Medicine - Science topic

I'm one who does not buy into the hype that AI is something discrete and brand new. In my view, AI is just more of the same, a continuous evolution of how we use computing power. I also didn't buy the hype about "the cloud." It too was more of the same, a continuously evolving WWW. Or even from before web browsers, when we had remote computing services available over x.25 networks.

Having caveated the term, I predict that so-called AI will play a big part in medicine, for example, in surgery. Much like surgeons practice new procedures, to determine potential outcomes before working on a real patient, computer models should be able to try out way more possible tactical approaches, and a lot faster than humans can. And learn from mistakes.

Internal medicine too, I suspect. Same idea, where computer modeling can speed up the trial and error process substantially.

A similar "revolution," let's call it that, was cause when finite element analysis, or finite element method (FEM), came into widespread use, I'd say during the 1970s.

The example I think applies here would be engine design. Before widespread use of FEM, engine design was largely a work of art. Different companies built a reputation on their own particular design choices, claiming the specific advantages of their engine artistry. (Same can be said for chassis designs, of course.)

With FEM, now any company can design whatever types of engine they need. Just give FEM your requirements and constraints and it will spit out your best design options.

My bet is, so-called AI will perform that same magic in the field of medicine. And yes, I would also predict, people will be sad to see the "artistry" aspect in medicine taking a back seat. But overall, it should be a beneficial change.

if you are passionate about bioinformatics and its application in medical industry then there is a lot of research going on in molecular and functional genomics now a days. certainly, you will have diverse arena of research from research from metagenomics to single cell RNA sequencing. If you like you can also try to develop a computational pipeline to analyze publicly available cancer genomics data, such as The Cancer Genome Atlas (TCGA) dataset. Focus on identifying potential biomarkers, genetic variants, or gene expression patterns associated with specific types of cancer, aiming to contribute to personalized medicine and targeted therapies. you should read about this and need to have clear understanding.

Esto también depende de los reglamentos internos que tiene cada institución dado que pueden obtenerse al alcanzar un promedio específico, realiza publicaciones con otros colaboradores, y asi sucesivamente.

The best review article is that focusing on a specific important topic, when you give all related ideas to that article, interconnect, and then conclude and recommend, the specific article will be the best. Some review articles are general, in that case you should go and collect all related results, then conclude. Regards.

I am preparing a case study in dermatoimmunology

Emerging technologies hold transformative potential for the future of medicine. Personalized medicine and precision therapies, catalyzed by genomic and proteomic technologies, can provide treatments tailored to individual patients. Artificial intelligence, inclusive of quantum machine learning, could revolutionize diagnostics and predictive modeling, potentially improving vaccine design by accelerating antigen discovery and reducing time to deployment. Nanotechnology promises targeted drug delivery, minimizing side effects. Biomanufacturing advancements, including 3D bioprinting, could reshape organ transplants by creating patient-specific organs. Digital health platforms and wearable technology are poised to enhance continuous patient monitoring and proactive health management. As such, we can expect these technologies to contribute significantly to the evolution of healthcare and pharmaceutical industries.

Well, the paper already has 29 citations and is a excellent piece of research. Access to papers in High quality journals has remained a challenge for readers. Here, despite the open access fee, its not open. A clarification from the Editor can be received.

Hello Abiola Olajide

The importance is a very big issue! I think it is because gynaecology covers such a wide area, relates to about half the population and deals with issues not experienced by the other 50% of the population!

Hence, there are many journals in this topic. Some examples are given here:

No doubt bee collected pollen have anticancer properties.

Allah Pak already mentioned in Holy Quran that use of honey is best for many diseases .

The same happened to me and I don't understand why. Even if the journal is indexed in databases, I cannot add

send your article to : editor@ijmhc.com

Dear professor,

sorry but I have many problems to partecipate at the Conference because of my cronic heath problems.

