Mood Disorders - Science topic

Emotion regulation flexibility (ERF) has the function of enabling individuals to adapt to social environments, and a lack of ERF is an important risk for the onset and development of mood disorders such as anxiety and depression. It has been suggested that low task-switching is a critical factor in the lack of ERF, but task-switching cannot benefit...

Background Gambling disorder has been consistently linked to suicidal ideation and suicide attempts, but few studies have investigated the association between gambling disorder and suicide mortality. This study examined the risk of suicide mortality associated with gambling disorder compared to the general population and other patient groups. Meth...

Introduction Hypertensive disorders of pregnancy (HDP) or prepregnancy overweight/obesity are independently associated with the risk for certain neurodevelopmental and psychiatric disorders in offspring. These two conditions often co‐exist but the risk from combined exposure is unknown. We investigated whether specific subtypes of maternal HDP, alo...

Objectives This study aimed to assess the prevalence of treatment-resistant depression (TRD) and associated factors among patients with major depressive disorder (MDD) on follow-up at Amanuel Mental Specialised Hospital, Addis Ababa, Ethiopia, 2021. Design and setting An institution-based cross-sectional study design was employed using systematic...

Background Lithium is our oldest continuously prescribed medication in psychopharmacology, with its history as an agent for treating mood disorders extending from the 19th century. Although clinicians prescribe it less frequently than in the past, its utility in treating bipolar disorder is unquestionable. Novel potential indications for its use in...

Mitochondria are organelles involved in different cellular functions, especially energy production. A relationship between mitochondrial dysfunction and mood disorders, especially bipolar disorder (BD), has been reported in the scientific literature, which suggests altered energy production and higher levels of oxidative stress compared to healthy...

Purpose Menstrually related mood disorder (MRMD) is marked by severe affective symptoms in the late luteal phase of the menstrual cycle. We hypothesized that women with MRMD experience relative neuroactive steroid deficiency, specifically low allopregnanolone levels due to reduced conversion of progesterone, in association with the onset of affecti...

Introduction Perinatal substance use continues to rise across the United States presenting unique challenges to providing antepartum care. Polysubstance use, limited and late engagement in health care, co‐occurring mood disorders, and several social barriers are well documented. This review seeks to summarize these barriers and present novel approa...

Background: The genetic determinants of peripartum depression (PPD) are not fully understood. Using a multi-polygenic score approach, we characterized the relationship between genome-wide information and the history of PPD in patients with mood disorders, with the hypothesis that multiple polygenic risk scores (PRSs) could potentially influence the...

Mood disorders are associated with complex disruptions in brain networks, including those associated with the orbitofrontal cortex (OFC) and pregenual anterior cingulate cortex (pACC). The functional contribution of the caudal OFC (cOFC) has remained largely unexplored. We investigated the functions of the cOFC and pACC in macaques performing an ap...

Os benzodiazepínicos conseguiram se popularizar por terem efeitos ansiolíticos e estão entre as drogas mais prescritas no mundo. São frequentemente utilizados no tratamento de pacientes com transtornos mentais. Todavia, estão relacionados a dificuldades do processo de aprendizagem e memória, além de prejudicar as funções psicomotoras e provocar dep...

Sex and gender differences play a significant role in the pathogenesis, clinical presentation, and treatment outcomes of various diseases. These differences arise from a complex interplay between biological, hormonal, genetic, and sociocultural factors. Understanding and recognizing these differences is crucial for providing personalized and effect...

Introdução: Os transtornos mentais estão entre as condições crônicas mais prevalentes, podem afetar indivíduos de qualquer classe social, em qualquer fase da vida. O estigma e a discriminação diminuem a qualidade de vida, interferem no desempenho de papeis sociais, impedem a integração social e o acesso ao tratamento, criando um ciclo de desvantage...

To reduce long hospitalization durations and the high rate of compulsory psychiatric hospitalization in Korea, a revision of the Mental Health Welfare law was passed and implemented in 2017. This study quantitatively analyzed changes in hospitalization use behavior of patients with psychotic and mood disorders after revision of the Mental Health We...

