoporosis, musculoskeletal and craniofacial alterations, short stature, bowing of long bones, vertebral anomalies, genu recu...
Article
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Staphylococcus lugdunensis (S. lugdunensis) is a coagulase‐negative staphylococcus (CoNS), found commonly as skin flora in humans. While most species of CoNS are clinically benign, S. lugdunensis can exhibit a similar virulence to that of S. aureus. However, there is scant data concerning S. lugdunensis infection in the pediatric population. To asc...
Article
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Idiopathic inflammatory myopathies (IIMs) are a group of rare, acquired autoimmune diseases characterized by profound muscle weakness and immune cell invasion into non-necrotic muscle. They are related to the presence of antibodies known as myositis-specific antibodies and myositis-associated antibodies, which are associated with various IIM phenot...
Article
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Introduction Depression is the leading cause of disability worldwide and is a major contributor to the overall global burden of disease. The prevalence of depression is rising and it often co-occurs with other physical diseases. Objectives The research aims to determine the comorbidity of depression and anxiety disorders with chronic physical dise...
Article
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Background In the musculoskeletal system, bone, tendon, and muscle form highly integrated multi-tissue units such as the rotator cuff complex, which facilitates functional and dynamic movement of the shoulder joint. Understanding the intricate interplay among these tissues within clinical, biological, and engineering contexts is vital for addressin...
Article
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To study the hindlimb connectivity patterns of aquatic birds, we compared the musculoskeletal multi-networks of non-divers (Numididae and Anatidae), wing-propelled divers (Alcidae and Sphenicidae), and foot-propelled divers (Anhingidae, Phalacrocoracidae, Podicipedidae, and Gaviidae). Anatomical multi-networks are undirected multigraphs where bones...
Article
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Purpose Non-invasive imaging is a key clinical tool for detection and treatment monitoring of infections. Existing clinical imaging techniques are frequently unable to distinguish infection from tumors or sterile inflammation. This challenge is well-illustrated by prosthetic joint infections that often complicate joint replacements. D-methyl-¹¹C-me...
Article
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Type 2 diabetes mellitus, a metabolic disorder characterized by abnormally elevated blood sugar, poses a growing social, economic, and medical burden worldwide. The skeletal muscle is the largest metabolic organ responsible for glucose homeostasis in the body, and its inability to properly uptake sugar often precedes type 2 diabetes. Although exerc...
Article
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Over 36 million adults over 65 years of age experience accidental falls each year. The underlying neuromechanics (whole-body function) and driving forces behind accidental falls, as well as the effects of aging on the ability of the musculoskeletal system to adapt, are poorly understood. We evaluated differences in kinematics (lower extremity joint...
Article
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Straining movements, repetitive movements, vibration, staying in inappropriate posture for prolonged periods cause complaints such as pain in the in the musculoskeletal system, injuries, sprains, hernia, tears and soft tissue injuries. Complaints of excessive strain and frequent repetitions over time can suddenly arise, causing a work injury. The a...
Article
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Context Vitamin D is an essential, fat soluble micronutrient long-known for its effects on calcium homeostasis and bone health. With advances in technology, it is being discovered that Vitamin D exerts its effects beyond the musculoskeletal system. Vitamin D has since been noted in nervous system health and functioning, and is becoming a target of...
Article
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Chronic chikungunya disease is associated with a poor quality of life and a variety of symptoms, not restricted to the musculoskeletal system. Patients with chronic chikungunya disease in Guadeloupe were evaluated in order to identify the main factors determining the quality of life. Patients were followed up at a mean of 36 months after chikunguny...
Article
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Objective: With the development of extracellular vesicles (EVs) based on stem cells research all over the world, our present study was aiming to discover the global trends in this field. Methods: All publications related to EVs based on stem cells from 1991 to 2021 were collected from the Science Citation Index-Expanded of Web of Science Subsequent...
Article
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Pertrochanteric fractures (PFs) are life threatening due to the prolonged immobilization of the elderly patient that affects, indirectly, the function of most organs. PFs may have an impact on the symmetry of the human body and contribute to poor global alignment. The aim of the study is to evaluate the functional, pedobarographic and radiological...
Conference Paper
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Background Human Anatomy is an essential precursor in the medical program that is deemed significant to learn and even more difficult to recall. Understanding of the body's anatomical structures is critical for surgical safety (Bergman et al.,2011) and a crucial pillar of medical curricula, whether integrated or traditional (Noorafshan et al., 201...
Article
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Background: The aging process can cause various problems including physical decline that impacts balance. Balance disorders are often found in the elderly caused by the nervous system, sensory system and musculoskeletal system. Square step and tandem walking exercises are implemented to improve dynamic balance in the elderly so that the activities...
Article
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The study related serum lead level to cardiopulmonary function, quality of life and musculoskeletal pain of welders in Enugu, Nigeria. Snowball sampling technique was adopted to reach over 100 Enugu resident welders. The first 100 who met the inclusion criteria and gave their consent to participate in the study were sampled. The welders' serum lead...
Article
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Objective: to identify the frequency of occurrence of sickness absenteeism, according to the profile of Primary Health Care (PHC) professionals, and verify if there was an impact of the pandemic on absence duration and reason. Methods: a cross-sectional study, from January/2019 to December/2020, with PHC professionals from a municipality in nort...
Article
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Typical harvesting baskets (TB) are used in various agricultural workplaces; however, no study to date has reported their effect on the musculoskeletal system. Therefore, this study aimed to evaluate the effects of a novel basket with attached rotational handles (RHB) to help alleviate the work-related physical burden of farmers. We analyzed the su...
Article
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Objective to identify the frequency of occurrence of sickness absenteeism, according to the profile of Primary Health Care (PHC) professionals, and verify if there was an impact of the pandemic on absence duration and reason. Methods a cross-sectional study, from January/2019 to December/2020, with PHC professionals from a municipality in northeas...
Article
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Background. Measurement of the length of the lower extremities is an important part of the assessment of the musculoskeletal system. If there is a discrepancy in the length of the legs, the accuracy of the measurement technique will determine the choice of further tactics for treating the patient. However, to date, there is no consensus among exper...
Article
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Persons with Cerebral Palsy (CP) have disabilities due to disorders of the musculoskeletal system that were often accompanied by various other symptoms with different degrees of severity, such as seizures, intellectual disabilities, bone deformities, learning disorders, etc. Those people have a higher risk of malnutrition and seizures, especially c...