All my best, Catina Feresin

Dear Eduardo Esteban Zubero ,

Unfortunately, there is nobody who can serve as a 'patron' to get your journal indexed. Both Scopus and Clarivate’s WoS (most likely first their ESCI index) is a matter of fulfilling to certain requirements. See for Scopus for example (round twenty inclusion requirements):

and for Clarivate’s WoS (basically 28 quality/impact criteria):

By the way when I have a look at your journal (https://www.iberoamjmed.com ) I see some good indicators like DOAJ membership, OASPA and CrossRef. Nicely and highly professional edited papers and free of charge open access are strong features as well.

Best regards.

you can use phrases to filter.. 'children with XXXXXX syndrome" so it will bring up only the articles which has the phrases.

sharing my Youtube video on how to search for research, hope it would be useful

https://youtu.be/S9PPgWwzKzo

Good suggestion to cut the cost of medicine produced by famous pharmaceuticals. The patent rights should be finshed after a period of 3-5 years and doctors should write generic medicine instead of expensive brands.

The type of children who are claimed to graduate from some universities (?), with an isolated self education and getting doctorates etc at the age of 10-15 years are of course not normal! Rather they get such fancy diplomas by the influence of their parents who have considerable personality disorders.

Yes.

Pollen from cactus plants is considered poisonous in China. In several immortalized and cancer cell cultures, it inhibited cell growth, suppressed tumor growth in nude mice, and modulated tumor-related genes.

Before pollen grains are considered for cancer treatment each pollen grain must be well differentiated and classified as all known pollen grains only then each one has to be studied individually and systemically tried in lab for the different cancers of different many animals when these sutdies reach to certain maturity approved by medical sciences then it can progress to human studies !

Alendronate:

Paclitaxel:

Thiophene:

Thiophene can be dissolved in various solvents including ethanol, ether, benzene, and toluene. The solubility of thiophene in water is very low (0.052 g/L at room temperature) and it is generally not recommended to dissolve it in water. To dissolve thiophene, it can be added to the solvent slowly with stirring and heating may also be necessary to increase solubility. It is important to handle thiophene with care as it is flammable and toxic.

Vahid Rakhshan

I apologize for any confusion my previous response may have caused. Let me clarify:

There is evidence that some synapses are stronger than others, and that synaptic strength can change over time through a process known as synaptic plasticity, which includes long-term potentiation (LTP) and long-term depression (LTD). These changes in synaptic strength are thought to be important for learning and memory.

However, it is not clear that any single axon-branch to dendrite mini-synapse involved in memory formation is larger or stronger than any other one in general. The strength of a synapse is determined by a variety of factors, including the amount of neurotransmitter released, the number and sensitivity of receptors on the postsynaptic membrane, and the properties of the presynaptic and postsynaptic neurons themselves. These factors can vary widely from synapse to synapse, even within the same neural circuit.

So, while there may be differences in synaptic strength between individual synapses, it is not accurate to say that any single synapse is always larger or stronger than any other one, or that the strength of a synapse is solely determined by its size. The idea of synaptic weighting and LTP/LTD remains an important and valid concept in the field of neuroscience.

On the other hand, I am also, among other things, a philosopher, a clinical psychologist and a theoretical physicist. I tend to look at commonly accepted definitions and paradigms from many different perspectives.

I worked as a neuroscientist for 2 years at the Medical University of Wrocław, I previously studied neuroscience at Duke University. I did not find answers to my questions. On the one hand, we are looking for something, while on the other hand, our accepted definitions and paradigms often lead us to contradictions.

What interests me are noumena (things in themselves). I look for them in everything, although they can be a difficulty in typically technical discussions. Nevertheless - I cannot believe in any theory, concept or description if I do not find assumptions deep enough in them. The foundations are often fragile.

Neuroscience is one of my favourite disciplines of knowledge, but I nevertheless think that its foundations are not clear enough. I think the same about theoretical physics.

Hence, I warn you that what I write may be risky at times, but I take part in this discussion because I myself very much want to understand and be able to reflect further.

