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Publications related to Medicines (10,000)
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Article
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The detection of metronidazole (MTZ) in pure and pharmaceutical formulations is now possible with a newly developed analytical technique based on turbidimetric measurement (from 0 to 180 degrees) utilizing a NAG-4SX3-3D analyzer. The technique relied on the fact that phosphotungstic acid and metronidazole would precipitate white in an acidic mediu...
Article
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With the advancement of technology, there is a growing demand for new nanoparticles that are viable, eco-friendly, non-toxic, and non-hazardous, as well as having unique chemical and physical properties. Silver nanoparticles are currently promising for antibacterial, antimicrobial, and photocatalytic applications. Because of their toxicity, nanosil...
Article
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Hypertension has been linked to a higher risk of getting some malignancies and a higher cancer-related mortality rate. Furthermore, many anticancer medicines have been linked to developing new high blood pressure or deteriorating previously well-controlled hypertension. The P53 tumor antigen is a mutation-hosting antigen. It is also one of the huma...
Article
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Varronia curassavica is a Brazilian native medicinal species. Among the critical points influencing the phytochemical quality of bioactive compounds is the spacing between plants, harvest and post-harvest. This research aimed evaluated the influence of plant distance, harvest season, and leaves drying temperature on the yield and phytochemical qual...
Article
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Background Spontaneous regression of advanced solid tumors is infrequent but may occur. Quantifying response rates from placebo in cancer drug trials may provide important information for physicians, patients, and regulators. We aimed to provide a pooled placebo response rate from drug trials in advanced solid tumors. Methods We pooled the overall...
Article
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In this 13th annual installment of the annual ‘Antibodies to Watch’ article series, we discuss key events in commercial antibody therapeutics development that occurred in 2021 and forecast events that might occur in 2022. Regulatory review of antibody therapeutics that target the SARS-CoV-2 coronavirus proceeded at an unprecedented pace in 2021, re...
Article
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Context Viruses have the characteristics of rapid transmission and high mortality. At present, western medicines still lack an ideal antiviral. As natural products, many traditional Chinese medicines (TCM) have certain inhibitory effects on viruses, which has become the hotspot of medical research in recent years. Objective The antiviral active in...
Article
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Lead (Pb) is a neurotoxicant that still remains ahealth problem despite many efforts to minimize its levels in the environment. , The use of medicinal plants in the treatment of many diseases and different toxic agents has become popular due to their effectiveness and lower costs. The Adansonia digitata L. (AD) fruit is called a super fruit because...
Article
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The governance of pharmaceutical medicines entails complex ethical decisions that should, in theory, be the responsibility of democratically accountable government agencies. However, in many Low- and Middle-Income Countries (LMICs), regulatory and health systems constraints mean that many people still lack access to safe, appropriate and affordable...
Article
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Objectives: Deliberative processes in Health Technologies Assessment (HTA) result in recommendations that determine the reimbursement of medicines, diagnostics or devices. These processes are governed by explicit criteria, but are also influenced by implicit factors. The objective of this work was to identify the implicit factors influencing HTA d...
Article
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In searching for new molecular drug targets, Carbonic Anhydrases (CAs) have emerged as valuable targets in diverse diseases. CAs play critical functions in maintaining pH and CO2 homeostasis, metabolic pathways, and much more. So, it is becoming attractive for medicinal chemists to design novel inhibitors for this class of enzymes with improved pot...
Article
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Antibody-drug conjugates (ADCs) are increasingly powerful medicines for targeted cancer therapy. Inspired by the trend to further improve their therapeutic index by generation of homogenous ADCs, we report here how the clinical-stage GlycoConnect™ technology uses the globally conserved N-glycosylation site to generate stable and site-specific ADCs...
Article
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Objectives This review aims to see the progress of several clinically-used monoclonal antibodies in treating ALL patients and how they improved patients' outcomes. Methods We searched Web of Science, Elsevier and PubMed for relevant published studies, and summarized eligible evidence on the management of newly-diagnosed and relapsed or refractory...
Article
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Human perceptions and knowledge of invasive alien plant species are increasingly recognised as important in the management of biological invasions, but there is limited research focus on the social dimensions of plant invasion. Using household surveys, this study assessed the perceptions, knowledge, and uses of Psidium guajava Linn. to rural commun...
Article
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Context Developing effective drugs to treat myocardial ischaemia-reperfusion (MI/R) injury is imperative. Traditional Chinese medicines (TCMs) have had considerable success in the treatment of cardiovascular diseases. Elucidating the mechanisms by which TCMs improve MI/R injury can supplement the literature on MI/R prevention and treatment. Object...
