Medicine - Science topic

Many efforts are spent to prevent, treat and stop COVID-19 spread.

but I think these efforts are fragmentary and not organized.

there is no platform for a scientific collaboration that could shorten the time of interesting findings, some nations hide some facts are a privilege of authorship or for other political reasons.

I think that all countries should a global platform for scientific collaboration.

Personally I have some ideas that could be proposed for the treatment of COVID-19 based on scientific facts but with the innovative mode of application, how and where can I try to apply them?

All nations should avoid wasting their time to find a solution for COVID-19 without international collaboration.

till india is in second phase, as per world patient data india spreading rate is very low. but it may increase exponential. what you think about outbreak of corona virus in india.

Hi,

I am conducting a research project to see whether demographic/patient factors can predict patients who are likely to suffer a post-operative death (Categorical outcome Y/N).

I have conducted univariate regression procedure using SPSS Firths regression as I have a small sample size with the dependant variable being a sparse event. This has given me 3-4 variables with P<0.10.

DO I now proceed to perform a multi-logistic regression? If so, do I run Firths regression with all of these variables selected as co-variates or do I perform a more traditional multi-nominal regression model instead?

Any help would be appreciated as I can't find any guidance on this issue.

Viruses can not be killed. If so does a person infected from CoViD-19 doesn't acts as a carrier after his cure?

That is if a person is infected with CoViD-19 and he is been cured by the medicine, does he has that virus in his body in deactivated form? Or the body kills the virus by phagocytosis by the WBC's?

COVID-19 is affecting all kinds of human activities, research is not exempted. Many ongoing research studies are not paused because of COVID-19, patient recruitment cannot be continued, follow up visits are not stict to schedule, intervention procedures may be delayed, blood test monitor are postponed.

I would expect a higher loss to follow up rate during this period, which would affect the reliability of research. Even after COVID-19, will the recruited subjects have some difference than those recruited before?

What do you think?

I ruminated a consideration on this proposal for the last couple of days as Germany is in anticipation of the surge.

To be clear: This is also just a theoretical exercise and – if applied - would count as a desperate measure in the case of patients otherwise not being ventilated at all.

What if the mode of ventilation chosen would not be conventional BIPAP but APRV/inverse ratio PCV?

The control parameters correspond to conventional ventilator settings as follows: P-high (P-insp), P-low (PEEP), T-high (insp. Time), T-low (exp. time) and FiO2. Note that implementing this mode of ventilation with conventional BIPAP, which is possible in some devices, will in some setups require calculation of respiratory rate, which is 60/(Thigh+Tlow). The slightly different terminology as well as specific algorithms for implementation have been characterized and properly published by experts in the field – which I am NOT. There have been promising studies in ARDS which I will attach below.

If one assumes that for two (or more) patients the key treatment goal would be oxygenation with a more liberal approach to CO2 removal, it should be possible to choose P-high, FiO2 and to some degree T-low to achieve safe oxygenation margins for both patients. This would still allow for some inhomogeneity in compliance between the patients as the lung is splinted to a rather high point in the P-V curve by P-high resulting in a high resting volume. This is the proposed “open-lung” aspect of this ventilation mode. Nevertheless, due to the sparse and brief passive pressure relief phases it is believed to go without higher frequency repeated expansion like in conventional PCV, resulting in less energy deposition into the tissue. The repeated overinflation/atelectasis due to inhomogeneos P-V dependencies had been my main concern when thinking about PCV in a shared circuit and a possible result of volutrauma/atelectotrauma in the patients.

In case of inhomogeneous severity between the patients/different disease progression the treatment goal could be set for the more severe patient accepting hyperoxia in the “more well” patient. In terms of CO2 removal a “common ground” target for the patients could be set in wider range of acceptable values, opting for permissive hypercapnia. As the passive release of the lung volume to exhalation in T-low will generate outflow which is cropped at a certain level of peak flow (by setting T-low) when conventionally setting up/adjusting this mode, it might be difficult to assess this control parameter for the individual patient in a shared circuit.

APRV does even allow for spontaneous breathing on P-high in weaning approaches which have been proposed as well. If flow for the device serving two patients would be dialed high enough to compensate for potential maximum inspiratory peak flow generated by both patients in spontaneous breathing, it could be fathomable to even conduct weaning with two spontaneously breathing patients sharing the same circuit.

