Migraine with Aura - Science topic

Dear Miky Timothy,

First of all, thank you for sharing your valuable knowledge with us.

Then, although, in terms of vasodilation, vasoconstriction and the action triptans as "5-HT1b/d agonists", you are right, in my opinion, these vascular alterations are compensatory changes that are the consequence/s of circuit-related alterations in the brain itself. So, we can consider the states such as CSD and the level of Oxidative Stress before vascular alterations in a migraine brain. Therefore, I think we have to seek the etiology and treatment of migraine from a neurodevelopmental perspective.

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Life style changes are also important for migraine management

Nazari, F., Safavi, M., & Mahmudi, M. (2010). Migraine and its relation with lifestyle in women. Pain Practice, 10(3), 228-234.

Have you read my major paper on CSD?

In the meantime, I will look up the nutraceutical, PEA. To begin with, you must have a strong and defensible INTRODUCTION.

Since you have elected to respond with alacrity (as if we are in a fencing match) without much reflection on a miniscule of what was written, and you are obviously enthralled by your own hypothesis, please also let us know how nausea and vomiting of pvd (if, as it seems, migraine must be due to pvd), resolves the headache of migraine in a sizable fraction of migraineurs--a finding noted by Hippocrates but ignored by scientists of the twentieth and the twenty-first century. A pinch of salt "may" help in many medical disorders, and if Google is to replace systematic in-depth medical research and commentary, God help humanity. Like Watson and Crick, a colleague who can dampen over-enthusiasm and acknowledge error is invaluable--simply because humans find it very difficult if not impossible to acknowledge errors or limitations. Dear Anthony, let the world remain flat. I rest the case and accept your version of the "truth".

Dear Atiyeh

through several measurements, habituation VEP response showed reliable and interesting findings according neural changes in migraine. i think it is better three phases are considered for migraine: preictal-ictal- interictal.  Interictal changes in cortical evoked potentials indicate that the  migraine attack is initiated within the central nervous system hours before the aura or the headache appears, and the early phases of the attack are associated with a quasi normalisation of cortical information processing. habituation VEP deficit in migraineurs is due to a reduced pre-activation level of sensory cortices and  enhanced activity in raphe–cortical serotonergic Pathways and dysfunctional monoaminergic nuclei  and NOT to increased cortical excitability or reduced intracortical inhibition that indicated based on low threshold of phosphenes.

Best regards to you