Questions related to Medicine
Heyer et al. in their recent paper "Remdesivir-induced emergence of SARS-CoV2 variants in patients with prolonged infection" published in Cell Reports Medicine have reported that remdesivir treatment can result in rapid fixation of newly acquired mutations. They have also noted that "Treatment-associated evolutionary bottlenecks promote emergence of novel variants". It's great to see that the validity of our early hypothesis has been confirmed by other researchers. We strongly believe that the "Remdesivir-induced emergence of SARS-CoV2 variants" is the dark side of the antivirals such as remdesivir that needes further investigation. Mehdizadeh AR, J Bevelacqua J, Mortazavi SAR, S Welsh J, Mortazavi SMJ. How Antivirals Might be Linked to the Emergence of New Variants of SARS-CoV-2. J Biomed Phys Eng. 2021 Apr 1;11(2):123-124. doi: 10.31661/jbpe.v0i0.2101-1275. PMID: 33937119; PMCID: PMC8064135. https://lnkd.in/d4U2UTK Heyer, A. et al. Remdesivir-induced emergence of SARS-CoV2 variants in patients with prolonged infection. Cell Reports Medicine 3, 100735 (2022). https://doi.org:https://lnkd.in/e7NQWhP7
Heyer, A. et al. Remdesivir-induced emergence of SARS-CoV2 variants in patients with prolonged infection. Cell Reports Medicine 3, 100735 (2022). https://doi.org:https://lnkd.in/e7NQWhP7
Would like to screen the health of the population. Where are certain doctors overrun? Therefore, looking for a platform with time for waiting lists for seeing a doctor, sorted by specialization (Cardio, HNO, etc....).
Haven't found much as of yet. Any ideas, on where to find a good platform? Probably some US states?
Im a PG student from faculty of medicine, Universiti of Malaya, Malaysia. I would like to ask about CAKI-2, we couldn't find them in Malaysia and we are committed to certain budget, deadlines and thesis based on this project, anyone from Malaysia willing to help us provide this cell line or any trusted source or a lab uses the cell line to give as aliquot ? Thank you in advance.
any suggestions for solving the free rider problem?
Signalling method does not seem to work.
Working in the research field, you will be weighted by your h-index.
However, publications might not be cited by others despite your hard work.
Do you think we should publish only citable research or publish as many as we could to contribute the academic field?
Looking for a monthly updated database for cardiac, cerebrovascular, and multisystemic events. No success as of yet to find one in Europe.
It should correspond to the monthly data of the CDC Wonder database in the USA:
Cherish your feedback.
I would like to write a literature review, to begin with, and continue to a more in-depth research paper, about the contributions of Indigenous American knowledge about healing and medicine that are used in western medicine practice today.
As Research shows, that Covid may cause permanent lung damage, fibrosis, etc., wondering at what point of destroyed lung volume (30%?, 40%?) it is not possible anymore to work the entire working day with a FFP2-Mask?
Where is the threshold?
-For physically working people
-For office people
Cherish your input.
I am an undergraduate at the University of Cross River State, Nigeria currently pursuing a microbiology program. For familiarity and enhanced understanding of the course, I wish to seek recommendations on the virtual/simulation laboratory software that would be very helpful to me and my colleagues. With my interest in research too, I will be pleased if a research simulator is recommended to help widen my understanding of Microbiological research.
Your recommendations would go a long way to significantly contribute to my academic career as well as my colleagues.
I am curious about the average quality of PhD research proposals, especially those with cancer research as a focus. Any suggestions, guidance, tricks, or words of wisdom?
some viruses seem to permanently destroy T cells. May these T-Cells be rebuilt by the body or are they forever gone?
When does the body build T cells during life? Is there an age cap?
Cherish your answers.
Before Covid and After Covid there has been long debate on adoption of appropriate Pedagogy techniques to improve teaching learning environment in Universities. Various concepts are suggested from blended learning to flipped, experiential, project based learning.
However, the technique has to be program based as to whether your program is History, Geography, Engineering or Medicine will decide which one is better or all these can be applied to subjects under consideration.
Another challenge is assessment and measurement of learning outcomes to improve pedagogy which should be in confirmation with the pedagogy adopted by the Teacher.
I think teaching community has to deliberate on these issue at great length and arrive at general consensus or the difference will prevail for all times to come!