This is the very difficult question.keep it

The type of memory you are describing is often referred to as highly superior autobiographical memory (HSAM) or hyperthymesia. Individuals with HSAM have the ability to recall detailed and specific information about events from their own life, as well as information from other domains, with exceptional accuracy and vividness. They often report that these memories come to mind involuntarily, without any conscious effort to retrieve them.

The inability to update or revise memories in individuals with HSAM may be related to the way their memories are stored and retrieved. Research suggests that individuals with HSAM have highly efficient and reliable retrieval processes, which allow them to access memories quickly and accurately. However, this efficiency may come at the cost of flexibility and updating, as memories may become so strongly encoded that they are resistant to change.

The causes and mechanisms underlying HSAM are not yet fully understood. Some research has suggested that HSAM may be related to differences in brain structure or function, such as increased connectivity between certain brain regions involved in memory processing. However, more research is needed to fully understand the underlying neural mechanisms of HSAM.

It's important to note that HSAM is a rare phenomenon, and not everyone with exceptional memory abilities has HSAM. While memory abilities can be enhanced through various techniques and strategies, the type of memory observed in individuals with HSAM appears to be a unique and innate ability.

I know a bit more about this from autopsy as well. I was also diagnosed with autism spectrum disorder as a child.

Am in line with Karl Pfeifer

A logotherapeutical approach for OCD is the paradoxical intention.

Vahid Rakhshan I will definitely spread the word about this amazing initiative. It's great to know that we can contribute to such a noble cause by simply utilizing our excess computer power. Thank you for bringing this opportunity to my attention. Let's join hands in making a difference in the fight against diseases.

Dear Geir Bjorklund, Duc M. Hoang, John Hildyard, thank you very much for your answers and recommendations!

Yes. Naturopathy and phytopharmacology, for example, make great sense, especially as balancing treatments and therapies.

Hello Prof SMJ Mortazavi

I agree with you and Dr Juan-Carlos López-Corbalán that anti-viral medications are often associated with resistance. That is the Law of Biology at work!

More importantly, I am concerned about the social impact. My experience is that many people seem to have the impression that now we have these anti-viral medications available that we will all be fine and there is nothing to worry about. I think this view is very false and misguided.

thank you very match

This question Tung Wah is old question. Hi index should be judged on scale of time, some like David L Morgan and Dean Whitehead suggest no citation is a waste of time. In this aspect like promotion etc it depends how the field |"like" you and if you have ``friends''. In fact, Michael W. Marek suggest that your promotion depends on this number. Yes, it is probably correct to a large extent. I would like to point what happen with time the real good ideas remain and rest is just a dust collection. For example Ohm (from Ohm law) was not cited. I believe there is no physics class today that does not mentioned Ohm law. I would agree that to have a paper that have such a breakthrough is not easy and more likely hard to judge. I believe such idea will even could encounter large resistance. For example, my advisor Eckert introduced dimensional analysis to heat and mass transfer. The critics suggest to burn his book. Even though he was part of the establishment as his advisor Schmidt was a prominent figure in the field. Let me brag a bit. I view my work more on the time scale, as my demonstration that the change of rotation location of ship render the whole work done until now in the field of ship stability as a waste of time. There is no citation on this point. I just notice that people coping my idea without citing it for example, Kostas J. Spyrou copy my stability dome after download my book. So there is effect but in time it will more pronounced.

In summary, in short terms it hi index is important, in the long time range it is not so important.

I think that the contribution of traditional medicinal systems (TCM, Ayurveda, European and American herbalism...) is quite underestimated in modern medicine.

Recently, a growing number of research studies is investigating the potential benefits of traditional remedies, including different physical therapies (acupuncture, massage, balneotherapy...) and medicinal herbs, as integrative treatment options for several diseases or as candidates for new drug development. In my opinion, it can be useful to study these treatments with an evidence-based approach in order to formulate specific clinical indications and ensure the best safety standards.