Suicidal ideation is a significant symptom associated with mood disorders. Ketamine is an emerging treatment with rapid and robust antidepressant and antisuicidal effects observed in clinical trial populations. Herein we assessed the real-world effectiveness of ketamine in ameliorating suicidality. A retroactive chart analysis of 96 adult TRD patie...

Transcranial Magnetic Stimulation (TMS) is a non-invasive neuromodulation technique, with minimal adverse effects and few contraindications. The procedure has been used in the therapeutic arsenal of patients with depression, showing therapeutic benefits proven in research around the world. TMS is a technique already widely used in the treatment of...

Purpose To describe the prevalence of fatigue in adults with colorectal cancer (CRC). Additionally, to explore the associations and correlations between fatigue and sociodemographic and clinical characteristics. Methods Patients with CRC at various phases of the disease were evaluated for fatigue using the Brief Fatigue Inventory (BFI), independen...

Use of large language models such as ChatGPT (GPT-4) for mental health support has grown rapidly, emerging as a promising route to assess and help people with mood disorders, like depression. However, we have a limited understanding of GPT-4's schema of mental disorders, that is, how it internally associates and interprets symptoms. In this work, w...

Dysregulation in the stress-response system as a result of genetical mutation can provoke the manifestation of affective disorders under stress conditions. Mutations in the human DISC1 gene is one of the main risk factors of affective disorders. It was known that DISC1 regulates a large number of proteins including BMAL1, which is involved in the r...

Postpartum depression (PPD) is prevalent and debilitating mood disorder that affects women during the postpartum period and severely impact maternal-infant bonding, child development, and family dynamics. This review aimed to provide a comprehensive analysis of the key risk factors contributing to the onset of Postpartum depression. The review inve...

In Japan, the Medical Treatment and Supervision Act (MTSA) was enacted in 2005 to provide intensive interventions aimed at reintegrating forensic psychiatric patients into society. However, these individuals face challenges with social reintegration and have an elevated risk of suicide. Therefore, identifying the risk factors for suicide among fore...

Background Reproductive mood disorders indicate that within-person variation in depressive symptoms across the menstrual cycle can be related to ovarian hormone changes. Until now, such cycle-related symptom changes have been measured once daily, even though depression research indicates systematic diurnal changes in symptoms. Further, previous res...

Introduction Accumulating data support the association between increased inflammation and bipolar disorder (BD), and preliminary data suggest that augmentation with low-dose aspirin (LDA) may protect against the onset and deterioration of BD via anti-inflammatory pathways. The A-bipolar randomised controlled trial (RCT) aims to investigate whether...

Question The optimal dose of lurasidone for bipolar depression is unclear. This study examined its dose–response relationship for efficacy, acceptability, and metabolic/endocrine profiles. Study selection and analysis Five databases and grey literature published until 1 August 2024, were systematically reviewed. The outcomes included efficacy (cha...

Resumen: Se ha demostrado que los estilos de crianza-EC-que ejercen los padres tienen un efecto sobre el rendimiento académico de sus hijos, sin embargo, resulta incierto si su salud mental y otras variables sociodemográficas también lo poseen. El objetivo de la presente investigación fue analizar la asociación entre los EC y el promedio, así como...

Hence, answering the question how a person is able to secure and maintain lifelong good mood would facilitate in deceiphering depression; a common and etiologically complex multi factorial mental health disorder which affects over 264 m individuals worldwide with tremendous effect on morbidity and economic burden. Here, our study results from more...

Obesity is a consequence of multiple factors, including genetics, lifestyle and nutritional choices, physical activity, sleep duration, screen time, and mood disorders. These behavioral elements can impair the regulation of energy balance and obesity management that link obesity to a constellation of chronic conditions that lead to a high prevalenc...

Acute pain is a physiologic, protective life-important warning neurological signal indicating multi-level tissue modulations caused by a broad spectrum of health adverse events such as stress overload, mechanical trauma, ischemia–reperfusion, sterile and infection-triggered inflammation, single- and multi-organ damage, acute and chronic wounds, tis...