I write this as I feel we are all staring in a potential abyss, which might force us to make choices that neither of us ever wanted to make.

Hence, this is a THEORETICAL CONSIDERATION and not a recommendation. Also I do not take any legal responsibility if patient harm ensues. I hope everybody understands that. Also probably someone already thought of this. But I thought: Sharing is caring.

Take care and stay strong.

C

Cane RD, Peruzzi WT, Shapiro BA. Airway pressure release ventilation in severe acute respiratory failure. Chest, Aug 1991: 100 (2); 460-3 Fergson ND, et al. High-frequency oscillation in early acute respiratory distress syndrome. New England Journal of Medicine 2013, 368 (9), 795-804 Frawley PM, Habashi NM. Airway pressure release ventilation: theory and practice. AACN Clinical Issues, 2001: 12 (2); 234-246 Garner W, Downs JB, Stock MC et al. Airway pressure release ventilation (APRV). A human trial. Chest, Oct 1988: 94 (4); 779-81 Habashi NM. Other approaches to open-lung ventilation: Airway pressure release ventilation. Crit Care Med 2005 Vol 33, No. 3 (suppl.) Maxwell RA, Green JM, Waldrop J et al. A randomized prospective trial of airway pressure release ventilation and low tidal volume ventilation in adult trauma patients with acute respiratory failure. The Journal of Trauma, Injury, Infection and Critical Care, 2010: 69; 501-511 Modrykamien A, Chatburn RL, Ashton RW. Airway pressure release ventilation: an alternative mode of mechanical ventilation in acute respiratory distress syndrome. Cleveland Clinic Journal of Medicine, 2011: 78 (2); 101-110 Rasanen J, Cane RD, Downs JB et al. Airway pressure release ventilation during acute lung injury: a prospective multicenter trial. Critical Care Medicine, Oct 1991: 19 (10); 1234-41 Roy S, et al. Early airway pressure release ventilation prevents ADRS – a novel preventative approach to lung injury. Shock 2013, 39 (1), 28-38

Bickel (2009) describes those who remain robust under stress as resilient. Those who can rapidly adapt to change in times of stress are resilient. So, my question to you is, how are you? How are you coping? Are you thriving? Make sure you have seen this -> https://youtu.be/CCe5PaeAeew

Bickel, J. (2009). Faculty resilience and career development: Strategies for strengthening academic medicine. In Faculty Health in Academic Medicine (pp. 83-92). Humana Press.

These days the hottest news of the world is about the rate of the victims of Coronavirus disease (COVID-19). It is very interesting if you share your valuable experiences here. Let's help each other.

Regards,

Yagyopathy question.

In my country, general practitioners also provide (sell) the medicine. What do you think of this practice? Please share your views concerning the advantages or disadvantages of this practice.

Do you know of places where it started like this; and then changed so that only pharmacists can dispense medicine? Thanks.

Why is the INDIAN GRANATE used in medicine. Do you know which medicines?

Does anyone know in which species the grass allergen Phl p5 occurs? It was originally isolated from the grass species Phleum pratense so it must at least occur in that species. It stand to reason that it might also occur in other species of the genus Phleum. A few papers states that it is universal in many grasses, but with poor documentation.

Can anyone provide conclusive evidence and/or references in which the authors state in which species (or cultivars) the allergen occurs and/or have been isolated from? I welcome answers from all researchers along with special interest from expert knowledge primarily from plant ecology, aerobiology, immunology and other health professionals.

Being invited to be reviewer for a conference or to be speaker is tempting for most young scientists. Not being aware of this businessplan I unfortunately accepted to review abstracts for one of such conference. Googleing around I realised I am not alone and that there are also several people wondering whether they should attend a conference or not as they are unsure if the organisers are genuine or not.

There are lists of predatory journals (e.g. https://predatoryjournals.com/journals/) but I did not find a good or comprehensive list of predatory conferences. So lets discuss such invitations to get a sense for those that can be trusted:

Oncology is a branch of medicine that deals with the prevention, diagnosis, and treatment of cancer. A medical professional who practices oncology is an oncologist. The name's etymological origin is the Greek word ὄγκος (óngkos), meaning 1. "burden, volume, mass" and 2. "barb", and the Greek word λόγος (logos), meaning "study".