Drug from Pfizer, design from Pfizer, researchers from Pfizer, statisticians from Pfizer and the result: drug works well!
It is not necessary to read whole manuscript!
"Maurer MS, Schwartz JH, Gundapaneni B, Elliott PM, Merlini G, Waddington-Cruz M, Kristen AV, Grogan M, Witteles R, Damy T, Drachman BM, Shah SJ, Hanna M, JudgeDP, Barsdorf AI, Huber P, Patterson TA, Riley S, Schumacher J, Stewart M, Sultan MB, Rapezzi C; ATTR-ACT Study Investigators. Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy. N Engl J Med. 2018 Sep 13;379(11):1007-1016. doi: 10.1056/NEJMoa1805689."
The problem is in the second treatment group we had a higher value. In such cases what are the other applicable statistical methods to find the optimum level.
So, we usually leave the CaOH intracanal medicament for 14 days and then finish the final obturation. I am keen to know if this time-interval can be reduced by addition of Silver nanoparticles/TAP to CaOH, maybe reduce it from 14 days to 7 days or even 10 days?
Has there any research been done on this?
While I am crossing two paths, such as medicine and technology, I see that there are often barriers to understanding the two, but I want to know from the researchers who deal with both what challenges still exist.
Hi, I would like to know what is the type of study for the following research:
- The researcher conducted a descriptive study of medication errors in a hospital over 3 years. The number and characteristics of medication errors were the comparison sample.
- The researcher implemented a medication error mitigation program.
- Then the researcher studied the number and characteristics of medication errors in the 3 years before the implementation of the mitigation program. And these results were compared with the 3-year sample prior to implementation.
What is the type of study for this research?
Is there any study showing that computer work causes increased eye pressure, a symptom representative of Glaucoma?
I have personally talked with several eye doctors, but they told me that it had not been proven so far. So, I am seeking such new researchers in this regard.
Hello everyone! I am currently applying for postdoc positions, and I have been running into problems with finding a PI's faculty e-mail address. I am running this issue a lot when looking into PIs affiliated with their home university's school of medicine. For example, there are many PIs in the NYU Grossman School of Medicine who I would like to contact for possible positions, but I cannot find their e-mail addresses listed on their faculty page. The only contact information listed is a phone number for a specific treatment facility. (ex: "call this number to reach the cancer center")
Can someone please give me some advice? How can I find the corresponding e-mails for publications written by a PI's lab?
I would love to receive some recommendations from experts in regards to the topic, whether there are valid findings in research on biological markers for anxiety disorders. I am trying to gain some stable insight and be able to argue in favor of the notion, that no anxiety disorder "comes from a malfunction/sickness of the brain".
Thank you in advance!
I have a question or a discussion regarding human evolution in the future, if technology makes human being overcome limits of physiological stress as extreme temperatures , how evolutionary forces could shape our future ? as consequence , changes in human future lineage are not related with the distribution of the species . How traits are selected if we preserve most of the genetic pool trough Medicine , Technology , etc ?
SHARE RECOMMENDED READING PLEASE.
I am here for specific answers or a list of investigation tools to determine the newly developed drugs/inhibitors/medicines.
A patient with desminopathy survived Covid-19 six months ago without pneumonia, but with a temporary loss of smell and taste. After Covid-19, we note an accelerated progression of desminopathy, penetration accelerates, new muscles are quickly involved in the pathological process, muscle mass decreases, and heart function worsens. Perhaps the infection or its consequences are somehow connected with the mechanism of progression of desminopathy?
To save life in desminopathy, can the body purposefully reduce muscle mass, for example, due to decreased heart function or for another reason?
It is known that when hypothermia, the body sacrifices limbs for survival. Is it possible with desminopathy a similar phenomenon?
A patient with desminopathy (mutation Thr341Pro DES in a heterozygous state) with the progression of the disease has a decrease in taste and smell, immunosuppression, and an increase in IgA in the blood.
Oddly enough, but all this is characteristic of infections, including viral ones. For example, it is known that if the hepatitis C virus is not treated, then death will occur in 20 years.
In the identified case of late onset desminopathy, muscle weakness manifests itself at the age of 30, and death occurs 20 years after the onset of the disease.
Could the desmin mutation in myofibrillar myopathy be caused by an infection?
