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Dear Scientists...
Hello everyone sincerely.
Today (November 3, 2024), the 9th World One Health Day...
I would like to open a topic that I am curious about for discussion. If you share your valuable opinions, I would be grateful.
Some scientists say the following when speaking about ONE HEALTH or in their scientific articles: The term "One Health" is not new. In fact, the origin of the idea begins with Hippocrates. Because they say, "Hippocrates was the first person to define and say that diseases are affected by the environment, air, and water."
Okay, it is impossible not to agree with this.
But as far as we know, during the time Hippocrates lived, there was "only" Medicine (human medicine). Even under the conditions of that day, there was no scientific Veterinary Medicine yet. The first scientific Veterinary Medicine education had started in 1762.
If "One Health is a collaborative, multisectoral, and transdisciplinary approach - working at local, national, and global levels - to achieve optimal health and well-being outcomes recognizing the interconnections between people, animals, plants, and their shared environment." how can Hippocrates be a "pioneer"? Also, since the concept and approach of "collaborative, multisectoral, and transdisciplinary approach" emphasized in the definition above did not exist during the Hippocratic period, isn't it contradictory to extend the "pioneer" of the ONE HEALTH THOUGHT beyond Virchow?
Moreover, Dr. Virchow's "There is no dividing line between human medicine and animal medicine - nor should there be. Even if the objects studied are different, the experience to be gained forms the basis of all medicine." Similar to the proposition, there is no call or proposition for "interprofessional cooperation" in Hippocrates... Unless, of course, the scientific archive is misleading me...
I am curious about your thoughts on this subject.
Best regards.
Rüştü TAŞTAN (rustu_tastan@yahoo.com.tr )
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Dear friends, I must disagree with "in the time of Hippocrates there was only Human Medicine". As far back as approximately 1,700 years BC, in Babylon, legal issues regarding Veterinary Medicine were already described in the famous Code of Hammurabi. Furthermore, in various ancient Egyptian papyri, diseases and treatments are described, indicating in some cases that similar diseases are observed in men and animals. Nontheless, if we refer to Shamanism, we will find expressions of the man/animal interrelation. Now, referring to the question, it is unthinkable that Hippocrates interpreted the concept of "One Health" in the context in which we understand it now. Virchow definitely understood, in that first "microbial" era, the importance of the man/animal/environment interrelation. Cheers
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I am a fifth-year medical student preparing to begin my clerkship soon. I am reaching out to inquire about potential research collaboration opportunities in the fields of neurosurgery, neurology, and neuroscience.
I have gained valuable experience working on various research projects throughout my studies and I am eager to further develop my skills and contribute to meaningful research in these areas. While I have not yet had the opportunity to publish my work, I am committed to advancing my knowledge the expertise in the field.
If you are aware of any ongoing projects or opportunities for collaboration, I would greatly appreciate your guidance or any connections you could provide. I am enthusiastic about the possibility of contributing to impactful research and learning from experienced professionals in the field.
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Hello, dear future colleague Allaham,
Approaching MS from a surgical vista has been the intention of www.ms-info.net. But, as Xun Liu warns above, you had better first find out whether clinical medicine might not clash with medical research here!
Best wishes as well
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Hello, I’m a second-year medical student eager to develop my research skills, particularly in cardiology and the surgical field. I’m looking for guidance on how to start exploring research opportunities in these areas. Does anyone have any idea where to get started?
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Hello. It is interesting that medical students show interest from the first years. I can support you a little depending on the time, tell me which country you are from and I will see what we can do. I had a research team of doctors and medical students who are already doctors or specialists. Kind regards Dr. Osvaldo Valdes
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Nanotechnology Based Medicine
#Nanotechnology #Medicine #HealthcareInnovation #FutureOfMedicine
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Nanotechnologias are very good access from interstiti throug réticulum endoplasmic along to nucleus potentially
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How is polylactic acid used in medicine?
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Used in tissue engineering or regenerative medicine, cardiovascular implants, dental niches, drug carriers, orthopedic interventions, cancer therapy, skin and tendon healing, and for medical tools equipment
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Dr. Faria is associated with Department of Biochemistry (U38-FCT), Faculty of Medicine, University of Porto , 4200-319 Porto, Portugal.
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Dear Dr. Brown,
Below is the email address of Dr. Faria.
Tel./Fax: +351 22 551 36 24
You may refer to the article attached below.
Best.
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As I teach disabilities and we talk about causes, treatment etc. Certain disabilities like intelectual impairment and autism along with epilepsy where cause is microcephaly, low birth weight still there is no treatment. It's life time dependency on medicine to avoid fits.
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It's good to see you realize that "current approaches focus mainly on symptom management rather than [causally, etiologically, or just pathogenetically orientated, physically grounded] cures," Dr. Agbo.
... By the way: Should "congenital" be understood as (we were taught to do!) sth. Hereditary, gene-determined, or as connatal, by anything?
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Inflation of unqualified unv-diplomas cause unemployment among graduates. Children of high social statue families most will be employed ! While others, most will be unemployed or underemployed. With board exams not only graduates but also universities will also be objectively classified for their BA/BS.
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The employment rate is not directly related to the number of graduates, but is largely due to the graduates themselves. They cannot afford high salaries, and are unwilling to work for low salaries
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I am a senior medical student in Zagazig University faculty of medicine (Egypt) with a strong interest in neurology, cardiology, and hematology/oncology, and I am eager to expand my research experience in these fields. I have foundational knowledge in medical research methods such as SRMA and have participated in clinical and laboratory-based projects during my studies.
I would like to inquire if there are any ongoing research projects or collaborations within these specialties where I could contribute, either through data analysis, literature reviews, or hands-on assistance in clinical studies. I am also open to participating in interdisciplinary projects related to general medicine.
Any advice or suggestions for getting involved in current research initiatives or learning opportunities in these areas would be greatly appreciated.
Thank you!
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I am a retired hospital RN who used to write about in-hospital resuscitation topics--with some success in getting published and much less success in bringing about changes in clinical practice. I'm trying to put all that behind me, but just recently one past frustration is coming up again. It's a simple idea that someone should explore, and I want to try to make that happen. I plan to send an email about once a week to anyone I can find on the web who might have the interest and clout to do a study.
I am completely retired now and have stopped writing for publication, but I still want to find someone to do a study along the lines I had in mind--perhaps a research fellow? They would have first authorship, and I'm indifferent about being on the author list at all. I even have a rough research proposal (attached) from some years back which they might want to use as a starting point.
The study could be conducted very quickly and easily. The main requirement would be clearance to access data in a hospital whose standard defibrillator is the LifePak 20/20e. The whole thing is laid out in more detail in an article here. I am absolutely sure that such a study would be publishable in a journal with a respectable impact factor.
Please let me know if you can help with this; it would delight me and also could be a boon to you.
Best regards,
John A Stewart RN, MA
jastewart325@gmail/com
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Acabei de publicar um livro sobre a ética da emancipação da medicina tradicional moçambicana:
Na sua opinião, o que deve acontecer para que haja maior valorização da medicina tradicional?
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Treatment
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Cure of cancer?, respectfully to whom it may concern:
If I found a cure of cancer, I’m wondering what I should do with it? I’m just coming out of a 40 days fast of only drinking maple syrup and pure lemon juice plus a little cinnamon powder and nothing else since I had unimaginable pain in my colon end. I figured out that although we humans can last for weeks on this diet /fast, cancer has no food on that and just goes away and the pain is gone too. I received this prescription by tuning in into the HeilstrOm and I figured out that it also enhances the reception of the HeilstrOm greatly, which brings great happiness too, as I describe in my book
Best regards, hope this helps someone
Chris K. Frueh
Independent Researcher
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@Seraphina Anderson good point
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Apollo Medicine is coming up with a special issue on Metabolic Syndromes.
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I will be glad to be the part of it
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In the identified case of familial desminopathy (T341P DES mutation in heterozygous state), the son has bradycardia, but the father did not have bradycardia. How can this fact be explained?
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The difference in clinical presentation between the son & the father, despite both having the T341P DES mutation in a heterozygous state, is dependent on other genetic variations, which can influence the expression & impact of the desmin mutation. These genetic modifiers can either exacerbate or mitigate the effects of the primary mutation, leading to different clinical outcomes. Epigenetic changes, like DNA methylation & histone modifications can also affect gene expression without altering the DNA sequence & can be influenced by environmental factors as well. Differences in lifestyle, diet, physical activity, exposure to environmental stressors can also impact how the mutation manifests. For example, factors like physical activity levels along with overall cardiovascular health can influence the development of bradycardia. The age at which symptoms appear can vary. The son might be at an age where the mutation's effects are more pronounced, while the father might not have exhibited symptoms at the same age or might have developed compensatory mechanisms over time. These factors highlight the complexity of genetic conditions and the importance of considering both genetic and non-genetic influences when assessing clinical presentations as such.