Background: Dysfunctions of the hypothalamic-pituitary-adrenal (HPA) axis can trigger multiple sclerosis (MS) symptoms. Mood disorders comorbid with MS are implicated in the HPA axis activation in most people with MS (pwMS). This study purposed to examine salivary cortisol (SC) levels and their association with mood disorders in pwMS. Methods: Fort...

The issue of substance use is increasingly being recognised as a significant global public health concern. In relation to its influence in the Arab world, scholarly investigation continues to be regarded as relatively constrained in scope. We aimed to investigate the prevalence of substance use among patients with psychiatric disorders, as well as...

Purpose of the study Psilocybin is a rapidly-emerging treatment for depression, yet its impact on sleep is not well understood. We sought to explore the literature on sleep and psilocybin use, and explore the topic using our own primary data. Findings Whilst clinical trials demonstrate large depressive symptom improvements, the impact of psilocybi...

Background. Children with cancer often undergo prolonged and recurrent hospitalization, which leads to an increased incidence of sleep disruptions and psychiatric disorders. This study aimed to objectively quantify the prevalence of sleep disruptions in hospitalized pediatric oncology patients and to determine the effects of psychiatric disorders,...

Background Post-stroke depression (PSD) is a common mood disorder associated with stroke. By investigating the differences in life quality factors among stroke survivors, the results of this study offer insights into how to better prevent and manage the onset and progression of depression. Methods This study is a cross-sectional study that selecte...

Maternal and Child Health (MCH) programs have long been integral to global public health initiatives, aiming to safeguard the well-being of both mothers and their offspring. However, amidst the comprehensive approach to physical health, the mental well-being of mothers has often been overlooked, representing a critical gap in these programs. This p...

A strict association exists between mood disorders and endogenous hypercortisolism, namely Cushing’s syndrome (CS). Indeed, CS is characterized by a wide range of mood disorders, such as major depression, generalized anxiety, panic disorders, bipolar disorders up to psychosis, with major depression being the most frequent, with a prevalence of 50–8...

Introduction and Purpose Brain tumors cause a variety of somatic and psychiatric symptoms, which vary depending on the age of the patient and the location and type of tumor. Symptomatology includes both physical symptoms, such as headache, nausea, seizures and weakness, and psychiatric symptoms, including mood, personality and cognitive dysfunction...

Background: Implantable cardioverter defibrillators (ICDs) are recommended for patients experiencing malignant tachyarrhythmias due to irreversible causes, who are clinically stable, and have a life expectancy exceeding one year. However, adverse socioeconomic and psychosocial conditions can adversely affect short-term survival and may render impla...

Background Non-suicidal self-injury(NSSI)is a widespread occurrence among adolescents, and this behavior can bring serious consequences. In recent years, the prevalence of NSSI continues to rise, which has attracted the attention of many researchers. But currently there is no research exploring the overall research distribution of NSSI in adolescen...

Resumo Fundamento: Os cardioversores-desfibriladores implantáveis (CDIs) são indicados para pacientes que apresentaram taquiarritmias malignas por causas irreversíveis, clinicamente estáveis e que tenham expectativa de vida maior que um ano. No entanto, condições socioeconômicas e psicossociais desfavoráveis impactam negativamente a sobrevida de cu...

Objective analizar las licencias laborales por trastornos del estado de ánimo entre 2018 y 2020 en Piauí. Método estudio censal, descriptivo-analítico, realizado en Piauí, Brasil, entre mayo y julio de 2021. Datos recolectados en la base de datos del Instituto Nacional del Seguro Social. Analizados con estadística descriptiva e inferencial. Resul...

Objective To analyze work absences due to mood disorders between 2018 and 2020 in Piauí. Method Census study, descriptive-analytical, carried out in Piauí, Brazil, between May and July 2021. Data was collected from the National Social Security Institute’s database. Analyzed with descriptive and inferential statistics. Results 1,717 leaves were id...