With regard to your topic, I assume you refer to North America (based on your affiliation) and I think that, before writing your literature review, you should take a look at this scoping review published in 2020:

This study can help you understand the state of the art and identify any significant gaps in knowledge, so that you can focus on what is actually needed to advance towards a full integration between modern and traditional medicine in North America.

If you need any methodological help to design a systematic literature review, do not hesitate to contact me.

Best wishes for your work and research.

Further readings:

Thermofisher Scientific has a virtual lab training option on cell culture. You can check here: https://www.thermofisher.com/bd/en/home/global/forms/cell-culture-basics.html

Hello Muhammad Habiburrahman

You should make sure that your research proposal in cancer is created meticulously, if you have to make it more appealing to prospective professors. The panel of experts should get convinced with regards to the significance of your research. The research proposal that you put forward should clearly project that you will be able to justify your research and that you will execute it as per the required standards.

In your introduction you should exemplify your problem which you will be attempting to resolve and emphasize its significance. You should prove to the panel of experts that you have a command on research in your field by providing them with an extensive review of existing literature. The research methodology should be chosen carefully, and you should justify why have you made such a choice so that the reader is convinced.

Effective management of time plays a crucial role, and therefore you should provide a realistic timeframe and the resources that you would require to complete your research. The research question should be very much clear to the panel of experts.

So, before you begin writing the PhD research proposal in cancer you need to have a detailed meeting with your guide to select the topic of research and the research methodology, both of which are of utmost importance. Plan your proposal and create a proper outline before you start writing. Extensive work must be done in reviewing the literature in your domain of research to understand the current gaps. This will help you to choose a unique topic, and you will not end up with a topic that has already being researched.

Good Luck!

I concur! There are some great answers here already, many pertaining to the theme of context. You may like to consider learning outcomes, assessment strategy, educational goals, teaching and learning resources availability, student characteristics, and educator skill set before identifying a pedagogical approach.

Active learning i.e learning by doing has been shown to have high learning efficacy e.g. constructivist, inquiry-based learning approaches, and collaborative learning. These approaches can support students to develop holistically, learning key concepts, hard knowledge, and soft skills needed for future employment opportunities.

Digital tools open new ways for educators to develop pedagogical approaches e.g smart pedagogy, technology enabled learning (TEL). Technology doesn't have all of the answers, but it can be effective when it is utilised within a sound pedagogical framework.

Science isn't what is used to be. Biomedical science is for sale in a neoliberal market, and big pharma knows very well how to handle it. Look at the Corona vaccin: more politics than health care for humans. It has the most powerful lobby and the largest profit margins of any businessmodel

Регрессия по 4 точкам? Если Вам необходимо найти оптимальную дозу лекарства, то сначала, на мой взгляд, стоит убедится в том, есть ли у этого лекарства эффективность большая, чем у плацебо. Мне, к сожалению, не совсем понятно, в контрольной группе в Вашем исследовании пациенты принимали плацебо или нет. А в остальном, зная численность групп, если они были взяты из однородной генеральной совокупности, конечно, можно дать ответ, есть ли статистически значимые отличия между средними в группах или этих отличий не имеется. С Уважением.

You could be addressed to the lemma Ag-Nanoparticle in the World Wide Web.

I am not a researcher, but dealing with policy formulation and strategy design in the context of digital transformation of health systems. Among what I have observed almost consistently over time, there is a lot of naivety: on site of technocrats as it concerns the complexity and "maturity" of the health care delivery system, on side of health professionals the expectation, technology would fix their problems ..., compounded by a lack of patience of politicians, policy makers and the industry.

Understanding 'maturity' of health systems for applying digital technologies is a key factor for designing systems that work. See for example:

The observational study whether cross sectional , prospective .Also retrospective study will help , it depends what type of error .Using trigger tool for specific errors can help too

P.S. Artificial Intelligence can only start from what is well known and identified.