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I want to study medicine, become a doctor. What courses should I self-study?
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Then study pharmacy, there u get the most knowledge you need.
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How does Homeopathy Artificial Intelligence relate the Innovative Implications of AI's Revolutionary Role in Homeopathic Medicine?
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Artificial Intelligence (AI) is revolutionizing homeopathic medicine by enhancing the precision and personalization of treatments. AI algorithms can analyze vast amounts of patient data, including symptoms and medical history, to identify the most suitable homeopathic remedies more efficiently than traditional methods. Machine learning models detect patterns and correlations that may not be evident to practitioners, leading to more effective treatment plans. Additionally, AI facilitates remote consultations and real-time monitoring of patient progress. This integration of AI brings innovative implications by improving patient outcomes, streamlining clinical workflows, and advancing research within homeopathic medicine.
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Hello everyone,
Does anyone know of any research papers on experimental drug effect analysis using deep learning? If so, I would appreciate it if you could share the name or link with me. That would be greatly helpful.
Additionally, I would love to hear your thoughts on experimental drug effect analysis and what key points should be included when writing a paper on this topic, especially when I'm not allowed to share the dataset or details of the experiment itself.
Thanks in advance!
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Cell count and segmentation are essential in experimental drug effect analysis, providing both quantitative and qualitative insights. Cell counting helps assess changes in cell proliferation, growth, or death, offering a clear measure of a drug's efficacy or toxicity. Segmentation enables detailed visualization of individual cells, allowing researchers to study drug-induced changes in cell morphology, structure, and specific subcellular components. Additionally, segmentation aids in tracking cell populations and behaviors, such as movement and differentiation. Together, these techniques offer a comprehensive view of drug impacts on cellular dynamics, helping to optimize drug effectiveness, dosage, and identify potential side effects.
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MOST human actions are subconscious. The more close-ended the task, the easier to automate. Perhaps SOME subconscious human acts are more close-ended, therefore easier to automate.
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Automating biological functions such as childbirth with AI is a highly complex and ethically sensitive area. While AI can significantly enhance and assist in many aspects of healthcare, full automation of biological functions, especially something as intricate and personal as childbirth, presents numerous challenges and limitations. Here's a breakdown of how AI can be involved, and the specifics of its application:
1. Monitoring and Diagnosis
  • Fetal Monitoring: AI can analyze data from fetal heart rate monitors and ultrasound images to detect signs of distress or abnormalities.
  • Predictive Analytics: AI algorithms can predict potential complications during pregnancy by analyzing historical data and risk factors.
2. Assisting in Decision-Making
  • Clinical Decision Support: AI tools can provide recommendations for treatment options based on current medical guidelines and patient data.
  • Personalized Care: AI can help tailor prenatal care plans to individual needs by analyzing various health metrics.
3. Automation of Procedures
  • Surgical Assistance: AI-driven robotic systems, like the Da Vinci Surgical System, assist surgeons in performing precise operations, which can be beneficial in cesarean sections and other surgical procedures.
  • Lab Automation: AI can streamline lab processes related to prenatal care, such as genetic testing and analysis.
4. AI in Healthcare Management
  • Workflow Optimization: AI can improve hospital workflows, manage patient records, and ensure timely care delivery.
  • Patient Engagement: AI-powered chatbots and virtual assistants can provide patients with information, reminders, and support throughout their pregnancy.
5. Ethical and Practical Considerations
  • Complexity of Childbirth: Childbirth involves complex physiological and emotional factors that are challenging to fully automate or control with AI.
  • Ethical Issues: Automating biological functions raises significant ethical concerns about safety, consent, and the role of human judgment in critical medical situations.
  • Human Factors: Human expertise and empathy play a crucial role in managing childbirth, making it difficult to fully replace with AI.
Current State and Future Potential
  • Current Technology: While AI significantly aids in the management and support of childbirth, it does not replace the need for human intervention and decision-making. It can, however, enhance safety, efficiency, and personalized care.
  • Future Prospects: Advancements in AI may further assist in predictive analytics, personalized medicine, and robotic surgery, but the automation of biological functions like childbirth will remain a collaborative effort between technology and human expertise.
Summary
AI can enhance and support various aspects of childbirth and prenatal care, such as monitoring, decision-making, and procedure assistance. However, the full automation of childbirth involves complex physiological, ethical, and human factors that cannot currently be fully addressed by AI alone. AI’s role is to complement and support human expertise rather than replace it.
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What is the best solution for the dilemma between evidence-based medicine (EBM) for populations and for individuals, which arises from the tension between general recommendations based on population-level data and the need to tailor medical decisions to an individual’s unique circumstances? What percentage of people in your practice require tailored care?
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The dilemma between population-level evidence-based medicine (EBM) and individual patient care is a well-recognized challenge. The best solution often lies in a balanced, integrative approach:
  1. Shared Decision-Making (SDM): This approach combines the best available evidence with patient preferences and values. While EBM provides generalized guidelines, SDM allows for personalized care by actively involving the patient in the decision-making process.
  2. Clinical Judgment: Experienced clinicians use their expertise to interpret EBM in the context of individual patient characteristics (e.g., genetics, co-morbidities, lifestyle). They weigh the evidence but adapt it to the patient's unique situation.
  3. Precision Medicine: Advances in genomics, pharmacogenetics, and biomarkers are increasingly allowing care to be individualized based on a patient's specific biological makeup, rather than solely relying on population-level data.
  4. Risk Stratification: Some patients benefit from stratification into risk categories that inform how strictly EBM should be applied or adapted, depending on factors such as age, gender, ethnicity, or pre-existing conditions.
Regarding the percentage of people in practice who require tailored care, it varies by specialty and patient population, but many studies suggest that 30-40% of patients need some form of individualized adaptation of EBM guidelines, particularly those with complex medical conditions, multiple comorbidities, or unique genetic factors. This number can increase in more complex cases or specialized fields.
What is your experience regarding how often you need to tailor care to your patients?
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I am reaching out to seek your advice regarding an issue I have been experiencing with the journal of Annals of Medicine. Our manuscript was accepted on 19 April 2024, and the editorial board told us the proof would be sent to us within 48 hours. However, despite multiple follow-ups, we have yet to receive the proof until now. Each time we contact the journal, we are informed that my paper is undergoing an additional check.
We have try to contact the Taylor&Francis, which is the publication company of Annals of Medicine, many times, but they never reply us.
Has anyone else encountered a similar situation? If so, how did you manage to resolve it? Any advice or suggestions on how I might expedite this process or get a clearer response from the journal would be greatly appreciated.
Thank you in advance for your insights and assistance.
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It sounds frustrating to experience delays in receiving proofs from the Annals of Medicine, especially after receiving initial assurances. Here are some strategies you might consider to expedite the process and get clearer responses:1. Document Everything:
  • Keep a detailed record of all your communications with the journal, including dates, times, and the content of your messages. This documentation can be helpful if you need to escalate the issue.
2. Follow Up Regularly:
  • Continue to follow up with the journal at regular intervals. A polite but persistent approach can sometimes yield results. If you haven't already, consider varying your communication methods (e.g., email, phone calls) to see if one is more effective than the other.
3. Contact Higher Authorities:
  • If you are not receiving satisfactory responses from the editorial team, consider reaching out to higher authorities within the journal or the publishing company, Taylor & Francis. Look for contact information for the editorial board or the publisher's customer service.
4. Seek Peer Support:
  • Engage with colleagues or peers who may have published in the same journal. They might have experienced similar issues and could offer insights or contacts that could help you.
5. Utilize Social Media:
  • Sometimes, public inquiries on platforms like Twitter or LinkedIn can prompt a quicker response from journals. If you choose this route, ensure your message is professional and respectful.
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If then which medicine production and name of the medicine what's is that?
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Egg shell is mainly calciumcarbonate. Is that used as a medicine?
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What are the most pressing ethical concerns surrounding the use of genetic engineering in agriculture, medicine, and other fields?
