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Publications related to Molecular Cell Biology (1,568)
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As academic journals have become more digital, scientific writers now have more chances to increase the visibility of their research and its citations globally. The metrics is the gold standard. It is used to decide the ranking and benchmark of the journals which will be determined using bibliometrics and different algorithms. Numerous predatory jo...
Article
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Dietary lipids (DLs), particularly sterols and fatty acids, are precursors for endogenous lipids that, unusually for macronutrients, shape cellular and organismal function long after ingestion. These functions – cell membrane structure, intracellular signalling, and hormonal activity – vary with the identity of DLs, and scale up to influence health...
Article
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Purpose: This study reflects on three technology integration strategies for enhanced student engagement, namely; keeping the learning social, keeping the learning authentic, and ensuring that the technology adds value to learning. Methodology: The study employed a student technology profiling survey involving 3rd Year Cell Molecular Biology, Microb...
Preprint
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Today’s marine calcifiers (coccolithophore algae, Foraminifera [protists], Mollusca, Crustacea, Anthozoa [corals], Echinodermata) remove carbon dioxide (CO 2 ) from the atmosphere, converting it into solid calcium carbonate (CaCO 3 ) which is stable for geological periods of time. These organisms could serve as a biotechnological carbon capture and...
Article
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We reviewed the many discoveries in cell biology, made since the 17th century, which have been based on red blood cells (RBCs). The advances in molecular and structural biology in the past 40 years have enabled the discovery with these cells, most notably, of the first water channel protein (WCP) called today aquaporin1 (AQP1). The main aim of our...
Article
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Oxysterol-binding protein (OSBP)-related protein (ORP) 6, a member of subfamily III in the ORP family, localizes to membrane contact sites between the endoplasmic reticulum (ER) and other organelles and functions in non-vesicular exchange of lipids including phosphatidylinositol-4-phosphate (PI4P) in neurons. In this study, we searched for the lipi...
Article
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Over the past two decades, molecular cell biology has graduated from a mostly analytic science to one with substantial synthetic capability. This success is built on a deep understanding of the structure and function of biomolecules and molecular mechanisms. For synthetic biology to achieve similar success at the scale of tissues and organs, an equ...
Preprint
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Today's marine calcifiers (coccolithophore algae, Foraminifera (protists), Mollusca, Crustacea, corals) remove carbon dioxide (CO2) from the atmosphere, converting it into solid calcium carbonate (CaCO3) which is stable for geological periods of time. Consequently, these organisms could serve as a biotechnological carbon capture and storage mechani...
Article
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Peroxisomes are ubiquitous, oxidative subcellular organelles with important functions in cellular lipid metabolism and redox homeostasis. Loss of peroxisomal functions causes severe disorders with developmental and neurological abnormalities. Zebrafish are emerging as an attractive vertebrate model to study peroxisomal disorders as well as cellular...
Article
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The state of red blood cells (RBCs) and their functional possibilities depend on the structural organization of the membranes. Cell morphology and membrane nanostructure are compositionally and functionally related to the cytoskeleton network. In this work, the influence of agents (hemin, endogenous oxidation during storage of packed RBCs, ultravio...
Research Proposal
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A post-doctoral position is available at the Institut Pasteur to join the Advanced Molecular Virology laboratory, which is focused on the basic study of the early steps of HIV-1 replication, with a particular emphasis on mechanisms implicated in the remodeling of the nuclear compartment during infection. Our studies contribute to highlight that amo...
Article
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Identification of cell fate-controlling lncRNAs is essential to our understanding of molecular cell biology. Here we present a human genome-scale forward-genetics approach for the identification of lncRNAs based on gene function. This approach can identify genes that play a causal role, and immediately distinguish them from those that are different...
Article
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Nature Review Molecular Cell Biology is one of the most prestigious journals in molecular and cellular biology. The focus of this research study is to use scientometric analysis to look at the publication trends of Nature Reviews Molecular Cell Biology. The data were collected from the Scopus database covering 20 years. The present study covers the...
Article
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Every type of nucleic acid in cells undergoes programmed chemical post-transcriptional modification. Generally, modification enzymes use substrates derived from intracellular metabolism, one exception is queuine (q)/queuosine (Q), which eukaryotes obtain from their environment; made by bacteria and ultimately taken into eukaryotic cells via current...
Article
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Plants continue to provide unlimited pharmacologically active compounds that can treat various illnesses, including cancer. The Solanaceae family, besides providing economically important food plants, such as potatoes and tomatoes, has been exploited extensively in folk medicine, as it provides an array of bioactive compounds. Many studies have dem...