Cancer survival has improved due to three main components: improved prevention efforts to reduce exposure to risk factors (e.g., tobacco smoking and alcohol consumption), improved screening of several cancers (allowing for earlier diagnosis), and improvements in treatment.

I am facing a problem when I try to calculate the hr from two different survival curves, here is the problem: in the first plot the experimental group's curve is more close to the placebo group then the second plot, even if the first plot's hr is smaller than the second plot. I wonder what the possible reasons are. Can you guys help me to solve this problem? Thanks.

The presence of alloys and their use in medicine was one of the most important events and achievements in medicine. Do you think that the mechanism can change to amend this achievement?

what should be the ratio of sodium benzoate in preparing a herbal suspension ?

Deleted by Research Gate....

Edited 2020-10-09: the reason one might find in Reply 001 of this particular compensational thread

PPI affect CYP system while clopidogrel depend on this system to be converted to its active form. (controversy issue)

I am aware this is a rather odd question but I couldn’t find any answers to this in the literature. One study has used sperm cells as a drug delivery tool (see below) but I was wondering if it might have broader implications. Would sperm injected into the bloodstream survive for long? What about if it was taken orally? Would appreciate any thoughts!

A more advanced method of training would be to perform explosive medicine ball exercises after a weightlifting exercise, i.e. Cleans or Back Squats followed by a medicine ball vertical toss. This method of training is more commonly known as complex training

Dear Colleaugues,

There was a proposal of a researcher who asked me to write down a paper which will more or less extend the poster (link bellow) published at ICCB 2016 in Prague. This all happened by an accident. I did not like to come at a conference without some presentation. Hence, I did quickly put the ideas that are resonating in my head for years on that poster to allow other researchers to benefit from it. Surprisingly, this poster is getting a great deal of attention. Therefore, I am thinking about to write down a review (prescription) how to design sel-organizing and emergennt systems with a rich example aparatus. If you like the idea then wisit the poster and let there a comment about it (bellow the poster).

The whole project is meant as a service to the community of biological and medical researchers who would like to know more but have no time to study mathematics and programming in depth.

All the best at your research,

Jiri

I'm working on making new compound medicine, but I don't know how to evaluate the chemical interaction in lab environment (cristalization and other interactions) please help me. If you know a book or article can help me, I will be so grateful.

Thanks

Simple search in Google Scholar shows that since 1960-70 many articles in peer-reviewed journals have supported various desirable effects of Transcendental Meditation (TM) but some people here and there claim that the research has always bee. Funded by certain organizations and people who benefit from advertising TM and the published evidences are not so reliable. Is that really true?

Dear colleagues! Your opinion, please! What are the ways and opportunities for registering orphan drugs? Thank you in advance for the information. Best regards Olga Shnaybel

If the aim is to approach to the target. Why do we use "precision medicine" instead of "accurate medicine" ?

There are a lot of problems in medicine that needs the newest technologies in computer science fields like Machine Learning and Deep Learning to solve them.

Can anyone mention some of these problems that are unsolved till now?

Can anybody help me to find out such website where i can find out solubility of any drug or medicine at one place?

I recently attended an Education Conference where they encouraged teachers to use VR in their classes. In most of the cases these were medicine courses, but is it possible to incorate that technology in accounting courses?

The global average surface temperature rose 0.6 to 0.9 degrees Celsius (1.1 to 1.6° F) between 1906 and 2005, and the rate of temperature increase has nearly been doubled in the last 50 years. Temperatures are certain to go up further and may lead to fast genetic mutations in some pathogenic microbes to become accustomed to the new climate and proliferate resistant gene distribution over geographies. In addition, the overuses of antibiotics is also triggering the issues at a great step. Near about 10 most deadly bacterial pathogens have already been registered as antibiotic-resistant. Mycobacterium tuberculosis is one of them, that has already been created a huge challenge to overcome in their own right and will only become harder to control as their resistance to antibiotics grows. The development of new antibiotics is slow and difficult work but bacterial resistance is decreasing our arsenal of existing drugs posing a catastrophic threat as ordinary infections become untreatable.

https://youtu.be/vl4sX8yYNC4

Human body is full of spatial fractals and temporal bifurcations. During treatment in medicine ( ultrasound, X-rays, photons, neutrons, ions...) in computerized tomography ( CT) is used nonlinear or locally linear ( linearized) theory ? It is on-line or off-line in different cases?