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Genetic engineering, while offering transformative potential across various fields such as agriculture and medicine, raises several pressing ethical concerns. These concerns can be categorized into several key areas:
1. Animal Welfare and Rights
The genetic engineering of animals poses significant ethical dilemmas. While it may lead to advancements in medicine and agriculture, there are intrinsic ethical concerns regarding the welfare of genetically modified animals. Critics argue that even if animal welfare can be safeguarded, the very act of altering an animal's genetic makeup raises moral questions about the rights of these beings and the potential for suffering.
Moreover, the pursuit of profit in agricultural production through genetic engineering can lead to practices that prioritize economic gain over animal welfare.
2. Human Genetic Engineering
The ethical implications of human genetic engineering, particularly germline editing, are profound. This technology could potentially eliminate genetic disorders, but it also raises concerns about unforeseen consequences, such as long-term health effects on future generations who cannot consent to these modifications.
Additionally, there is a fear of creating a societal divide where only certain groups can access enhancements, leading to inequality.
3. Environmental Impact
In agriculture, the use of genetically modified organisms (GMOs) can have unintended environmental consequences. These include potential biodiversity loss and the risk of genetically modified traits spreading to wild populations, which could disrupt ecosystems. The ethical question here revolves around the responsibility of scientists and corporations to ensure that their innovations do not harm the environment or contribute to ecological imbalance.
4. Socio-Economic Disparities
The commercialization of genetic engineering technologies often leads to concerns about access and equity. There is a risk that these technologies will primarily benefit wealthy individuals or nations, exacerbating existing inequalities in health and food security. Ensuring that genetic engineering is accessible to all, regardless of socioeconomic status, is a critical ethical consideration.
5. Informed Consent and Autonomy
In the context of gene therapy, ethical issues arise regarding informed consent, especially when the subjects of genetic modifications are not yet born. This raises questions about autonomy and the rights of individuals who may be affected by genetic changes made by others. The ethical principle of respecting individual autonomy must be balanced against the potential benefits of genetic interventions.
Conclusion
The ethical landscape surrounding genetic engineering is complex and multifaceted. It requires ongoing dialogue among scientists, ethicists, policymakers, and the public to navigate these challenges responsibly. As genetic engineering continues to evolve, addressing these ethical concerns will be crucial to ensuring that its applications benefit society as a whole without compromising ethical standards.
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Epigenetics refers to the study of changes in gene expression that do not involve alterations to the underlying DNA sequence. This field has garnered significant attention for its potential to influence aging, combat diseases, and mitigate unwanted side effects of genetic engineering.
Aging is associated with various epigenetic changes, such as DNA methylation and histone modifications, which can lead to altered gene expression and contribute to age-related diseases like cancer and neurodegenerative disorders. By targeting these epigenetic modifications, researchers believe it may be possible to reverse or slow down the aging process. For instance, interventions that modify epigenetic markers could potentially restore youthful gene expression patterns, thereby improving cellular function and longevity.
Epigenetic therapies hold promise for treating a range of diseases. By understanding the specific epigenetic alterations associated with conditions like cancer, researchers can develop targeted therapies that either activate or repress certain genes without changing the genetic code itself. This approach could lead to more effective treatments with fewer side effects compared to traditional genetic engineering methods, which often involve irreversible changes to the genomeOne of the significant concerns with genetic engineering is the potential for unintended consequences, such as off-target effects or the activation of harmful genes. Epigenetic modifications can provide a more flexible approach to gene regulation, allowing for temporary changes that can be reversed if necessary.
This flexibility could help in fine-tuning therapeutic interventions, reducing the risk of adverse effects associated with permanent genetic alterations.
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I was on line with famous nephrologist and come to know about kidneys treatment by allopathic medicine.
Then my question ❓ is kidney will get back normal' position.
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When it comes to treating kidney disease, particularly in the second stage of chronic kidney disease (CKD), both homeopathy and allopathy offer different approaches, and the effectiveness can vary based on individual circumstances.
Homeopathy is often touted for its potential to stimulate the body's immune system, which may help improve kidney function. Some practitioners claim that homeopathic treatments can lead to significant improvements in kidney health, potentially allowing patients to withdraw from dialysis or avoid more invasive treatments like transplantation. Homeopathy is believed to work by addressing the underlying causes of kidney issues and promoting overall health, which can be particularly beneficial for patients with conditions like diabetes and hypertension that complicate kidney disease
Allopathic medicine, which includes conventional treatments such as medications, dialysis, and kidney transplants, focuses on managing symptoms and preventing further damage to the kidneys. While allopathic treatments do not cure kidney disease, they can effectively manage the condition and prolong life by performing the essential functions of the kidneys.
For patients in the second stage of CKD, allopathic treatments may include medications to control blood pressure, manage diabetes, and reduce proteinuria, which can help slow the progression of kidney disease.
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Preparing a review about potential distinct effects of North and South poles (or upward/downward) in biology, chemistry, chirality, etc, I would appreciate any signaling of publications to supplement a databank dedicated to this overlooked parameter, whether confirming or invalidating.
Also, any comments, exchanges or collaboration will be welcome.
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Thank you for your answers but your replies don't really meet the topic whether there are distinct effects of what different research teams consider as:
- magnetic upward and downward fields (relative to gravity) effects,
- or only magnetic field direction (regardless of spatial orientation),
- or magnetic north and south polarities (by the way, note that many papers in English use reversed namings of the North and South poles of magnets!).
To help understand this discussion, here are examples of papers mentioning this side of the issue (whether positive or no effect):
- Life on Magnet: Long-Term Exposure of Moderate Static Magnetic Fields on the Lifespan and Healthspan of Mice
- Hematological parameters’ changes in mice subchronically exposed to static magnetic fields of different orientations
- Effect of pre-sowing treatment with permanent magnetic field on germination and growth of chilli
- Effects of Cholinergic Receptor Activation and Magnetic Fields on Motor Behavior in Ischemic Gerbils
- Magneto-mechanical stimulation modulates osteocyte fate via the ECM-integrin-CSK axis
- Homogeneous static magnetic field of different orientation induces biological changes in subacutely exposed mice
- Comparative effect of positive and negative static magnetic fields on heart rate and blood pressure in healthy adults
Thanks for your patience!
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European Society of Medicine sent an invitation for a special theme issue on COVID-19. Is this invitation genuine?
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📢 Call for Papers: New Asian Journal of Medicine, Volume 2 – Issue 2, 2024 📢 We are delighted to announce that the New Asian Journal of Medicine (NAJM) is now inviting submissions for our 2024 issues. In our commitment to advancing global medical knowledge, we are offering free publication for all articles accepted in 2024. Submission Deadline: 🗓️ July 31, 2024 Topics of Interest Include, But Are Not Limited To: Clinical Medicine Public Health Initiatives Medical Ethics Infectious Diseases Chronic Disease Management Medical Imaging Surgical Techniques Healthcare Policy Patient Safety and Quality Improvement Medical Education We welcome submissions from researchers across the globe, aiming to reflect the diverse nature of medical science and practice. Types of Submissions Accepted: Original Research Narrative Reviews Systematic Reviews Editorials Clinical Trials Perspectives Opinions Letters to the Editor Commentaries Submission Guidelines: All submissions must adhere to NAJM guidelines and are subject to a robust peer review process to maintain the highest standards of scholarly integrity and scientific excellence. How to Submit: Please submit your manuscripts through the NAJM online submission system at [https://nasianjmed.com/index.php/najm/announcement/view/2]. If you encounter any difficulties or have questions, contact our editorial office at [editor@nasianjmed.com].
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Can I upload original Research related to Dentistry ?
Thank you
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A new medicine PCSK9 inhibitor for lowering LDL has been developed.How does PCSK9 inhibitor differed from statin which has earlier been used s​i​nce many years to lower cholesterol levels in the blood.
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These are inhibitors of the PCSKexin and are used often in combination therapy to achieve target goals for lipid therapy. They are available in injection forms are their cost are very high at the moment.
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Over the past few years, there has been tremendous advancement in artificial intelligence (AI). Faculty from across the Yale Department of Internal Medicine are using AI as a tool to help improve the way they learn, teach, conduct research, and advance the field of medicine. “By using the power of AI, we are unlocking new opportunities to improve the way we conduct research and teach students—all with the ultimate goal of making health care better for our patients.”
source: Gary Désir, MD, Paul B. Beeson Professor of Medicine
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Dear Eduard Babulak , wouldn't an obvious (yet cheap, I know) answer be to point to the interests of food industry targeting children with unhealthy food? Don't know how relevant this is though.
Best Wishes,
Haris
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Definitely yes
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I just had an email from the European Society of Medicine asking for a contribution to the journal Medical Research Archives. There is a similar journal on Cabell's published by KEI publishers, however I am unsure if this is the same journal. The European Society of Medicine from the website seems legit. Can anyone offer their personal experiences with the European Society of Medicine?