Perhaps the infection contributes to the progression of desminopathy?
Hello everyone, for my master thesis I investigate the acceptance of AI in medicine from patient side and therefore conduct a study. I would be thankful if someone of you would like to fill out the questionnaire, to help me out investigating this important topic. Thank you!
There are news on COVID-19 outbreak on ship, no matter cruise or military one.
And few aircraft carriers are also involved.
What is special about the ship arrangement that facilitated all these?
Nature 580, 18 (2020)
Limiting spread of COVID-19 from cruise ships - lessons to be learnt from Japan,
QJM: An International Journal of Medicine, , hcaa092,
COVID-19 outbreak on the Diamond Princess cruise ship: estimating the epidemic potential and effectiveness of public health countermeasures,
Journal of Travel Medicine, , taaa030,
Public Health Responses to COVID-19 Outbreaks on Cruise Ships — Worldwide, February–March 2020. MMWR Morb Mortal Wkly Rep 2020;69:347-352. DOI: http://dx.doi.org/10.15585/mmwr.mm6912e3
Estimating the asymptomatic proportion of coronavirus disease 2019 (COVID-19) cases on board the Diamond Princess cruise ship, Yokohama, Japan, 2020.
Euro Surveill. 2020;25(10):pii=2000180.
Chest CT Findings in Cases from the Cruise Ship “Diamond Princess” with Coronavirus Disease 2019 (COVID-19)
With an increasing number of countries implementing digital health and digital public health tools, questions arise about whether these tools are effective and how to implement them best nationally. The lack of a validated and standard list of indicators complicates the comparison of digital health maturity between countries. We need guidance for governments in setting up strategies for the effective implementation and adoption of digital public health tools in routine care and the prevention of diseases.
To address this challenge, we want to invite researchers and practitioners from medicine, public health, economics, computer science, law, cultural studies, sociology, or other comparable disciplines. Participants should know about the development, implementation and evaluation of digital public health systems to take part in a Delphi study to choose the leading quality indicators to assess the maturity of national digital public health systems from four perspectives:
1. The information-telecommunication-technology requirements
2. The political support and legal regulation for the implementation and use of health technologies and the generated data
3. The application of concrete digital health tools to the national health system
4. The collective social willingness to use these tools
We are using a snowball approach to reach as many experts as possible. Please join our effort by participating in this Delphi study https://bit.ly/3raMsVY. Please forward this message to all your mailing lists of colleagues that might fit the purpose of this study. Every participation will be greatly appreciated and contribute to a better understanding of international digital public health systems.
This Delphi study will be conducted within the German Leibniz ScienceCampus Digital Public Health research project entitled "Developing a Maturity Measurement Model for Digital Public Health: The Digital Public Health Readiness Index".
Best regards and take care,
(on behalf of the digital public health readiness index team and the EUPHA Digital Health Section)
Link to Survey: https://bit.ly/3raMsVY
Complex systems are becoming one of very useful tools in the description of observed natural phenomena across all scientific disciplines. You are welcomed to share with us hot topics from your own area of research.
Nowadays, no one can encompass all scientific disciplines. Hence, it would be useful to all of us to know hot topics from various scientific fields.
Discussion about various methods and approaches applied to describe emergent behavior, self-organization, self-repair, multiscale phenomena, and other phenomena observed in complex systems are highly encouraged.
In my previous question I suggested using the Research Gate platform to launch large-scale spatio temporal comparative researches.
The following is the description of one of the problems of pressing importance for humanitarian and educational sectors.
For the last several decades there has been a gradual loss in quality of education on all its levels . We can observe that our universities are progressively turning into entertaining institutions, where students parties, musical and sport activities are valued higher than studying in a library or working on painstaking calculations.
In 1998 Vladimir Arnold (1937 – 2010), one of the greatest mathematicians of our times, in his article “Mathematical Innumeracy Scarier Than Inquisition Fires” (newspaper “Izvestia”, Moscow) stated that the power players didn’t need all the people to be able to think and analyze, only “cogs in machines,” serving their interests and business processes. He also wrote that American students didn’t know how to sum up simple fractions. Most of them sum up numerator and denominators of one simple fraction with the ones of the other, i.e. as they did it, 1/2+ 1/3 according to their understand is equal to 2/5 . Vladimir Arnold pointed out that with this kind of education, students can’t think, prove and reason – they are easy to turn into a crowd, to be easily manipulated by cunning politicians because they don’t usually understand causes and effects of political acts. I would add, for myself, that this process is quite understandable and expected because computers, internet and consumer society lifestyle (with its continuous rush for more and newer commodities we are induced to regard as a healthy behavior) have wiped off young people’s skills in elementary logic and eagerness to study hard. And this is exactly what the consumer economics and its bosses, the owners of international businesses and local magnates, need.