A patient with hereditary desminopathy (Thr341Pro DES mutation in a heterozygous state) was recommended to refuse toothpaste. He continued to brush his teeth twice a day with a toothbrush with only water. As a result, within one month we noted a significant increase in strength and muscle mass in this patient. The patient did not take any medications during this period. After 30 days, the muscle condition returned to its original level. How can this positive effect be explained?

Is it possible to use a medical computed tomography (CT) machine for the inspection of 3D printed parts?

Some may have normal iron level.

Hi, I attach an article on 'Milk Therapy' that has been recently published and you may be interested in knowing it. Best regards, Tomasz tomasz@plusultra.pl

Hello everyone!

I have a theoretical problem with a statistical analysis. I was looking a lot at different fora but I could not find an easy explanation for my problem.

I want to compare means of two groups of data. In a simple case, I would use "t-test". However, in each group, I have few measurements for each individual. First, I wanted to measure a mean for every individual in a group, then compare the means of groups, but I know that it is not a good idea (mean of means/average of averages...).

For example how to compare this data sets:

GROUP A:

Individual 1: 5, 6, 7

Individual 2: 5, 7, 7, 6

Individual 3: 6, 7, 7

GROUP B:

Individual 1: 4, 5, 4

Individual 2: 7, 8, 6

Individual 3: 4, 3, 4, 2

You can imagine two groups of people. A - treated, B - untreated. In each group there are 3 people and some variable were measured with 3-4 repeats.

As you can see there are two groups made of few individuals for which few repeated measurements were made. I would like to compare two groups using means calculated for individuals, not measure simple mean for the whole group.

I have read a lot about pooled data, weighed means etc. but I still do not know how to perform t-test in that case (or another).

I hope you can help me!

Eating in illness

The modern world is returning back to the nature! Organic/ Natural/ Unprocessed/ Wholemeal foods for good health, longevity - have become a craze now. But in case of treatment and prophylaxis - why do everyone opts for allopathic (the science based modern) medicine? Why not first the traditionals: Ayurveda/ Homeopathy/ Oriental/ Herbal/ Naturopathy/ Acupuncture/ Massage/ Yoga/ Dietary etc?

Aren't these scientific enough? Are they developing in appropriate pace with allopathy?

Why do modern clinicians still neglect/tease some of theses modes of therapies?

Why the new generation not getting solid confidence on these natural treatments?

The involvement of excessive statistical terms made the Medical research difficult. A doctor remain most of the time busy in clinical practice. The involvement of unnecessary statistical tests and terms made research difficult for Doctors of Medicine. Moreover, it is experienced that Statisticians only keep the medical students confused in unnecessary formulas and terminologies but don't teach them the software like SPSS to evaluate their data their-selves. After cramming a lot of the statistical formula passing the subject of bio-statistics the student remain dependent on statistician for the analysis of data. Am I wrong? (it is my personal opinion)

Which parts of Dinda are important from medicinal use point of view?

How that medicine extracted from same plant part.

Do you know any medicinal properties of chlorophyll?

Please share your ideas

Anyone who expert in this topic...

It is expected that participants who will engage in medicine ball exercises will determine better performance in horizontal jumps. Participants who will not take part in medicine ball exercises will have trouble with horizontal jumps. Participants who will engage in medicine ball exercises will prove more explosive power and overall body strength which will improve their ability to make horizontal jumps.

How could I possibly prepare 10, 25, 50 and 100 mg/ml solution from a 500mg medicine tablet of Mebendazole? Thanks for answering.

This because table sugar is extracted naturally from sugar cane or sugar beets and hydrolyzed to glucose and fructose and never could reach the body cells in its origin form. The hydrolysis process occurs in mouth, stomach and small intestine which the products of sucrose in body may be in a similar manner to that of honey and bread. In other words, sucrose is a carbohydrate that occurs naturally in every fruit and vegetable. But, why there is no similar propaganda to the not natural synthesized chemical candy such as aspartame and so on.

In a patient with hereditary desminopathy (Thr341Pro DES mutation in the heterozygous state), a significant loss of muscle mass is observed after a night's sleep, with its replacement by adipose tissue. How to reduce muscle loss during sleep?