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Multiple emails from Medical Research Archives of the European Society of Medicine asked me to contribute. The editor is someone named L. Smith who is not mentioned anywhere online. At first, I ignored them but eventually, after repeated emails I said yes. After that they asked me to pay to contribute and graciously offered me a 15%discount when I said I couldn't.
This is a predatory journal that looks out for young researchers from developing countries who might be relatively more desperate to get published. My advice is to stay away from such journals. They are a scam.
Below is the email i received asking me to pay to contribute as if they are doing me a favor.
"
Thank you for your response. As an open-access journal with zero subscription or advertising revenue, we do have to charge a publication fee to keep the journal running. However, we do have some lower-priced options available.
Members of the society are exempt from the publication fees. Standard membership is $999 and reduced membership for developing countries is $499. This is the most economical option and includes 3 article publications per year. More details and the signup page may be found here.
Alternatively, if you don't want to go the membership route, I can offer a 15% discount on the regular publication fees. The discount code to enter on the registration form is ESMED23
Which of these options would work best for you?
Sincerely,
L. Smith
Chair of Editorial Committee
Medical Research Archives
European Society of Medicine
Online ISSN: 2375-1924
Print ISSN: 2375-1916
View on PubMed"
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Generally life extension and anti-aging. A lower death rate cancels out a low birthrate. https://www.researchgate.net/publication/382049802_Correcting_Cell_Errors
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This can be achieved by improving socioeconomic status of individual, and reduce economic hardshi.p
Reduce the depopulation strategies of contraceptive usage.
Frop the islamic point of view encourage polygamy where man is entitle to four wives provided he can cater for their well-being
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It is known that patients with desminopathy often die from pneumonia. Have pathomorphological studies of the lungs been performed in patients with desminopathy?
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Dear Sagar Nanaso Salunkhe, thank you very much for your detailed answers!
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I need materials on intersection between literature and medicine.
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Recommended "Doctors from hell" by Vivian Spitz, about Nuremberg war crimes.
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The focus is on the lack of research for culturally tailored interventions to provide effective treatment for the NA/AN population. There are cultural barriers surround distrust, misinterpretation, disparities between Western medicine and traditional healing, and more.
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implicit bias is one reason; the other reason is lack of funding and educational resources
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I'd trying the several countries with several religions on young and older. what are which books so far. Sound Medicine, Music Medicine on many religions working now.
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All kind of music are good therapy according to the case response e.g classic is excellent for psychetric respose
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Respected researchers. Our team would be happy to work with anyone who is interested in contributing to the writing of a single review paper on veterinary homoeopathy. The collaborator ought to be sincere and have some writing experience in the scientific field or publishing. You can directly message me on ResearchGate or email me at dr.abrar79@gmail.com with a brief introduction about yourself.
Warm Regards
Dr. Abrar
Scientist, Department of Medicine
GADVASU, Ludhiana, Punjab
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I will help if you needed In Ayurved veterinary medicine review paper.
thanks for recommending me..
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Is the design of new pharmaceutical formulations through the involvement of AI technology, including the creation of new drugs to treat various diseases by artificial intelligence, safe for humans?
There are many indications that artificial intelligence technology can be of great help in terms of discovering and creating new drugs. Artificial intelligence can help reduce the cost of developing new drugs, can significantly reduce the time it takes to design and create new drug formulations, the time it takes to conduct research and testing, and can thus provide patients with new therapies for treating various diseases and saving lives faster. Thanks to the use of new technologies and analytical methods, the way healthcare professionals treat patients has been changing rapidly in recent times. As scientists manage to overcome the complex problems associated with lengthy research processes, and the pharmaceutical industry seeks to reduce the time it takes to develop life-saving drugs, so-called precision medicine is coming to the rescue. It takes a lot of time to develop, analyze, test and bring a new drug to market. Artificial intelligence technology is particularly helpful in this regard, including reducing the aforementioned time to create a new drug. When creating most drugs, the first step is to synthesize a compound that can bind to a target molecule associated with the disease. The molecule in question is usually a protein, which is then tested for various influencing factors. In order to find the right compound, researchers analyze thousands of potential candidates of different molecules. When a compound that meets certain characteristics is successfully identified, then researchers search through huge libraries of similar compounds to find the optimal interaction with the protein responsible for the specific disease. In contrast, many years of time and many millions of dollars of funding are required to complete this labor-intensive process today. In a situation where artificial intelligence, machine learning and deep learning are involved in this process, then the entire process can be significantly reduced in time, costs can be significantly reduced and the new drug can be brought to the pharmaceutical market faster by pharmaceutical companies. However, can an artificial intelligence equipped with artificial neural networks that has been taught through deep learning to carry out the above-mentioned processes get it wrong when creating a new drug? What if the drug that was supposed to cure a person of a particular disease produces a number of new side effects that prove even more problematic for the patient than the original disease from which it was supposed to be cured? What if the patient dies due to previously unforeseen side effects? Will insurance companies recognize the artificial intelligence's mistake and compensate the family of the deceased patient? Who will bear the legal, financial, ethical, etc. responsibility for such a situation?
I described the key issues of opportunities and threats to the development of artificial intelligence technology in my article below:
OPPORTUNITIES AND THREATS TO THE DEVELOPMENT OF ARTIFICIAL INTELLIGENCE APPLICATIONS AND THE NEED FOR NORMATIVE REGULATION OF THIS DEVELOPMENT
In view of the above, I address the following question to the esteemed community of scientists and researchers:
Is the design of new pharmaceutical formulations through the involvement of AI technologies, including the creation of new drugs to treat various diseases by artificial intelligence, safe for humans?
Is the creation of new drugs by artificial intelligence safe for humans?
What do you think about this topic?
What is your opinion on this issue?
Please answer,
I invite everyone to join the discussion,
Thank you very much,
Best wishes,
Dariusz Prokopowicz
The above text is entirely my own work written by me on the basis of my research.
In writing this text I did not use other sources or automatic text generation systems.
Copyright by Dariusz Prokopowicz
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Why AlphaFold 3 Needs to Be Open Source
The powerful AI-driven software from DeepMind was released without making its code openly available to scientists...
"IMAGINE A WORLD where in a matter of minutes, scientists could identify drugs to treat incurable diseases, design chemicals that could break down plastics to clean up pollution, and develop new materials that can suck excess carbon dioxide out of the air to help address climate change. This is the promise of new biology- and chemistry-based models that use artificial intelligence, or AI, to perform traditionally time-consuming tasks such as determining the structures of proteins.
Google DeepMind, a private research subsidiary of Google, released the highly anticipated AlphaFold 3 model last month as a paper in Nature. This model claims to be an improvement over its earlier version, AlphaFold 2, because it can predict not just protein structures, but also how they interact with RNA, DNA, and — most importantly — drugs. DeepMind said that it hopes AlphaFold 3 will “transform our understanding of the biological world and drug discovery.”...
In an editorial response published on May 22, Nature claimed that by allowing peer-reviewed publications from the private sector, it “promotes the sharing of knowledge, verification of the research and the reproducibility researchers strive for” and that its policy states that the editors reserve the right to decide if all code needs to be released. However, it’s unclear to me how one can verify research without having the tools available to do so..."
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What factors contribute to the value of a review article, and
how is this value related to scientific criteria?
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Can you explain the process involved in preparing a
systematic review, as outlined in the article?
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What is the PRISMA statement, and how does its checklist
help in structuring a review article?
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How is a research question typically formulated in the
context of review articles, and what is the significance of
using the PICO format?
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How does the hierarchy of evidence help in assessing the
quality of studies based on different research questions?
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A reviewer is needed for a WOS journal with general medicine topics.
should be at least an associate professor.
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I HAVE.