Background Rock climbing (RC) has gained attention as a therapeutic tool in psychiatric settings that merges physical exertion with mental engagement. It has potential to enhance mental health, through improved self-efficacy and social interaction, making it a novel intervention for addressing anxiety, depression, and behavioral issues in adolescen...

Objective To analyze work absences due to mood disorders between 2018 and 2020 in Piauí. Method Census study, descriptive-analytical, carried out in Piauí, Brazil, between May and July 2021. Data was collected from the National Social Security Institute’s database. Analyzed with descriptive and inferential statistics. Results 1,717 leaves were id...

Background Producing relevant knowledge on the prevalence of mood disorders (MDs) requires a clear identification of people living with the condition. Analyzing this multifaceted disease from the perspective of health administrative data and population‐based surveys could contribute to document inconsistencies between these data sources and highlig...

Background Teenage suicide-related behaviors have been highlighted in Japan in recent years, but the background factors and characteristics of these behaviors have not been clarified. Therefore, we investigated the characteristics of teenage suicide attempters who were admitted to an emergency room. Methods The subjects were suicide attempters in...

The first two years of the COVID-19 pandemic and subsequent health mandates resulted in significant disruptions to daily life, creating a period of heightened psychosocial stress in myriad aspects. Understanding the impact of this period on pregnant individuals’ bacteriomes is crucial as pregnancy is a period of heightened vulnerability to stress a...

Background: There is limited evidence on how the United States Food and Drug Administration’s (FDA) proposed ban on menthol cigarettes and flavored cigars will impact individuals with mood disorders who smoke menthol cigarettes. This study aimed to evaluate how individuals with mood disorders who smoke menthol cigarettes might respond to a hypothet...

Objectives: Smartphone apps can be highly effective in supporting young people experiencing mood disorders, but an appealing visual design is a key predictor of engagement with such apps. However, there has been little research about the interaction between visual design, mood and wellbeing in young people using a mental health app. This study aime...

In many medical settings, medications are typically administered in the morning or evening, aligning with patients’ daily routines. This practice does not stem from chronotherapy, which involves scheduling drug administration to enhance its effectiveness, but rather from the way clinical operations are structured. The timing of drug administration...

Major depressive disorder (MDD) and bipolar disorder (BD) are two of the most prevalent mood disorders that seriously jeopardize both physical and mental health. The current diagnosis of MDD and BD relies primarily on clinical symptoms. However, correctly differentiating between MDD and BD during depressive episode states remains a substantial clin...

Objective The objective of this study is to identify the top 10 research priorities on reducing and stopping psychiatric medication that reflect the perspectives and unmet needs of three key stakeholder groups (people with lived experience, family members/carers/supporters and healthcare professionals). Methods A priority-setting partnership was c...

Aim Spouses experience conflicting emotions when caring for partners with severe mental illnesses. They can have negative emotions while also regarding caregiving as positive and may develop a better marital relationship through the caregiving process. This study investigated factors affecting the negative and positive emotions of husbands and wive...

Background Non-suicidal self-injury (NSSI) behaviors among adolescents with mood disorders represent a significant global public health concern. This study aimed to assess the prevalence and identify key predictors of NSSI behaviors in Chinese adolescents diagnosed with depressive or bipolar disorders, addressing a critical gap in the literature....

Polycystic Ovary Syndrome (PCOS) is a prevalent endocrine disorder among women of reproductive age, associated with various health impacts. It is characterised by hormonal imbalances, such as hyperandrogenism and insulin resistance, which lead to metabolic and reproductive complications. Beyond the physical symptoms, PCOS has significant psychologi...

Understanding the impact of depression on brain aging benefits the prognosis of this disease and of the risk that other age‐related brain disorders will develop in the same population. The aim of the present study was to explore the genetic effect of depression on longitudinal changes in brain structure throughout the lifespan using a Mendelian ran...

Aripiprazole is approved for various severe mental disorders in adults and adolescents. However, off-label prescribing is common, especially in children and adolescents (youth) in whom aripiprazole therapeutic serum level reference ranges are lacking for any disorders. The aim of the study was to evaluate the relationship between aripiprazole dose...