What shall be the choice: manual or automatic? It is clear from research and practice that inaccuracies exist with automatic BP use while manual seem preferable or yet not really? Some claim that automatic exclude bias in measurement.

Inaccurate reads of blood pressure lead to consumption of medications otherwise not needed if blood pressure measurements would be accurate. It affects lives-health. Which BP monitor shall be used? Both? How to resolve this dilemma in our age of automatisation?

I know that much inquiries are made by me but its a life related investigation.

Thank you in advance for contributions.

Generally PH Level, TFM, Apart wish to have healthy discussion in the aspect of revealing what all are the major metric, Qualitative, Quantitative factor we need to consider in cosmetic products and research.

Is there any website that can tell me when this adverse reaction will occur? For example, will this adverse reaction occur after repeated exposure? Or can occur after first dose? Or can be delayed?

Like some syrups, can tablets and capsules be flavor coated? Especially for children and adults who can't take regular tablets or capsules. Are there any side effects for flavor-coating a tablet or capsule? Besides masking taste of the medicine, can the smell of medicine be masked?

Autopsies show that there are two abnormal structures in the brain with AD called plaques and tangles. Plaques are made from a protein known as Beta-amyloid and tangles are made of Tau protein. These proteins also exist in a healthy brain. What make them to lose their normal function and cause the cell death?

Many studies reported an association between nutrition and human hearing loss. These studies showed the incidence of hearing loss was increased with the lack of micro-nutrients such as vitamins A, B, C, E, zinc, magnesium, selenium and iron.Moreover, high carbohydrate, fat, and cholesterol intake, or lower protein intake, are responsible for poor hearing status.

Dear colleagues, Any more studies or experience about the relation between nutrition and hearing loss?

Helicobacter pylori inhabit the gastrointestinal tract, one person’s poison may be another’s cure. Helicobacter pylori, the bacterium that causes gastric ulcers and stomach cancer in some people, may actually protect against cancer of the esophagus. So, What about your experience in the paradoxical effect of Helicobacter pylori infection? and why their resistance to treatment was increased?

What is fitness definition in your opinion ?

Coffee is a simple beverage, but it’s full of complex compounds with health benefits. It contains hundreds of bioactive components including vitamins, minerals, and anti-inflammatory polyphenols such as flavonoids. The amount of caffeine in a cup of coffee can vary, depending on factors ranging from the type of bean used. So, What about the healthy daily amount of caffeine was recommended to be healthy with no risk?

Will nanotechnology solve the world problems such as water purification problem and delivery of medicine?

What about of its health and dangerous effects? How can nanotechnology domain with these potential effects?

Thanks

When dealing with isolated conditions or common condition with rare presentation, case reports are practically helpful than any other studies.individual case reports will lead us to precision medicine.

Is it a trip to the moon, a discovery of electricity, an Internet discovery, achievements in medicine, biology, psychology, astronomy, IT-technologies, electronics, finding printing, engine, aircraft, etc.?

Please let me know that is there a complete and successful treatment of Vitiligo invented scientifically? A treatment which people can use to save their skin from a white dots and patches? If no, then anyone who has a project on inventing a medicine for treatment?

Some pictures has been added for the examples of Vitiligo.

- Muhammad Sinan

Is anybody aware of documented sources on Traditional Fijian Medicine and Midwifery?

Every athlete requires an adequate amount of protein. It’s not only good to increase lean muscle mass , it will also optimize anabolic hormone levels, increase metabolism relative to other nutrients and improve cardiovascular risk profiles.

So which are better protein supplements or protein in foods ?

Homeopathy has a long history and relaid on utilization of natural substances to cure diseases without performing any modifications of body parts as done in Allopathy.

Virus is living only inside living host whereas outside the host , it remains inactive but not dead

Chemically it is a protein in combination with DNA or RNA

Can it be possible to destroy or kill it by proteolytic enzyme or any other relevant chemical

1. En dientes anteriores superiores e inferiores de canino a canino.

R:

2. En dientes premolares superiores e inferiores.

R:

3. En molares superiores e inferiores.

R:

4. El costo del tratamiento incluye la consulta médica?

R:

I want to know how widely such new drug as trehalose (approved by FDA) is used in practical medicine for example for treatment of neurodegeneration. Majority of trials with it seems to be without definite answer.