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Dear colleagues,
I have received an invitation to the Global Conference on Development in Medicine, Science, and Education (GCDMSE - 2024), but I need to find out the organizers. Does anyone know more and can provide me with information, experiences and the like? Thanks a lot and best regards
Ottomar Bahrs
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Hi Dr. Ottomar
I received an email about this conference; please let me know if someone has answered you or provided you with the info. Thanks
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📢 Call for Papers: New Asian Journal of Medicine, Volume 2 – Issue 2, 2024 📢 We are delighted to announce that the New Asian Journal of Medicine (NAJM) is now inviting submissions for our 2024 issues. In our commitment to advancing global medical knowledge, we are offering free publication for all articles accepted in 2024. Submission Deadline: 🗓️ July 31, 2024 Topics of Interest Include, But Are Not Limited To: Clinical Medicine Public Health Initiatives Medical Ethics Infectious Diseases Chronic Disease Management Medical Imaging Surgical Techniques Healthcare Policy Patient Safety and Quality Improvement Medical Education We welcome submissions from researchers across the globe, aiming to reflect the diverse nature of medical science and practice. Types of Submissions Accepted: Original Research Narrative Reviews Systematic Reviews Editorials Clinical Trials Perspectives Opinions Letters to the Editor Commentaries Submission Guidelines: All submissions must adhere to NAJM guidelines and are subject to a robust peer review process to maintain the highest standards of scholarly integrity and scientific excellence. How to Submit: Please submit your manuscripts through the NAJM online submission system at [https://nasianjmed.com/index.php/najm/announcement/view/2]. If you encounter any difficulties or have questions, contact our editorial office at [editor@nasianjmed.com].
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We are working to index it inScopus, and after that in PubMed. We are working hard......
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Hello
Are diuretic medicine, thiazide type
Inhibits Na absorption from DCT or PCT?
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Work through inhibition of Na reabsorbtion at DCT
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Has medicine become a trade and not a humanitarian profession, but rather a commercial and investment profession?
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Profiteering-from-disease Rasha A Waheeb has become the standard model of the medical profession, i.e. the disease-centered model of treatment (mainly drugs and surgery) is consequently a low empathy model, based on monetary profit.
It has to be mentioned here that treatment and healing are not the same; there exist other practical models for the medical profession, e.g. person-centered health care, integral health care, but the physician is always part of a society, i.e. certain working conditions, e.g. highly industrialized medical institutions.
Data on the health of health of (our) physicians are also alarming, i.e. the whole machinery comes with a price to pay, not only for the patients.
Conclusion:
A change in perspective is a must. As long as ‘modern medicine’ adheres to the tenets of ‘classical science’, subjects will be regarded as objects, consciousness will be reduced to (DNA) matter, and living beings as cadavers. This is not a figure of speech. Medical students still spend much time studying cadavers; without considering how this alienates them from contact with living beings.
Modern medicine manipulates politicians and the public by referring to the merits of classical science. Classical science is a deadly foundation for health care ! Classical science addressed invariance: action + reaction=0///No-change).Invariance was traditionally called Hell (closed system).
Modern’ medicine uses the philosophy of mechanical material control and domination (a war model) to overrule all ‘other’ forms of healing.
Few people (and fewer doctors) are aware how the medical model is crippled by ‘belief’ in classical science. The mechanistic material model is associated with control and mass production; it was developed for (and from) the study of inert matter. Living beings are thereby regarded by the mechanical material ‘laws of inertia/dead matter’.
Since 1900 science underwent drastic changes, not matter, but information is now the essence. The focus shifted from (classical, material) matter of physics, to (relativistic, molecular) chemical processes, to (probabilistic, atomic) electromagnetic interactions, and now to (phase-field) information integrity. All of these considerations can be recognised in the living being; but still need to be included in the classical medical model.
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Can you provide examples of how evidence-based medicine has positively impacted patient outcomes or healthcare practices?
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Evidence-based medicine (EBM) has had a significant positive impact on patient outcomes and healthcare practices across various clinical specialties. Here are some examples:
  1. Reduction in Mortality and Morbidity: Implementation of evidence-based guidelines and protocols for acute myocardial infarction (heart attack) management, such as timely administration of aspirin, thrombolytics, and percutaneous coronary intervention (PCI), has led to significant reductions in mortality rates and complications associated with myocardial infarction.
  2. Improved Cancer Screening and Treatment: Evidence-based screening guidelines for breast, colorectal, cervical, and prostate cancers have increased early detection rates, leading to earlier diagnosis, more effective treatment interventions, and improved survival outcomes for patients with cancer.
  3. Prevention of Healthcare-associated Infections: Adherence to evidence-based infection prevention and control practices, such as hand hygiene protocols, aseptic techniques, and appropriate use of antimicrobial agents, has resulted in reductions in healthcare-associated infections (HAIs) and related morbidity and mortality rates in hospitals and healthcare facilities.
  4. Enhanced Surgical Outcomes: Adoption of evidence-based surgical practices, including preoperative optimization, surgical checklists, enhanced recovery after surgery (ERAS) protocols, and minimally invasive surgical techniques, has led to improvements in surgical outcomes, shorter hospital stays, and reduced postoperative complications for patients undergoing surgery.
  5. Management of Chronic Diseases: Evidence-based management strategies for chronic diseases such as diabetes, hypertension, asthma, and chronic obstructive pulmonary disease (COPD) have improved disease control, reduced disease progression, and prevented complications, resulting in better quality of life and health outcomes for patients with chronic conditions.
  6. Reduction in Medication Errors: Implementation of evidence-based medication reconciliation processes, computerized physician order entry (CPOE) systems, clinical decision support tools, and pharmacist-led medication therapy management programs has helped reduce medication errors, adverse drug events, and medication-related hospitalizations.
  7. Promotion of Patient Safety and Quality Improvement: Integration of evidence-based patient safety practices, such as standardized protocols for handoffs and communication, checklists for surgical procedures, and root cause analysis of adverse events, has contributed to improvements in patient safety culture, reduction in medical errors, and enhancement of healthcare quality and reliability.
  8. Optimization of Maternal and Neonatal Health: Evidence-based practices in obstetrics and neonatology, such as antenatal screening, intrapartum monitoring, use of evidence-based protocols for labor induction and cesarean section, and implementation of neonatal resuscitation guidelines, have improved maternal and neonatal outcomes, reduced maternal and infant mortality rates, and enhanced perinatal care.
Overall, evidence-based medicine has revolutionized healthcare practices by providing clinicians with the tools, knowledge, and guidelines needed to deliver high-quality, patient-centered care, improve clinical outcomes, and enhance patient safety and satisfaction across diverse clinical settings and patient populations.
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How does evidence-based medicine help clinicians make informed decisions about patient care?
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Evidence-based medicine (EBM) helps clinicians make informed decisions about patient care by integrating the best available research evidence with clinical expertise and patient values and preferences. Here's how EBM facilitates informed decision-making:
  1. Access to Best Available Evidence: EBM emphasizes the importance of using the best available evidence from high-quality research studies, such as randomized controlled trials (RCTs), systematic reviews, and meta-analyses, to inform clinical practice. Clinicians have access to a wealth of evidence-based resources, including medical journals, clinical practice guidelines, online databases, and evidence summaries, to stay updated on the latest research findings and treatment recommendations.
  2. Critical Appraisal of Evidence: EBM equips clinicians with skills for critically appraising research evidence to assess its validity, relevance, and applicability to clinical practice. Clinicians evaluate the methodological quality, study design, outcome measures, statistical analysis, and potential sources of bias in research studies to determine the strength of evidence supporting specific interventions or treatments.
  3. Integration of Clinical Expertise: EBM recognizes the importance of clinical expertise and judgment in interpreting research evidence and applying it to individual patient cases. Clinicians integrate their knowledge of pathophysiology, diagnostic reasoning, therapeutic options, and patient preferences with the best available evidence to make personalized and context-specific decisions about diagnosis, treatment, and management.
  4. Consideration of Patient Values and Preferences: EBM emphasizes the importance of considering patient values, preferences, goals, and priorities in shared decision-making. Clinicians engage patients in meaningful discussions about treatment options, risks, benefits, uncertainties, and realistic expectations for outcomes, empowering them to make informed choices that align with their values and preferences.
  5. Promotion of Evidence-Based Practice Guidelines: EBM supports the development and dissemination of evidence-based clinical practice guidelines, which synthesize research evidence, expert consensus, and patient input to provide recommendations for optimal patient care. Clinicians use practice guidelines as a framework for decision-making, treatment planning, and quality improvement initiatives, ensuring consistency and standardization of care across healthcare settings.
  6. Continuous Learning and Improvement: EBM fosters a culture of lifelong learning and professional development among clinicians, encouraging them to stay updated on the latest evidence, guidelines, and advances in their field. Clinicians participate in continuing education activities, journal clubs, case discussions, and quality improvement projects to enhance their knowledge and skills in evidence-based practice.
  7. Evaluation of Treatment Effectiveness and Outcomes: EBM enables clinicians to evaluate the effectiveness, safety, and outcomes of interventions in real-world clinical practice. Clinicians monitor patient responses to treatment, assess adherence to evidence-based guidelines, and collect data on clinical outcomes and quality indicators to inform continuous quality improvement efforts and optimize patient care.