Article
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Context The extracts of Aspongopus chinensis Dallas (Pentatomidae), an insect used in traditional Chinese medicine, have a complex chemical composition and possess multiple pharmacological activities. Objective This study comprehensively characterizes the chemical constituents of A. chinensis by an integrated targeted and untargeted strategy using...
Book
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Diets rich in plant polyphenols or dietary polyphenols are the subject of increasing scientific interest because of their diverse range of health benefits and medicinal uses. This book, Dietary Polyphenols in Human Diseases-Advances and Challenges in Drug Discovery, fills the gap that exists in the current knowledge by presenting the latest informa...
Poster
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The conference will focus on the early modern reception of Galenic pharmacology, and especially on works such as "De simplicium medicamentorum temperamentis ac facultatibus" and "De alimentorum facultatibus." Transmitted through the centuries in Greek, Persian, Arabic and then Latin translations, these texts have constituted the bedrock on which W...
Poster
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To analyze the broad variety of intermolecular interactions like receptor ligand contacts, Surface plasmon resonance (SPR) sensors have become a very important tool for analysis. After comparing with conventional analysis methods used in sensing of intermolecular interactions, technology using SPR sensors is categorized with high accuracy and sensi...
Book
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Phytochemistry, Computational Tools and Databases in Drug Discovery presents the state-of-the-art in computational methods and techniques for drug discovery studies from medicinal plants. Various tools and databases for virtual screening and characterization of plant bioactive compounds and their subsequent predictions on biological targets for the...
Article
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In recent years, nanotechnology has drawn an immense attention in food industry, agriculture sector, textile industry and medicinal industry. Nanoparticles have advantage of having large surface area and environment sustainability. Nanoparticles are especially designed to enhance the special properties at the nanoscale level. Some metals like silve...
Poster
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In the past the relevance of plants amongst indigenous inhabitants of the Mariana islands was crucial. They provided food, raw material for building and crafting wooden objects including ships and canoes, but also for ritual and medicinal purposes. Up to now, archaeobotanical research in the Pacific has focused mostly on the translocation of severa...
Article
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Cancer is a large group of diseases that can start in almost any organ or tissue of the body. It is fundamentally uncontrollable growth of cells. Cancer is the secomd leading cause of death globally. It is exerting tremendous strain physicaly, emotionaly and financialy on individuals, families and countries. Hybrid formation is the process of combi...
Article
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Cushing’s Disease is caused by pituitary adenoma which produces adrenocorticotropic hormone causing hypercortisolemia. First-line treatment involves operative removal of the tumor, however, in some patients it proves ineffective. In those cases, pharmacological treatment is necessary as untreated Cushing’s Disease may be lethal. In 2020 a new stero...
Article
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Introducción a búsqueda del bienestar animal para nuestras mascotas ha provocado la disposición de sustancias que han sido poco estudiadas desde el punto de vista veterinario, siendo hasta el momento "una moda" de medicina alternativa no legalizada en México (Robles-Soto 2019). En este sentido, esta moda se refiere al uso de los derivados de cannab...
Article
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Lignin is one of the most important secondary metabolites and essential to the formation of cell walls. Changes in lignin biosynthesis have been reported to be associated with environmental variations and can influence plant fitness and their adaptation to abiotic stresses. However, the molecular mechanisms underlying this association remain unclea...
Article
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Ginseng (Panax ginseng C.A.Mey.) is the dry root and rhizome of the Araliaceae ginseng plant. It has always been used as a tonic in China for strengthening the body. Cardiovascular disease is still the main cause of death in the world. Some studies have shown that the functional components of ginseng can regulate the pathological process of various...
Chapter
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Clusters for high-value crops are ubiquitous in China and in African countries. Drawing from three case studies (potato cluster in China, medicinal and aromatic cluster in Egypt, and dates cluster in Tunisia), this chapter discusses the major challenges facing cluster development and the roles of different agents (e.g., entrepreneurs, business asso...
Article
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Background The health supply chain system is essential for the optimum performance of the healthcare system. Despite increased investments in the health supply chain system, access to quality Essential Medicines and Health Supplies remain a big challenge in Uganda. This article discusses the structure, performance, and challenges of the health supp...
Article
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Excessive antibiotic prescriptions as well as their misuse in agriculture are the main causes of antimicrobial resistance which poses a growing threat to public health. It necessitates the search for novel chemicals to combat drug resistance. Since ancient times, naturally occurring medicines have been employed and the enormous variety of bioactive...