Robot passes medical exam and become a doctor in medicine.

Hi! I am curious about the perspectives of bioresorbable Fe-based biomaterials. Are you aware of its real applications in medicine? What are the key issues to be solved before it comes to the market?

A possible answer in A. Tugui, D. Danciulescu, M.-S. Subtirelu (2019, The Biological as a Double Limit for Artificial Intelligence: Review and Futuristic Debate. INTERNATIONAL JOURNAL OF COMPUTERS COMMUNICATIONS & CONTROL, 14(2), 253-271, April 2019 https://doi.org/10.15837/ijccc.2019.2.3536).

http://univagora.ro/jour/index.php/ijccc/article/view/3536/pdf

"Fascinated by the secrets of medicine, in an informal discussion in 2014, we asked the famous surgeon I. Lascar, a professor at the University of Medicine and Pharmacy in Bucharest, what the secret was to a successful operation. Among the syntheses and content-related explanations, Professor Lascar pointed out that surgery is assisted, besides a number of strictly scientific factors, by a so-called invisible hand that contributes to the success of an operation and which all physicians rely on. In this context, the success of biocomputing research and development as part of the bio computer could be the catalyst for leaping to a level of AI that surprises us in terms of intelligent performance and behavior. Current achievements, such as the design of the biological transducer; the monitoring, programming, and behavioral control of the live cell (via logical operations AND, OR, and NOT); and technological challenges such as the decoding of live cell communication and the future development of a natural language of living cells (N2LC) used in biocomputing could turn biocomputing into the invisible hand of biological systems stretched towards artificial systems, especially AI."

It is obvious, when it concerns patients (addicts, schizophrenic, bipolars, borderline). It seems that medical personel, mainly phisicians may have an experience of being somehow stigmatized. What may be reasons? Consequences? Prophylaxis?

Would you contribute the development of the list of diseases known with the names of the physicians, who identified them, in the world of medicine?

As known; Some diseases in the world of medicine are known by the name of physicians who identify them. Looking at the examples:

BEHCET : Dr. Hulusi Behçet

HODGKIN : Dr. Thomas Hodgkin

ALZHEIMER: Dr. Alois Alzheimer

CUSHING : Dr. Harvey Cushing

...............

Can you help improve this list with examples you know about it?

The effects of acute exercise on plasma glutamine concentration appear to be largely dependent on the duration and intensity of exercise. Many studies showed that when there is a deficiency of glutamine or when the amount of glutamine is reduced during increased stress or exercise, the body experiences a suppression of the immune system until glutamine levels are restored through either diet or supplements. So I need your experience about the efficacy of L-glutamine supplement on sport training and athletes?

Thanks

The operation (Vaginal Hysterectomy) took place 14 days ago, and she will undergo K.U.B scan (Radiology procedure) and she is wondering if taking castor oil (oral) will affect her negatively?

Medical History:

53 Y F, last degree prolapsed uterus presents with four ulcers, 2 on the surface of the uterus, one on the surface of cervix and another one (Can't recall the location). There is daily discharge. What is the appropriate treatment to eliminate the discharge until she undergoes vaginal hysterectomy? Local antibiotic therapy or what?

Medications she takes:

Bisoprolol 2.5 mg once daily for Atrial Fibrillation

Cetirizine 10 mg once daily for Allergic Rhinitis

Daflon 500 mg once daily for chronic venous insufficiency

Non-Alcoholic-Fatty liver disease (Not managed with medications)

Blood tests were done and no other abnormalities.

What is the best way to learn anatomy?

When do you go the medical literature (primary - journal articles) instead of going to well known databases like Lexicomp, PDR, etc..with regard to adverse reactions/effects?

Is it when you check OTC medications? Herbal Medications? Or what?

The data of castor oil are conflicting unfortunately! And I'm not sure if it is safe or not!! What is your recommendation?

How good is empagliflozin for DM type 2? Is there any role of this medicine in primary prevention of CVD?

How do you Control and manage your mood swings without drug therapy ?

Emotional nutrition could be defined as constantly giving you a positive mindset and keeping yourself away from negativity. So, what is the most important for a healthy emotional nutrition ?