By incorporating principles of evidence-based medicine into clinical practice, clinicians can make informed decisions that are grounded in the best available evidence, aligned with clinical expertise and judgment, respectful of patient values and preferences, and conducive to improving patient outcomes and healthcare quality.
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What are the different levels of evidence in evidence-based medicine, and how are they categorized?
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Evidence-based medicine (EBM) utilizes various levels of evidence to guide clinical decision-making, with each level representing the strength of evidence supporting a particular intervention or practice. These levels are commonly categorized using a hierarchical framework, such as the one proposed by the Oxford Centre for Evidence-Based Medicine (OCEBM). Here are the different levels of evidence in EBM, categorized from the highest to lowest level:
  1. Level 1: Systematic Reviews and Meta-Analyses: Systematic reviews and meta-analyses of randomized controlled trials (RCTs) represent the highest level of evidence in EBM. These studies systematically gather, critically appraise, and synthesize existing research evidence on a specific clinical question or topic. Meta-analysis combines data from multiple RCTs to provide a quantitative summary of treatment effects, enhancing the precision and reliability of the findings.
  2. Level 2: Randomized Controlled Trials (RCTs): RCTs are experimental studies in which participants are randomly assigned to different treatment groups to evaluate the efficacy and safety of interventions. RCTs are designed to minimize bias and confounding factors, allowing for causal inference regarding the effects of interventions. Well-designed RCTs with appropriate randomization, blinding, and control groups provide high-quality evidence for clinical decision-making.
  3. Level 3: Cohort Studies: Cohort studies are observational studies that follow a group of individuals over time to assess the association between exposure to risk factors or interventions and the development of outcomes. Cohort studies provide valuable information about the natural history of diseases, the etiology of conditions, and the long-term effects of interventions. Prospective cohort studies, in which participants are followed forward in time, are considered stronger evidence than retrospective cohort studies.
  4. Level 4: Case-Control Studies: Case-control studies are observational studies that compare individuals with a particular outcome (cases) to those without the outcome (controls) to investigate potential risk factors or exposures associated with the outcome. While case-control studies are useful for exploring associations between exposures and outcomes, they are prone to biases such as recall bias and selection bias, which limit their ability to establish causality.
  5. Level 5: Case Series and Case Reports: Case series and case reports describe the clinical characteristics, management, and outcomes of individual patients or a small group of patients with a particular condition or intervention. While case series and case reports provide valuable insights into rare or novel conditions, treatments, or adverse events, they are considered low-level evidence due to their descriptive nature and lack of comparison groups.
  6. Level 6: Expert Opinion and Consensus Statements: Expert opinion and consensus statements represent the lowest level of evidence in EBM and are based on the collective judgment and expertise of clinical experts in the field. While expert opinion and consensus statements provide valuable clinical guidance in the absence of empirical evidence, they are susceptible to bias and may vary depending on the opinions and perspectives of individual experts.
It's important to note that the hierarchy of evidence is not absolute, and the appropriateness of evidence depends on the specific clinical question, context, and available resources. In practice, healthcare providers often integrate evidence from multiple levels to inform clinical decision-making and provide the best possible care for their patients.
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I'm a current medicine student and I'm in my first scientific initiation in my graduation. Currently, me and my professor are having some troubles with contamination in our cells. This is a bottle with HCT-116 cells (colorretal cancer). This cells were, previously frozen with contaminated fetal bovine serum. My professor said she thought she treated the cells, but this contamination keep returning. We supplement our media with penicilin and B- anfotericin at 1% each. The weird thing is: The bottle keeps healthy and, suddenly, from one day to another, these clouds appears and the bottle liquid looks cloudy. Could anyone, please, help me by advising what could I do or what fungus is this (If this is a fungus)?
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It is extremely difficult to completely eliminate bacteria from contaminated cells, and the contamination can return. Many labs have HCT116 cells. Therefore, if your cells are not invaluable (transfected for example), the best thing to do is to throw away your culture and request the cell line from a nearby lab.
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Most of the researchers use to teach at university. In some careers, professionals who exert their profession without doing research share teaching spaces. When I was a chemistry student, 100% of my teachers were researchers ranging from PhD candidates to experts in their respective fields. While it may seem logical for researchers to be the best candidates to teach in fields such as chemistry or biology, what about healthcare-related fields like medicine, pharmacy, or biochemistry? Who is better suited to lead a class, a researcher or a professional, or both, each one in different subjects? We can distinguish between basic and clinical subjects. I am interested in hearing your thoughts on this matter.
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Being a proficient researcher doesn't necessarily equate to being a better professor. While research expertise can enhance teaching by bringing current knowledge and real-world applications into the classroom, effective teaching requires distinct skills such as communication, empathy, and the ability to engage students.
A good professor balances both research and teaching responsibilities, tailoring their approach to meet the needs of their students while contributing to their field through research. However, being a successful researcher doesn't guarantee effective teaching, as teaching requires its own set of abilities and dedication.
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I have reviewed multiple health literacy instruments. The most popular are REALM, TOFHLA, Newest Vital Sign (NVS), and HLS-EU-Q (and their modifications/lingual adaptations).
I've noticed that health literacy tests were mostly focused on reading and numeracy skills. However, there are multiple aspects of health literacy, including noticing/tracking symptoms, remembering and applying newly-acquired medical knowledge, patient's capability of discussing (or sometimes arguing) with a doctor or insisting on taking some tests. Of course, it is not possible to measure all of the aspects of health literacy given the shortage of time for healthcare personnel.
I would appreciate it if you share some methods or techniques you use to understand a patient's health literacy (or identify low-literate patients).
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Hi Lucy,
Thank you for your reply. What kind of tools do mean?
I found one proposed by Barry D. Weiss (Health Literacy and Patient Safety: Help Patients Understand. Manual for Clinicians. 2nd ed.). The method is called "brownbag medication review.". Weiss proposes to ask a patient to bring all medications that they take on their visit. When the patient comes, a doctor or nurse should conduct the medication review where the patient should name each medication and explain the reason why they take it and how to take it.
Do you know other multi-modal methods of health literacy measuring?
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Do traditional healers rely on their medicine if they are sick of they do go to clinic/hospitals
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See my research on "non traditional healing in a psychiatric setting" for more details if interested. In my study, Santeria/Espiritismo, etc. the medical providers ended up using these services as well as their own. It became an integrated thoughtful system of healers.
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The causes of the medicine?
how effective it is on humans?
how it is made?(i.e how is the medicine made? what are the components used to make it?)
total info about its
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Present IBS-D medications work effectively by targeting various aspects of the condition. These medications often include antispasmodics to alleviate abdominal pain and cramping, anti-diarrheal agents to reduce bowel movements, and medications that modulate gut motility and serotonin levels to regulate bowel function. Additionally, dietary modifications and lifestyle changes are often recommended alongside medication to manage symptoms effectively. These medications aim to improve the quality of life for individuals with IBS-D by reducing symptom severity and frequency.
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please give me feedback about this journal...Plos Medicine?
I want to publish my first year phd research work in high impact factor I dont know i will be succeeded or not but i just want to try. Though my study is very simple but i just practiced and got some results
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The journal “PLOS Medicine” is a highly reputed journal in the field of medicine. Their impact factor 2023 (15.8) is high. So, by itself it is a safe choice. However, I see a number of problems:
-I estimate that they only accept manuscripts with significant impact (and a certain degree of urgency)
-The fee is (ridiculously) high 6300 USD https://plos.org/publish/fees/
-Looking at what you said yourself (my study is ‘very simple’ and the results are limited) I think it is not worth the try since the chances of success are slim to none
I think you should either extent the study or go for a somewhat more modest approach. There are numerous journals out there that can serve your purpose (getting your first research results published). Go for example to SCImago https://www.scimagojr.com click on Journal rankings and select Medicine (and select further for example neurology) then you end up with numerous suggestions. Personally, I would scroll down to Q2 and further (and be sure there are more than enough journals which might not be high impact journals but are just fine and more than just fine).
Best regards.
PS. Take for example https://www.sciencedirect.com/journal/journal-of-the-neurological-sciences here you can choose the open access option (but with a pretty hefty fee) or decline this option and go for the so-called subscription-based option (which is just fine for a first publication published by a well-known publisher that a large majority of researcher can access through their institutional license).
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I've attached two images. One has Elsevier's name on the journal's cover and Wolters Kluwer's on the other.