Conference Paper
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【序論、目的】肥満やメタボリックシンドロームといった生活習慣病は、社会問題となっている。近年、寒冷時の体温維持や代謝に重要な非震え熱産生器官の褐色脂肪組織(BAT)は、抗肥満作用の点から注目されている。薬剤や食物成分によりBATを活性化し、熱産生を増やすことは、肥満改善の新たな方法となり得る。 私達は、女性ホルモンのエストラジオール(E2)は、雌ラットにおいて体温調節中枢である視床下部内側視索前野に作用し、寒冷時の体温維持に寄与することを報告した(文献1)。また、E2の末梢を介した作用を、感覚神経に発現する末梢冷受容分子TRPM8(transient receptor potential melastatin-8)の作動薬であるメントールを用いて調べると、E2はメントール誘導性の体温上昇を抑...
Preprint
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In molecular cell biology, reporter assays are frequently used to investigate gene expression levels. Reporter assays employ a gene that encodes a light-emitting protein, of which the luminescence is quantified as a proxy of gene expression. Commercial parties provide reporter assay kits that include protocols and specialized detection machinery. H...
Article
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The British Society for Parasitology (BSP) holds a biannual symposium devoted to the kinetoplastids, and seeks to cover the full gamut of research into these important organisms, and alternates with the Woods Hole Kinetoplastid Molecular Cell Biology meeting that serves a similar community. While normally embedded within the main BSP Spring meeting...
Article
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Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) play important roles in different stages of progression and drug resistance in many types of cancers, including breast, colon, endometrial, liver cancer and melanoma. GH receptor (GHR) is highly expressed in melanoma and promotes cancer proliferation and multidrug efflux pumps mediated dr...
Article
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The profound impact that vision loss has on human activities and quality of life necessitates understanding the etiology of potentially blinding diseases and their clinical management. The unique anatomic features of the eye and its sequestration from peripheral immune system also provides a framework for studying other diseases in immune privilege...
Article
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Intracellular adaptor proteins are indispensable for the transduction of receptor‐derived signals, as they recruit and connect essential downstream effectors. The SLy/SASH1‐adaptor family comprises three highly homologous proteins, all of them sharing conserved structural motifs. The initial characterization of the first member SLy1/SASH3 (SH3 prot...
Article
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CellPAINT is an interactive digital tool that allows non-expert users to create illustrations of the molecular structure of cells and viruses. We present a new release with several key enhancements, including the ability to generate custom ingredients from structure information in the Protein Data Bank, and interaction, grouping, and locking functi...
Article
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Purpose: Glioblastoma multiforme is a highly malignant primary brain cancer with a poor prognosis. We recently reported that ARID4B could potentially serve as a biomarker associated with poor survival in glioma patients. However, the function of ARID4B in human gliomas remains unclear. The aim of this study is to investigate the molecular cell bio...
Book
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El presente libro reúne los resúmenes de todas las charlas presentadas, revisados por un comité científico conformado por jóvenes que están cambiando al país con su esfuerzo por mostrar a la ciencia como una alternativa de vida, que, en momentos difíciles como este, es el camino para que la humanidad señale nuevas metas, enfocándose en el desarroll...
Article
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The phytopathogenic smut fungus Ustilago maydis is a versatile model organism to study plant pathology, fungal genetics, and molecular cell biology. Here, we report several strategies to manipulate the genome of U. maydis by the CRISPR/Cas9 technology. These include targeted gene deletion via homologous recombination of short double-stranded oligon...
Article
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Although largely overlooked compared to bacterial infections, fungal infections pose a significant threat to the health of humans and other organisms. Many pathogenic fungi, especially Candida species, are extremely versatile and flexible in adapting to various host niches and stressful situations. This leads to high pathogenicity and increasing re...
Cover Page
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Faculty Position in Molecular & Cell Biology The Department of Anatomy in the Howard University College of Medicine in Washington, D.C., is seeking applicants for a full-time Assistant Professor tenure-track position to start in the summer of 2021. Applicants must possess a Ph.D. and have postdoctoral experience. Within the context of molecular and...
Article
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Background The adaptation to hypoxia is mainly controlled by the HIF transcription factors. Increased expression/activity of HIF-1α correlates with poor prognosis in cancer patients. PARP-1 inhibitors are used in the clinic to treat BRCAness breast/ovarian cancer and have been shown to regulate the hypoxic response; therefore, their use could be ex...
Article
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Translation is one of the main steps in the synthesis of proteins. It consists of ribosomes that translate sequences of nucleotides encoded on mRNA into polypeptide sequences of amino acids. Ribosomes bound to mRNA move unidirectionally, while unbound ribosomes diffuse in the cytoplasm. It has been hypothesized that finite diffusion of ribosomes pl...