Article
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The review of previous studies on Paulownia spp. showed that these plants are valuable raw materials with polyfunctional use among which are medicinal, forage, energetic, etc. This study demonstrated the accumulation of selected biochemical components in the different parts of Paulownia tomentosa (Thunb.) Steud. genotypes plants by the end of veget...
Article
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Acorus calamus var. angustatus Besser (ATT) is a traditional herb with a long medicinal history. The volatile oil of ATT (VOA) does possess many pharmacological activities. It can restore the vitality of the brain, nervous system and myocardial cells. It is used to treat various central system, cardiovascular and cerebrovascular diseases. It also s...
Article
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Background This exploratory study investigated four repurposed anti-infective drug regimens in outpatients with COVID-19. Methods This phase 2, single centre, randomised, open-label, clinical trial was conducted in South Africa between 3rd September 2020 and 23rd August 2021. Symptomatic outpatients aged 18–65 years, with RT-PCR confirmed SARS-CoV...
Article
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Various plants form the basis of multiple traditional ethnic cuisines and ethnomedicinal practices across the globe. The ethnic cuisines cater to the nutritional, dietary and medicinal requirements of the tribal and rural communities even today. Using literature from various scholarly databases, this study was conducted to consolidate a comprehensi...
Article
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In the aftermath of a disaster event, it is of utmost important to ensure efficient allocation of emergency resources (e.g. food, water, shelter, medicines) to locations where the resources are needed (need-locations). There are several challenges in this goal, including the identification of resource-needs and resource-availabilities in real time,...
Article
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Abstract Introduction Palliative care aims to improve quality of life through optimal symptom control and pain management. Cannabis-based medicinal products (CBMPs) have a proven role in the treatment of chemotherapy-induced nausea and vomiting. However, there is a paucity of high-quality evidence with regards to the optimal therapeutic regimen, sa...
Article
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In this hectic life, women often suffer from different kind of menstrual problems. Among these one of the most common problems which gynaecologist encounter is secondary amenorrhoea in different age groups. According to homoeopathy, menses can be suppressed in an individual due to any mental or physical reasons. There are lots of homoeopathic medic...
Article
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Harm with inappropriate and irrational use of medications is a global challenge. The need for and patient access to medicines optimisation services is apparent globally and amplified in India due to multiple reasons. Clinical pharmacists are ideally placed to promote patient safety with medicines use optimisation and other pharmaceutical care servi...
Article
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Chinese herbal medicines (CHMs) have unique advantages in the prevention and treatment of diseases, which are widely recognized in the world. More and more CHMs are becoming increasingly popular in the international markets. However, the quality control of CHMs is a significant issue for their acceptance and recognition in the international market....
Article
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Background: Polypharmacy is the administration of an excessive number of medicines and a significant irrational medicine use practice. Little is known about this practice in South Africa. This study aimed to determine the level of polypharmacy and potential drug-drug interactions amongst the geriatric patient population in a facility in South Afri...
Article
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Background Migraine is a chronic disease characterized by episodic headache attacks. No recent studies have, however been conducted on the epidemiology of migraine or the treatment landscape in Japan. This study was conducted as a fact-finding survey using medical claims data and an online survey on migraine and headaches, conducted among members o...
Article
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Carbapenem-resistant Gram-negative bacteria are frequent causes of sepsis and septic shock in intensive care unit (ICU) and thus considered a public health threat. Until now, the best available therapies consist of combinations of preexisting or new antibiotics with β-lactamase inhibitors (either new or preexisting). Several mechanisms of resistanc...
Article
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Tuberculosis (TB) is on the rise in Pakistan and there could be multiple reasons including poverty, difficulty in access to TB treatment services, non-compliance with treatment, social stigma etc. According to the TB program managers, limited treatment and testing sites for tuberculosis and lack of trained human resources play a major role in compr...
Article
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Abstract Background Resistance to colistin was an uncommon phenomenon traditionally linked to chromosome point mutations, but since the first description of a plasmid-mediated colistin-resistance in late 2015, transmissible resistance to colistin has become a Public Health concern. Despite colistin is considered as a human last resort antibiotic, i...
Article
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Introduction In the European Union (EU), a Risk Management Plan (RMP) is submitted as part of the dossier for initial marketing authorization of a medicinal product or with an application involving a significant change to an existing marketing authorization. A comprehensive revision of the EU Guideline on Good Pharmacovigilance Practices (GVP) Modu...
Article
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Background Transparency and reproducibility are expected to be normative practices in clinical trials used for decision-making on marketing authorisations for new medicines. This registered report introduces a cross-sectional study aiming to assess inferential reproducibility for main trials assessed by the European Medicines Agency. Methods Two r...