I recall a funny incident that happened in Kharkov (Ukraine). One Biology student was asked what “two squared” was. He answered that it was the number 2 inscribed into a square.
The level and the scale of education and intellectual decline described can be easily measured with the help of the Research Gate platform. It could be appropriate to test students’ logic abilities, instead of guess-the-answer tests which have taken over all the universities within the framework of Bologna Process which victorious march on the territories of former Soviet states. Many people can remember the fact that Soviet education system was one of the best in the world. I have therefore suggested the following tests:
1. In a Nikolai Bogdanov-Belsky (1868-1945) painting “Oral accounting at Rachinsky's People's school”(1895) one could see boys in a village school at a mental arithmetic lesson. Their teacher, Sergei Rachinsky (1833-1902), the school headmaster and also a professor at the Moscow University in the 1860s, offered the children the following exercise to do a mental calculation (http://commons.wikimedia.org/wiki/File:BogdanovBelsky_UstnySchet.jpg?uselang=ru):
(10 х 10 + 11 х 11 + 12 х 12 + 13 х 13 + 14 х 14) / 365 = ?
(there is no provision here on Research Gate to write square of the numbers,thats why I have writen through multiplication of the numbers )
19th century peasant children with basted shoes (“lapti”) were able to solve such task mentally. This year, in September, this very exercise was given to the senior high school pupils and the first year students of a university with major in Physics and Technology in Kyiv (the capital of Ukraine) and no one could solve it.
2. Exercise of a famous mathematician Johann Carl Friedrich Gauss (1777–1855): to calculate mentally the sum of the first one hundred positive integers:
1+2+3+4+…+100 = ?
3. Albrecht Dürer’s (1471-1528) magic square (http://en.wikipedia.org/wiki/Magic_square)
The German Renaissance painter was amazed by the mathematical properties of the magic square, which were described in Europe firstly in Spanish (the 1280s) and Italian (14th century) manuscripts. He used the image of the square as a detail for in his Melancholia I painting , which was drawn in 1514, and included the numbers 15 and 14 in his magic square:
16 3 2 13
5 10 11 8
9 6 7 12
4 15 14 1
Ask your students to find regularities in this magic square. In case this exercise seems hard, you can offer them Lo Shu (2200 BC) square, a simpler variant of magic square of the third order (minimal non-trivial case):
4 9 2
3 5 7
8 1 6
4. Summing up of simple fractions.
According to Vladimir Arnold’s popular articles, in the era of computers and Internet, this test becomes an absolute obstacle for more and more students all over the world. Any exercises of the following type will be appropriate at this part:
3/7 + 7/3 = ? and 5/6 + 7/15=?
I think these four tests will be enough. All of them are for logical skills, unlike the tests created under Bologna Process.
Dear colleagues, professors and teachers,
You can offer these tasks to the students at your colleges and universities and share the results here, at the Research Gate platform, so that we all can see the landscape of the wretchedness and misery resulted from neoliberal economics and globalization.
What is the best (or at least the most commonly used in medicine) way to put a Pearson's correlation coefficient into (strong, medium, weak) categories?
 strong (0.7 - 0.89), medium (0.5 - 0.69), weak (0.3 - 0.49)
 strong (0.6 - 0.79), medium (0.4 - 0.59), weak (0.2 - 0.39)
Casodex (or bicalutamide) is available only as a racemic mixture (S and R enatiomers): 1) the pharmacologically active R (-)-enantiomer, and 2) S-Casodex, the inactive (+) enantiomer. The S-enantiomer is thus the non-working compound but is also metabolized at a much lower rate. In other word, much higher plasma levels are the result. Does anybody know if casodex can increase emotional instability/anxiety? And which enantiomer is causing this?