Article
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The renal collecting duct plays a critical role in setting urinary volume and composition, with principal cells transporting Na⁺ and K⁺ and intercalated cells mediating Cl⁻ reabsorption. Published evidence implies Angiotensin II (Ang II) is a potent regulator of the collecting duct apical transport systems in response to systemic volume depletion....
Book
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Major developments in chemistry, molecular cell biology and genetics have enabled a deeper understanding of numerous life processes around us. However, much remains to be explored and revealed. The purpose of this book is to provide a more complete theory of emerging concepts in chemical and biological sciences.
Article
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HDGF-related protein 2 (HRP-2) is a member of the Hepatoma-Derived Growth Factor-related protein family that harbors the structured PWWP and Integrase Binding Domain, known to associate with methylated histone tails or cellular and viral proteins, respectively. Interestingly, HRP-2 is a paralog of Lens Epithelium Derived Growth Factor p75 (LEDGF/p7...
Article
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Komagataella phaffii ( Pichia pastoris ) is one of the most extensively applied yeast species in pharmaceutical and biotechnological industries, and, therefore, also called the biotech yeast. However, thanks to more advanced strain engineering techniques, it recently started to gain attention as model organism in fundamental research. So far, the m...
Article
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During vertebrate embryonic development, a population of dorsal neural tube-derived stem cells, termed the neural crest (NC), undergo a series of morphogenetic changes and extensive migration to become a diverse array of cell types. Around the developing eye, this multipotent ocular NC cell population, called the periocular mesenchyme (POM), compri...
Poster
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Comprender la estructura tridimensional de las biomoléculas es difícil, pues aun cuando se emplean visualizadores, no siempre se logra. La Realidad Aumentada (RA) es una tecnología emergente, que permite al usuario entrar a un entorno real con información adicional generado por el ordenador. Ofrece beneficios en el ámbito educacional como: ayuda al...
Article
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Aims Amyloid‐β (Aβ) oligomers trigger synaptic degeneration that precedes plaque and tangle pathology. However, the signalling molecules that link Aβ oligomers to synaptic pathology remain unclear. Here, we addressed the potential role of RAPGEF2 as a novel signalling molecule in Aβ oligomer‐induced synaptic and cognitive impairments in human‐mutan...
Article
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Eukaryotic initiation factor 2B (eIF2B) serves as a vital control point within protein synthesis and regulates translation initiation in response to cellular stress. Mutations within eIF2B result in the fatal disease, leukoencephalopathy with vanishing white matter (VWM). Previous biochemical studies on VWM mutations have illustrated that changes i...
Article
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Background Metastasis is the leading cause of death in patients with bladder cancer (BC). However, current available treatments exert little effects on metastatic BC. Moreover, traditional grading and staging have only a limited ability to identify metastatic BC. Accumulating evidence indicates that the aberrant expression of microRNA is intimately...
Article
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Diabetes is one of the most common diseases that researchers are interested in studying around the world, due to the devastating effects of the disease on patients. The test evaluation at showed in Biochemistry and molecular cell biology for complications of diabetes of General Hospitals Al Sadr General Teaching in Al Najaf (Iraq) from May 2018 to...
Article
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Kinases are critical components of intracellular signaling pathways and have been extensively investigated in regards to their roles in cancer. p21-activated kinase-1 (PAK1) is a serine/threonine kinase that has been previously implicated in numerous biological processes, such as cell migration, cell cycle progression, cell motility, invasion, and...
Presentation
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Un átomo mide típicamente el tamaño de 10−10 metros. Esta cantidad es denominada Amstrong (Å), con lo cual los átomos miden aproximadamente un Å (Clemente & Torre, 1998), y un nanómetro es una mil millonésima de metro o lo que es lo mismo 10-9 m. Manipular en la escala de un átomo, justo como lo especuló Feynman, nos ha permitido indagar en un nuev...
Article
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Although microscopy has long been used as a valuable teaching tool, the use of computer animation in teaching has recently expanded. Animation can have advantages over microscopy, including simplification, unlimited resolution and magnification, ability to highlight certain symbols within a complex background, control of motion, shape, or color cha...
Article
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Underperforming students are often unaware of deficiencies requiring improvement until after poor performance on summative exams. The goal of the current study was to determine whether inclusion of individual end-of-class formative quizzes, which comprise of higher level Bloom's questions, could encourage students to reflect on and address deficien...
Article
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David Yaffe, PhD passed away on July 3, 2020 at the age of 91. His funeral and burial were held at his kibbutz in Israel, Givat Brenner. At the time of his death, he was emeritus professor of molecular cell biology at the Weizmann Institute of Science. If there is one word to describe David, it would be “pioneer”, Halutz in Hebrew. He participated...