In literature and most population based survey, no correlation between intraocular pressure and computer use has been reported neither has it been established that there is increased risk of intraocular pressure elevation with use of computer. However, more study is needed to prove or dispute this claim.

Best wishes

Dear Mozhgan Norouzi, thank you very much for your reply!

Once Daily (OD) or 24 hourly, both can be written.

Dear @Muneeb Faiq , if the goal of medicine is to solve longstanding problems in the field just as the goal of physicists such as Max Planck was the solution of problems which Einstein's theoretical papers of 1905 helped them solve, then no special journal is required for the field that solves such problems.

Annalen Physik, the journal that published Einstein's 1905 papers was not a journal dedicated to publishing theoretical papers. So every journal of medicine should publish theoretical papers which will move medicine forward.

We should not refer to a field of medicine which does not yet have any experimental basis as theoretical medicine. It is medicine that lacks experimental basis without such medicine that is the equivalent of the theoretical physics of Einstein, which is the only one that can be justifiably referred to as theoretical medicine. After all, it is this theoretical medicine that has the capacity to give experimental basis to concepts such as "disease" and "immunity" on which the premises that are basic to experimentation in medicine rest.

Such is the importance of theoretical medicine.

This is an excellent detailed and practical article which demonstrates the importance of Artificial Intelligence in the crucial field of diagnostics:

https://sitn.hms.harvard.edu/flash/2019/artificial-intelligence-in-medicine-applications-implications-and-limitations/

Best regards and good wishes!

Have a look at this useful RG link for insights.

Dear colleagues, thank you very much for your initiative. I will distribute your call in my network. It might be a good idea to use the Netzwerk Technikfolgenabschätzung to reach out to more experts. Best regards Karsten Weber

Dear Vladimir M Moskovkin . See the following useful link: https://www.jica.go.jp/jica-ri/IFIC_and_JBICI-Studies/english/publications/reports/study/topical/approaches/pdf/higher_02.pdf

Hemorrhagic fever with renal syndrome is a non- transmissible viral zoonosis widespread in Russia. It is considered one of the most important natural focal diseases. We examined leptospirosis and tularemia as climate-dependent diseases of bacterial etiology. Leptospirosis is transmitted only non-transmissively, while tularemia, in addition to a number of non-transmissible pathways, is characterized by a facultative- transmissible pathway, and arthropods, primarily blood- sucking dipterans, act as mechanical carriers.

Among the transmissible natural focal diseases of various etiologies, we examined tick-borne encephalitis, ixodid mites-borne borreliosis (Lyme disease), mites- borne typhus (mites-borne rickettsiosis), and Crimean hemorrhagic fever.

West Nile fever is one of the most important natural focal diseases transmitted by mosquitoes. The most unfavorable situation was observed in Astrakhan, Volgograd, and Rostov regions. They account for the vast majority of cases of the disease.

A classic example of anthroponosis is malaria. The epidemiological situation at the present time can be considered favorable given that the number of imported cases is small (about a hundred per year) and local cases are rare. However, malaria is also a classic example of a disease that can quickly regain its position when control is loosened.

Model analysis of changes in the distribution of Ixodidae

mites and malaria mosquitoes showed that their habitats were influenced by the observed climate change which is significantly expanding in the northern and eastern regions, and the reduction is negligible.

The prerequisites for an increase in the incidence of these infections and their wider spread persist.

Climate-related risk factors include expansion of the areas of arthropod vectors and an increase in their numbers, as well as a similar increase in the number and expansion of the areas of vertebrates, mainly murine rodents, which are reservoirs of natural focal infections and carriers of vectors in nature. A new risk factor is the importation of exotic vectors into the territory of Russia, as well as their rooting, the importance of which increases with the expected warming.

