Science topic
Melanosis - Science topic
Disorders of increased melanin pigmentation that develop without preceding inflammatory disease.
Questions related to Melanosis
Dear all, please, what are the main differences between pigmentation disorders in fish (albinism, melanosis and xanthochroism) and colour polymorphism. could they be essentially the same? are they both mutations? permanent? inheritable? I can't find any reference to differentiate between them. Thank you in advance
Topical corticosteroids are well known to produce dermal atrophy and hypopigmentation which may justifies thier use alone or incombination for treating skin disease like melasma. Also these effects represent a chellenging side effects and explain the wide spread misuse of topical steroids for skin bleaching.So any idea about the molecular mechanism/s of the hypopigemting effects of topical steroids?
Various chromosomal abnormalities have been described in this disease ( at least 10 types). In our patient the skin -hypomelanosis and the central nervous system is involved. The common belief was that all of them had problems with chromosome morphology. Is FISH a good method to detect the change of chromosomes, or is there another method that can be used? What kind of sample should we have (mosaicism, skin fibroblast, cultured primary, or only cut-out skin, etc.)?
Chronic diarrhea (started at 4 months of age - anamnesis); colonoscopy shows non-specific aspect - friability of the mucosa, hyperemia, edematous in the recto-sigmoid area, other segments are not explored!).
Rectal mucosa shows no architectural disturbance, no pathologic inflammation, no other significant pathologic changes but evident pseudomelanosis coli.
Thanky you!