Article
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Background Progressive neuronal death in monoaminergic nuclei and widespread accumulation of α-synuclein are neuropathological hallmarks of Parkinson's disease (PD). Given that α-synuclein may be an early mediator of the pathological cascade that ultimately leads to neurodegeneration, decreased α-synuclein synthesis will abate neurotoxicity if deli...
Article
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The receptor for advanced glycation end products (RAGE) plays a key role in mammal physiology and in the etiology and progression of inflammatory and oxidative stress-based diseases. In adults, RAGE expression is normally high only in the lung where the protein concentrates in the basal membrane of alveolar Type I epithelial cells. In diseases, RAG...
Article
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Worldwide, a mandatory course in Molecular Cell Biology is often part of the (para-) medical curricula. Student audiences are regularly not receptive to such relatively theoretical courses and teachers often struggle to convey the necessary information. Here, positive experience is shared on rigorously embedding a genetic disease that severely affe...
Article
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Course-based Undergraduate Research Experience in a Senior Cell & Molecular Biology Laboratory Course Laura L. Atkinson, Mount Royal University Course-based undergraduate research experiences (CUREs) offer students the ability to experience research during their undergraduate studies. While independent studies projects have generally achieved this...
Article
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The readers and authors of the journal are all neuroscientists. The purpose of such review in this journal is to make them familiar with an emerging worldview that the brain is not the source of consciousness and cognitive faculty could not be localised within the specifics of the brain. Further, the relationship between consciousness, cognition an...
Article
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Targeted exosomal delivery systems for precision nanomedicine attract wide interest across areas of molecular cell biology, pharmaceutical sciences, and nanoengineering. Exosomes are naturally derived 50–150 nm nanovesicles that play important roles in cell‐to‐cell and/or cell‐to‐tissue communications and cross‐species communication. Exosomes are a...
Article
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The plasma membrane surrounds every single cell and essentially shapes cell life by separating the interior from the external environment. Thus, maintenance of cell membrane integrity is essential to prevent death caused by disruption of the plasma membrane. To counteract plasma membrane injuries, eukaryotic cells have developed efficient repair to...
Article
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Molecular imaging is a technique for imaging the processes occurring in a living body at a molecular level in real-time, combining molecular cell biology with advanced imaging technologies using molecular probes and fluorescence. Gastrointestinal endoscopic molecular imaging shows great promise for improving the identification of neoplasms, providi...
Article
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Alba Diz-Muñoz studied human biology at the Universitat Pompeu Fabra in Barcelona, Spain and joined the Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany, for her PhD on cell migration in zebrafish embryos, co-supervised by Ewa Paluch and Carl-Philipp Heisenberg. In 2012, Alba moved to California, USA, for her postdoctor...
Article
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Tracking of objects in cellular environments has become a vital tool in molecular cell biology. A particularly important example is single molecule tracking, which enables the study of the motion of a molecule in cellular environments by locating the molecule over time and provides quantitative information on the behavior of individual molecules in...
Article
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Mutational signatures provide a powerful alternative for understanding the pathophysiology of cancer. Currently, experimental efforts aimed at validating and understanding the etiologies of cancer-derived mutational signatures are underway. In this review, we highlight key aspects of mutational signature experimental design and describe the analyti...
Article
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Background Gouty arthritis is a common metabolic disease caused by long-term purine metabolic disorder and elevated serum uric acid. Jiang-Suan-Chu-Bi recipe (JSCBR), a traditional Chinese herbal formula prescribed according to utilization frequency and cluster analysis, has been clinically validated remedy for gouty arthritis. However, its therape...
Article
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Sophie Acton received her Master of Pharmacology from the University of Bath, UK, and subsequently started her PhD in the laboratory of Erik Sahai at Cancer Research UK London Research Institute and University College London to study the motility of cancer cells in vivo. In 2008, Sophie moved to her postdoctoral position as a Henry Wellcome fellow...
Article
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The work carried out by David Zwicker and collaborators at the Max Planck Institute for the Physics of Complex Systems and the Max Planck Institute of Molecular Cell Biology and Genetics, both in Dresden leads to a concrete candidate for protocells as a water droplet containing proteins and able to exchange molecules with environment. In a simplifi...
Article
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Permeabilization of the mitochondrial outer membrane is a key step in the intrinsic apoptosis pathway, triggered by the release of mitochondrial intermembrane space proteins into the cytoplasm. The BCL-2-associated X apoptosis regulator (BAX) protein critically contributes to this process by forming pores in the mitochondrial outer membrane. Howeve...
Preprint
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Background: Excessive neuronal activity promotes amyloid-β (Aβ) production in the brain. The Aβ oligomer triggers synaptic degeneration that precedes plaque and tangle pathology. However, the signaling molecules that link Aβ oligomers to synaptic pathology remain unclear. RAPGEF2, a guanine-nucleotide exchange factor for the small GTPase Rap, plays...