I submitted my manuscript to one of the Lancet Journals. The status remained as “submitted to Journal” till mid February.After that it changed to “Decision in Process”. The status has remained so till April. I have also written to the journal thrice but did not receive any reply from them. I am very confused about the status of my manuscript. There seems to be no option to retract the manuscript too. My mentor is not allowing me to contact the Ombudsman.
I have previously submitted manuscripts twice to Lancet journals but they Would make an editorial decision within 3 days.
Is the current case just a technical glitch or are they pondering over my manuscript? What are the chances of a positive response from the journal based on my case? Also how do I go about the situation?
I want to find some medicines which have the neuroprotection effects, as i hope that it has been researched in other diseases but not the field i am researching now. I know maybe i could find the suitable medicine if i have read many related papers, but is there another way to find it? Thanks.
A plant-based diet is a diet based on fruits, vegetables, whole grains, and legumes while a vegan diet is strictly against all animal products. Whats your openion about PBD and vegan and their effects on our health?
I am working on my MSc dissertation, investigating breast protection bras for female boxers. I am looking at their protection but also the fit and shaping of them and how this relates to their comfort during wear. Is there any sort of classification of the shape of women's breasts? How would I describe the natural breast shape?
The recent changes in the COVID-19 epidemic have led to the emergence of a new SARS-CoV-2 Variant of Concern (VOC), named "Omicron," and the number of Omicron cases were consistently increasing around the world. The health professional's knowledge is of utmost importance to prevent and control the spreading of the SARS-CoV-2 Omicron Variant of COVID-19. In this regard, we would likely to know the level of knowledge and Perceptions of health professionals about the SARS-CoV-2 Omicron Variant; this can provide a greater opportunity to understand the existing knowledge gaps about the novel Omicron variant and to scale up the interventional strategies. Thus, I invite you to participate in this short survey and provide your
valuable opinion regarding the SARS-CoV-2 Omicron variant.
Thanking you in advance
What is the extent of bias risk between standard and autobiographical case reports in medicine and is there any medical journal (indexed or not indexed in MEDLINE) publishing or having a history of publishing autobiographical case reports?
In the structure of many drugs, there is a carboxylic group
What is the significance of this group? Why should it exist in the structure of a drug?
Do you know any article or book or reference about this subject?
Thanks a lot
COVID-19 is mainly a respiratory disease that affects the lung, although other organ structures with endothelium seems to be affected too.
When should we do imaging?
What is the aim of the imaging?
How can it help with management?
Do you agree with the following consensus statement?
How will you adjust your own practice and difficulties encountered? Why?
The Role of Chest Imaging in Patient Management during the COVID-19 Pandemic: A Multinational Consensus Statement from the Fleischner Society. Chest. 2020 Apr 07.
What types of exercises and training variables (volume, intensity, repetitions, frequency, exercise selection, exercise order, and rest) are recommended for patients with Multiple sclerosis (MS)?
COVID-19 is changing the social life of all people. Jumping out of the personal aspect, how does it affect the family as a whole.
Family is regarded as the fundamental structure of the society, will COVID-19 changes the future family structure, unit and model?
How is it affecting gender issues too?
Besides, why is domestic violence increasing? Is psychology and psychiatry playing a role?
 Campbell AM. An increasing risk of family violence during the Covid-19 pandemic: Strengthening community collaborations to save lives.
Forensic Science International: Reports vol. 2 (2020): 100089.
COVID-19: Reducing the risk of infection might increase the risk of intimate partner violence
The pandemic paradox: The consequences of COVID‐19 on domestic violence
J Clin Nurs
To be a better medicine what will we consider as chemically potential?? in terms of Chemical Reactivity of Targeted Drug Molecules with other potential molecules
Artificial intelligence is being used more and more in all medical fields. What do you think will be the development directions for the next 5 years?
Expanded Disability Status Scale (EDSS) is a method of quantifying disability in multiple sclerosis that is the most widely used measurement tool to describe disease progression in patients with MS.
I have received the following polite email request from Medical Research Archives, European Society of Medicine a number of times.