Countermeasures (adaptation measures) against climate-dependent infections include prevention (vaccination), strengthening monitoring of the species composition and number of vectors and reservoirs of infections, and increasing the scale and effectiveness of combating them. These measures also include personal protective equipment against them. The enhancement of the effectiveness of these measures should be based not only on the actual improvement of these funds but also on the improvement of the sanitary and epidemiological

Ahmed Bakr, I can’t really comment, but it sounds reasonable! You could also classify them as “weaker” and “stronger”, implying that these are relative rather than absolute. Sometimes we get caught up in the statistics… try picking out one of the weak ones and try to understand what is going on in the real world, not from a statistical perspective - what is correlated with what, and what sorts of influences (in real life) might be weakening the relationship?

Best !!

AN

interested

Re: anxiety as a side effect of bicalutamide

THIS IS FROM WIKIPEDIA [paraphrased and abbreviated]: Side effects due to androgen deprivation include mild-to-moderate breast tenderness and enlargement in up to 80% of men, along with feminisation. Reduced body hair and muscle mass, feminine fat distribution, reduced penile length, and decreased semen volume can occur, along with hot flashes, sexual dysfunction, depression, fatigue, weakness and anemia. Bicalutamide monotherapy has also been associated with an increase in the rate of heart failure.

MY OPINION: in view of this side effect profile, depression, anxiety and id-percieved stress, in a percentage of subjects, is to be expected.

Stress-related intracellular hypothyroidism (IC), producing CFS-like symptoms including anxiety, confusion and cognitive loss, will result.

Incidentally, cardiomyopathy resulting from IC is the probable cause of the heart failure mentioned in the Wikipedia article.

I advise you to just be patient and be at rest since the decision is still in progress on your manuscript, it might end up in your favor

Dear colleagues, how is it possible to protect neurons, oligodendrocytes, any cell against injurious agencies that are poorly known, or if relevant evidence is not paid attention to, as shown at www.ms-info.net and in similar publications?

I think that the best way is keep the house especially the room of the patients clean and healthy. Not dusty, full of ash, smoke residu, spider web, bad humidity, and other poluttants. Sun light and fresh air are also very important.

Housework is important to help this kind of case.

Healthy plant-based foods may lower risk and severity of COVID-19.

Thank you

Till upto OmicronBA.1-BA1.1- B.A.2 variant -https://nature.us17.list-manage.com/track/click?u=2c6057c528fdc6f73fa196d9d&id=1400a357d2&e=5944515236.

Besides the ethics, this case report can be controlled and criticized by others officially, in order to be approved.

Nalidixic acid - A NSAID grs of drugs or pain killer .REF : en.wikipedia.org ( Image Source ) .

I personally believe that imaging examinations in covid should be rapid, simple and executable at the patient's bedside and therefore I believe that the most useful is LUS.

Unfortunately still today is used the chest X-ray that has been proven useless.

The purpose of LUS is to stage the pathology in order to predict its evolution, unfavorable or favorable. With LUS and blood gas analysis we can determine which patients should be discharged at home in a period when bed meals are scarce in all hospitals.

Dear Hamidreza Khalounejad , there are various types of modalities that can be beneficial for persons with MS.

I have explained all types with detailed information such as volume, repetitions, exercise selection, etc particularly during COVID-19 in my latest article, which you can find it here:

Dear Dr Sunny Chi Lik Au . See the following useful RG link:

Dear Eleas,

If I understand correctly your question is with respect to the chemical reactivity of an NCE for its target.

Most commonly high chemical reactivity is not seen as an advantage. First the molecule needs sufficient stability for shelf life, limit impurities... Then reactivity may lead to safety issues if this leads to reaction with proteins other than your intended target. A variation on this theme is also formation of reactive metabolites that can cause liver toxicity; this is linked to the original molecule having reactive features or groups that are made reactive when oxidized (oxygenated).

However, reactivity towards the intended target can be very effective for inhibition from covalent binding. This can for example allow to decuple PK and PD (prolonged PD depending on target turn-over). For this to be effective it needs to be specific: reactive "warhead" reacts only with the intended target when molecule specifically bound and not with relevant off-targets. An example of this you can read about is remibrutinib.