Article
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Recently, The Lancet published a study on the effectiveness of COVID-19 vaccines and the waning of immunity with time. The study showed that immune function among vaccinated individuals 8 months after the administration of two doses of COVID-19 vaccine was lower than that among the unvaccinated individuals. According to European Medicines Agency re...
Article
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Background In most countries, including those with national health insurance or comprehensive public insurance, some expenses for cancer treatment are borne by the ill and their families. Objectives This study aims to identify the areas of out-of-pocket (OOP) spending in the last half-year of the lives of cancer patients and examine the extent of...
Article
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The fast diffusion of the SARS-CoV-2 pandemic have called for an equally rapid evolution of the therapeutic options. The Human recombinant monoclonal antibodies (mAbs) have recently been approved by the Food and Drug Administration (FDA) and by the Italian Medicines Agency (AIFA) in subjects aged ≥12 with SARS-CoV-2 infection and specific risk fact...
Article
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Background Despite calls for the use of additional real-world evidence (RWE) during drug development, rates of inclusion at the regulatory stage remain low. The medicine adoption model suggests that providing additional RWE to regulators would result in a wider indicated population than providing randomised-controlled trial evidence (RCTE) alone. H...
Article
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Background: In many areas of the globe, chronic kidney disease (CKD) is a widespread health concern defined by the progressive loss of kidney function. The genetic contribution to the development of kidney disease is essential in forecasting risk variables and resolving genetic enigmas. Objective: Genetic variations are among the factors that might...
Article
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Soybean ( Glycine max ) is one of the major sources of nutrition and is used as a raw material for food and as a source of feed for livestock. The efficacy of soybeans on skin health includes their ability to reduce wrinkles and pigmentation and increase skin elasticity and moisture content. Black soybean has been consumed worldwide for a long time...
Article
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Background Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent neurological disorder. ADHD has been linked to epilepsy. Main body ADHD was found to be present in 30–40% of epileptic children. Researchers have developed numerous theories to explain how and why ADHD and epilepsy coexist. Whether ADHD and epilepsy symptoms are caused by co...
Article
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Background Clinical trials report systemic hypertension is an adverse effect of vascular signalling pathway inhibitor (VSPi) use. There are limited data from routine clinical practice. We aimed to estimate the real-world incidence and risk factors of new-onset and aggravated hypertension for cancer patients dispensed VSPi in whole-of-population Aus...
Article
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The genus Sanghuangporus is well-known for its edible and medicinal values. In this study, the most comprehensive occurrence records of Sanghuangporus with accurate species identification are subjected to MaxEnt, to model the current geographic distribution and future range shifts under multiple climate change scenarios in China. The current potent...
Article
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Background A lot of studies have revealed that chronic urticaria (CU) is closely linked with COVID-19. However, there is a lack of further study at the gene level. This research is aimed to investigate the molecular mechanism of COVID-19-related CU via bioinformatic ways. Methods The RNA expression profile datasets of CU (GSE72540) and COVID-19 (G...
Article
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Background In China, health technology assessment (HTA) has recently been adopted in pricing negotiation for medicine listing in the National Reimbursement Drug List. At present, how HTA is applied to inform the decision-making process remains underreported. In order to explore how the adoption of HTA was translated into listing and price negotiati...
Article
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Background Pharmaceutical advertising is not only considered a key factor in the successful launch of pharmaceutical products, but is also an important source of public health information with a significant impact on consumer choice and behavior. Nowadays, advertising has become the broadest dissemination channel for various products, including med...
Article
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Spinach is a leafy green vegetable cultivated in most part of the world due to its nutritive and medicinal value. Fifty-one germplasm of spinach (Spinacia oleracea L.) collected from diverse geographical region of Bangladesh were evaluated to assess their diversity using several qualitative and quantitative characters. Variation was found in all th...
Article
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Background Amyloid light-chain (AL) amyloidosis is an ultra-rare disease associated with significant morbidity and mortality. Few studies have examined the global epidemiology of this condition. Methods This study estimated the diagnosed incidence and 1-year, 5-year, 10-year, and 20-year period prevalence of AL amyloidosis in 2018 for countries in...
Article
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Quercetin, a natural flavonoid compound with a widespread occurrence throughout the plant kingdom, exhibits a variety of pharmacological activities. Because of the wide spectrum of health-promoting effects, quercetin has attracted much attention of dietitians and medicinal chemists. An updated review of the literature on quercetin was performed usi...