Is it legitimate? Would you mind sharing your thoughts if you have any experience of this kind? Thanks
Dear Dr. Yegnanew A. Shiferaw,
If you have a few minutes I wanted to discuss your COVID-19 research. I am serving as the editor of a special theme issue on Advancements in COVID-19 which will be released by the European Society of Medicine next year and I was thinking that something related to your work on "Regime shifts in the COVID-19 case fatality rate dynamics: A Markov-switching autoregressive model analysis" would be interesting to include in the issue. Perhaps you could tell me more about your research in this area.
This could be in the form of a research article or even a review article.
Might this be a possibility?
L. Smith, M.D.
Medical Research Archives
European Society of Medicine
Online ISSN: 2375-1924
Print ISSN: 2375-1916
PubMed ID: 101668511
If I have an experience but no certificate in Machine Learning, and have both experience and certifcate in Medicine (Urology) ... and want to publish a peper that include an interaction between these 2 feilds, in either Urology or CS journals. Should i add a coauthor who is certified in Data science or CS? ... if not, Would it be necessary to prove my competency in ML by any means?
I hope you had a wonderful Christmas. Im very much interested in teaching and I would like to ask your views on a highly ( to me at least) interesting topic. There are probably as many methods of teaching methods as there are lecturers but here are a few types accepted in literature.
- Student-Centered / Constructivist Approach.
- Inquiry-Based Learning.
- Flipped Classroom.
- Cooperative Learning.
- Personalised Education.
Which one do you use and why?
Best wishes Henrik
What types of exercise and training variables (volume, intensity, repetitions, frequency, exercise selection, exercise order, and rest) are recommended for patients with Multiple sclerosis (MS)?
In a patient with hereditary desminopathy (mutation Thr341Pro DES in the heterozygous state) over the past three years, an increase in the blood uric acid level up to 440-480 µmol / l was established by 1.5 times (the norm is 428.4 µmol / l). With the progression of the disease, the level has risen and is above normal. It is known that uric acid is an antioxidant. Is it necessary to reduce the level of uric acid? The patient has no problems with the joints.
TB is transmitted through the air. The droplet nuclei generated when a sputum positive pulmonary TB patients coughs, mixes in the air and are carried to a susceptible person in the vicinity or by air currents to longer distances. Sputum Negative TB patients may also contribute in transmission of infection to a smaller extent. Now my concern is that, "Can housefly provides an additional epidemiological link to spread TB infection in the community?"
Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally regulate each other, are among the well-known cancer hallmarks. Studies have reported use of Onco-metabolites to metabolically reprogram the epigenetic of cancer. I was wondering what might be major limitations of such techniques?
Jufa is a European native plant and being used in Ayurveda and Unani system of medicine since long. It's one of the ingredients of Gojivhadi kashyam and Jufex of Aimil Pharma.
Have you ever imagined how the physically disabled people feel under COVID-19?
Which type of disability is most impacting these minority under COVID-19?
Autism? Cleft patients? Mental health patients? Deaf? Dumb? Blind? Loss of limbs?
How can we help them?
I am thinking about adapting neuroscience tools for identifying the patient’s reactions in making the diagnosis. I know there is a debate, but I cannot find any literature. Could anyone help me?
Hello, good day.
Please I'm working on a project which needs a "review of relevant theories" of the study "medical negligence behavior"
I found 2 theories relating to this study (conflict theory and theory of negligence), but they are not enough.
Please can I get more theories concerning medical negligence?
Would you describe it as brown? And if so does this mean that purpura preceded this color? And what could be the differential diagnosis of this color?
I started my studies on histology and I realized most of well established text-books don't use scale bars in their images, except the books of the American-German Thieme Publishing Group. I think it is a lack of technical rigorosity, even though most of books treat the issue only on a qualitative point of view. So, what do you think about that? Should the publishers in that area change their concept to increase their accuracy?
Vertigo is a condition that can make it feel like you or your surroundings are spinning, sometimes leading to a loss of balance, according to the U.S. National Library of Medicine.
Coronavirus 2019 or COVID-19 is a novel entity which had led to many challenges among physicians due to its rapidly evolving nature. Vertigo or dizziness has recently been described as a clinical manifestation of COVID-19.
So, Are dizziness and vertigo COVID-19 Symptoms? and why?
Applications of bioinformatics in medicine is a key factor in technological advancement in the field of modern medical technologies.
In which areas of medical technology are the technological achievements of bioinformatics used?
What are the applications of bioinformatics in medicine?
I invite you to the discussion
Thank you very much