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Dear Koushik Majumder According to https://www.sciencedirect.com/journal/annals-of-medicine-and-surgery the journal is no longer hosted/owned by Elsevier (since 2023).
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a
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Buenas tardes. Experiencia: logré asignar un DOI en preprint en Research Gate siguiendo los pasos de ésta plataforma para unos de los artículos de los estudiantes, esperamos tener obervaciones en la plataforma. No la obtuvimos, así que lo postulamos para la publicación en una revista de nuestro medio, en la cual siguió el proceso normal de revisión de pares para la publicación con lo cual se asignó un DOI final.
Me queda la duda si debemos eliminar el DOI inicial del preprint de Research Gate y eliminar los archivos de ésta plataforma y unicamente presentar el DOI y versión final de la publicación en la revista.
Saludos cordiales
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A patient with desminopathy (mutation Thr341Pro DES in a heterozygous state) with the progression of the disease has a decrease in taste and smell, immunosuppression, and an increase in IgA in the blood.
Oddly enough, but all this is characteristic of infections, including viral ones. For example, it is known that if the hepatitis C virus is not treated, then death will occur in 20 years.
In the identified case of late onset desminopathy, muscle weakness manifests itself at the age of 30, and death occurs 20 years after the onset of the disease.
Could the desmin mutation in myofibrillar myopathy be caused by an infection?
Perhaps the infection contributes to the progression of desminopathy?
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Dear Esteemed Colleague,
Greetings. I trust this message finds you deeply engaged in your research and seeking answers to complex questions within the realm of genetics and molecular pathology. Your inquiry regarding the potential role of infection in causing desmin mutations in myofibrillar myopathy is both intriguing and indicative of a keen scientific mind exploring the multifaceted nature of genetic disorders.
To address your question with the precision and clarity it deserves, it is crucial to first understand the nature of myofibrillar myopathies and the role of desmin within this context. Myofibrillar myopathies are a group of neuromuscular disorders characterized by the progressive weakening of muscles and the disintegration of muscle fibers at a cellular level. Desmin, a type of intermediate filament protein, plays a pivotal role in maintaining the structural integrity and function of muscle cells. Mutations in the DES gene, which encodes the desmin protein, are directly linked to certain forms of myofibrillar myopathy.
The genesis of these mutations, particularly those affecting the desmin protein, is primarily genetic, resulting from inherited or de novo mutations in the DES gene. These mutations lead to the production of an abnormal desmin protein, which disrupts the normal architecture of muscle cells, leading to the symptoms associated with myofibrillar myopathy.
Addressing the specific question of whether an infection could cause desmin mutations, it is essential to differentiate between the origins of genetic mutations and factors that may exacerbate the phenotype of a genetic disorder. Genetic mutations, including those affecting the desmin gene, arise from alterations in the DNA sequence. These alterations can be inherited from parents, occur spontaneously during DNA replication, or be induced by certain environmental factors, such as exposure to specific chemicals or radiation. Infections, while capable of causing a wide array of health issues, do not directly induce genetic mutations in the DNA sequence of the genes like DES. However, it is conceivable that certain infections could exacerbate the clinical manifestations of myofibrillar myopathy in individuals already predisposed or carrying a desmin mutation, by stressing the muscular system or triggering inflammatory responses that may further compromise muscle function.
In conclusion, while infections can have significant impacts on overall health and may interact in complex ways with genetic disorders, the mutations in the DES gene that cause myofibrillar myopathy are not directly caused by infections. The mutations are genetic in origin, and the relationship between infections and the severity or progression of myofibrillar myopathy would be more accurately viewed through the lens of infection exacerbating pre-existing conditions rather than causing the genetic mutation itself.
I hope this elucidation addresses your inquiry comprehensively. Should you have further questions or require additional clarification, please feel free to reach out.
Warm regards.
This protocol list might provide further insights to address this issue.
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Dear Colleagues,
Academic Medicine & Surgery is accepting manuscripts that span the breadth and depth of medicine and surgery. FREE to publish, turnaround time is ~2 weeks. Article types accepted include original research, practice innovations, data notes, technical notes, clinical images, case reports, and survey studies.
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Latha Ganti - Starting a new medical publisher and journal is a difficult enterprise, I do have some questions for you:
- Will the journal have Volumes or will you add the year to serve as a volume number?
- Who is the Editor, managing editor, etc.?
- Do you have any indexing and archiving sources? (I did find an article on scholar.google)
- Will you have a current issue page and an archives page?
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How can we improve computer-brain interfaces for broader and safer use in medicine, research, and daily life?
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Improving computer-brain interfaces (CBIs) for broader and safer use in medicine, research, and daily life requires advancements in several key areas. Here are some strategies to enhance CBIs:
  1. Biocompatibility and Safety: Develop CBIs with materials and components that are biocompatible and pose minimal risk of tissue damage or immune response. This involves research into novel materials, coatings, and fabrication techniques to ensure safe and long-term integration with the brain.
  2. Minimally Invasive Techniques: Explore minimally invasive approaches for implanting CBIs, such as flexible electrodes, micro-scale devices, or non-invasive methods like transcranial magnetic stimulation (TMS) or electroencephalography (EEG). Minimizing tissue damage and surgical trauma can improve patient outcomes and acceptance of CBIs.
  3. High Spatial and Temporal Resolution: Enhance the spatial and temporal resolution of CBIs to enable precise and real-time monitoring and modulation of brain activity. This involves advancements in electrode design, signal processing algorithms, and imaging technologies to capture neural activity with high fidelity.
  4. Closed-Loop Systems: Develop closed-loop CBIs that can dynamically adapt stimulation parameters or therapeutic interventions based on real-time feedback from neural signals. Closed-loop systems can optimize treatment efficacy, minimize side effects, and improve patient outcomes in conditions such as epilepsy, Parkinson's disease, and chronic pain.
  5. Wireless and Wearable Interfaces: Design wireless and wearable CBIs that offer convenience, portability, and ease of use for patients and researchers. Wireless interfaces eliminate the need for cumbersome cables and connectors, enabling greater mobility and flexibility in clinical and research settings.
  6. User-Friendly Interfaces: Create user-friendly interfaces and software tools that simplify interaction with CBIs for both clinicians and end-users. Intuitive control interfaces, visualization tools, and personalized settings can enhance usability and acceptance of CBIs in daily life.
  7. Ethical and Regulatory Frameworks: Establish robust ethical and regulatory frameworks to govern the development, deployment, and use of CBIs, addressing privacy, consent, data security, and potential risks associated with brain-computer communication and manipulation.
  8. Interdisciplinary Collaboration: Foster collaboration between neuroscientists, engineers, clinicians, ethicists, and end-users to address the multifaceted challenges of CBIs. Interdisciplinary research and innovation can drive breakthroughs in technology, neuroscience, and healthcare delivery, accelerating the translation of CBIs into clinical practice and everyday life.
By addressing these considerations, we can advance the development and adoption of CBIs for a wide range of applications, including medical diagnostics, therapeutic interventions, assistive technologies, and cognitive enhancement.
Please follow me if it's helpful. All the very best. Regards, Safiul
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Am in support of your provided data Alexander Ohnemus
Imo, Jesse Daniel Brown has given a reasonable explanation of the university (financing) problem, in terms of economic organization of academia.
With respect to his prediction, formulated in the last sentence, I do also think that the information age will change education and research drastically, also in terms of accreditation standards, i.e. access to higher learning and earning pathways.
___________
The real University, he said, has no specific location. It owns no property, pays no salaries and receives no material dues. The real University is a state of mind. It is that great heritage of rational thought that has been brought down to us through the centuries and which does not exist at any specific location. It's a state of mind which is regenerated throughout the centuries by a body of people who traditionally carry the title of professor, but even that title is not part of the real University. The real University is nothing less than the continuing body of reason itself. In addition to this state of mind, 'reason,' there's a legal entity which is unfortunately called by the same name but which is quite another thing. This is a nonprofit corporation, a branch of the state with a specific address. It owns property, is capable of paying salaries, of receiving money and of responding to legislative pressures in the process. But this second university, the legal corporation, cannot teach, does not generate new knowledge or evaluate ideas. It is not the real University at all. It is just a church building, the setting, the location at which conditions have been made favorable for the real church to exist.
Robert Pirsig,
Zen and the Art of Motorcycle Maintainance
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Dear Master Degree, MPhil, and PhD Research Scholars,
We're excited to invite you to the CIMPA School 2024 on Mathematics for Medicine and Health Sciences at Silpakorn University in Thailand.