INTRODUÇÃO | As doenças mentais se apresentam como as mais incapacitantes no mercado de trabalho (WHO, 2020). Dentre elas, ressalta-se o estresse ocupacional e a síndrome de burnout (Evans; Charney, 2003). O estresse ocupacional, decorrente de demandas excessivas e condições de trabalho desafiadoras, pode levar ao burnout, uma resposta prolongada...

Background: Autistic individuals frequently experience psychiatric co-occurring conditions, but the association with self-harm/suicidality according to these conditions was not yet elucidated. We aimed to summarize the association between self-harm/suicidality and psychiatric co-occurring conditions in autistic people. Methods: We systematically s...

We apply an evolving granular-computing modeling approach, called evolving Optimal Granular System (eOGS), to bipolar mood disorder (BD) diagnosis based on speech data streams. The eOGS online learning algorithm reveals information granules in the flow and design the structure and parameters of a granular rule-based model with a certain degree of i...

Objectives To investigate the prevalence, associated factors, treatment status and burden of constipation in workers with depression or anxiety. Study design This was a retrospective observational study using a pre-existing database. Setting Claims data from October to November 2022 and data from the survey conducted in November 2022 were extract...

Aim: Schizophrenia and bipolar disorder are two major types of mental illness that cause cognitive, social, and emotional problems.Many studies have shown that individuals with these illnesses have structural brain abnormalities.In particular, people with schizophrenia often have enlarged ventricles and reduced gray matter in the frontotemporal reg...

Introduction : La santé mentale des étudiants est préoccupante. La littérature scientifique affirme le mal-être des étudiants qui se traduit par une détresse psychologique. Cette détresse se manifeste par des troubles de l’humeur, du sommeil, de l’alimentation, une dépression, de l’anxiété, un stress chronique. L’accès au monde universitaire est un...

The orbitofrontal cortex (OFC) plays a crucial role in mood disorders; however, its specific role in the emotional behaviors of mice remains unclear. This study investigates the bidirectional control of emotional behaviors using population calcium dynamics and optogenetic manipulation of OFC neurons. Fiber photometry of OFC neurons revealed that OF...

Background In schizophrenia (SZ), impairments in cognitive functions, such as working memory, have been associated with alterations in certain types of inhibitory neurons that utilize the neurotransmitter γ -aminobutyric acid (GABA) in the dorsolateral prefrontal cortex (DLPFC). For example, GABA neurons that express parvalbumin (PV) or somatostati...

Background There is a compelling need for innovative intervention strategies for patients with affective disorders, given their increasing global prevalence and significant associated disability and impaired functioning. This study aimed to investigate whether a comprehensive multimodule individualized intervention (AWARE), targeting known mediator...

Introduction: Decreased plasma BDNF (pBDNF) levels have been proposed as a biomarker in the illness phases of mood disorders. This cross-sectional study aimed to evaluate the pBDNF and BDNF promoters’ DNA methylation levels in workers exposed to occupational stress and suffering from work-related stress disorders. Methods: the pBDNF and BDNF exon I...

Background Although repeatedly confirmed, the molecular nature of gene-environment (GxE) interactions has rarely been investigated in the clinical context of mood disorders. This study assesses the relationship between HTR2A genetic variants and the modulatory effect of inflammation in a collective cohort of patients with major depressive disorder...

Introduction Late-life depression (LLD) is a global public health issue, often accompanied by cognitive impairments that can exacerbate the severity of depression and impair social functioning. Despite being a well-established treatment for LLD, the suitability of problem-solving therapy (PST) for individuals with LLD and varying degrees of cogniti...

Advances in deep learning hold promise for predicting clinical factors from human brain images. In this study, we applied a spherical harmonics-based convolutional neural network approach (SPHARM-Net) to MRI-derived brain shape metrics to predict age, sex, and Alzheimer’s disease (AD) diagnosis. MRI-derived brain features included vertex-wise corti...