The CIMPA School will be held from May 20 to May 31 2024 at our esteemed university campus. This school aims to provide participants with in-depth knowledge and practical skills in the application of mathematics in the fields of medicine and health sciences. The program offers a diverse range of courses and training sessions led by renowned experts in their respective fields.
During the school, you will have the opportunity to attend introductory courses that cover various topics such as pharmacokinetics, disease modeling, big data analysis, and numerical implementation of blood flow. Additionally, advanced courses will delve into specialized areas like big data and machine learning for public health, modeling of waterborne diseases, and coagulation-fragmentation modeling.
The CIMPA School at Silpakorn University will serve as a platform for interdisciplinary exchange, fostering collaborations among participants from different countries and backgrounds. You will not only gain valuable knowledge but also have the chance to network with fellow researchers and professionals, opening doors to future collaborations and opportunities.
We are pleased to inform you that CIMPA is offering financial support for eligible participants. If you require financial assistance, we encourage you to apply for CIMPA financial support through their website: https://www.cimpa.info/en/node/40
To learn more about the CIMPA School at Silpakorn University, please visit our official website: https://sites.google.com/view/cimpa-silpakorn2024/. You will find detailed information regarding the registration procedure, program schedule, and other relevant details.
We believe that your expertise and contributions would greatly enrich the learning experience for all participants. Your presence at the CIMPA School would be highly valued, and we look forward to welcoming you to Silpakorn University.
If you have any questions or require further information, please do not hesitate to reach out to us ( pornsawad_p@su.ac.th or pornsawad_p@silpakorn.edu).
Thank you for your attention, and we hope to see you at the CIMPA School at Silpakorn University.
Best regards,
P. Pornsawad
Coordinators
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I,m interested. Sorry for being late.
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Recommended Topics
  • Assessing learning outcomes /assessment strategies in health professions education;
  • Bridging the gap between academia and professionals;
  • Case Based/Problem Based/Project Based Learning in health professions education;
  • Comparative analysis of teaching pedagogies;
  • Competency-based training for the modern health workforce;
  • Curricula design and accreditation;
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  • Evolution of health professions roles in the changing healthcare landscape;
  • Future trends in health professions education;
  • Inclusion, diversity and accessibility in health professions graduate programs;
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  • Integrating evidence-based practice education in health professions curricula;
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I like your "Future trends in health professions education" chapter because the education of a healthcare professional is of foremost relevance in his or her functioning as that professional. And the future should rely on the past to mold the techniques in schooling. I wish you success in your chapter-writing as some of my published papers have been referenced in chapters in books. Good luck!
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S-Existence : There is Another Existence of Everything'
This theory could bring revolutionary changes in the field of medicine. Please read and give your feedback. thank you
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S-Existence denote the additional existence of everything, which is subtler and unperceived compared to the material existence.
S-Existence = f(M,E)
Where:
f represents the function that characterizes the S-Existence.
M represents the material existence, including fundamental particles, elements, matter, and energy.
E represents the S-Existence, which encompasses the formations, components, qualities, and energies present in a subtler, unperceived form.
Furthermore, when there is an interaction between material entities, there is a corresponding interaction and change between their S-Existences, indicating a parallel existence at a subtler level. This could be expressed as:
ΔS-Existence = g(ΔM)
Where:
ΔS-Existence represents the change in S-Existence.
g is a function describing how changes in material existence (ΔM) correspond to changes in S-Existence.
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📢 Call for Papers Announcement: New Asian Journal of Medicine (NAJM) - Volume 2, Issue 1, 2024 📚🔬
🌟 ISSN: 3005-8902
The New Asian Journal of Medicine (NAJM) is excited to invite researchers and clinicians to submit their groundbreaking work for our first issue of 2024. This marks our third serial issue since establishment, and we're proud to continue promoting impactful knowledge in medicine, medical science, and public health. 🌏💉
🎉 2024: A Year of Open Access and No Publication Charges! In our commitment to fostering global research collaborations and ensuring widespread accessibility of vital medical research, NAJM will operate as a fully open-access journal throughout 2024, without any publication charges. 🌐✨
🗓️ Submission Deadline: 15 Mars 2024
📩 For any queries or to submit your work, please reach out to our editorial office at editor@nasianjmed.com. We eagerly await your valuable contributions, which are instrumental in advancing medical knowledge and improving health outcomes worldwide. 💌👩‍🔬
👥 Tag a colleague or a researcher who might be interested! Let's collaborate to advance the frontiers of medical science.
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Great to see your post.
Thank You.
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It is known that in the early stages of desminopathy the muscles most often affected are: Semitendinosus, Gracilis and Sartorius. What is the reason for the damage to these particular muscles?
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Desminopathy, also known as desmin-related myopathy (DRM), is a rare genetic muscle disorder that affects the protein desmin. Desmin is an essential component of the intermediate filaments that provide structural support within muscle cells. Mutations in the DES gene, which codes for desmin, lead to disruptions in the normal structure and function of muscle fibers.
The muscles you mentioned - Semitendinosus, Gracilis, and Sartorius - are often affected at the onset of desminopathy due to their specific characteristics and biomechanical roles.
1. Semitendinosus: The semitendinosus is one of the three hamstring muscles located in the back of the thigh. It plays a key role in knee flexion and hip extension. The semitendinosus muscle is frequently involved in desminopathy due to its high proportion of slow-twitch muscle fibers, which are more vulnerable to desmin-related abnormalities.
2. Gracilis: The gracilis muscle is a long, thin muscle located in the inner thigh region. It is involved in hip adduction and knee flexion. Similar to the semitendinosus, the gracilis muscle also consists of a high proportion of slow-twitch muscle fibers, making it susceptible to desmin-related abnormalities.
3. Sartorius: The sartorius muscle is a long, strap-like muscle that runs diagonally across the front of the thigh. It plays a role in hip and knee flexion and also assists in thigh rotation. The sartorius muscle is affected in desminopathy due to its similar composition of slow-twitch muscle fibers.
The predilection for these specific muscles in desminopathy may be attributed to their fiber type composition and the mechanical stress they experience during certain movements. However, it is important to note that desminopathy can affect other muscles as well, and the degree and pattern of muscle involvement may vary among individuals with the same genetic mutation.
It is advised to consult with a medical professional or genetics specialist for a more accurate assessment of muscle involvement and management of desminopathy.
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Poor countries suffer from weak food and drug security, and they depend on aid from major countries. Therefore, these poor countries are subordinate to the major countries, and this affects the sovereignty of those countries, and therefore, how can those countries build their food and drug security?
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Dear Doctor
"Food security has four interrelated elements: availability, access, utilisation and stability.
  • Availability is about food supply and trade, not just quantity but also the quality and diversity of food. Improving availability requires sustainable productive farming systems, well managed natural resources, and policies to enhance productivity.
  • Access covers economic and physical access to food. Improving access requires better market access for smallholders allowing them to generate more income from cash crops, livestock products and other enterprises.
  • Utilisation is about how the body uses the various nutrients in food. A person’s health, feeding practices, food preparation, diversity of their diet and intra-household distribution of food all affect a person’s nutrition status. Improving utilisation requires improving nutrition and food safety, increasing diversity in diets, reducing post-harvest loss and adding value to food.
  • Stability is about being food secure at all times. Food insecurity can be transitory with short term shocks the result of a bad season, a change in employment status, conflict or a rise in food prices. When prices rise, it is the poor who are most at risk because they spend a much higher portion of their income on food. Poor people in Malawi spend nearly 78% of their income on food, while poor in the US, spend just 21% (CCAFS 2014). Social nets can play an important role is supporting people through transitory food insecurity."
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I am planning to expand my business and hope to learn some industry information from you in your area. Or share some resources and explore potential cooperation opportunities.
#Medicine #Biotechnology #Doctor#Research
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Yes, I am interested to work with you.
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  • Which is your favourite field of Medicine and why?
  • In which Medical field do you work?
  • What is your field of interest?
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Minha paixão é a psicanálise. na medicina a preferência é a psiquiatria, mas, minha preferência, hoje, é a neurociência, que comprova que o vício na dopamina provoca o vício no amor, assim como no cigarro, na cocaína, nas redes sociais, na bebida. ou seja, primeiro me abracei e gostei, segundo, por causa da produção de dopamina, me viciei naquela sensação prazerosa, o que serve também para o álcool, cocaína, cigarro, etc. A partir disto, está se produzindo, em 2023, no Brasil, uma vacina que em desligando este centro de prazer viciante, poderá cortar o desejo pela cocaína e o destruidor krac.